Major Histocompatibility Complex Mhc In Health And Disease

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Major Histocompatibility Complex (MHC) in Health and Disease

Author : Jerzy K. Kulski
Publisher : MDPI
ISBN 13 : 3039280724
Total Pages : 374 pages
Book Rating : 4.0/5 (392 download)

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Book Synopsis Major Histocompatibility Complex (MHC) in Health and Disease by : Jerzy K. Kulski

Download or read book Major Histocompatibility Complex (MHC) in Health and Disease written by Jerzy K. Kulski and published by MDPI. This book was released on 2020-01-15 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt: The major histocompatibility complex (MHC) is a highly polymorphic and diverse multigene locus in all jawed vertebrate species that has an integral role in adaptive/innate immune systems, transplantation, and infectious and autoimmune diseases. The MHC supra-locus in mammalian vertebrates is usually partitioned into three distinct regions, known as classes I, II, and III, which, to varying extents, can be found conserved in nonmammalian jawed vertebrates, such as bony fish, amphibians, and bird lineages. The MHC gene region is characterized particularly by the expression of class I and class II glycoproteins that bind peptides derived from intracellular or extracellular antigens to circulating T-cells. While this expressed antigenic specificity remains the predominant interest with respect to MHC function and polymorphism in a population, a broader concept has emerged that examines the MHC as a multifunctional polymorphic controller that facilitates and regulates genome diversity with a much greater array of functions and effects than just MHC-restricted antigen recognition. This volume of 19 reprints presented by various experts and collected from the Special Issue of Cells on “MHC in Health and Disease” covers a broad range of topics on the genomic diversity of the MHC regulatory system in various vertebrate species, including MHC class I, II, and III genes; innate and adaptive immunity; neurology; transplantation; haplotypes; infectious and autoimmune diseases; fecundity; conservation; allelic lineages; and evolution. Taken together, these articles demonstrate the immense complexity and diversity of the MHC structure and function within and between different vertebrate species.

Janeway's Immunobiology

Author : Kenneth Murphy
Publisher : Garland Science
ISBN 13 : 9780815344575
Total Pages : pages
Book Rating : 4.3/5 (445 download)

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Book Synopsis Janeway's Immunobiology by : Kenneth Murphy

Download or read book Janeway's Immunobiology written by Kenneth Murphy and published by Garland Science. This book was released on 2010-06-22 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.

Major Histocompatibility Complex (MHC) in Health and Disease

Author : Jerzy K. Kulski
Publisher :
ISBN 13 : 9783039280735
Total Pages : 375 pages
Book Rating : 4.2/5 (87 download)

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Book Synopsis Major Histocompatibility Complex (MHC) in Health and Disease by : Jerzy K. Kulski

Download or read book Major Histocompatibility Complex (MHC) in Health and Disease written by Jerzy K. Kulski and published by . This book was released on 2020 with total page 375 pages. Available in PDF, EPUB and Kindle. Book excerpt: The major histocompatibility complex (MHC) is a highly polymorphic and diverse multigene locus in all jawed vertebrate species that has an integral role in adaptive/innate immune systems, transplantation, and infectious and autoimmune diseases. The MHC supra-locus in mammalian vertebrates is usually partitioned into three distinct regions, known as classes I, II, and III, which, to varying extents, can be found conserved in nonmammalian jawed vertebrates, such as bony fish, amphibians, and bird lineages. The MHC gene region is characterized particularly by the expression of class I and class II glycoproteins that bind peptides derived from intracellular or extracellular antigens to circulating T-cells. While this expressed antigenic specificity remains the predominant interest with respect to MHC function and polymorphism in a population, a broader concept has emerged that examines the MHC as a multifunctional polymorphic controller that facilitates and regulates genome diversity with a much greater array of functions and effects than just MHC-restricted antigen recognition. This volume of 19 reprints presented by various experts and collected from the Special Issue of Cells on “MHC in Health and Disease” covers a broad range of topics on the genomic diversity of the MHC regulatory system in various vertebrate species, including MHC class I, II, and III genes; innate and adaptive immunity; neurology; transplantation; haplotypes; infectious and autoimmune diseases; fecundity; conservation; allelic lineages; and evolution. Taken together, these articles demonstrate the immense complexity and diversity of the MHC structure and function within and between different vertebrate species.

