Measuring And Correlating Blood And Brain Gene Expression Levels

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Measuring and Correlating Blood and Brain Gene Expression Levels

Author : Mary Elizabeth Winn
Publisher :
ISBN 13 : 9781124937069
Total Pages : 182 pages
Book Rating : 4.9/5 (37 download)

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Book Synopsis Measuring and Correlating Blood and Brain Gene Expression Levels by : Mary Elizabeth Winn

Download or read book Measuring and Correlating Blood and Brain Gene Expression Levels written by Mary Elizabeth Winn and published by . This book was released on 2011 with total page 182 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microarray-based gene expression profiling is a frequently utilized tool in the search for disease-specific molecular patterns and the development of clinically relevant panels of biomarkers. Although advances in high-throughput gene expression technology make for more reliable and interpretable studies, investigations of living humans are often limited by tissue accessibility. This is especially true for neural-based illnesses, where studies rely heavily on post-mortem brain tissue. As a result, medical researchers have focused on blood, a more easily accessible and clinically obtainable tissue. In this work I explore : 1.) the technical aspects associated with assessing peripheral whole blood gene expression via microarray; and 2.) the biological significance of blood-based gene expression patterns with respect to brain-based gene expression patterns and behavioral phenotypes in mice and humans. I describe the effects of globin reduction on blood-based gene expression in mice by comparing gene expression patterns before and after globin reduction of mouse whole blood (Chapter 2). Globin reduction was found to improve the ability to detect low abundance, biologically relevant genes. I also evaluated globin reduction in the context of human blood and two Illumina gene expression assays : (i) the IVT-based direct hybridization assay; and (ii) the WG-DASL assay (Chapter 4). As in mice, I was able to recapitulate the known benefits of globin reduction in both assays, while WG-DASL appeared to be more sensitive compared to IVT. Lastly, I characterized the correlations between blood gene expression levels and behavioral phenotypes and compared blood gene expression-trait correlations with brain gene expression-trait correlations in respect to neuropsychiatric phenotypes in mice (Chapter 3) and autism in humans (Chapter 5). In both mice and humans, blood was only able to capture a small portion of the associations identified in the brain on an individual gene level. At a pathway level, blood was able to capture a larger portion of the associated brain pathways in humans as compared to mice. I conclude blood gene expression, although it may capture a small portion of the expression patterns associated with 'primary' neural insults, is more likely to capture variation due to 'secondary' perturbations or other biological and environmental insults.

Population Neuroscience

Author : Tomas Paus
Publisher : Springer Science & Business Media
ISBN 13 : 3642364500
Total Pages : 198 pages
Book Rating : 4.6/5 (423 download)

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Book Synopsis Population Neuroscience by : Tomas Paus

Download or read book Population Neuroscience written by Tomas Paus and published by Springer Science & Business Media. This book was released on 2013-03-23 with total page 198 pages. Available in PDF, EPUB and Kindle. Book excerpt: Is Newton’s brain different from Rembrandt’s? Does a mother’s diet during pregnancy impact brain growth? Do adolescent peers leave a signature in the social brain? Does the way we live in our middle years affect how our brains age? To answer these and many other questions, we can now turn to population neuroscience. Population neuroscience endeavors to identify environmental and genetic factors that shape the function and structure of the human brain; it uses the tools and knowledge of genetics (and the “omics” sciences), epidemiology and neuroscience. This text attempts to provide a bridge spanning these three disciplines so that their practitioners can communicate easily with each other when working together on large-scale imaging studies of the developing, mature and aging brain. By understanding the processes driving variations in brain function and structure across individuals, we will also be able to predict an individual’s risk of (or resilience against) developing a brain disorder. In the long term, the hope is that population neuroscience will lay the foundation for personalized preventive medicine and, in turn, reduce the burden associated with complex, chronic disorders of brain and body.

