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Matrix Metalloproteinases In The Central Nervous System
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Book Synopsis Matrix Metalloproteinases In The Central Nervous System by : Katherine Conant
Download or read book Matrix Metalloproteinases In The Central Nervous System written by Katherine Conant and published by World Scientific. This book was released on 2005-07-26 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the reader with an understanding of the role played by matrix metalloproteinases (MMPs) in the normal and diseased central nervous system (CNS). These enzymes may be important to brain development, and may also contribute to tissue destruction, which is observed with inflammatory and degenerative conditions of the brain. The book provides a background on the biology of MMPs, and on the stimuli and conditions that are linked to an increase in their production and activity. It describes the targets of MMPs, which include matrix proteins such as collagen, soluble cytokines and chemokines, and cell surface receptors. Studies implicating MMPs in neuronal process outgrowth and cell migration in CNS development are covered. The book also touches on studies suggesting that, in certain situations, dysregulated MMP activity and/or production may be critical to blood-brain barrier breakdown and neuronal damage./a
Book Synopsis Matrix Metalloproteinases in the Equine Central Nervous System by : Cristina Sogaro Robinson
Download or read book Matrix Metalloproteinases in the Equine Central Nervous System written by Cristina Sogaro Robinson and published by . This book was released on 2007 with total page 136 pages. Available in PDF, EPUB and Kindle. Book excerpt: Abstract: Many diseases of the central nervous system share common pathophysiological processes, such as disruption of the blood-brain barrier (BBB), remodeling of the extracellular matrix (ECM), inflammation and oxidative stress. In the last two decades it has become evident that matrix metalloproteinases (MMPs) play an essential role in many of these processes. Several studies have focused on the regulation and expression of these proteases in experimental models of neurologic diseases, revealing that inhibition of MMPs in early stages of disease has the potential to reduce the extent of damage to nervous tissue and improve functional neurologic recovery. Research is currently focusing on defining the role of MMP in specific neurologic conditions to determine whether MMP inhibitors would be appropriate in clinical settings. Selective MMP inhibitors are currently used in research settings. However, commonly used drugs, such as corticosteroids and tetracyclines, are non selective MMPs inhibitors which are used in horses with neurologic disease. These drugs may alter the outcome of said disease by modification of MMP activity. This first part of this work, a review of MMP role in central nervous system diseases, has been made in attempt to translate some of the knowledge from human and laboratory species to the equine species and explore possible treatment options in horses affected by neurologic diseases. In the second part, we evaluated MMP-9 activity in the CSF of 40 horses affected by neurologic diseases. On gelatin zymography all horses had low but present MMP-9 activity.
Book Synopsis Tissue Destruction, Matrix Metalloproteinases and Tuberculosis of the Central Nervous System by :
Download or read book Tissue Destruction, Matrix Metalloproteinases and Tuberculosis of the Central Nervous System written by and published by . This book was released on 2007 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Chemokines and Matrix Metalloproteinases in Cerebrospinal Fluid from Children with Leukemia by : Christina Saner
Download or read book Chemokines and Matrix Metalloproteinases in Cerebrospinal Fluid from Children with Leukemia written by Christina Saner and published by . This book was released on 2003 with total page 58 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Mt1-Mmp Regulates Central Nervous System Development Through Notch Signaling by : Jin Zhou
Download or read book Mt1-Mmp Regulates Central Nervous System Development Through Notch Signaling written by Jin Zhou and published by . This book was released on 2017-01-26 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation, "MT1-MMP Regulates Central Nervous System Development Through Notch Signaling" by Jin, Zhou, 周瑾, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: The central nervous system (CNS) development is a highly organized process involving cell proliferation, cell death and cell migration. The mechanisms that goven this process are complex and remain one of the most challenging question in neurobiology. Notch signaling is among the most important pathways that participate in the CNS development. The absence of Notch signaling causes precocious neuronal differentiation and reduced generation of neurons. On the contrary, activation of Notch signaling