Mechanism Of Telomerase Inhibition Using A Small Inhibitory Rnas And Induction Of Breast Tumor Cell Sensitization

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Mechanism of Telomerase Inhibition Using Small Inhibitory RNAs and Induction of Breast Tumor Cell Sensitization

Author :
Publisher :
ISBN 13 :
Total Pages : 15 pages
Book Rating : 4.:/5 (742 download)

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Book Synopsis Mechanism of Telomerase Inhibition Using Small Inhibitory RNAs and Induction of Breast Tumor Cell Sensitization by :

Download or read book Mechanism of Telomerase Inhibition Using Small Inhibitory RNAs and Induction of Breast Tumor Cell Sensitization written by and published by . This book was released on 2005 with total page 15 pages. Available in PDF, EPUB and Kindle. Book excerpt: Telomerase, a ribonucleoprotein enzyme composed of an RNA template (hTR) and a catalytically active protein subunit (hTERT), synthesizes telomeres after cell divisions and is obligatory for continuous tumor cell proliferation as well as malignant progression of breast cancer cells. Telomerase is an attractive anti-cancer therapeutic agent because telomerase activity is present in over 90% of human breast cancers but is undetectable in most normal somatic cells. Traditional therapies (surgery, chemotherapy, radiotherapy, etc.) lack the ability to effectively control and cure breast cancer, primarily because residual cells are or become resistant to DNA damaging modalities including standard chemo- and radio-therapies. Since telomerase requires its associated hTR for repeat synthesis, we have chosen to use RNA interference as a method to inactivate hTR and hence telomerase. RNA interference (RNAI) has become a powerful tool for the analysis of gene function in that RNAI allows sequence specific inhibition of gene expression. Another protein we targeted is p21, which has long been established as a requirement for senescence. We wanted to further examine its relationship to senescence and apotosis, in an attempt to sensitize breast tumor cells more effectively.

Mechanism of Telomerase Inhibition Using a Small Inhibitory RNAs and Induction of Breast Tumor Cell Sensitization

Author :
Publisher :
ISBN 13 :
Total Pages : 53 pages
Book Rating : 4.:/5 (15 download)

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Book Synopsis Mechanism of Telomerase Inhibition Using a Small Inhibitory RNAs and Induction of Breast Tumor Cell Sensitization by :

Download or read book Mechanism of Telomerase Inhibition Using a Small Inhibitory RNAs and Induction of Breast Tumor Cell Sensitization written by and published by . This book was released on 2007 with total page 53 pages. Available in PDF, EPUB and Kindle. Book excerpt: Telomerase, a ribonucleoprotein enzyme minimally composed of an RNA template (hTR) and a catalytically active protein subunit (hTERT), synthesizes telomeric repeats onto chromosome ends and is obligatory for continuous tumor cell proliferation, as well as malignant progression of breast cancer cells. Telomerase is an attractive anti-cancer therapeutic target because its activity is present in over 90% of human cancers, including more than 95% of breast carcinomas, but undetectable in most somatic cells. Traditional chemo- and radiotherapies lack the ability to effectively control and cure breast cancer, in part because residual cells are or become resistant to DNA damaging modalities. While various telomerase inhibition strategies cause cancer cells to undergo apoptosis or senescence, there is often a lag period between administration and biologic effect (Corey, 2002). Our goal in this study was to compare the efficacy of different telomerase inhibition strategies in concert with standard chemotherapeutic agents at triggering senescence and/or apoptosis in cultures of breast cancer cells. We hypothesized that telomerase inhibition strategies will sensitize breast cancer cells to traditional chemotherapies, potentially reducing the lag phase, allowing for more potent anti-tumor effects at lower doses, and therefore ultimately imparting less toxicity to the patient.