Translational Research in Traumatic Brain Injury

Author : Daniel Laskowitz
Publisher : CRC Press
ISBN 13 : 1498766579
Total Pages : 388 pages
Book Rating : 4.4/5 (987 download)

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Book Synopsis Translational Research in Traumatic Brain Injury by : Daniel Laskowitz

Download or read book Translational Research in Traumatic Brain Injury written by Daniel Laskowitz and published by CRC Press. This book was released on 2016-04-21 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: Traumatic brain injury (TBI) remains a significant source of death and permanent disability, contributing to nearly one-third of all injury related deaths in the United States and exacting a profound personal and economic toll. Despite the increased resources that have recently been brought to bear to improve our understanding of TBI, the developme

Neurobehavioral Genetics

Author : Byron C. Jones
Publisher : CRC Press
ISBN 13 : 1420003569
Total Pages : 522 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Neurobehavioral Genetics by : Byron C. Jones

Download or read book Neurobehavioral Genetics written by Byron C. Jones and published by CRC Press. This book was released on 2006-08-30 with total page 522 pages. Available in PDF, EPUB and Kindle. Book excerpt: A complete background to concepts and principles of behavioral genetics, Neurobehavioral Genetics: Methods and Applications, Second Edition features a broad spectrum of the most current techniques in neurobehavioral genetics in a single source. International researchers incorporate several new developments in the field, including: De

Brain Banking

Author :
Publisher : Elsevier
ISBN 13 : 0444636420
Total Pages : 448 pages
Book Rating : 4.4/5 (446 download)

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Book Synopsis Brain Banking by :

Download or read book Brain Banking written by and published by Elsevier. This book was released on 2018-02-27 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: Brain Banking, Volume 150, serves as the only book on the market offering comprehensive coverage of the functional realities of brain banking. It focuses on brain donor recruitment strategies, brain bank networks, ethical issues, brain dissection/tissue processing/tissue dissemination, neuropathological diagnosis, brain donor data, and techniques in brain tissue analysis. In accordance with massive initiatives, such as BRAIN and the EU Human Brain Project, abnormalities and potential therapeutic targets of neurological and psychiatric disorders need to be validated in human brain tissue, thus requiring substantial numbers of well characterized human brains of high tissue quality with neurological and psychiatric diseases. Offers comprehensive coverage of the functional realities of brain banking, with a focus on brain donor recruitment strategies, brain bank networks, ethical issues, and more Serves as a valuable resource for staff in existing brain banks by highlighting best practices Enhances the sharing of expertise between existing banks and highlights a range of techniques applicable to banked tissue for neuroscience researchers Authored by leaders from brain banks around the globe – the broadest, most expert coverage available

Biomarkers for Traumatic Brain Injury

Author : Svetlana Dambinova
Publisher : Royal Society of Chemistry
ISBN 13 : 1849733899
Total Pages : 247 pages
Book Rating : 4.8/5 (497 download)

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Book Synopsis Biomarkers for Traumatic Brain Injury by : Svetlana Dambinova

Download or read book Biomarkers for Traumatic Brain Injury written by Svetlana Dambinova and published by Royal Society of Chemistry. This book was released on 2012 with total page 247 pages. Available in PDF, EPUB and Kindle. Book excerpt: Due to injuries sustained in sports and in combat, interest in traumatic brain injury (TBI) has never been greater. This book will fulfill a gap in understanding of what is occurring in the brain following injury that can subsequently be detected in biological fluids and imaging.

The Mouse Nervous System

Author : Charles Watson
Publisher : Academic Press
ISBN 13 : 0123694973
Total Pages : 815 pages
Book Rating : 4.1/5 (236 download)

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Book Synopsis The Mouse Nervous System by : Charles Watson

Download or read book The Mouse Nervous System written by Charles Watson and published by Academic Press. This book was released on 2011-11-28 with total page 815 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Mouse Nervous System provides a comprehensive account of the central nervous system of the mouse. The book is aimed at molecular biologists who need a book that introduces them to the anatomy of the mouse brain and spinal cord, but also takes them into the relevant details of development and organization of the area they have chosen to study. The Mouse Nervous System offers a wealth of new information for experienced anatomists who work on mice. The book serves as a valuable resource for researchers and graduate students in neuroscience. Systematic consideration of the anatomy and connections of all regions of the brain and spinal cord by the authors of the most cited rodent brain atlases A major section (12 chapters) on functional systems related to motor control, sensation, and behavioral and emotional states A detailed analysis of gene expression during development of the forebrain by Luis Puelles, the leading researcher in this area Full coverage of the role of gene expression during development and the new field of genetic neuroanatomy using site-specific recombinases Examples of the use of mouse models in the study of neurological illness

Weighted Network Analysis

Author : Steve Horvath
Publisher : Springer Science & Business Media
ISBN 13 : 144198819X
Total Pages : 433 pages
Book Rating : 4.4/5 (419 download)

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Book Synopsis Weighted Network Analysis by : Steve Horvath

Download or read book Weighted Network Analysis written by Steve Horvath and published by Springer Science & Business Media. This book was released on 2011-04-30 with total page 433 pages. Available in PDF, EPUB and Kindle. Book excerpt: High-throughput measurements of gene expression and genetic marker data facilitate systems biologic and systems genetic data analysis strategies. Gene co-expression networks have been used to study a variety of biological systems, bridging the gap from individual genes to biologically or clinically important emergent phenotypes.

