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Author : Fritz Melchers
Publisher :
ISBN 13 : 9783907946640
Total Pages : 450 pages
Book Rating : 4.9/5 (466 download)
Download or read book Mechanisms of B Cell Neoplasia 1991 written by Fritz Melchers and published by . This book was released on 1991 with total page 450 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Michael Potter
Publisher : Springer Science & Business Media
ISBN 13 : 3642792758
Total Pages : 453 pages
Book Rating : 4.6/5 (427 download)
Download or read book Mechanisms in B-Cell Neoplasia 1994 written by Michael Potter and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 453 pages. Available in PDF, EPUB and Kindle. Book excerpt: The 12th Workshop on "Mechanisms in B-Cell Neoplasia" continues this series of meetings on intriguing new developments in human and experimental B-cell tumors. The integration of knowledge from basic B-cell biology to the clinical problems of multiple myelomas, follicular lymphoma, mantle cell lymphoma and B-CLL present the challenges that were discussed in the meeting. The discussion focusses on: - Cellular components of the "myeloma clone" - Genomic instability in B-cells and B-cell tumors - The CD5 antigen and B1 cells - Regulation of cell cycle and apoptosis - Role of IL-6, BCL-2, BCL-1, myc in B-cell development.
Author : Michael Potter
Publisher : Springer Science & Business Media
ISBN 13 : 3642758894
Total Pages : 371 pages
Book Rating : 4.6/5 (427 download)
Download or read book Mechanisms in B-Cell Neoplasia 1990 written by Michael Potter and published by Springer Science & Business Media. This book was released on 2013-03-12 with total page 371 pages. Available in PDF, EPUB and Kindle. Book excerpt: The eighth workshop in this series on Mechanisms in B-Cell Neoplasia 1990 was held in Wilson Hall at the National Institutes of Health, Bethesda, Maryland on March 28-30. Five major topics formed the basis for the discussions: 1) progress in experimental models of B-cell tumorigenesis, 2) the role of IL-6 in plasma cell tumor formation with particular emphasis on human myeloma, 3) immortaliza tion and regulation of mitosis in B-cells, 4) the mYQ gene in B-cell neoplasia, and 5) the role of EBV and other oncogenes in transforma tion of human B-Iymphocytes. A meeting on the Epidemiology of Myeloma was held at the N. I. H. on the preceding day, and many of those interested in the clinical aspects of myeloma were also participants at the workshop. Experimental Models of B-Cell Tumor Development We have seen in the last eight years the steady growth of model experimental systems, many of which have been designed to be counter parts of the major forms of human B cell tumors, e. g. , follicular lymphomas, Burkitt's lymphomas, acute B-cell leukemia and multiple myeloma. A variety of novel ways of inducing these tumors has been described. Advantage has been taken of the "experiments in nature" to identify critical genes that playa role in tumor pathogenesis. These genes have been identified by being near to viral insertion and chromosomal translocation sites, or by having been incorporated or transduced into a defective transforming retrovirus.
Author : Michael Potter
Publisher : Springer
ISBN 13 :
Total Pages : 412 pages
Book Rating : 4.F/5 ( download)
Download or read book Mechanisms in B-cell Neoplasia 1990 written by Michael Potter and published by Springer. This book was released on 1990 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Michael Potter
Publisher : Springer Science & Business Media
ISBN 13 : 3642740065
Total Pages : 349 pages
Book Rating : 4.6/5 (427 download)
Download or read book Mechanisms in B-Cell Neoplasia 1988 written by Michael Potter and published by Springer Science & Business Media. This book was released on 2013-03-07 with total page 349 pages. Available in PDF, EPUB and Kindle. Book excerpt: The papers in this book were presented at the 6th Workshop on Mechanisms in B-Cell Neoplasia, held in Bethesda, March 23-25, 1988. On alternate years this meeting is sponsored by the . ;. Basel Institute of Immunology in Basel, Switzerland and by the National Cancer Institute in Bethesda, and is attended by 100 to 150 parti cipants. This 6th workshop, like the preceding five, was characterized by intense and enthusiastic discussion which reflects, we think, the exciting growth and development of this field. It is quite clear, however, that despite many general advances an understanding of the precise underlying mechanisms in B-cell tumor development is not yet defined. Probably, there is no single mechanism for all the various forms of B-cell neo plastic development. Many different forms of B-cell neoplasms are known, and these are distinguished by several characteristics: 1) the stage of development attained by the tumor stem cells; 2) mode of growth (slow or fast); 3) association with natural or inductive etiologic agents and 4) specific and consistent mutational mechanisms such as retroviral insertion, chromosomal rearrangement. Those charac teristic forms which arise naturally in relatively high frequency or those tumors with hallmark properties which can be induced consistently are the models most frequently studied, e. g. , endemic Burkitt's lymphoma, follicular lymphoma, acute and chronic lymphocytic leukemia and mUltiple myeloma in man; bursal lymphoma in chickens; Abelson virus induced pre B cell lymphomas and plasmacytomas in mice and immunocytomas in rats. Each model system, has special problems and advantages.