Mechanism of Telomerase Inhibition Using Small Inibitory RNAs and Induction of Breast Tumor Cell Sensitivity

Author :
Publisher :
ISBN 13 :
Total Pages : 21 pages
Book Rating : 4.:/5 (227 download)

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Book Synopsis Mechanism of Telomerase Inhibition Using Small Inibitory RNAs and Induction of Breast Tumor Cell Sensitivity by :

Download or read book Mechanism of Telomerase Inhibition Using Small Inibitory RNAs and Induction of Breast Tumor Cell Sensitivity written by and published by . This book was released on 2007 with total page 21 pages. Available in PDF, EPUB and Kindle. Book excerpt: Telomerase, a ribonucleoprotein enzyme composed of an RNA template (hTR) and a catalytically active protein subunit (hTERT), synthesizes telomeres after cell divisions and is obligatory for continuous tumor cell proliferation as well as malignant progression of breast cancer cells. Telomerase is an attractive anti-cancer therapeutic agent because telomerase activity is present in over 90% of human breast cancers but is undetectable in most normal somatic cells. Traditional therapies (surgery, chemotherapy, radiotherapy, etc.) lack the ability to effectively control and cure breast cancer, primarily because residual cells are or become resistant to DNA damaging modalities including standard chemo- and radio-therapies. Since telomerase requires its associated hTR for repeat synthesis, we have chosen to use RNA interference as a method to inactivate hTR and hence telomerase. RNA interference (RNAi) has become a powerful tool for the analysis of gene function in that RNAi allows sequence specific inhibition of gene expression. Another protein we targeted is p21, which has long been established as a requirement for senescence. We wanted to further examine its relationship to senescence and apotosis, in an attempt to sensitize breast tumor cells more effectively.

Telomeres and Telomerase in Cancer

Author : Keiko Hiyama
Publisher : Springer Science & Business Media
ISBN 13 : 1603278796
Total Pages : 375 pages
Book Rating : 4.6/5 (32 download)

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Book Synopsis Telomeres and Telomerase in Cancer by : Keiko Hiyama

Download or read book Telomeres and Telomerase in Cancer written by Keiko Hiyama and published by Springer Science & Business Media. This book was released on 2009-03-18 with total page 375 pages. Available in PDF, EPUB and Kindle. Book excerpt: Telomerase, an enzyme that maintains telomeres and endows eukaryotic cells with immortality, was first discovered in tetrahymena in 1985. In 1990s, it was proven that this enzyme also plays a key role in the infinite proliferation of human cancer cells. Now telomere and telomerase are widely accepted as important factors involved in cancer biology, and as promising diagnostic tools and therapeutic targets. Recently, role of telomerase in “cancer stem cells” has become another attractive story. Until now, there are several good books on telomere and telomerase focusing on biology in ciliates, yeasts, and mouse or basic sciences in human, providing basic scientists or students with updated knowledge.

Telomerase Inhibition and Sensitization of Breast Tumor Cells

Author : Ann Kennon Rigby Poynter
Publisher :
ISBN 13 :
Total Pages : 294 pages
Book Rating : 4.:/5 (276 download)

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Book Synopsis Telomerase Inhibition and Sensitization of Breast Tumor Cells by : Ann Kennon Rigby Poynter

