Mechanism Of Action Of Antibacterial Agents

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Antibacterial Agents

Author : Rosaleen Anderson
Publisher : John Wiley & Sons
ISBN 13 : 1118325443
Total Pages : 379 pages
Book Rating : 4.1/5 (183 download)

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Book Synopsis Antibacterial Agents by : Rosaleen Anderson

Download or read book Antibacterial Agents written by Rosaleen Anderson and published by John Wiley & Sons. This book was released on 2012-05-30 with total page 379 pages. Available in PDF, EPUB and Kindle. Book excerpt: Antibacterial agents act against bacterial infection either by killing the bacterium or by arresting its growth. They do this by targeting bacterial DNA and its associated processes, attacking bacterial metabolic processes including protein synthesis, or interfering with bacterial cell wall synthesis and function. Antibacterial Agents is an essential guide to this important class of chemotherapeutic drugs. Compounds are organised according to their target, which helps the reader understand the mechanism of action of these drugs and how resistance can arise. The book uses an integrated “lab-to-clinic” approach which covers drug discovery, source or synthesis, mode of action, mechanisms of resistance, clinical aspects (including links to current guidelines, significant drug interactions, cautions and contraindications), prodrugs and future improvements. Agents covered include: agents targeting DNA - quinolone, rifamycin, and nitroimidazole antibacterial agents agents targeting metabolic processes - sulfonamide antibacterial agents and trimethoprim agents targeting protein synthesis - aminoglycoside, macrolide and tetracycline antibiotics, chloramphenicol, and oxazolidinones agents targeting cell wall synthesis - β-Lactam and glycopeptide antibiotics, cycloserine, isonaizid, and daptomycin Antibacterial Agents will find a place on the bookshelves of students of pharmacy, pharmacology, pharmaceutical sciences, drug design/discovery, and medicinal chemistry, and as a bench reference for pharmacists and pharmaceutical researchers in academia and industry.

Mechanism of Action of Antieukaryotic and Antiviral Compounds

Author : Fred E. Hahn
Publisher : Springer Science & Business Media
ISBN 13 : 3642464076
Total Pages : 484 pages
Book Rating : 4.6/5 (424 download)

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Book Synopsis Mechanism of Action of Antieukaryotic and Antiviral Compounds by : Fred E. Hahn

Download or read book Mechanism of Action of Antieukaryotic and Antiviral Compounds written by Fred E. Hahn and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 484 pages. Available in PDF, EPUB and Kindle. Book excerpt: When Antibiotics I was published in 1967, the teleological view was held by some that" antibiotics" were substances elaborated by certain microorgan isms for the purpose of competing with other microorganisms for survival in mixed ecological environments. However, not only had J. EHRLICH and his associates shown 15 years earlier that chloramphenicol was produced by Strepto myces venezuelae in cultures of sterilized soils but not in parallel cultures of the same soils which were not sterilized, but operationally, the search for anti cancer antibiotics was actively under way (Antibiotics I reporting on numerous such substances), although the concept of antibiosis could not logically justify such undertakings. This editor hesitates to accept the use of the term "antibiotic" for anti microbial agents of non microbiological origins which is sometimes encountered, but neither does he subscribe to the view that antibiotics are in some fundamental manner different from chemotherapeutic substances of other origins. Modes and mechanisms of action of chemotherapeutic compounds are not systematic functions of their origins nor of the taxonomical position of the target organisms. Consequently, in the selection of topics for Antibiotics III (published in 1975), synthetic drugs and natural products of higher plants (alkaloids) were represented, along with antibiotics in the strict sense of the definition. We now present Antibiotics V, for whose assembly the same selection criteria were applied as for Antibiotics Ill. The aggregate length of the contributions rendered it impractical to place the entire text between the covers of one book.