Non-coding RNA and the Reproductive System

Author : Dagmar Wilhelm
Publisher : Springer
ISBN 13 : 940177417X
Total Pages : 201 pages
Book Rating : 4.4/5 (17 download)

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Book Synopsis Non-coding RNA and the Reproductive System by : Dagmar Wilhelm

Download or read book Non-coding RNA and the Reproductive System written by Dagmar Wilhelm and published by Springer. This book was released on 2015-12-11 with total page 201 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an overview of the role and function of regulatory RNAs that lack protein-coding potential in key reproductive tissues. This includes the role of small interfering RNAs (siRNAs), microRNAs (miRNAs), PIWI-interacting RNAs (piRNAs), small nucleolar RNAs (snoRNAs) and long non-coding RNAs (lncRNAs). Through clear, detailed and comprehensive debate, international leading experts discuss the role these novel regulators in normal development of sexual dimorphisms, including the differentiation of ovaries and testes, the genital tract including prostate, epididymis and uterus, as well as mammary glands. In addition, particular attention is paid on their role in pathophysiological processes within the reproductive tract. The power of next generation sequencing has proved to be an invaluable tool to discover new non-coding RNAs. While the identification of non-coding RNA is relatively easy, analysing their function represents still a challenge today. In this book, authors present historical and conceptual background information, highlight the ways in which non-coding RNAs function is analysed and present their vision of the future research in their key research area.

Sturkie's Avian Physiology

Author : Colin G. Scanes
Publisher : Elsevier
ISBN 13 : 0124072437
Total Pages : 1055 pages
Book Rating : 4.1/5 (24 download)

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Book Synopsis Sturkie's Avian Physiology by : Colin G. Scanes

Download or read book Sturkie's Avian Physiology written by Colin G. Scanes and published by Elsevier. This book was released on 2014-06-30 with total page 1055 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sturkie's Avian Physiology is the classic comprehensive single volume on the physiology of domestic as well as wild birds. The Sixth Edition is thoroughly revised and updated, and features several new chapters with entirely new content on such topics as migration, genomics and epigenetics. Chapters throughout have been greatly expanded due to the many recent advances in the field. The text also covers the physiology of flight, reproduction in both male and female birds, and the immunophysiology of birds. The Sixth Edition, like the earlier editions, is a must for anyone interested in comparative physiology, poultry science, veterinary medicine, and related fields. This volume establishes the standard for those who need the latest and best information on the physiology of birds. Includes new chapters on endocrine disruptors, magnetoreception, genomics, proteomics, mitochondria, control of food intake, molting, stress, the avian endocrine system, bone, the metabolic demands of migration, behavior and control of body temperature Features extensively revised chapters on the cardiovascular system, pancreatic hormones, respiration, pineal gland, pituitary gland, thyroid, adrenal gland, muscle, gastro-intestinal physiology, incubation, circadian rhythms, annual cycles, flight, the avian immune system, embryo physiology and control of calcium Stands out as the only comprehensive, single volume devoted to bird physiology Offers a full consideration of both blood and avian metabolism on the companion website (http://booksite.elsevier.com/ 9780124071605). Tables feature hematological and serum biochemical parameters together with circulating concentrations of glucose in more than 200 different species of wild birds

Handbook on the State of the Art in Applied Psychology

Author : Peter Graf
Publisher : John Wiley & Sons
ISBN 13 : 1119627699
Total Pages : 528 pages
Book Rating : 4.1/5 (196 download)

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Book Synopsis Handbook on the State of the Art in Applied Psychology by : Peter Graf

