Mathematical Modelling Of Particle Transport And Deposition In The Acinar Region Of The Lung

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Mathematical Modelling of Particle Transport and Deposition in the Acinar Region of the Lung

Author : Pierre-Antoine Muller
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (8 download)

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Book Synopsis Mathematical Modelling of Particle Transport and Deposition in the Acinar Region of the Lung by : Pierre-Antoine Muller

Download or read book Mathematical Modelling of Particle Transport and Deposition in the Acinar Region of the Lung written by Pierre-Antoine Muller and published by . This book was released on 2011 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The context of this thesis is the modelling of particle deposition in the human lung in order to optimise the administration of inhaled drugs. As the alveolar region plays a crucial role both physiologically and functionally, especially for systemic delivery, the objective of this work is to set-up a particle deposition model specific to the acinar region which could be integrated in whole lung deposition model. The first two chapters concentrate on the anatomical and functional aspects of the lung and on the physical principles involved in the flow and particle transport mechanisms in the lung. Then a computational fluid dynamics model was setup in a simplified alveolar geometry. Aerosol bolus transport was studied through an Eulerian approach, for one or several breathing cycles. The impact of flow irreversibilities on bolus dispersion was quantified. The last chapter deals with the integration of the previous results in an analytical model of particle deposition in the whole lung. The results generated by this model are then compared to experimental data from the literature or obtained from an ongoing clinical trial. The results of the new theoretical model show an increase of particle deposition in the acinar region which improves correlation of theory with experimental data. This model could favourably help designing therapies targeting the alveolar region of the lung.

Study of Airflow and Particle Transport in Acinar Airways of the Human Lung

Author : Haribalan Kumar
Publisher :
ISBN 13 :
Total Pages : 158 pages
Book Rating : 4.:/5 (77 download)

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Book Synopsis Study of Airflow and Particle Transport in Acinar Airways of the Human Lung by : Haribalan Kumar

Download or read book Study of Airflow and Particle Transport in Acinar Airways of the Human Lung written by Haribalan Kumar and published by . This book was released on 2011 with total page 158 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this work, airflow and particle transport are studied using mathematical and image-based models of pulmonary acinus. Numerical results predict that airflow in the presence of wall motion in a three-dimensional honey-comb like geometry is characterized by the presence of a recirculation region within the alveolar cavity and a weak entraining flow between alveolar duct and cavity. Alveolar flow in distal generations is characterized by higher alveolar flow rates, larger entrainment of ductal flow and absence of recirculatory flow inside alveoli. The study of transport constitutes assessment of mixing visualized by the tracking of massless particles and the study of transport and deposition of aerosols. The phenomenon of steady streaming is found to hold the key to the origin of kinematic mixing in the alveolus, the alveolar mouth and the alveolated duct. This mechanism provides the explanation for observed folding of material lines and increases in material surface area, and has no bearing on whether the geometry is expanding or if flow separates within the cavity or not. Streaming results in non-zero drift of particles between the beginning and end of a breathing cycle. Based on flow conditions and resultant convective mixing measures, we conclude that significant convective mixing in the duct and within an alveolus could originate only in the first few generations of the acinar tree as a result of non-zero inertia, flow asymmetry and large KC number. Evidence of streaming and related Lagrangian drift is also observed in image-based acinar models. Finally, particle deposition calculations are performed on the models of pulmonary acinus considered in this study.

Modeling Particle Transport and Deposition in the Human Lung

Author : Seong Suk Park
Publisher :
ISBN 13 :
Total Pages : 282 pages
Book Rating : 4.:/5 (74 download)

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Book Synopsis Modeling Particle Transport and Deposition in the Human Lung by : Seong Suk Park

Download or read book Modeling Particle Transport and Deposition in the Human Lung written by Seong Suk Park and published by . This book was released on 2006 with total page 282 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Respiratory Flows in the Pulmonary Acinus

Author : Josué Sznitman
Publisher : Sudwestdeutscher Verlag Fur Hochschulschriften AG
ISBN 13 : 9783838106847
Total Pages : 248 pages
Book Rating : 4.1/5 (68 download)

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Book Synopsis Respiratory Flows in the Pulmonary Acinus by : Josué Sznitman

Download or read book Respiratory Flows in the Pulmonary Acinus written by Josué Sznitman and published by Sudwestdeutscher Verlag Fur Hochschulschriften AG. This book was released on 2009 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: The pulmonary acinus, known as the gas exchange region of the lung, encompasses the complex of millions of sub-millimeter alveoli and may represent a potential host for pulmonary complications and diseases. These health disorders may require the inhalation of therapeutic drugs typically administered in the form of aerosolized particles. Both a precise understanding of the mechanisms leading to particle deposition as well as the need to target aerosols to specific pulmonary sites, remain ongoing challenges and depend directly on the fluid dynamics in the lung, and specifically on the microflows present in the acinar region. These considerations call not only for a deepening of our understanding of the fluid mechanics pertinent to the acinar region of the lung, but also, for the potential development of novel strategies towards improved and enhanced particle deposition inside the lung. The present thesis, which lies at the interface between engineering and medicine, is concerned with the role of convective respiratory flows in the acinar region of the lung, in conjunction with the transport and deposition of inhaled particles.