The Effects on Human Health of Subtherapeutic Use of Antimicrobials in Animal Feeds

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309030447
Total Pages : 393 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis The Effects on Human Health of Subtherapeutic Use of Antimicrobials in Animal Feeds by : National Research Council

Download or read book The Effects on Human Health of Subtherapeutic Use of Antimicrobials in Animal Feeds written by National Research Council and published by National Academies Press. This book was released on 1980-02-01 with total page 393 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Antimicrobial Chemotherapy

Author : Roger Finch
Publisher : OUP Oxford
ISBN 13 : 0191628654
Total Pages : 409 pages
Book Rating : 4.1/5 (916 download)

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Book Synopsis Antimicrobial Chemotherapy by : Roger Finch

Download or read book Antimicrobial Chemotherapy written by Roger Finch and published by OUP Oxford. This book was released on 2012-01-05 with total page 409 pages. Available in PDF, EPUB and Kindle. Book excerpt: Antimicrobial agents are essential for the treatment of life-threatening infections and for managing the burden of minor infections in the community. In addition, they play a key role in organ and bone marrow transplantation, cancer chemotherapy, artificial joint and heart valve surgery. Unlike other classes of medicines, they are vulnerable to resistance from mutations in target microorganisms, and their adverse effects may extend to other patients (increased risk of cross-infection). As a consequence, there is a constant requirement for new agents, as well as practices that ensure the continued effective prescribing of licensed agents. Public awareness and concerns about drug resistant organisms has led to widespread publicity and political action in the UK, Europe and worldwide. The control of drug resistance and the implementation of good prescribing practice are now legal requirements in the UK as a result of the UK Health Act (2008). These fundamental changes underscore the need for a thorough understanding of the advantages and risks associated with specific antibiotic choices. This sixth edition of Antimicrobial Chemotherapy continues to be a valuable resource for undergraduates and graduates requiring a thorough grounding in the scientific basis and clinical application of these drugs. This new edition is updated to include the most recently licensed agents, notably in the treatment of viral infections including HIV/AIDS, and contains new guidance on prescribing practice and infection control practices that limit the development and spread of resistant organisms.

Mechanisms of antibiotic resistance

Author : Jun Lin
Publisher : Frontiers Media SA
ISBN 13 : 2889195260
Total Pages : 226 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis Mechanisms of antibiotic resistance by : Jun Lin

Download or read book Mechanisms of antibiotic resistance written by Jun Lin and published by Frontiers Media SA. This book was released on 2015-06-01 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: Antibiotics represent one of the most successful forms of therapy in medicine. But the efficiency of antibiotics is compromised by the growing number of antibiotic-resistant pathogens. Antibiotic resistance, which is implicated in elevated morbidity and mortality rates as well as in the increased treatment costs, is considered to be one of the major global public health threats (www.who.int/drugresistance/en/) and the magnitude of the problem recently prompted a number of international and national bodies to take actions to protect the public (http://ec.europa.eu/dgs/health_consumer/docs/road-map-amr_en.pdf: http://www.who.int/drugresistance/amr_global_action_plan/en/; http://www.whitehouse.gov/sites/default/files/docs/carb_national_strategy.pdf). Understanding the mechanisms by which bacteria successfully defend themselves against the antibiotic assault represent the main theme of this eBook published as a Research Topic in Frontiers in Microbiology, section of Antimicrobials, Resistance, and Chemotherapy. The articles in the eBook update the reader on various aspects and mechanisms of antibiotic resistance. A better understanding of these mechanisms should facilitate the development of means to potentiate the efficacy and increase the lifespan of antibiotics while minimizing the emergence of antibiotic resistance among pathogens.