leads to the maintenance of embryonic telencephalic cells in an undifferentiated status. Moreover, Notch signaling first inhibits neuron fate while promotes glial fate and later promotes astroglia production and suppresses oligodendroglia differentiation. Membrane-type 1 matrix metalloproteinase (MT1-MMP) is the first identified membrane tethered matrix metalloproteinase which is best and first known for its role in tumor metastasis. Since then, it has been shown that MT1-MMP is important for proper generation of many tissues and organs, such as the skeleton, lung or B-cells. In addition, MT1-MMP is also involved in several pathological conditions, particularly in cancer. It functions in extracellular matrix (ECM) turnover and membrane-anchored molecules cleavage hence it is important for cell-ECM interactions, soluble molecules releasing and cell signaling regulation. Indeed, recent findings showed that MT1-MMP sheds DLL1 to negatively regulate Notch signaling in bone marrow stroma cells (BMSCs) which ultimately causes defective B-cell development in MT1-MMP knockout mice. However, the function of MT1-MMP during CNS development has never been studied before. In this study, I hypothesize that MT1-MMP may be involved in CNS development and, together with the recent findings in our lab, its function may be mediated by Notch signaling. The expression pattern of MT1-MMP in CNS was for the first time described in this study. Loss of MT1-MMP affects CNS development with impaired ventricle development in forebrain and neural tube closure problem in the midbrain at embryonic stage. At postnatal stage, MT1-MMP loss causes enlarged lateral ventricle (LV) size, altered cortex pattern, accelerated cell death and defective differentiation into OLs. Furthermore, increased amount of Nestin+/GFAP+ cells in the MT1-MMP knockout as well as the larger size of the MT1-MMP-/- neurospheres were found, indicating that MT1-MMP participates in neural stem cell (NSC) and neural progenitor cell (NPC) proliferation, self-renewal and/or survival. DAPT treatment can rescue the phenotype of MT1-MMP-/- neurospheres and thus these results suggest that MT1-MMP controls CNS development through at least the regulation of Notch signaling. Notch signaling was demonstrated to be abnormally activated at both embryonic and postnatal stages as well as either in vivo or in vitro in the absence of MT1-MMP. Additional functions of MT1-MMP in the ECM and neuroepithelial cell (NEC) polarity can also be considered. The amount and distribution of the ECM component fibronectin and its main receptor β1-integrin are affected by loss of MT1-MMP. Besides, less primary cilium and cell surface accumulation of β-catenin and N-cadherin occurs in the MT1-MMP-/- neuroepithelium. In short, I found that MT1-MMP regulates Notch signaling in CNS. Indeed, loss of MT1-MMP causes abnormally activated Notch signaling that contributes to defective CNS de
Book Synopsis Matrix Metalloproteinases in Tissue Remodelling and Inflammation by : Vincent Lagente
Download or read book Matrix Metalloproteinases in Tissue Remodelling and Inflammation written by Vincent Lagente and published by Springer Science & Business Media. This book was released on 2008-11-07 with total page 177 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides new advances regarding the involvement of MMPs in various diseases associated with inflammatory processes. Moreover, the recent development of selective and non selective inhibitors of MMPs give new insights in the relationship between activation of inflammatory cells and tissue remodelling and advise new therapeutics possibilities to the treatment of inflammatory disease. The volume has an international authorship and is written by leading experts in the field.
Book Synopsis Matrix Metalloproteinase Inhibitors in Cancer Therapy by : Neil J. Clendeninn
Download or read book Matrix Metalloproteinase Inhibitors in Cancer Therapy written by Neil J. Clendeninn and published by Springer Science & Business Media. This book was released on 2000-09-17 with total page 371 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cutting-edge investigators review the current status of the entire field, from the biology of MMPs through the current clinical studies. The authors include many leading scientists from pharmaceutical companies who present all the latest concepts and results on the preferred design strategies for MMP inhibitors, their molecular mechanisms, and their substrates. In addition, they fully describe their personal research on specific MMP inhibitors, detailing vanguard design strategies, their in vitro activity, the outcome of animal model studies and, where available, their toxicology, safety, efficacy in human clinical trials. Comprehensive and state-of-the-art, Matrix Metalloproteinase Inhibitors in Cancer Therapy offers basic and clinical investigators alike a richly informative summary of all the latest research on these powerful new drugs, and their high promise as emerging cancer therapeutics.