Morphometry of the Human Lung

Author : Ewald R. Weibel
Publisher : Academic Press
ISBN 13 : 1483225798
Total Pages : 164 pages
Book Rating : 4.4/5 (832 download)

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Book Synopsis Morphometry of the Human Lung by : Ewald R. Weibel

Download or read book Morphometry of the Human Lung written by Ewald R. Weibel and published by Academic Press. This book was released on 2013-10-22 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt: Morphometry of the Human Lung considers the developments in understanding the quantitative anatomy of the lung, and in the correlation of anatomy with physiology. This book is composed of 11 chapters, and begins with an overview of a systematic approach to a quantitative morphologic analysis of the architecture of the human lung, followed by a presentation of general problems of methodology and the derivation of reliable dimensional models of this organ. The subsequent chapters describe the methods of preparation of tissues, methods of random sampling, and adaptation of methodologies from other fields of science. These topics are followed by discussions the mathematical formulations for the translation of the data into the desired geometric forms and a technique of counting. The final chapters look into the mode of distribution and geometric forms that should eventually facilitate mathematical and physical considerations regarding the function of the lungs. These chapters also consider the application of these quantitative methods to the study of pathologic specimens, providing a most timely renovation of morphologic pathology. This book will be of value to pulmonologists, physiologists, and researchers who are interested in lung morphometry.

Aerobiology

Author : Harry Salem
Publisher : Royal Society of Chemistry
ISBN 13 : 1849735948
Total Pages : 518 pages
Book Rating : 4.8/5 (497 download)

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Book Synopsis Aerobiology by : Harry Salem

Download or read book Aerobiology written by Harry Salem and published by Royal Society of Chemistry. This book was released on 2016-04-26 with total page 518 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focusses on the toxicological aspects of aerobiology, considering the adverse health effects associated with the inhalation of airborne biological particulates.

Computational Fluid and Particle Dynamics in the Human Respiratory System

Author : Jiyuan Tu
Publisher : Springer Science & Business Media
ISBN 13 : 9400744870
Total Pages : 383 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Computational Fluid and Particle Dynamics in the Human Respiratory System by : Jiyuan Tu

Download or read book Computational Fluid and Particle Dynamics in the Human Respiratory System written by Jiyuan Tu and published by Springer Science & Business Media. This book was released on 2012-09-18 with total page 383 pages. Available in PDF, EPUB and Kindle. Book excerpt: Traditional research methodologies in the human respiratory system have always been challenging due to their invasive nature. Recent advances in medical imaging and computational fluid dynamics (CFD) have accelerated this research. This book compiles and details recent advances in the modelling of the respiratory system for researchers, engineers, scientists, and health practitioners. It breaks down the complexities of this field and provides both students and scientists with an introduction and starting point to the physiology of the respiratory system, fluid dynamics and advanced CFD modeling tools. In addition to a brief introduction to the physics of the respiratory system and an overview of computational methods, the book contains best-practice guidelines for establishing high-quality computational models and simulations. Inspiration for new simulations can be gained through innovative case studies as well as hands-on practice using pre-made computational code. Last but not least, students and researchers are presented the latest biomedical research activities, and the computational visualizations will enhance their understanding of physiological functions of the respiratory system.

ICRP Publication 130

Author : ICRP,
Publisher : SAGE Publications Limited
ISBN 13 : 9781473944404
Total Pages : 0 pages
Book Rating : 4.9/5 (444 download)

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Book Synopsis ICRP Publication 130 by : ICRP,

Download or read book ICRP Publication 130 written by ICRP, and published by SAGE Publications Limited. This book was released on 2016-04-18 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Lung Mechanics

Author : Jason H. T. Bates
Publisher : Cambridge University Press
ISBN 13 : 0521509602
Total Pages : 237 pages
Book Rating : 4.5/5 (215 download)

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Book Synopsis Lung Mechanics by : Jason H. T. Bates

Download or read book Lung Mechanics written by Jason H. T. Bates and published by Cambridge University Press. This book was released on 2009-07-30 with total page 237 pages. Available in PDF, EPUB and Kindle. Book excerpt: A modern quantitative study of lung mechanics, relating mathematical modeling and engineering principles to lung function, structure, mechanics, and disease.