Antibiotic Drug Resistance

Author : José-Luis Capelo-Martínez
Publisher : John Wiley & Sons
ISBN 13 : 1119282527
Total Pages : 730 pages
Book Rating : 4.1/5 (192 download)

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Book Synopsis Antibiotic Drug Resistance by : José-Luis Capelo-Martínez

Download or read book Antibiotic Drug Resistance written by José-Luis Capelo-Martínez and published by John Wiley & Sons. This book was released on 2019-09-24 with total page 730 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a thorough and authoritative overview of the multifaceted field of antibiotic science – offering guidance to translate research into tools for prevention, diagnosis, and treatment of infectious diseases. Provides readers with knowledge about the broad field of drug resistance Offers guidance to translate research into tools for prevention, diagnosis, and treatment of infectious diseases Links strategies to analyze microbes to the development of new drugs, socioeconomic impacts to therapeutic strategies, and public policies to antibiotic-resistance-prevention strategies

Antibiotics

Author : Claudio O. Gualerzi
Publisher : John Wiley & Sons
ISBN 13 : 3527659706
Total Pages : 549 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Antibiotics by : Claudio O. Gualerzi

Download or read book Antibiotics written by Claudio O. Gualerzi and published by John Wiley & Sons. This book was released on 2013-09-05 with total page 549 pages. Available in PDF, EPUB and Kindle. Book excerpt: Most of the antibiotics now in use have been discovered more or less by chance, and their mechanisms of action have only been elucidated after their discovery. To meet the medical need for next-generation antibiotics, a more rational approach to antibiotic development is clearly needed. Opening with a general introduction about antimicrobial drugs, their targets and the problem of antibiotic resistance, this reference systematically covers currently known antibiotic classes, their molecular mechanisms and the targets on which they act. Novel targets such as cell signaling networks, riboswitches and bacterial chaperones are covered here, alongside the latest information on the molecular mechanisms of current blockbuster antibiotics. With its broad overview of current and future antibacterial drug development, this unique reference is essential reading for anyone involved in the development and therapeutic application of novel antibiotics.

Antibiotics in Laboratory Medicine

Author : Victor Lorian
Publisher : Lippincott Williams & Wilkins
ISBN 13 : 9780781749831
Total Pages : 924 pages
Book Rating : 4.7/5 (498 download)

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Book Synopsis Antibiotics in Laboratory Medicine by : Victor Lorian

Download or read book Antibiotics in Laboratory Medicine written by Victor Lorian and published by Lippincott Williams & Wilkins. This book was released on 2005 with total page 924 pages. Available in PDF, EPUB and Kindle. Book excerpt: Implement the most current science and practice in antimicrobial research. Now, find the newest approaches for evaluating the activity, mechanisms of action, and bacterial resistance to antibiotics with this completely updated, landmark reference. Turn to this comprehensive reference for groundbreaking evidence on the molecular link between chemical disinfectants, sterilants, and antibiotics. On the latest methods for detecting antibacterial resistance genes in the clinical laboratory, and antivirogram use to select the most active antiviral components against your patient's HIV.

Essentials of Antimicrobial Pharmacology

Author : Paul H. Axelsen
Publisher : Springer Science & Business Media
ISBN 13 : 9780896038424
Total Pages : 156 pages
Book Rating : 4.0/5 (384 download)

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Book Synopsis Essentials of Antimicrobial Pharmacology by : Paul H. Axelsen

Download or read book Essentials of Antimicrobial Pharmacology written by Paul H. Axelsen and published by Springer Science & Business Media. This book was released on 2002 with total page 156 pages. Available in PDF, EPUB and Kindle. Book excerpt: For many medical students and physicians, the task of quickly obtaining sufficient, accurate, and up-to-date information about the pharmacology of antimicrobials often involves consulting either lengthy textbooks or inadequate tabular guides. In Essentials of Antimicrobial Pharmacology: A Guide to Fundamentals for Practice, Dr. Axelsen superbly addresses this problem by concisely summarizing the essential medical data concerning the leading antimicrobials used in fighting infectious diseases and clearly illustrating their mechanisms of action. The agents described range from antibacterial and antifungal to antiparasitic and antiviral agents, and include immunomodulators and immunizing agents. For each drug discussed, the book allows rapid access to the essential facts concerning its structure and mechanism of action, the spectrum of its activity, its pharmacokinetics, its adverse effects, and its resistance. Background discussions explain the fundamentals of measuring antibiotic effect, administering antibiotics, distribution and elimination, sensitivity testing, and dose-response relationships. Essentials of Antimicrobial Pharmacology: A Guide to Fundamentals for Practice provides medical students, physicians, and allied health professionals with rapid access to the core principles of antimicrobial pharmacology, and a foundation for decisions about the use of antimicrobials in daily practice.