Book Synopsis Molecular Properties of Human Matrix Metalloproteinase-9 from Cell Cultures and the Central Nervous System by : Jon R. Backstrom
Download or read book Molecular Properties of Human Matrix Metalloproteinase-9 from Cell Cultures and the Central Nervous System written by Jon R. Backstrom and published by . This book was released on 1994 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Role of Matrix Metalloproteinases in Inflammatory Demyelination of the Peripheral Nervous System by : P. M. Hughes
Download or read book Role of Matrix Metalloproteinases in Inflammatory Demyelination of the Peripheral Nervous System written by P. M. Hughes and published by . This book was released on 1997 with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Involvement of Matrix Metalloproteinases in the Repair of the Peripheral Nervous System by : Maria Demestre
Download or read book The Involvement of Matrix Metalloproteinases in the Repair of the Peripheral Nervous System written by Maria Demestre and published by . This book was released on 2001 with total page 255 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Matrix Metalloproteinases and Tissue Remodeling in Health and Disease: Target Tissues and Therapy by :
Download or read book Matrix Metalloproteinases and Tissue Remodeling in Health and Disease: Target Tissues and Therapy written by and published by Academic Press. This book was released on 2017-06-26 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: Matrix Metalloproteinases and Tissue Remodeling in Health and Disease: Target Tissues and Therapy, Volume, Volume 148, the latest volume in the Progress in Molecular Biology and Translational Science series covers a variety of timely topics, with chapters focusing on The Role of Matrix Metalloproteinases in Development, Repair, and Destruction of the Lungs, Matrix Metalloproteinases in Kidney Disease: Role in Pathogenesis and Potential as a Therapeutic Target, Regulation of Matrix Metalloproteinase in the Pathogenesis of Diabetic Retinopathy, Matrix Metalloproteinases in Normal Pregnancy and Preeclampsia, and Matrix Metalloproteinases, Neural Extracellular Matrix, and Central Nervous System Pathology. This volume is the second part of a thematic on matrix metalloproteinases and tissue remodeling in health and disease. It focuses on the role of MMPs in other systems, target tissues, and pathological disorders and the potential benefits of MMP inhibitors in various disorders. Serves as the second part of a thematic on matrix metalloproteinases and tissue remodeling in health and disease Focuses on cardiovascular remodeling Contains contributions from leading authorities on the topics Publishes cutting-edge reviews in molecular biology
Book Synopsis Matrix Metalloproteinases in Tissue Remodelling and Inflammation by : Vincent Lagente
Download or read book Matrix Metalloproteinases in Tissue Remodelling and Inflammation written by Vincent Lagente and published by Birkhäuser. This book was released on 2009-08-29 with total page 168 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides new advances regarding the involvement of MMPs in various diseases associated with inflammatory processes. Moreover, the recent development of selective and non selective inhibitors of MMPs give new insights in the relationship between activation of inflammatory cells and tissue remodelling and advise new therapeutics possibilities to the treatment of inflammatory disease. The volume has an international authorship and is written by leading experts in the field.
Book Synopsis Molecular Targets of CNS Tumors by : Miklos Garami
Download or read book Molecular Targets of CNS Tumors written by Miklos Garami and published by IntechOpen. This book was released on 2011-09-22 with total page 688 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Targets of CNS Tumors is a selected review of Central Nervous System (CNS) tumors with particular emphasis on signaling pathway of the most common CNS tumor types. To develop drugs which specifically attack the cancer cells requires an understanding of the distinct characteristics of those cells. Additional detailed information is provided on selected signal pathways in CNS tumors.
