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Author : Robert C. Brown
Publisher :
ISBN 13 : 9780303440918
Total Pages : 589 pages
Book Rating : 4.4/5 (49 download)
Download or read book Mechanisms in Fibre Carcinogenesis written by Robert C. Brown and published by . This book was released on 1991 with total page 589 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : A. B. Kane
Publisher :
ISBN 13 :
Total Pages : 164 pages
Book Rating : 4.:/5 (318 download)
Download or read book Mechanisms of Fibre Carcinogenesis written by A. B. Kane and published by . This book was released on 1996 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt: The result of a meeting held at IARC early in 1996, this volume provides a thorough and up-to-date synthesis of the mechanisms of fibre carcinogenesis. A consensus document assesses the strengths, weaknesses and gaps in the data concerning fibre characterization and genotoxicity, fibre-related cell proliferation and activation, gene expression, animal models, mixed dust exposure and interactions with other carcinogens. The relevance of mechanistic data from in vitro and in vivo assays to the evaluation of fibre carcinogenicity are also discussed. Authored review papers, also published in this volume, provide the background material for much of the discussion.
Author : Robert A. Baan
Publisher : International Agency for Research on Cancer
ISBN 13 : 9789283222170
Total Pages : 0 pages
Book Rating : 4.2/5 (221 download)
Download or read book Tumour Site Concordance and Mechanisms of Carcinogenesis written by Robert A. Baan and published by International Agency for Research on Cancer. This book was released on 2019-05-22 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Scientific Publication reviews the information on cancer sites and mechanistic events for the more than 100 agents classified in Group 1 (carcinogenic to humans) by the IARC Monographs Program. This category of agents is diverse and includes chemicals and chemical mixtures; occupations; metals, dusts, and fibres; radiation; viruses and other biological agents; personal habits; and pharmaceuticals. For the Group 1 agents, there were cross-cutting questions about the relevance to humans of certain cancer sites or mechanistic pathways in animals. This publication is based on a systematic identification and comparison of the cancer sites observed in humans and those observed in experimental animals, and a compilation of mechanistic events for agents known to cause cancer in humans. Relevant information was analyzed on all the agents classified in Group 1 in Monographs up to and including Volume 109, most of which are reviewed in Volume 100A-F. A database of tumor sites seen in humans and animals was used to examine the degree of concordance by use of an anatomically based tumor classification scheme. The analysis of mechanistic aspects of the IARC Group 1 agents focused on 10 key characteristics of human carcinogens developed during the course of this work. Genotoxicity was the most prevalent mechanistic characteristic, consistent with the process of carcinogenesis necessarily involving genomic changes. The IARC concordance database represents a useful source of information for comparing animal and human data with respect to the tumors caused in different species. The results of the mechanistic analysis can provide a basis for future efforts to categorize mechanistic data for carcinogens through a systematic review process. These reviews and analyses were discussed during a two-part Workshop on Tumour Site Concordance and Mechanisms of Carcinogenesis convened by IARC. This Scientific Publication is the report of that Workshop and of subsequent work by the participants, both individually and collectively. This publication also presents a statement of consensus among the Workshop participants, which summarizes the main findings and their implications for human cancer risk assessment.
Author : Robert C. Brown
Publisher : Springer Science & Business Media
ISBN 13 : 1468413635
Total Pages : 564 pages
Book Rating : 4.4/5 (684 download)
Download or read book Mechanisms in Fibre Carcinogenesis written by Robert C. Brown and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 564 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Editors are sorry that the production of this volume was delayed by the ill health of one of them and we hope that this does not detract from the value of the con tents. For once this delay is not the fault of any of the authors only the editors are to blame. Many of the workers in the field of fibre toxicology became convinced by the middle 1980's that the worst of the furore over asbestos was over although we were left with an intriguing problem - how does asbestos cause disease? It was expected that the future impact of fibres on human health would be very small since asbestos exposure would be controlled and there was little chance that man-made fibres would prove haz ardous. These man-made fibres are much thicker than asbestos and, in most cases, they are less durable in the body. Both of these properties are believed to make them much less likely to cause disease. However many of us had fallen into the habit of calling these materials "asbestos substitutes" and thus they have acquired a little of the notoriety at tached to the natural fibrous minerals. Very few of these man-made fibres are actually used as replacements for asbestos. Asbestos was not suitable for the uses to which the insulation wools are usually put and the ceramic fibres are replacements for fire brick not asbestos which is destroyed at the temperatures at which these materials are used.