Biochemistry of Antimicrobial Action

Author : Trevor John Franklin
Publisher : Springer
ISBN 13 : 148993412X
Total Pages : 235 pages
Book Rating : 4.4/5 (899 download)

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Book Synopsis Biochemistry of Antimicrobial Action by : Trevor John Franklin

Download or read book Biochemistry of Antimicrobial Action written by Trevor John Franklin and published by Springer. This book was released on 2013-11-11 with total page 235 pages. Available in PDF, EPUB and Kindle. Book excerpt: The rapid advances made in the study of the synthesis, structure and function of biological macromolecules in the last fifteen years have enabled scientists concerned with antimicrobial agents to achieve a considerable measure of understanding of how these substances inhibit cell growth and division. The use of antimicrobial agents as highly specific inhibitors has in turn substantially assisted the investigation of complex biochemical processes. The literature in this field is so extensive however, that we considered an attempt should be made to draw together in an introductory book the more significant studies of recent years. This book, which is in fact based on lecture courses given by us to undergraduates at Liverpool and Manchester Universities, is therefore intended as an introduction to the biochemistry of antimicrobial action for advanced students in many disciplines. We hope that it may also be useful to established scientists who are new to this area of research. The book is concerned with a discussion of medically important antimicrobial compounds and also a number of agents that, although having no medical uses, have proved invaluable as research tools in biochemistry. Our aim has been to present the available information in a simple and readable way, emphasizing the established facts rather than more controversial material. Whenever possible, however, we have indicated the gaps in the present knowledge of the subject where further information is required.

Kucers' The Use of Antibiotics

Author : M. Lindsay Grayson
Publisher : CRC Press
ISBN 13 : 1498747965
Total Pages : 4894 pages
Book Rating : 4.4/5 (987 download)

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Book Synopsis Kucers' The Use of Antibiotics by : M. Lindsay Grayson

Download or read book Kucers' The Use of Antibiotics written by M. Lindsay Grayson and published by CRC Press. This book was released on 2017-10-02 with total page 4894 pages. Available in PDF, EPUB and Kindle. Book excerpt: Kucers’ The Use of Antibiotics is the definitive, internationally-authored reference, providing everything that the infectious diseases specialist and prescriber needs to know about antimicrobials in this vast and rapidly developing field. The much-expanded Seventh Edition comprises 4800 pages in 3 volumes in order to cover all new and existing therapies, and emerging drugs not yet fully licensed. Concentrating on the treatment of infectious diseases, the content is divided into four sections - antibiotics, anti-fungal drugs, anti-parasitic drugs, and anti-viral drugs - and is highly structured for ease of reference. Each chapter is organized in a consistent format, covering susceptibility, formulations and dosing (adult and pediatric), pharmacokinetics and pharmacodynamics, toxicity, and drug distribution, with detailed discussion regarding clinical uses - a feature unique to this title. Compiled by an expanded team of internationally renowned and respected editors, with expert contributors representing Europe, Africa, Asia, Australia, South America, the US, and Canada, the Seventh Edition adopts a truly global approach. It remains invaluable for anyone using antimicrobial agents in their clinical practice and provides, in a systematic and concise manner, all the information required when prescribing an antimicrobial to treat infection.