Download or read book Telomerase Inhibition and Sensitization of Breast Tumor Cells written by Ann Kennon Rigby Poynter and published by . This book was released on 2007 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: Telomerase, a ribonucleoprotein enzyme minimally composed of an RNA template (hTR) and a catalytically active protein subunit (hTERT), synthesizes telomeric repeats onto chromosome ends and is obligatory for continuous tumor cell proliferation, as well as malignant progression of breast cancer cells. Telomerase is an attractive anticancer therapeutic target because its activity is present in over 90% of human cancers, including more than 95% of breast carcinomas, but undetectable in most somatic cells. Traditions chemo- and radio-therapies lack the ability to effectively control and cure breast cancer, in part because residual cells are or become resistant to DNA damaging modalities. While various telomerase inhibition strategies cause cancer cells to undergo apoptosis car senescence, there is often a lag period between administration and biologic effect (Corey, 2002). Our goal in this study was to compare the efficacy of different telomerase inhibition strategies in concert with standard chemotherapeutic agents at triggering senescence and/or apoptosis in cultures of breast cancer cells. We hypothesized that telomerase inhibition strategies will sensitize breast cancer cells to traditional chemotherapies, potentially reducing the lag phase, allowing for more potent anti-tumor effects at lower doses, and therefore ultimately imparting less toxicity to the patient. We blocked telomerase by targeting hTR and hTERT, individually and collectively utilizing synthetic short interfering RNA (siRNA), short hairpin RNA (siRNA), and a dominant negative form of hTERT (DN-hTERT) in MCF-7 breast cancer cells. We analyzed the efficiency of telomerase inhibition for each strategy alone and then treated the cells with two mainstay chemotherapeutic agents, Adriamycin (AdR) and Taxol. The most effective telomerase inhibition strategies were synthetic siRNA and DN-hTERT, individually. After treatment with various concentrations of AdR or Taxol, breast cancer cells with inhibited telomerase grew significantly slower and exhibited widespread senescence or apoptosis within a much shorter time period and at a dose that is insufficient to trigger cytostasis. In addition, we provide evidence that cells in which telomerase was inhibited were more sensitive to anti-cancer agents, whether the drug inhibited topoisomerase II resulting in DNA damage (AdR) or blocked mitosis via protracted microtubule stabilization (Taxol). Collectively, our data indicate that alone, anti-telomerase inhibition strategies differ in their efficacy. However, when used in the adjuvant setting with diverse acting chemotherapeutic agents, there is a potent synergy resulting in chemotherapeutic sensitization characterized in part by widespread senescence and/or apoptosis.

Investigations of the Telomerase Template Antagonist GRN163L and Implications for Augmenting Breast Cancer Therapy

Author :
Publisher :
ISBN 13 :
Total Pages : 306 pages
Book Rating : 4.:/5 (434 download)

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Book Synopsis Investigations of the Telomerase Template Antagonist GRN163L and Implications for Augmenting Breast Cancer Therapy by :

Download or read book Investigations of the Telomerase Template Antagonist GRN163L and Implications for Augmenting Breast Cancer Therapy written by and published by . This book was released on 2008 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: Breast cancer is the second most common cancer among women in the US after skin cancer. While early detection and improved therapy has led to an overall decline in breast cancer mortality, metastatic disease remains largely incurable, indicating a need for improved therapeutic options for patients. Telomeres are repetitive (TTAGGG)n DNA sequences found at the end of chromosomes that protect the ends from recombination, end to end fusions, and recognition as damaged DNA. The enzyme telomerase acts to stabilize short telomeres, preventing apoptosis or senescence due to genomic instability. Telomerase is active in 85-90% of cancers, and inactive in most normal cells, making telomerase an attractive target for cancer therapy. Use of the telomerase-specific, lipidated oligonucleotide GRN163L can antagonize telomerase activity and telomere maintenance in cancer cells by preventing telomerase from binding to telomeres. GRN163L has been shown by our laboratory to inhibit breast cancer cell growth and metastasis in animal models. However, the mechanisms of cancer cell growth and metastatic inhibition via GRN163L are not completely understood. The overall goal of this research project was to further elucidate the role of telomerase in breast cancer cell survival by: 1) determining the effects of combining telomere dysfunction induced by GRN163L with a DNA damage inducer (irradiation); 2) elucidating the mechanisms underlying the cellular response to GRN163L and the effect of combination therapy with the mitotic inhibitor paclitaxel; and 3) testing the hypothesis that a telomerase inhibitor can augment the effects of trastuzumab in breast cancer cells with HER2 amplification. Results support the central hypothesis that the telomere dysfunction, structural and proliferative changes in breast cancer cells induced by GRN163L can synergize with irradiation, paclitaxel, and trastuzumab to inhibit the tumorigenicity of breast cancer cells both in vitro and in vivo. Furthermore, GRN163L can restore sensitivity of therapeutically resistant breast cancer cells to trastuzumab. These results provide insight into the role of telomerase in cancer cell growth. Additionally, implications of this research support GRN163L as an important part of therapeutic regimens for primary tumors, recurrence, and metastatic disease.