The Major Histocompatibility Complex (MHC/ HLA) in Medicine

Author : Federico Garrido
Publisher : Springer Nature
ISBN 13 : 3031598660
Total Pages : 116 pages
Book Rating : 4.0/5 (315 download)

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Book Synopsis The Major Histocompatibility Complex (MHC/ HLA) in Medicine by : Federico Garrido

Download or read book The Major Histocompatibility Complex (MHC/ HLA) in Medicine written by Federico Garrido and published by Springer Nature. This book was released on with total page 116 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Hla and Mhc

Author : Michael Browning
Publisher :
ISBN 13 : 9780122204388
Total Pages : 438 pages
Book Rating : 4.2/5 (43 download)

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Book Synopsis Hla and Mhc by : Michael Browning

Download or read book Hla and Mhc written by Michael Browning and published by . This book was released on 1999-09-01 with total page 438 pages. Available in PDF, EPUB and Kindle. Book excerpt: The major histocompatibility complex (MHC) and its gene products have a major impact on health and disease through their central role in the regulation of the immune response. While the MHC has evolved as part of the host's defense strategy to protect against infection with pathogenic microorganisms, its gene products also form the major targets for rejection of allogenetic tissues in organ transplantation and susceptibility to a variety of diseases. This complex role in the health of the host has made the MHC the focus of attention in many fields of biological research. HLA and MHC: Genes, Molecules and Function is an authoritative review of the major histocompatibility complex, from the molecular genetics of the MHC through the structure and function of MHC-encoded molecules and their role in health and disease. The emphasis is on the human MHC, but relevant animal studies are also included to provide a comprehensive coverage of the subject. Internationally recognized experts in their respective fields of research have contributed individual chapters. This major new publication will be of interest not only to immunologists, but also to scientists and clinicians in a wide range of fields in which immune response plays a role.

Major Histocompatibility Complex

Author : Natalya V. Semiletova
Publisher : Nova Science Publishers
ISBN 13 : 9781619429994
Total Pages : 0 pages
Book Rating : 4.4/5 (299 download)

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Book Synopsis Major Histocompatibility Complex by : Natalya V. Semiletova

Download or read book Major Histocompatibility Complex written by Natalya V. Semiletova and published by Nova Science Publishers. This book was released on 2012 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book represents original findings and observations that were made recently on the role and function of MHC proteins in different laboratories around the globe. The articles in this book cover topics from the importance of MHC diversity to the health of the wildlife to intimate molecular mechanisms of MHC exchange between cells. This book will be useful to a wide range of scientists and clinicians who are working in the field of immunology, transplantation and cancer research.

The Major Histocompatibility Complex (MHC) Gene Expression in Health and Disease

Author : Ratanasuda Roslin Russell
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (89 download)

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Book Synopsis The Major Histocompatibility Complex (MHC) Gene Expression in Health and Disease by : Ratanasuda Roslin Russell

Download or read book The Major Histocompatibility Complex (MHC) Gene Expression in Health and Disease written by Ratanasuda Roslin Russell and published by . This book was released on 2004 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

HLA in Health and Disease

Author : Robert Lechler
Publisher : Academic Press
ISBN 13 :
Total Pages : 506 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis HLA in Health and Disease by : Robert Lechler

Download or read book HLA in Health and Disease written by Robert Lechler and published by Academic Press. This book was released on 2000-05-09 with total page 506 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive and definitive work succeeds and expands on the highly successful HLA and Disease published in 1994. This new edition has been updated, redesigned and reorganised into three sections making it an invaluable reference. The introductory section summarises current knowledge on the structure, function, genetics and evolution of the HLA system. It clarifies its complex and ever changing nomenclature and discusses the mechanisms underlying disease associations with HLA alleles. The second section deals with the importance of HLA in the context of different clinical specialities. Individual chapters describe the association between HLA polymorphism and each disease. The final section features chapters on current laboratory practice in histocompatibility and tissue typing. HLA in Health and Disease is essential reading for basic and clinical researchers working in immunology and immunogenetics, transplantation medicine and autoimmunity. It will also be of interest to anyone in the fields of rheumatology, diabetology, nephrology, allergy, dermatology, neurology, endocrinology, cancer biology, respiratory medicine, haematology, molecular biology and biochemistry. Key Features Structure, function and genetics of HLA HLA nomenclature Evolution of HLA polymorphisms HLA associations in arthritis and rheumatology, renal disease, neurology, diabetes and endocrinology, gastroenterology, respiratory disease, ophthalmology, infections, dermatology and psychiatry HLA and organ transplantation Serological and PCR-based methods in HLA typing Cellular techniques in testing histocompatibility Edited and written by an international panel of experts in the field

Major Histocompatibility Complex

Author : Natalya V. Semiletova
Publisher : Nova Science Publishers
ISBN 13 : 9781620810088
Total Pages : 198 pages
Book Rating : 4.8/5 (1 download)

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Book Synopsis Major Histocompatibility Complex by : Natalya V. Semiletova

Download or read book Major Histocompatibility Complex written by Natalya V. Semiletova and published by Nova Science Publishers. This book was released on 2012-05-01 with total page 198 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book represents original findings and observations that were made recently on the role and function of MHC proteins in different laboratories around the globe. The articles in this book cover topics from the importance of MHC diversity to the health of the wildlife to intimate molecular mechanisms of MHC exchange between cells. This book will be useful to a wide range of scientists and clinicians who are working in the field of immunology, transplantation and cancer research.