Antibiotics and Antibiotic Resistance

Author : Ola Sköld
Publisher : John Wiley & Sons
ISBN 13 : 1118075587
Total Pages : 181 pages
Book Rating : 4.1/5 (18 download)

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Book Synopsis Antibiotics and Antibiotic Resistance by : Ola Sköld

Download or read book Antibiotics and Antibiotic Resistance written by Ola Sköld and published by John Wiley & Sons. This book was released on 2011-10-07 with total page 181 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book, which is the translated version of a Swedish book, combines a general introduction of a variety of antibiotics with a more in-depth discussion of resistance. The focus on resistance in learning about antibiotics will help future scientists recognize the problem antibiotics resistance poses for medicinal and drug-related fields, and perhaps trigger more research and discoveries to fight antibiotic resistant strains. Current overviews of the topic are included, along with specific discussions on the individual mechanisms (betalactams, glycopeptides, aminoglycosides, etc) used in various antibacterial agents and explanations of how resistances to those develop. Methods for counteracting resistance development in bacteria are discussed as well.

Treating Infectious Diseases in a Microbial World

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309180686
Total Pages : 102 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Treating Infectious Diseases in a Microbial World by : National Research Council

Download or read book Treating Infectious Diseases in a Microbial World written by National Research Council and published by National Academies Press. This book was released on 2006-01-03 with total page 102 pages. Available in PDF, EPUB and Kindle. Book excerpt: Humans coexist with millions of harmless microorganisms, but emerging diseases, resistance to antibiotics, and the threat of bioterrorism are forcing scientists to look for new ways to confront the microbes that do pose a danger. This report identifies innovative approaches to the development of antimicrobial drugs and vaccines based on a greater understanding of how the human immune system interacts with both good and bad microbes. The report concludes that the development of a single superdrug to fight all infectious agents is unrealistic.

Introduction to Basics of Pharmacology and Toxicology

Author : Abialbon Paul
Publisher : Springer Nature
ISBN 13 : 9813360097
Total Pages : 1156 pages
Book Rating : 4.8/5 (133 download)

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Book Synopsis Introduction to Basics of Pharmacology and Toxicology by : Abialbon Paul

Download or read book Introduction to Basics of Pharmacology and Toxicology written by Abialbon Paul and published by Springer Nature. This book was released on 2021-03-13 with total page 1156 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explains the pharmacological relationships between the various systems in the human body. It offers a comprehensive overview of the pharmacology concerning the autonomic, central, and peripheral nervous systems. Presenting up-to-date information on chemical mediators and their significance, it highlights the therapeutic aspects of several diseases affecting the cardiovascular, renal, respiratory, gastrointestinal, endocrinal, and hematopoietic systems. The book also includes drug therapy for microbial and neoplastic diseases. It also comprises sections on immunopharmacology, dermatological, and ocular pharmacology providing valuable insights into these emerging and recent topics. Covering the diverse groups of drugs acting on different systems, the book reviews their actions, clinical uses, adverse effects, interactions, and subcellular mechanisms of action. It is divided into 11 parts, subdivided into several chapters that evaluate the basic pharmacological principles that govern the different types of body systems. This book is intended for academicians, researchers, and clinicians in industry and academic institutions in pharmaceutical, pharmacological sciences, pharmacy, medical sciences, physiology, neurosciences, biochemistry, molecular biology and other allied health sciences.

Penicillins and Cephalosporins

Author : Robert B. Morin
Publisher : Academic Press
ISBN 13 : 1483277194
Total Pages : 594 pages
Book Rating : 4.4/5 (832 download)

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Book Synopsis Penicillins and Cephalosporins by : Robert B. Morin