Development of a Novel In-Situ Telomere Length Qualification System to Address Suitability of Telomerase Inhibitor Therapy to Breast Cancer Following Corrective Surgery

Download Development of a Novel In-Situ Telomere Length Qualification System to Address Suitability of Telomerase Inhibitor Therapy to Breast Cancer Following Corrective Surgery PDF Online Free

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Publisher :
ISBN 13 :
Total Pages : 17 pages
Book Rating : 4.:/5 (742 download)

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Book Synopsis Development of a Novel In-Situ Telomere Length Qualification System to Address Suitability of Telomerase Inhibitor Therapy to Breast Cancer Following Corrective Surgery by :

Download or read book Development of a Novel In-Situ Telomere Length Qualification System to Address Suitability of Telomerase Inhibitor Therapy to Breast Cancer Following Corrective Surgery written by and published by . This book was released on 2003 with total page 17 pages. Available in PDF, EPUB and Kindle. Book excerpt: Normal breast epithelial cells undergo progressive telomeric shortening throughout their replicative lifespan culminating in critically short telomeres, which trigger replicative senescence. Breast cancer cells are able to bypass this growth-arrest mechanism through deregulated expression of telomerase, which maintains telomeres above the minimal critical length. Based on this observation the suitability of these tumors to telomerase inhibitors as direct or adjuvant therapy needs to be determined. To do this we have developed a novel 3-D quantitative fluorescence in-situ hybridization system to analyze total nuclear telomeric signal from normal and tumor-derived breast epithelial cells in tissue culture. This technique has been applied to tumor-derived breast epithelial cells successfully and will be applied to two normal Human Mammary Epithelial Cell (HMEC) lines, HME13 and HME17. Collection of regular cell and DNA samples has enabled us to determine the mean telomere lengths and rate of shortening for these HMEC lines. We will use Q-FISH to determine a per nuclei telomere dynamic. These findings will then be applied to 3-D models before finally generating predictions of telomere lengths within resected breast tumor samples. This will allow us to determine the suitability of telomerase inhibitors in vivo.

Use of Telemorace Inhibition in Combination with Anti-Cancer Drugs to Induce Cell Death in Tumor Cells

Author :
Publisher :
ISBN 13 :
Total Pages : 30 pages
Book Rating : 4.:/5 (227 download)

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Book Synopsis Use of Telemorace Inhibition in Combination with Anti-Cancer Drugs to Induce Cell Death in Tumor Cells by :

Download or read book Use of Telemorace Inhibition in Combination with Anti-Cancer Drugs to Induce Cell Death in Tumor Cells written by and published by . This book was released on 2006 with total page 30 pages. Available in PDF, EPUB and Kindle. Book excerpt: Telomerase is a ribonucleoprotein complex that maintains the stability of chromosome ends the telomeres and regulates cell replicative potential. The enzyme minimally contains a catalytic subunit with reverse transcriptase activity (hTERT) and a RNA subunit (hTR) with a region complementary to the telomeric repeats that is used as template. Telomerase is up-regulated in 05% of breast carcinoma but not in adjacent normal tissues and its activity increases with tumor aggressiveness. Therefore targeting telomerase may represent a promising approach for cancer therapy. Inhibition of telomerase would result in telomere shortening and cell death due to dysfunctional telomeres. The major limitation of this approach is the time necessary for the telomeres to shorten sufficiently to engage cell death. One possibility to overcome this lag phase is to target the telomeres by introducing hTRs with mutations in the template region which results in decreased cell viability and increased apoptosis. The aim of this study is to investigate the feasibility of a new anti-cancer approach based on the combination of telomere disturbances induced by mutant hTR and chemotherapeutic drugs. Our results show that interfering with telomere maintenance in breast cancer cells results in increased susceptibility to anti-cancer drugs independently of initial telomere length and mechanisms of telomere maintenance. These results suggest that this strategy could lead to the development of a general approach for the treatment of all human cancers.