Author : Giorgio Bronzetti
Publisher : Springer
ISBN 13 : 9781461362999
Total Pages : 0 pages
Book Rating : 4.3/5 (629 download)
Download or read book Antimutagenesis and Anticarcinogenesis Mechanisms III written by Giorgio Bronzetti and published by Springer. This book was released on 2012-11-02 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lifestyle, in any part of the world, is associated with the occurrence of major chronic diseases, including coronary heart disease, hypertension, and stroke; many distinct types of cancer; and adult onset diabetes (11,22,70,75). One important element of lifestyle is tobacco use, which appreciably increases the risk of a number of chronic diseases (21). Other lifestyle factors relate to nutritional traditions, alcohol use, and exercise (11,30,58,60,70,71). The underlying evidence is, in part, based on the evidence of specific diseases in relation to dietary habits in a given geographic region, as well as changes in such disease occurrences in migrant populations from a low risk to a high risk area, and vice versa (25,42). Populations that customarily consume fruits and vegetables and also whole grain cereal products generally have a lower risk of cardiovascular diseases and specific types of cancer than populations with a lower intake of such foods, everything else being equal (63). In the last few years, research has provided mechanistic explanations as to the reasons for the protective effects of specific foods. This paper will emphasize the mechanisms whereby cancer risks are reduced by dietary modification.
Author : A. B. Kane
Publisher : International Agency for Research on Cancer (I A R C)
ISBN 13 : 9789283221401
Total Pages : 166 pages
Book Rating : 4.2/5 (214 download)
Download or read book Mechanisms of Fibre Carcinogenesis written by A. B. Kane and published by International Agency for Research on Cancer (I A R C). This book was released on 1996 with total page 166 pages. Available in PDF, EPUB and Kindle. Book excerpt: The result of a meeting held at IARC early in 1996, this volume provides a thorough and up-to-date synthesis of the mechanisms of fibre carcinogenesis. A consensus document assesses the strengths, weaknesses and gaps in the data concerning fibre characterization and genotoxicity, fibre-related cell proliferation and activation, gene expression, animal models, mixed dust exposure and interactions with other carcinogens. The relevance of mechanistic data fromin vitroandin vivoassays to the evaluation of fibre carcinogenicity are also discussed. Authored review papers, also published in this volume, provide the background material for much of the discussion.
Author : Yin-Tak Woo
Publisher : Academic Press
ISBN 13 : 1483216020
Total Pages : 895 pages
Book Rating : 4.4/5 (832 download)
Download or read book Natural, Metal, Fiber, and Macromolecular Carcinogens written by Yin-Tak Woo and published by Academic Press. This book was released on 2013-10-22 with total page 895 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemical Induction of Cancer: Structural Bases and Biological Mechanisms, Volume IIIC: Natural, Metal, Fiber, and Macromolecular Carcinogens covers structure-carcinogenicity relationships of carcinogenic mycotoxins, carcinogenic substances generated by plants, carcinogenic metals and metalloids, and foreign-body carcinogens. The book discusses the metabolism and mechanism of carcinogenic action, physicochemical properties, other biological activities (principally mutagenicity and teratogenicity), modification of carcinogenic activity, formation and environmental significance. The text also describes the carcinogenic water-soluble high polymers and explores the intriguing problems of the carcinogenic effect of osmotic imbalance in tissue microenvironment, as well as of spontaneous malignant transformation occurring in cell cultures in vitro. Studies on tumor induction and carcinogenesis modification by nonviral nucleic acids, by nucleases, proteases, histones, and by antigenic stimulation as well as by antibodies are also considered. The book further tackles tumor-released factors as possible modifiers of carcinogenesis. The text will prove invaluable to chemists and people involved in cancer research.