Book Synopsis Brain Extracellular Matrix in Health and Disease by :
Download or read book Brain Extracellular Matrix in Health and Disease written by and published by Elsevier. This book was released on 2014-10-30 with total page 521 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the central nervous system, extracellular matrix (ECM) molecules, including hyaluronic acid, chondroitin and heparan sulfate proteoglycans, tenascins, reelin and agrin, along with their remodelling enzymes, such as neurotrypsin, neuropsin, plasminogen activators, and metalloproteinases, are secreted by neural and non-neural cells into the extracellular space to form the ECM and signal via ECM receptors. Despite recent advances in the ECM field, the importance of neural ECM for physiological and pathological processes is currently less widely recognized than that of other CNS elements. This book will enlighten recent progress in our understanding of mechanisms by which neural ECM, its receptors and activity-dependent ECM remodeling regulate neural development, synaptic plasticity, and contribute to pathological changes in the brain. In the first part, the roles of ECM signaling and proteolytic modification of ECM in neurogenesis, neural migration, axonal pathfinding, synaptogenesis, synaptic and homeostatic plasticity will be discussed. The second part will focus on the emerging ECM-dependent mechanisms associated with CNS injury, epilepsy, neurodegenerative and neuropsychiatric diseases. For further development of neural ECM field, a very important contribution is the third part of the book, which is devoted to neural ECM-targeting tools and therapeutics. The concluding fourth part will highlight advances in development of artificial ECM and ECM-based systems suitable for multisite recording and stimulation of neural cells. - Authors are the leading experts in the field of brain extracellular matrix in health and disease - Book covers the most important aspects of brain extracellular matrix in health and disease - Interesting for both scientists and clinicians
Book Synopsis Matrix Metalloproteinases and TIMPs by : J. F. Woessner
Download or read book Matrix Metalloproteinases and TIMPs written by J. F. Woessner and published by . This book was released on 2023 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This study covers the sequence information, three-dimensional structures, activation, protein substrates, specificity requirements, inhibition, and biological roles of identified MMPs.
Book Synopsis Endothelial Cell Plasticity in the Normal and Injured Central Nervous System by : Esperanza Melendez Herrera
Download or read book Endothelial Cell Plasticity in the Normal and Injured Central Nervous System written by Esperanza Melendez Herrera and published by CRC Press. This book was released on 2015-01-28 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book highlights the importance of endothelial cells as key players in the functioning of the nervous system under both normal and pathological conditions. The book demonstrates that endothelial cells are an essential and dynamic cell population in the central nervous system, with multiple and complex roles, not only in the maintenance of homeo
Book Synopsis Vascular Development by : Derek J. Chadwick
Download or read book Vascular Development written by Derek J. Chadwick and published by John Wiley & Sons. This book was released on 2007-08-20 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: The formation of blood vessels is an essential aspect of embryogenesis in vertebrates. It is a central feature of numerous post-embryonic processes, including tissue and organ growth and regeneration. It is also part of the pathology of tumour formation and certain inflammatory conditions. In recent years, comprehension of the molecular genetics of blood vessel formation has progressed enormously and studies in vertebrate model systems, especially the mouse and the zebrafish, have identified a common set of molecules and processes that are conserved throughout vertebrate embryogenesis while, in addition, highlighting aspects that may differ between different animal groups. The discovery in the past decade of the crucial role of new blood vessel formation for the development of cancers has generated great interest in angiogenesis (the formation of new blood vessels from pre-existing ones), with its major implications for potential cancer-control strategies. In addition, there are numerous situations where therapeutic treatments either require or would be assisted by vasculogenesis (the de novo formation of blood vessels). In particular, post-stroke therapies could include treatments that stimulate neovascularization of the affected tissues. The development of such treatments, however, requires thoroughly understanding the developmental properties of endothelial cells and the basic biology of blood vessel formation. While there are many books on angiogenesis, this unique book focuses on exactly this basic biology and explores blood vessel formation in connection with tissue development in a range of animal models. It includes detailed discussions of relevant cell biology, genetics and embryogenesis of blood vessel formation and presents insights into the cross-talk between developing blood vessels and other tissues. With contributions from vascular biologists, cell biologists and developmental biologists, a comprehensive and highly interdisciplinary volume is the outcome.