Author : Fritz Melchers
Publisher : Springer Science & Business Media
ISBN 13 : 3642601626
Total Pages : 409 pages
Book Rating : 4.6/5 (426 download)
Download or read book Mechanisms of B Cell Neoplasia 1998 written by Fritz Melchers and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 409 pages. Available in PDF, EPUB and Kindle. Book excerpt: Workshops on the mechanisms of B cell neoplasia have been organized alternatively in Bethesda and Basel since 1983. Prog ress in our understanding of the development and responses of B lymphocytes is presented and discussed with the aim and hope to understand what might go wrong when B lymphocytes are transformed into malignant cells. Such knowledge might lead to better diagnosis, prevention and even cure of these terri ble diseases. The presentations at the Bethesda workshops are published as papers in volumes of Current Topics in Microbiol ogy and Immunology, while the presentations and discussions in Basel were transcribed and published in Editions Roche. For the first time, a Basel workshop (held 4th-6th October 1998) that has been recorded and, in part, transcribed is being published as papers and discussions within Current Topics. This volume is the latest of a long series which documents the excitements of ground-breaking discoveries as well as the frustrations of our inability to fully understand the mechanisms leading to B cell neoplasia. The papers at the workshop are presented when possible in the sequence in which they were given. However, to facilitate the organization and reading of the book and to highlight gen eral topics and themes, the papers are organized into five sec tions: I B Cell and Plasma Cell Development II Chemokines and Chemokine Receptors III Chromosomal Translocations, DNA Rearrangements and Somatic Hypermutations IV Biology of Lymphomagenesis, B-CLL, Autoimmunity V Myeloma, Plasmacytomas and Related Subjects.
Author : Michael Potter
Publisher : Springer Science & Business Media
ISBN 13 : 3642776337
Total Pages : 484 pages
Book Rating : 4.6/5 (427 download)
Download or read book Mechanisms in B-Cell Neoplasia 1992 written by Michael Potter and published by Springer Science & Business Media. This book was released on 2013-03-08 with total page 484 pages. Available in PDF, EPUB and Kindle. Book excerpt: Main topics covered: B-Cell Development; Immunoglobulin Gene Rearrangement; Multiple Myeloma, Plasmactomas; Lymphomas: B-CLL, Folli- cular Lymphomas BCL-2, BCL-1; Lymphomas: EBV, AIDS Associa- ted Lymphomas; Oncogenes and Transcriptional Factors (text to follow)
Author : Fritz Melchers
Publisher :
ISBN 13 :
Total Pages : 396 pages
Book Rating : 4.F/5 ( download)
Download or read book Mechanisms in B-cell Neoplasia written by Fritz Melchers and published by . This book was released on 1986 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Michael Potter
Publisher :
ISBN 13 :
Total Pages : 340 pages
Book Rating : 4.:/5 (154 download)
Download or read book Mechanisms in B-cell Neoplasia 1988 written by Michael Potter and published by . This book was released on 1984 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Institüt für Immunologie (Basilea).
Publisher :
ISBN 13 :
Total Pages : 394 pages
Book Rating : 4.:/5 (112 download)
Download or read book Mechanisms in B-cell Neoplasia written by Institüt für Immunologie (Basilea). and published by . This book was released on 1983 with total page 394 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Michael Potter
Publisher :
ISBN 13 :
Total Pages : 340 pages
Book Rating : 4.:/5 (658 download)
Download or read book Mechanisms in B-cell Neoplasia, 1988 written by Michael Potter and published by . This book was released on 1988 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Melchers
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (11 download)
Download or read book Mechanisms of B Cell Neoplasia 1998 written by Melchers and published by . This book was released on 1999 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Tomohiro Kurosaki
Publisher : Springer
ISBN 13 : 3319261339
Total Pages : 231 pages
Book Rating : 4.3/5 (192 download)
Download or read book B Cell Receptor Signaling written by Tomohiro Kurosaki and published by Springer. This book was released on 2015-12-26 with total page 231 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume details our current understanding of the architecture and signaling capabilities of the B cell antigen receptor (BCR) in health and disease. The first chapters review new insights into the assembly of BCR components and their organization on the cell surface. Subsequent contributions focus on the molecular interactions that connect the BCR with major intracellular signaling pathways such as Ca2+ mobilization, membrane phospholipid metabolism, nuclear translocation of NF-kB or the activation of Bruton’s Tyrosine Kinase and MAP kinases. These elements orchestrate cytoplasmic and nuclear responses as well as cytoskeleton dynamics for antigen internalization. Furthermore, a key mechanism of how B cells remember their cognate antigen is discussed in detail. Altogether, the discoveries presented provide a better understanding of B cell biology and help to explain some B cell-mediated pathogenicities, like autoimmune phenomena or the formation of B cell tumors, while also paving the way for eventually combating these diseases.