Author : Elizabeth K. Weisburger
Publisher : Springer Science & Business Media
ISBN 13 : 9400925263
Total Pages : 210 pages
Book Rating : 4.4/5 (9 download)
Download or read book Mechanisms of Carcinogenesis written by Elizabeth K. Weisburger and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt: but also the possibility of intervention in specific stages. In Human behavior, including stress and other factors, plays an important role in neoplasia, although too little is known addition, variables which affect cancer development as well on the reasons for such development. Carcinogens, which as some endogenous factors can be better delineated help initiate the neoplastic process, may be either synthetic through such investigations. The topics of this volume encompass premalignant non or naturally-occurring. Cancer causation may be ascribed to invasive lesions, species-specific aspects of carcinogenicity, certain chemicals, physical agents, radioactive materials, viruses, parasites, the genetic make-up of the organism, and radiation, viruses, a quantum theory of carinogenesis, onco bacteria. Humans, eumetazoan animals and vascular plants genes, and selected environmental carcinogens. are susceptible to the first six groups of cancer causes, whe reas the last group, bacteria, seems to affect only vascular plants. Neoplastic development may begin with impairment ofJmdy defenses by a toxic material (carcinogen) which acts as an initiator, followed by promotion and progression to an overt neoplastic state. Investigation of these processes Series Editor Volume Editor allows not only a better insight into the mechanism of action Hans E. Kaiser Elizabeth K. Weisburger vii ACKNOWLEDGEMENT Inspiration and encouragement for this wide ranging project on cancer distribution and dissemination from a comparative biological and clinical point of view, was given by my late friend E. H. Krokowski.
Author : Patricia A. Buffler
Publisher : IARC Scientific Publications
ISBN 13 :
Total Pages : 464 pages
Book Rating : 4.:/5 (318 download)
Download or read book Mechanisms of Carcinogenesis written by Patricia A. Buffler and published by IARC Scientific Publications. This book was released on 2004 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the last two decades, molecular epidemiology has become an important discipline in cancer research. It has evolved towards the development, validation and application of markers of susceptibility and, more recently, markers of mechanisms of cancer development. This volume on mechanisms of carcinogenesis covers from an interdisciplinary perspective, the contribution of molecular epidemiology to the understanding of mechanisms of carcinogenesis, and represents a further contribution to the development of molecular epidemiology as a major cancer research domain.
Author : IARC Working Group on the Evaluation of Carcinogenic Risks to Humans
Publisher : World Health Organization
ISBN 13 : 9283212819
Total Pages : 434 pages
Book Rating : 4.2/5 (832 download)
Download or read book Man-made Vitreous Fibres written by IARC Working Group on the Evaluation of Carcinogenic Risks to Humans and published by World Health Organization. This book was released on 2002 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt: "This publication represents the views and expert opinions of an IARC working group on the evaluation of carcinogenic risks to humans, which met in Lyon, 9-16 October 2001."
Author : National Research Council
Publisher : Legare Street Press
ISBN 13 : 9781015698871
Total Pages : 0 pages
Book Rating : 4.6/5 (988 download)
Download or read book Diet Nutrition And Cancer written by National Research Council and published by Legare Street Press. This book was released on 2022-10-27 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work is in the "public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.
Author :
Publisher :
ISBN 13 :
Total Pages : 728 pages
Book Rating : 4.:/5 (318 download)
Download or read book How Tobacco Smoke Causes Disease written by and published by . This book was released on 2010 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
Author : J H Duffus
Publisher : Woodhead Publishing
ISBN 13 : 1782424415
Total Pages : 296 pages
Book Rating : 4.7/5 (824 download)
Download or read book Carcinogenicity of Inorganic Substances written by J H Duffus and published by Woodhead Publishing. This book was released on 2014-01-31 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: Focuses on the state of scientific knowledge about the carcinogenicity of metals, their compounds and other inorganic substances. It provides a valuable guide for chemists involved in risk assessment, health and safety and toxicology.