Development of a Novel In-situ Telomere Length Quantification System to Address Suitability of Telomerase Inhibitor Therapy to Breast Cancer Following Corrective Surgery

Download Development of a Novel In-situ Telomere Length Quantification System to Address Suitability of Telomerase Inhibitor Therapy to Breast Cancer Following Corrective Surgery PDF Online Free

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ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (946 download)

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Book Synopsis Development of a Novel In-situ Telomere Length Quantification System to Address Suitability of Telomerase Inhibitor Therapy to Breast Cancer Following Corrective Surgery by :

Download or read book Development of a Novel In-situ Telomere Length Quantification System to Address Suitability of Telomerase Inhibitor Therapy to Breast Cancer Following Corrective Surgery written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Normal breast epithelial cells undergo progressive telomeric shortening throughout their replicative lifespan culminating in critically short telomeres, which trigger replicative senescence. Breast cancer cells are able to bypass this growth-arrest mechanism through deregulated expression of telomerase, which maintains telomeres above the minimal critical length. Based on this observation the suitability of these tumors to telomerase inhibitors as direct or adjuvant therapy needs to be determined. To do this we have developed a novel quantitative fluorescence in-situ hybridization system to analyze total nuclear telomeric signal from normal and tumor-derived breast epithelial cells in tissue culture. This technique has been applied to normal human fibroblasts (W138) successfully and will be applied to two normal Human Mammary Epithelial Cell (HMEC) lines, HMEl3 and HME 17%. Through collection of regular cell and DNA samples we will determine the mean telomere lengths and rate of shortening for each HMEC line and use Q-FISH to determine a per nuclei telomere dynamic. These findings will then be applied to 3-D matrigel models before finally generating predictions of telomere lengths within resected breast tumor samples. This will allow us to determine the suitability of telomerase inhibitors in vivo.

Key Developments in the Telomerase Revolution

Author : Applied Research Applied Research Press
Publisher :
ISBN 13 : 9781519203557
Total Pages : 236 pages
Book Rating : 4.2/5 (35 download)

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Book Synopsis Key Developments in the Telomerase Revolution by : Applied Research Applied Research Press

Download or read book Key Developments in the Telomerase Revolution written by Applied Research Applied Research Press and published by . This book was released on 2015-11-09 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: This article collection reviews key developments in the medical applications of telomerase biochemistry and includes 22 open access research papers by various authors. Topics include: Insights into the evolution of mammalian telomerase: Platypus TERT shares similarities with genes of birds and other reptiles and localizes on sex chromosomes; Mesenchymal stem cells with high telomerase expression do not actively restore their chromosome arm specific telomere length pattern after exposure to ionizing radiation; A mutation in the H/ACA box of telomerase RNA component gene (TERC) in a young patient with myelodysplastic syndrome; siRNA inhibition of telomerase enhances the anti-cancer effect of doxorubicin in breast cancer cells; Effect of a qigong intervention program on telomerase activity and psychological stress in abused Chinese women: a randomized, wait-list controlled trial; Glucose restriction decreases telomerase activity and enhances its inhibitor response on breast cancer cells: possible extra-telomerase role of BIBR 1532; Telomerase immunity from bench to bedside: round one; Polymorphisms within the Telomerase Reverse Transcriptase gene (TERT) in four breeds of dogs selected for difference in lifespan and cancer susceptibility; Epstein-Barr virus and telomerase: from cell immortalization to therapy; Telomerase inhibition by siRNA causes senescence and apoptosis in Barrett's adenocarcinoma cells: mechanism and therapeutic potential; Inhibition of telomerase activity preferentially targets aldehyde dehydrogenase-positive cancer stem-like cells in lung cancer; PinX1 suppresses bladder urothelial carcinoma cell proliferation via the inhibition of telomerase activity and p16/cyclin D1 pathway; miR-375 activates p21 and suppresses telomerase activity by coordinately regulating HPV E6/E7, E6AP, CIP2A, and 14-3-3zeta; Targeting DNA-PKcs and telomerase in brain tumour cells; Inhibition of telomerase activity by HDV ribozyme in cancers; Telomerase inhibition improves tumor response to radiotherapy in a murine orthotopic model of human glioblastoma; Telomere length and telomerase activity in non-small cell lung cancer prognosis: clinical usefulness of a specific telomere status; Telomerase and breast cancer; Complex roles for telomeres and telomerase in breast carcinogenesis; Sequence variation in telomerase reverse transcriptase (TERT) as a determinant of risk ofcardiovascular disease: the Atherosclerosis Risk in Communities (ARIC) study; Aberrant gene expression profiles, during in vitro osteoblast differentiation, of telomerase deficient mouse bone marrow stromal stem cells (mBMSCs); The role of telomeres and telomerase in hematologic malignancies and hematopoietic stem cell transplantation.