Proteolytic Signaling in Health and Disease

Author : Andre Zelanis
Publisher : Academic Press
ISBN 13 : 0323856977
Total Pages : 308 pages
Book Rating : 4.3/5 (238 download)

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Book Synopsis Proteolytic Signaling in Health and Disease by : Andre Zelanis

Download or read book Proteolytic Signaling in Health and Disease written by Andre Zelanis and published by Academic Press. This book was released on 2021-10-13 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, powered by evolving technologies and experimental design, studies have better illuminated the regulating role of proteolytic enzymes across human development and pathologies. Proteolytic Signaling in Health and Disease provides an in-depth discussion of fundamental physiological and developmental processes regulated by proteases, from protein turnover and autophagy to antigen processing and presentation and major histocompatibility complex (MHC) molecules. Moving on from basic biology, international chapter authors examine a range of pathological conditions associated with proteolysis, including inflammation, wound healing, and cancer. Later chapters discuss the newly discovered network of connected events among proteases (and their inhibitors), the so-called ‘protease web’, and how best to study it. This book also empowers new research with up-to-date analytical methods and step-by-step protocols for studying proteolytic signaling events. Examines biological events triggered by proteolytic enzyme activity across human development and pathologies Discusses the role of proteolytic signaling in inflammation, wound healing, and cancer, among other disease types Features methods and protocols supporting further study of proteolytic signaling events Includes chapter contributions from international leaders in the field

Modulation of MHC Antigen Expression and Disease

Author : G. Eric Blair
Publisher : Cambridge University Press
ISBN 13 : 9780521495783
Total Pages : 462 pages
Book Rating : 4.4/5 (957 download)

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Book Synopsis Modulation of MHC Antigen Expression and Disease by : G. Eric Blair

Download or read book Modulation of MHC Antigen Expression and Disease written by G. Eric Blair and published by Cambridge University Press. This book was released on 1995-11-09 with total page 462 pages. Available in PDF, EPUB and Kindle. Book excerpt: The major histocompatibility complex (MHC) genes are involved in the immune system's response to tumor and infected cells and in generating an immune response. This book brings together basic aspects of the regulation of MHC antigens with important clinical applications (in viral infection, viral oncology, cancer biology and autoimmunity). There is a strong emphasis on situations where MHC expression is modulated (either stimulated or repressed). The book's major themes are: the mechanisms of MHC expression--explored at several levels including the transcription and translation of MHC genes and the insertion of MHC protein molecules into plasma membranes; the effect of cytokines on MHC expression--both in the etiology of certain diseases and in possible immunotherapeutic approaches to disease; and the use of gene therapy to modify MHC expression in cancer cells, and thereby cause tumor rejection. This book will be valuable to researchers and clinicians in molecular biology, immunology, oncology, and virology.

The HLA Complex in Biology and Medicine

Author : Narinder K Mehra
Publisher : Boydell & Brewer Ltd
ISBN 13 : 9788184488708
Total Pages : 616 pages
Book Rating : 4.4/5 (887 download)

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Book Synopsis The HLA Complex in Biology and Medicine by : Narinder K Mehra

Download or read book The HLA Complex in Biology and Medicine written by Narinder K Mehra and published by Boydell & Brewer Ltd. This book was released on 2010-11-26 with total page 616 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive guide to the HLA (Human Leukocyte Antigen) system for immunologists and clinicians, this book contains up-to-date information on the MHC (Major Histocompatibility Complex) and its role in the immune response and in various diseases. The book explores the biological significance and role of the HLA system in organ and haematopoietic stem cell transplantation management. This volume is an invaluable guide to the full spectrum of HLA-related science while also serving as a conceptual and technical resource for those involved in HLA-related research and in clinical or surgical practice. In addition, it will be a primary point of contact for individuals working in other areas who suddenly find that their research is drawing them into the complexities of HLA genetics.