Download or read book Handbook on the State of the Art in Applied Psychology written by Peter Graf and published by John Wiley & Sons. This book was released on 2021-01-20 with total page 528 pages. Available in PDF, EPUB and Kindle. Book excerpt: Learn the most up-to-date developments in applied psychology with one authoritative collection The Handbook on the State of the Art in Applied Psychology delivers 19 state-of-the-art addresses on a selected topic in applied psychology. Together, they constitute an up-to-date and authoritative reference that describes the most cutting-edge material in the most prominent domains of applied psychology. The accomplished academics and editors Dr. Peter Graf and Dr. David Dozois put the focus on areas where the most profound recent progress has been made. They also emphasize the link between science and practice, showcasing basic science research that has practical implications for real world problems. Readers will benefit from up-to-date research on topics as varied as occupational commitment and organizational productivity, forgiveness, shared cultural spaces, environmental decision making, and the early identification of reading problems. In addition to the papers included in the collection, the Handbook on the State of the Art in Applied Psychology features: An insightful preface focused on the theme of connecting basic research to practical solutions in the real world An overview of the chapters and their arrangement in the collection An author and subject index to assist readers in finding the information they seek A focus on the most cutting-edge advancements in the field of applied psychology, with an emphasis on the impact of technological innovation and increased recognition of cultural determinants of behavior Perfect for applied psychology researchers, workers, teachers, and students around the world, Handbook on the State of the Art in Applied Psychology also belongs on the bookshelves of anyone looking for an efficient way to get up to speed on the latest developments on a wide variety of relevant topics in applied psychology.

Magnetic Resonance of Myelin, Myelination, and Myelin Disorders

Author : Jacob Valk
Publisher : Springer Science & Business Media
ISBN 13 : 366202568X
Total Pages : 734 pages
Book Rating : 4.6/5 (62 download)

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Book Synopsis Magnetic Resonance of Myelin, Myelination, and Myelin Disorders by : Jacob Valk

Download or read book Magnetic Resonance of Myelin, Myelination, and Myelin Disorders written by Jacob Valk and published by Springer Science & Business Media. This book was released on 2013-04-17 with total page 734 pages. Available in PDF, EPUB and Kindle. Book excerpt: Magnetic resonance imaging (MRI) is now considered the imaging modality of choice for the majority of disorders affecting the central nervous system. This is particularly true for gray and white matter disorders, thanks to the superb soft tis sue contrast in MRI which allows gray matter, unmyelinated, and myelinated white matter to be distinguished and their respective disorders identified. The pre sent book is devoted to the disorders of myelin and myelination. A growing amount of detailed in vivo information about myelin, myelination, and myelin dis orders has been derived both from MRI and from MR spectroscopy (MRS). This prompted us to review the clinical, laboratory, biochemical, and pathological data on this subject in order to integrate all available information and to provide im proved insights into normal and disordered myelin and myelination. We will show how the synthesis of all available information contributes to the interpretation of MR images. After a brief historical review about the increasing knowledge on myelin and my elin disorders, we propose a new classification of myelin disorders based on the subcellular localization of the enzymatic defects as far as the inborn errors of me tabolism are concerned. This classification serves as a guide throughout the book. All items of the classification will be discussed and, whenever relevant and possi ble, be illustrated by MR images.

Brain Neurotrauma

Author : Firas H. Kobeissy
Publisher : CRC Press
ISBN 13 : 1466565993
Total Pages : 718 pages
Book Rating : 4.4/5 (665 download)

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Book Synopsis Brain Neurotrauma by : Firas H. Kobeissy

Download or read book Brain Neurotrauma written by Firas H. Kobeissy and published by CRC Press. This book was released on 2015-02-25 with total page 718 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the contribution from more than one hundred CNS neurotrauma experts, this book provides a comprehensive and up-to-date account on the latest developments in the area of neurotrauma including biomarker studies, experimental models, diagnostic methods, and neurotherapeutic intervention strategies in brain injury research. It discusses neurotrauma mechanisms, biomarker discovery, and neurocognitive and neurobehavioral deficits. Also included are medical interventions and recent neurotherapeutics used in the area of brain injury that have been translated to the area of rehabilitation research. In addition, a section is devoted to models of milder CNS injury, including sports injuries.

Glucose Sensing

Author : Chris D. Geddes
Publisher : Springer Science & Business Media
ISBN 13 : 0387330151
Total Pages : 460 pages
Book Rating : 4.3/5 (873 download)

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Book Synopsis Glucose Sensing by : Chris D. Geddes

Download or read book Glucose Sensing written by Chris D. Geddes and published by Springer Science & Business Media. This book was released on 2007-12-29 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt: An essential reference for any laboratory working in the analytical fluorescence glucose sensing field. The increasing importance of these techniques is typified in one emerging area by developing non-invasive and continuous approaches for physiological glucose monitoring. This volume incorporates analytical fluorescence-based glucose sensing reviews, specialized enough to be attractive to professional researchers, yet appealing to a wider audience of scientists in related disciplines of fluorescence.