Author : Robert C. Brown
Publisher : Springer
ISBN 13 : 9781468413656
Total Pages : 608 pages
Book Rating : 4.4/5 (136 download)
Download or read book Mechanisms in Fibre Carcinogenesis written by Robert C. Brown and published by Springer. This book was released on 2012-02-22 with total page 608 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Editors are sorry that the production of this volume was delayed by the ill health of one of them and we hope that this does not detract from the value of the con tents. For once this delay is not the fault of any of the authors only the editors are to blame. Many of the workers in the field of fibre toxicology became convinced by the middle 1980's that the worst of the furore over asbestos was over although we were left with an intriguing problem - how does asbestos cause disease? It was expected that the future impact of fibres on human health would be very small since asbestos exposure would be controlled and there was little chance that man-made fibres would prove haz ardous. These man-made fibres are much thicker than asbestos and, in most cases, they are less durable in the body. Both of these properties are believed to make them much less likely to cause disease. However many of us had fallen into the habit of calling these materials "asbestos substitutes" and thus they have acquired a little of the notoriety at tached to the natural fibrous minerals. Very few of these man-made fibres are actually used as replacements for asbestos. Asbestos was not suitable for the uses to which the insulation wools are usually put and the ceramic fibres are replacements for fire brick not asbestos which is destroyed at the temperatures at which these materials are used.
Author : Joseph C. Arcos
Publisher :
ISBN 13 : 9780120593538
Total Pages : 869 pages
Book Rating : 4.5/5 (935 download)
Download or read book Chemical Induction of Cancer written by Joseph C. Arcos and published by . This book was released on 1968 with total page 869 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Lewis L. Smith
Publisher : CRC Press
ISBN 13 : 100000600X
Total Pages : 235 pages
Book Rating : 4.0/5 ( download)
Download or read book Molecular and Cellular Mechanisms of Toxicity written by Lewis L. Smith and published by CRC Press. This book was released on 2019-06-04 with total page 235 pages. Available in PDF, EPUB and Kindle. Book excerpt: First Published in 1995: Written by specialists in their fields, this book contains short reviews intended to highlight points of growing interest in mechanistic toxicology. The first section considers selected aspects of molecular mechanisms, including selectivity of toxic agents and repair processes in the nervous system, toxicity of oxygen, fibers and aflatoxins. The second section discusses the interactions of carcinogens with DNA, and other targets, and their relevance to both molecular dosimetry of exposure and development of cancer. The final part is concerned with cellular and genetic aspects and includes coverage of some of the most recent and rapidly developing problems in toxicology.
Author : Curtis C. Harris
Publisher : CSHL Press
ISBN 13 : 9780879693619
Total Pages : 226 pages
Book Rating : 4.6/5 (936 download)
Download or read book Cellular and Molecular Aspects of Fiber Carcinogenesis written by Curtis C. Harris and published by CSHL Press. This book was released on 1991 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: Airborne fibers have long been recognized as a major health hazard in certain industries and exposure to fibers in the general environment may also cause adverse effects such as cancer, in particular, mesothelioma. Asbestos is the best-known fiber carcinogen and, in the construction industry, is being widely replaced by substitute materials. Yet to perform properly, these materials must physically resemble asbestos. Does this mean that they too are hazardous? In this volume, invited experts in cell and tumor biology review the processes of cell division and the influence of fibers upon them. The biology of tumors and other diseases of the lung is discussed in some detail and in several papers the molecular basis of malignant transformation in mesothelioma cells is considered. These contributions combine to give the book a unique, scientific slant on an important environmental issue. It will interest research scientists investigating carcinogenesis and the biology of cell division, thoracic physicians, public health specialists, and those concerned with environmental control policy.