Exhaled Biomarkers

Author : I. Horvath
Publisher : European Respiratory Society
ISBN 13 : 1849840059
Total Pages : 261 pages
Book Rating : 4.8/5 (498 download)

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Book Synopsis Exhaled Biomarkers by : I. Horvath

Download or read book Exhaled Biomarkers written by I. Horvath and published by European Respiratory Society. This book was released on 2010-09-01 with total page 261 pages. Available in PDF, EPUB and Kindle. Book excerpt: Exhaled air contains numerous substances, often in extremely low concentrations. The development of sensitive detection techniques has made it possible to examine the composition of exhaled air in relation to a variety of airway diseases and other disorders. In this book, an overview of current cutting-edge breath analysis techniques and their clinical applications is provided for the clinician. The various contributions give a fascinating perspective of a future where new, highly sensitive methodologies will enable clinicians to diagnose and monitor a wide variety of diseases merely by taking.

Pulmonary Immunotoxicology

Author : Mitchell D. Cohen
Publisher : Springer Science & Business Media
ISBN 13 : 9780792378433
Total Pages : 492 pages
Book Rating : 4.3/5 (784 download)

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Book Synopsis Pulmonary Immunotoxicology by : Mitchell D. Cohen

Download or read book Pulmonary Immunotoxicology written by Mitchell D. Cohen and published by Springer Science & Business Media. This book was released on 2000-06-30 with total page 492 pages. Available in PDF, EPUB and Kindle. Book excerpt: A reference for investigators in pulmonary toxicology and immunotoxicology and for people involved in administrating and regulating matters related to inhale materials, and serviceable as a textbook for a graduate or advanced undergraduate course in pulmonary immunotoxicology. US researchers from academic and industrial laboratories provide information concerning the effects of various inhaled materials on the immune system of the respiratory tract. They cover basic background concepts including the normal structure and function of the respiratory system and its basic immunology, the major types of pathological consequences that can arise from immunomodulation within the respiratory tract, the specific major classes of airborne agents that are known to alter immune function, and risk assessment. Annotation copyrighted by Book News, Inc., Portland, OR

Tree-Shaped Fluid Flow and Heat Transfer

Author : António F. Miguel
Publisher : Springer
ISBN 13 : 3319732609
Total Pages : 108 pages
Book Rating : 4.3/5 (197 download)

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Book Synopsis Tree-Shaped Fluid Flow and Heat Transfer by : António F. Miguel

Download or read book Tree-Shaped Fluid Flow and Heat Transfer written by António F. Miguel and published by Springer. This book was released on 2018-04-20 with total page 108 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides the first comprehensive state-of-the-art research on tree (dendritic) fluid flow and heat transfer. It covers theory, numerical simulations and applications. It can serve as extra reading for graduate-level courses in engineering and biotechnology. Tree flow networks, also known as dendritic flow networks, are ubiquitous in nature and engineering applications. Tree-shaped design is prevalent when the tendency of the flow (fluid, energy, matter and information) is to move more easily between a volume (or area) and a point, and vice versa. From the geophysical trees to animals and plants, we can observe numerous systems that exhibit tree architectures: river basins and deltas, lungs, circulatory systems, kidneys, vascularized tissues, roots, stems, and leaves, among others. Tree design is also prevalent in man-made flow systems, both in macro- and microfluidic devices. A vast array of tree-shaped design is available and still emerging in chemical engineering, electronics cooling, bioengineering, chemical and bioreactors, lab-on-a-chip systems, and smart materials with volumetric functionalities, such as self-healing and self-cooling. This book also addresses the basic design patterns and solutions for cooling bodies where there is heat generation. Several shapes of fin as well as assemblies of fins are addressed. An up-to-date review of cavities, i.e., inverted or negative fins, for facilitating the flow of heat is also presented. Heat trees using high thermal conductivity material can be used in the cooling of heat-generating bodies, and can also be applied to the cooling of electronics.

Health Risks of Radon and Other Internally Deposited Alpha-Emitters

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309037891
Total Pages : 623 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Health Risks of Radon and Other Internally Deposited Alpha-Emitters by : National Research Council

Download or read book Health Risks of Radon and Other Internally Deposited Alpha-Emitters written by National Research Council and published by National Academies Press. This book was released on 1988-02-01 with total page 623 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes hazards from radon progeny and other alpha-emitters that humans may inhale or ingest from their environment. In their analysis, the authors summarize in one document clinical and epidemiological evidence, the results of animal studies, research on alpha-particle damage at the cellular level, metabolic pathways for internal alpha-emitters, dosimetry and microdosimetry of radionuclides deposited in specific tissues, and the chemical toxicity of some low-specific-activity alpha-emitters. Techniques for estimating the risks to humans posed by radon and other internally deposited alpha-emitters are offered, along with a discussion of formulas, models, methods, and the level of uncertainty inherent in the risk estimates.