Genes, Brain Function, and Behavior

Author : Douglas Wahlsten
Publisher : Academic Press
ISBN 13 : 0128128321
Total Pages : 300 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Genes, Brain Function, and Behavior by : Douglas Wahlsten

Download or read book Genes, Brain Function, and Behavior written by Douglas Wahlsten and published by Academic Press. This book was released on 2019-03-01 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genes, Brain Function, and Behavior offers a concise description of the nervous system that processes sensory input and initiates motor movements. It reviews how behaviors are defined and measured, and how experts decide when a behavior is perturbed and in need of treatment. Behavioral disorders that are clearly related to a defect in a specific gene are reviewed, and the challenges of understanding complex traits such as intelligence, autism and schizophrenia that involve numerous genes and environmental factors are explored. New methods of altering genes offer hope for treating or even preventing difficulties that arise in our genes. This book explains what genes are, what they do in the nervous system, and how this impacts both brain function and behavior. Presents essential background, facts, and terminology about genes, brain function, and behavior Builds clear explanations on this solid foundation while minimizing technical jargon Explores in depth several single-gene and chromosomal neurological disorders Derives lessons from these clear examples and highlights key lessons in boxes Examines the intricacies of complex traits that involve multiple genetic and environmental factors by applying lessons from simpler disorders Explains diagnosis and definition Includes a companion website with Powerpoint slides and images for each chapter for instructors and links to resources

Nutrigenomics and Proteomics in Health and Disease

Author : Martin Kussmann
Publisher : John Wiley & Sons
ISBN 13 : 1119101263
Total Pages : 493 pages
Book Rating : 4.1/5 (191 download)

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Book Synopsis Nutrigenomics and Proteomics in Health and Disease by : Martin Kussmann

Download or read book Nutrigenomics and Proteomics in Health and Disease written by Martin Kussmann and published by John Wiley & Sons. This book was released on 2017-03-21 with total page 493 pages. Available in PDF, EPUB and Kindle. Book excerpt: Now in a revised second edition, Nutrigenomics and Proteomics in Health and Disease brings together the very latest science based upon nutrigenomics and proteomics in food and health. Coverage includes many important nutraceuticals and their impact on gene interaction and health. Authored by an international team of multidisciplinary researchers, this book acquaints food and nutrition professionals with these new fields of nutrition research and conveys the state of the science to date. Thoroughly updated to reflect the most current developments in the field, the second edition includes six new chapters covering gut health and the personal microbiome; gut microbe-derived bioactive metabolites; proteomics and peptidomics in nutrition; gene selection for nutrigenomic studies; gene-nutrient network analysis, and nutrigenomics to nutritional systems biology. An additional five chapters have also been significantly remodelled. The new text includes a rethinking of in vitro and in vivo models with regard to their translatability into human phenotypes, and normative science methods and approaches have been complemented by more comprehensive systems biology-based investigations, deploying a multitude of omic platforms in an integrated fashion. Innovative tools and methods for statistical treatment and biological network analysis are also now included.

Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 030916785X
Total Pages : 223 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research by : National Research Council

Download or read book Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research written by National Research Council and published by National Academies Press. This book was released on 2003-08-22 with total page 223 pages. Available in PDF, EPUB and Kindle. Book excerpt: Expanding on the National Research Council's Guide for the Care and Use of Laboratory Animals, this book deals specifically with mammals in neuroscience and behavioral research laboratories. It offers flexible guidelines for the care of these animals, and guidance on adapting these guidelines to various situations without hindering the research process. Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research offers a more in-depth treatment of concerns specific to these disciplines than any previous guide on animal care and use. It treats on such important subjects as: The important role that the researcher and veterinarian play in developing animal protocols. Methods for assessing and ensuring an animal's well-being. General animal-care elements as they apply to neuroscience and behavioral research, and common animal welfare challenges this research can pose. The use of professional judgment and careful interpretation of regulations and guidelines to develop performance standards ensuring animal well-being and high-quality research. Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research treats the development and evaluation of animal-use protocols as a decision-making process, not just a decision. To this end, it presents the most current, in-depth information about the best practices for animal care and use, as they pertain to the intricacies of neuroscience and behavioral research.