Author : Anna Porwit
Publisher : Cambridge University Press
ISBN 13 : 1108548830
Total Pages : 248 pages
Book Rating : 4.1/5 (85 download)
Download or read book Multiparameter Flow Cytometry in the Diagnosis of Hematologic Malignancies written by Anna Porwit and published by Cambridge University Press. This book was released on 2018-01-25 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: Master implementation of the techniques of flow cytometry in diagnosing complex haematological diseases and malignancies in patients, worldwide. Featuring World Health Organization recommendations on pre-analytical steps, instrument settings and panel construction, this invaluable manual offers invaluable support for those researching, practising and analyzing the cause of hematological malignancies. Authored by leading experts, this book puts flow-cytometry into everyday context. With a focus on multicolour panels, the manual provides readers an experienced understanding of effective, implementation techniques. Practitioners of all levels are offered a background in a variety of diseases presented alongside the most current methodology. Wide-ranging and comprehensive; detailed images of healthy blood, bone marrow and lymph-nodes are illustrated throughout, allowing for effective diagnosis. Through engaging with differential diagnoses, the manual offers an understanding of similar symptoms and mimicking malignancies, avoiding inaccurate results. Featuring in-depth descriptions of chronic diseases; users can reach accurate diagnosis, first time.
Author : Margarita Guenova
Publisher : BoD – Books on Demand
ISBN 13 : 178923350X
Total Pages : 212 pages
Book Rating : 4.7/5 (892 download)
Download or read book Hematology written by Margarita Guenova and published by BoD – Books on Demand. This book was released on 2018-06-27 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hematology has constantly been advancing in parallel with technological developments that have expanded our understanding of the phenotypic, genetic, and molecular complexity and extreme clinical and biological heterogeneity of blood diseases. This has in turn allowed for developing more effective and less toxic alternative therapeutic approaches directed against critical molecular pathways. The continuous and rather extensive influx of new information regarding the key features and underlying mechanisms as well as treatment options in hematology requires a frequent update of this topic. The primary objective of this book is to provide the specialists involved in the clinical management and experimental research in hematological diseases with comprehensive and concise information on some important theoretical and practical developments in the biology, clinical assessment, and treatment of patients, as well as on some molecular and pathogenetic mechanisms and the respective translation into novel therapies.
Author : Michael Potter
Publisher : Springer Science & Business Media
ISBN 13 : 3642608019
Total Pages : 288 pages
Book Rating : 4.6/5 (426 download)
Download or read book C-Myc in B-Cell Neoplasia written by Michael Potter and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: The papers in this book were presented at the 14th Mechanisms in B-cell Neoplasia meeting that was held in Bethesda, Maryland October 21-23, 1996. In 1995 the organizers decided that the format of the meeting would be changed and that specific topics relevant to B-cell neoplasia would be discussed. This year's topic is on the c-myc oncogene in B-cell neoplasia which has been discussed in virtually every previous meeting. Some of the presentations announced for the first time dramatic advances in our understanding of c-myc and because this subject has become highly complex it was thought that devoting the whole meeting to this theme would be appropriate. The book, therefore, repre sents a review of many aspects of the myc problem but by no means is truly comprehensive. In a recent Medline search there were 8,505 references to myc, fully illustrating the magnitude of the interest and depth of this field. The organizers of the meeting have each contributed review chapters that summarize different aspects of the meeting. We thank the National Cancer Institute for sponsoring this workshop and the staff of Cygnus, Inc. , for their outstanding organizational assistance. The organizers are most grateful to Vickie Rogers for assembling the book and dealing with the edi torialization of the manuscripts. MICHAEL POlTER FRITZ MELCHERS Table of Contents M. POlTER and K. B. MARCU The c-myc Story: Where We've Been, Where We Seem to be Going. With 2 Figures . . . . . . . . . . . . . . . . . . . . . . . . I F.
Author : David Gray
Publisher : Springer Science & Business Media
ISBN 13 : 3642752446
Total Pages : 147 pages
Book Rating : 4.6/5 (427 download)
Download or read book Immunological Memory written by David Gray and published by Springer Science & Business Media. This book was released on 2013-03-07 with total page 147 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although immunologists know rather a lot about the manif estation of immunological memory, an understanding of the mechanism of memory at cellular and biochemical levels eludes us. Indeed, as we shall see, it is not even clear which of the several models used to explain the working of memory approximates to the truth. It is in order to report on approaches to this problem and on recent experimental advances in the field of memory cells that this volume has been put together. In the past 4-5 years cell surface molecules that may enable us to define memory Band T cells have been identified. It may now be possible to ask how memory cells are generated and to define what signals are required during or after antigenic encounter for a cell to enter the memory cell pool rather than to terminally differentiate into an effector cell. The transition from virgin cell to memory cell is clearly accompanied by several biochemical changes. For B cells, isotype switching and somatic mutations (leading to affinity maturation) are well-defined phenomena, although the molecular mechanisms remain mys terious. Both have received attention in many excellent reviews of late and so are not considered in detail in this book. Neither switching nor somatic mutation is a feature of peripheral T-cell maturation; biochemical differences between virgin and mem ory T cells may only relate to differing activation requirements and possibly changes in the expression of accessory molecules.