Download or read book Penicillins and Cephalosporins written by Robert B. Morin and published by Academic Press. This book was released on 2014-05-10 with total page 594 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemistry and Biology of ?-Lactam Antibiotics, Volume 1: Penicillins and Cephalosporins provides information pertinent to the study of antibiotics containing the ?-lactam moiety. This book discusses the occurrence of a group of ?-lactam antibiotics structurally related to cephalosporin C. Organized into five chapters, this volume begins with an overview of the mechanism of action of ?-lactam antibiotics that caused many microbiologists to develop screening tools for the detection of the ?-lactam moiety. This text then discusses the discovery of the nocardicins, the thienamycins, and olivanic acids. Other chapters provide a summary of the essential penicillin sulfoxide chemistry that gave rise to many compounds. This book discusses as well the ability of chemists to predict the level of biological activity of a compound from knowledge of its structure through theoretical and physicochemical studies. The final chapter deals with quantitative structure–activity relationships. This book is a valuable resource for microbiologists, chemists, and scientists.

Practical Handbook of Microbiology

Author : Lorrence H Green
Publisher : CRC Press
ISBN 13 : 1000245039
Total Pages : 2032 pages
Book Rating : 4.0/5 (2 download)

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Book Synopsis Practical Handbook of Microbiology by : Lorrence H Green

Download or read book Practical Handbook of Microbiology written by Lorrence H Green and published by CRC Press. This book was released on 2021-05-04 with total page 2032 pages. Available in PDF, EPUB and Kindle. Book excerpt: Practical Handbook of Microbiology, 4th edition provides basic, clear and concise knowledge and practical information about working with microorganisms. Useful to anyone interested in microbes, the book is intended to especially benefit four groups: trained microbiologists working within one specific area of microbiology; people with training in other disciplines, and use microorganisms as a tool or "chemical reagent"; business people evaluating investments in microbiology focused companies; and an emerging group, people in occupations and trades that might have limited training in microbiology, but who require specific practical information. Key Features Provides a comprehensive compendium of basic information on microorganisms—from classical microbiology to genomics. Includes coverage of disease-causing bacteria, bacterial viruses (phage), and the use of phage for treating diseases, and added coverage of extremophiles. Features comprehensive coverage of antimicrobial agents, including chapters on anti-fungals and anti-virals. Covers the Microbiome, gene editing with CRISPR, Parasites, Fungi, and Animal Viruses. Adds numerous chapters especially intended for professionals such as healthcare and industrial professionals, environmental scientists and ecologists, teachers, and businesspeople. Includes comprehensive survey table of Clinical, Commercial, and Research-Model bacteria. The Open Access version of this book, available at http://www.taylorfrancis.com, has been made available under a Creative Commons Attribution-Non Commercial-No Derivatives 4.0 license. Chapter 21, "Archaea," of this book is freely available as a downloadable Open Access PDF under a Creative Commons Attribution-Non Commercial-No Derivatives 4.0 license available at http://www.taylorfrancis.com See Emanuel Goldman's Open Access article: "Lamarck redux and other false arguments against SARS-CoV-2 vaccination," https://www.embopress.org/doi/full/10.15252/embr.202254675

The Use of Drugs in Food Animals

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309175771
Total Pages : 276 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis The Use of Drugs in Food Animals by : National Research Council

Download or read book The Use of Drugs in Food Animals written by National Research Council and published by National Academies Press. This book was released on 1999-01-12 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: The use of drugs in food animal production has resulted in benefits throughout the food industry; however, their use has also raised public health safety concerns. The Use of Drugs in Food Animals provides an overview of why and how drugs are used in the major food-producing animal industriesâ€"poultry, dairy, beef, swine, and aquaculture. The volume discusses the prevalence of human pathogens in foods of animal origin. It also addresses the transfer of resistance in animal microbes to human pathogens and the resulting risk of human disease. The committee offers analysis and insight into these areas: Monitoring of drug residues. The book provides a brief overview of how the FDA and USDA monitor drug residues in foods of animal origin and describes quality assurance programs initiated by the poultry, dairy, beef, and swine industries. Antibiotic resistance. The committee reports what is known about this controversial problem and its potential effect on human health. The volume also looks at how drug use may be minimized with new approaches in genetics, nutrition, and animal management.