Heat Shock Proteins in Cancer

Author : Stuart K. Calderwood
Publisher : Springer Science & Business Media
ISBN 13 : 1402064012
Total Pages : 399 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Heat Shock Proteins in Cancer by : Stuart K. Calderwood

Download or read book Heat Shock Proteins in Cancer written by Stuart K. Calderwood and published by Springer Science & Business Media. This book was released on 2007-09-09 with total page 399 pages. Available in PDF, EPUB and Kindle. Book excerpt: Heat shock proteins are emerging as important molecules in the development of cancer and as key targets in cancer therapy. These proteins enhance the growth of cancer cells and protect tumors from treatments such as drugs or surgery. However, new drugs have recently been developed particularly those targeting heat shock protein 90. As heat shock protein 90 functions to stabilize many of the oncogenes and growth promoting proteins in cancer cells, such drugs have broad specificity in many types of cancer cell and offer the possibility of evading the development of resistance through point mutation or use of compensatory pathways. Heat shock proteins have a further property that makes them tempting targets in cancer immunotherapy. These proteins have the ability to induce an inflammatory response when released in tumors and to carry tumor antigens to antigen presenting cells. They have thus become important components of anticancer vaccines. Overall, heat shock proteins are important new targets in molecular cancer therapy and can be approached in a number of contrasting approaches to therapy.

Nanopharmaceuticals: Principles and Applications Vol. 3

Author : Vinod Kumar Yata
Publisher : Springer Nature
ISBN 13 : 3030471209
Total Pages : 340 pages
Book Rating : 4.0/5 (34 download)

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Book Synopsis Nanopharmaceuticals: Principles and Applications Vol. 3 by : Vinod Kumar Yata

Download or read book Nanopharmaceuticals: Principles and Applications Vol. 3 written by Vinod Kumar Yata and published by Springer Nature. This book was released on 2020-08-19 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the third volume on this subject and focuses on the recent advances of nanopharmaceuticals in cancer, dental, dermal and drug delivery applications and presents their safety, toxicity and therapeutic efficacy. The book also includes the transport phenomenon of nanomaterials and important pathways for drug delivery applications. It goes on to explain the toxicity of nanoparticles to different physiological systems and methods used to assess this for different organ systems using examples of in vivo systems.