First Principles of Meteorology and Air Pollution

Author : Mihalis Lazaridis
Publisher : Springer Science & Business Media
ISBN 13 : 9400701624
Total Pages : 368 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis First Principles of Meteorology and Air Pollution by : Mihalis Lazaridis

Download or read book First Principles of Meteorology and Air Pollution written by Mihalis Lazaridis and published by Springer Science & Business Media. This book was released on 2010-11-18 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book’s main objective is to decipher for the reader the main processes in the atmosphere and the quantification of air pollution effects on humans and the environment, through first principles of meteorology and modelling/measurement approaches. The understanding of the complex sequence of events, starting from the emission of air pollutants into the atmosphere to the human health effects as the final event, is necessary for the prognosis of potential risk to humans from specific chemical compounds and mixtures of them. It fills a gap in the literature by providing a solid grounding in the first principles of meteorology and air pollution, making it particularly useful for undergraduate students. Its broad scope makes it a valuable text in many related disciplines, containing a comprehensive and integrated methodology to study the first principles of air pollution, meteorology, indoor air pollution, and human exposure. Problem-solving exercises help to reinforce concepts.

Smoking and Health

Author : United States. Surgeon General's Advisory Committee on Smoking and Health
Publisher :
ISBN 13 :
Total Pages : 406 pages
Book Rating : 4.3/5 (121 download)

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Book Synopsis Smoking and Health by : United States. Surgeon General's Advisory Committee on Smoking and Health

Download or read book Smoking and Health written by United States. Surgeon General's Advisory Committee on Smoking and Health and published by . This book was released on 1964 with total page 406 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Inhaled Medicines

Author : Stavros Kassinos
Publisher : Academic Press
ISBN 13 : 0128149752
Total Pages : 439 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Inhaled Medicines by : Stavros Kassinos

Download or read book Inhaled Medicines written by Stavros Kassinos and published by Academic Press. This book was released on 2021-01-20 with total page 439 pages. Available in PDF, EPUB and Kindle. Book excerpt: Inhaled medicines are widely used to treat pulmonary and systemic diseases. The efficacy and safety of these medicines can be influenced by the deposited fraction, the regional deposition pattern within the lungs and by post-depositional events such as drug dissolution, absorption and clearance from the lungs. Optimizing performance of treatments thus requires that we understand and are able to quantify these product and drug attributes. Inhaled Medicines: Optimizing Development through Integration of In Silico, In Vitro and In Vivo Approaches explores the current state of the art with respect to inhalation drug delivery, technologies available to assess product performance, and novel in silico methods now available to link in vitro product performance to clinical performance. Recent developments in the latter field, especially the prospect of integration of three-dimensional Computational Fluid Particle Methods (3D-CFPD) with physiologically based pharmacokinetic (PBPK models), unlocks the potential for in silico population studies that can help inform and optimize treatment and product development strategies. In this highly multidisciplinary field, where progress occurs at the intersection of several disciplines of engineering and science, this work aims to integrate current knowledge and understanding and to articulate a clear vision for future developments. Considers the healthcare needs driving the field, and where inhaled drugs could have the maximum impact Gives a concise account of the state of the art in key areas and technologies such as device and formulation technologies, clinically relevant in vitro performance assessment, medical imaging, as well as in silico modelling and simulation Articulates how the combination of in vitro product performance data, medical imaging and simulations technologies in the framework of large scale in silico pre-clinical trials could revolutionize the field Provides systematic and thorough referencing to sources offering a more-in-depth analysis of technical issues

Introductory Biomechanics

Author : C. Ross Ethier
Publisher : Cambridge University Press
ISBN 13 : 1139461826
Total Pages : 10 pages
Book Rating : 4.1/5 (394 download)

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Book Synopsis Introductory Biomechanics by : C. Ross Ethier

Download or read book Introductory Biomechanics written by C. Ross Ethier and published by Cambridge University Press. This book was released on 2007-03-12 with total page 10 pages. Available in PDF, EPUB and Kindle. Book excerpt: Introductory Biomechanics is a new, integrated text written specifically for engineering students. It provides a broad overview of this important branch of the rapidly growing field of bioengineering. A wide selection of topics is presented, ranging from the mechanics of single cells to the dynamics of human movement. No prior biological knowledge is assumed and in each chapter, the relevant anatomy and physiology are first described. The biological system is then analyzed from a mechanical viewpoint by reducing it to its essential elements, using the laws of mechanics and then tying mechanical insights back to biological function. This integrated approach provides students with a deeper understanding of both the mechanics and the biology than from qualitative study alone. The text is supported by a wealth of illustrations, tables and examples, a large selection of suitable problems and hundreds of current references, making it an essential textbook for any biomechanics course.