MHC Molecules: Expression, Assembly and Function

Author : Robert G. Urban
Publisher : Springer Science & Business Media
ISBN 13 : 1468464620
Total Pages : 304 pages
Book Rating : 4.4/5 (684 download)

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Book Synopsis MHC Molecules: Expression, Assembly and Function by : Robert G. Urban

Download or read book MHC Molecules: Expression, Assembly and Function written by Robert G. Urban and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: 3 nant expression systems have been used to make MHC molecules con taining a single peptide of interest. To date, fifteen single peptide class I structures (incorporating three different HLA and two different H-2 allotypes/isotypes) and four additional class II structures (two single peptide complexes and two superantigen complexes) have been reported. These advances have enabled us to study the atomic detail of antigen presentation and the general mechanisms behind peptide binding, and begin to construct models of T cell recognition. Another area of research which has exploded over the past five years has been the identification of MHC-associated peptides. There are several methods one can use to determine the sequence identity of MHC restricted peptides. Historically, the most successful technique, albeit crude and encumbered with serious limitations, has been the use of overlapping synthetic peptides and T cell clones. Unfortunately, this method absolutely requires: (i) knowledge of the target antigen; (ii) availability of T cell clones; and (iii) a relatively short overall length for the target source protein, such that a set of overlapping pep tides can be affordably synthesized. Briefly, the entire sequence of the tar get protein is chemically synthesized using overlapping peptides which are then screened for biological activity using standard T cell presen tation assays. Despite its limitations, this method was used to identify the first immunodominant epitopes reported in the literature and con tinues to be used successfully today.

Molecular Biology of the Cell

Author :
Publisher :
ISBN 13 : 9780815332183
Total Pages : 0 pages
Book Rating : 4.3/5 (321 download)

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Book Synopsis Molecular Biology of the Cell by :

Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

MHC Volume 1

Author : N. Fernandez
Publisher : Oxford University Press
ISBN 13 : 0191565520
Total Pages : 237 pages
Book Rating : 4.1/5 (915 download)

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Book Synopsis MHC Volume 1 by : N. Fernandez

Download or read book MHC Volume 1 written by N. Fernandez and published by Oxford University Press. This book was released on 1997-08-21 with total page 237 pages. Available in PDF, EPUB and Kindle. Book excerpt: The major histocompatibility complex is the subject of much research in the immunology area. There is great interest in the structure of MHC proteins and in their function as antigen presenting molecules. Many immunology labs are now faced with the prospect of tackling biochemical and genetic techniques in order to study these molecules, and these two Practical Approach volumes provide the ideal introduction. MHC 1, Antigen Processing and Presentation, is complemented by MHC 2, Genes, Cells, and Molecules.

Primary Immunodeficiency Diseases

Author : Hans D. Ochs
Publisher :
ISBN 13 : 019514774X
Total Pages : 745 pages
Book Rating : 4.1/5 (951 download)

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Book Synopsis Primary Immunodeficiency Diseases by : Hans D. Ochs

Download or read book Primary Immunodeficiency Diseases written by Hans D. Ochs and published by . This book was released on 2007 with total page 745 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of Primary Immunodeficiency Diseases presents discussions of gene identification, mutation detection, and clinical and research applications for over 100 genetic immune disorders--disorders featuring an increased susceptibility to infections and, in certain conditions, an icreased rate of malignancies and autoimmune disorders. Since the publication of the first edition, a flurry of new disease entities has been defined and new treatment regimens have been introduced, the most spectacular being successful treatment by gene therapy for two genotypes of combined immunodeficiency. The first edition marked a historic turning point in the field of immunodeficiencies, demonstrating that many of the disorders of the immune systam could be understood at a molecular level. This new edition can proudly document the tremendous pace of progress in dissecting the complex immunologic networks responsible for protecting individuals from these disorders.

MHC Ligands and Peptide Motifs

Author : Hans-Georg Rammensee
Publisher : Springer Science & Business Media
ISBN 13 : 3662221624
Total Pages : 467 pages
Book Rating : 4.6/5 (622 download)

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Book Synopsis MHC Ligands and Peptide Motifs by : Hans-Georg Rammensee

Download or read book MHC Ligands and Peptide Motifs written by Hans-Georg Rammensee and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 467 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is centered on a comprehensive list of MHC peptide motifs and ligands as known to date, together with selected T cell epitopes, arranged in an easy-to-read fashion. This information is put into context by chapters on MHC gene organization, MHC structure, T cell epitope prediction, antigen processing and T cell responses. In addition, the book provides a great deal of complementary information: amino acid sequences of MHC class I alpha1 and alpha2 domains and of class II alpha1 and beta1 domains, the established or predicted composition and specificity of MHC pockets, notes on MHC nomenclature including old assignments and reference to useful internet addresses. A handy reference manual that should be helpful for all those dealing with MHC-associated peptides.