Molecular and Cellular Changes in the Cancer Cell

Author :
Publisher : Academic Press
ISBN 13 : 0128096039
Total Pages : 618 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Molecular and Cellular Changes in the Cancer Cell by :

Download or read book Molecular and Cellular Changes in the Cancer Cell written by and published by Academic Press. This book was released on 2016-11-16 with total page 618 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular and Cellular Changes in the Cancer Cell,the latest volume in the Progress in Molecular Biology and Translational Science series, includes a comprehensive summary of the evidence accumulated thus far on the molecular and cellular regulation of the various adaptations taking place in response to exercise. This volume examines some of the latest advances, highlighting some of the most important molecular and cellular alterations and environmental influences that collectively cause a normal cell to become cancerous. Special emphasis is given to changes that take place at the molecular and cellular level. Comprehensive and up-to-date survey of current knowledge on the cancer cell Includes the latest advances and the most important molecular and cellular alterations and environmental influences collectively causing cells to become cancerous Written by leading experts in the field

Systems Biology of Cancer

Author : Sam Thiagalingam
Publisher : Cambridge University Press
ISBN 13 : 0521493390
Total Pages : 597 pages
Book Rating : 4.5/5 (214 download)

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Book Synopsis Systems Biology of Cancer by : Sam Thiagalingam

Download or read book Systems Biology of Cancer written by Sam Thiagalingam and published by Cambridge University Press. This book was released on 2015-04-09 with total page 597 pages. Available in PDF, EPUB and Kindle. Book excerpt: An overview of the current systems biology-based knowledge and the experimental approaches for deciphering the biological basis of cancer.

Quadruplex Nucleic Acids As Targets For Medicinal Chemistry

Author :
Publisher : Academic Press
ISBN 13 : 0128210184
Total Pages : 564 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Quadruplex Nucleic Acids As Targets For Medicinal Chemistry by :

Download or read book Quadruplex Nucleic Acids As Targets For Medicinal Chemistry written by and published by Academic Press. This book was released on 2020-08-26 with total page 564 pages. Available in PDF, EPUB and Kindle. Book excerpt: The realisation that human, animal, viral and bacterial genomes all contain over-representation of higher-order quadruplex structures in regulatory and other pharmacologically-useful regions, has led to a large number of studies aimed at exploiting this findings for therapeutic and diagnostic purposes. Quadruplex-binding small molecules are starting to be evaluated in human clinical trials. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Annual Reports in Medicinal Chemistry series

Holland-Frei Cancer Medicine

Author : Robert C. Bast, Jr.
Publisher : John Wiley & Sons
ISBN 13 : 111900084X
Total Pages : 2004 pages
Book Rating : 4.1/5 (19 download)

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Book Synopsis Holland-Frei Cancer Medicine by : Robert C. Bast, Jr.

Download or read book Holland-Frei Cancer Medicine written by Robert C. Bast, Jr. and published by John Wiley & Sons. This book was released on 2017-03-10 with total page 2004 pages. Available in PDF, EPUB and Kindle. Book excerpt: Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates

Role of Nutraceuticals in Cancer Chemosensitization

Author :
Publisher : Academic Press
ISBN 13 : 0128123745
Total Pages : 400 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Role of Nutraceuticals in Cancer Chemosensitization by :

Download or read book Role of Nutraceuticals in Cancer Chemosensitization written by and published by Academic Press. This book was released on 2017-10-18 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: Role of Nutraceuticals in Chemoresistance to Cancer, Volume Two, focuses on nutraceuticals, the compounds derived from natural sources, which are usually multi-targeted as a means to overcome chemoresistance. This book discusses the role of several compounds related to nutraceuticals and chemoresistance, such as curcumin, resveratrol, indole 3-carbinol, tocotrienols, ursolic acid, fisetin, celastrol, gambogic, butein, catechins and silymarin. It is a valuable resource for cancer researchers, oncologists and members of several areas of the biomedical field who are interested in understanding how to use nutraceuticals as a sensitizing agent for chemotherapy. Brings updated information on natural compounds used as specific inhibitors of cell signaling pathways as reviewed by experts in the field Presents experts analysis and summary of reported and novel findings and potential translational application in cancer patients Describes molecular mechanisms with new and helpful approaches for the readers to use in their own investigations