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Magnetic Resonance And Its Applications In Drug Formulation And Delivery
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Book Synopsis Magnetic Resonance and its Applications in Drug Formulation and Delivery by : Michael D Mantle
Download or read book Magnetic Resonance and its Applications in Drug Formulation and Delivery written by Michael D Mantle and published by Royal Society of Chemistry. This book was released on 2024-03-27 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book details the latest research and development in the use of magnetic resonance imaging and spectroscopy as tools to give quantitative insights concerning late stage pharmaceutical formulation, tablet manufacturing and drug dissolution behaviour. The book combines different facets of magnetic resonance and highlights the use of spatial resolution (MRI) and how this adds to the knowledge base to further our understanding of the microscopic physicochemical processes occurring during drug release from solid dosage forms. New topics, that have not been thoroughly reviewed elsewhere, are covered including the applications of solution state magnetic resonance in process scale up, reaction monitoring/understanding and process analytical technologies (PAT); dissolution testing; and counterfeit analysis. Solid state NMR and its role in understanding phase separation in dispersions, polymorphism and crystallography are included and magnetic resonance imaging and its use in assessing tablet dissolution performance, mass transport and mixing in hot melt extrusion (HME) are covered. Focusing on late stage development rather than molecular drug discovery provides a unique approach and the book will appeal to a diversity of disciplines using spectroscopy for study. Aimed at researchers in drug development, manufacture and formulation in both industry (pharmaceutical companies) and academia (pharmacy program), it includes examples, where appropriate, of studies on commercially available pharmaceutical products.
Book Synopsis Use of Magnetic Resonance Imaging in Drug Delivery to the Gastrointestinal Tract by : Bridget O'Mahony
Download or read book Use of Magnetic Resonance Imaging in Drug Delivery to the Gastrointestinal Tract written by Bridget O'Mahony and published by . This book was released on 1998 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Drug Delivery Applications of Noninvasive Imaging by : Chun Li
Download or read book Drug Delivery Applications of Noninvasive Imaging written by Chun Li and published by John Wiley & Sons. This book was released on 2013-10-14 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cost-effective strategies for designing novel drug delivery systems that target a broad range of disease conditions In vivo imaging has become an important tool for the development of new drug delivery systems, shedding new light on the pharmacokinetics, biodistribution, bioavailability, local concentration, and clearance of drug substances for the treatment of human disease, most notably cancer. Written by a team of international experts, this book examines the use of quantitative imaging techniques in designing and evaluating novel drug delivery systems and applications. Drug Delivery Applications of Noninvasive Imaging offers a full arsenal of tested and proven methods, practices and guidance, enabling readers to overcome the many challenges in creating successful new drug delivery systems. The book begins with an introduction to molecular imaging. Next, it covers: In vivo imaging techniques and quantitative analysis Imaging drugs and drug carriers at the site of action, including low-molecular weight radiopharmaceuticals, peptides and proteins, siRNA, cells, and nanoparticles Applications of imaging techniques in administration routes other than intravenous injection, such as pulmonary and oral delivery Translational research leading to clinical applications Imaging drug delivery in large animal models Clinical applications of imaging techniques to guide drug development and drug delivery Chapters are based on a thorough review of the current literature as well as the authors' firsthand experience working with imaging techniques for the development of novel drug delivery systems. Presenting state-of-the-technology applications of imaging in preclinical and clinical evaluation of drug delivery systems, Drug Delivery Applications of Noninvasive Imaging offers cost-effective strategies to pharmaceutical researchers and students for developing drug delivery systems that accurately target a broad range of disease conditions.
Book Synopsis Development of a Series of Novel Nanoparticles with Applications in Drug Delivery and Magnetic Resonance Imaging by : Eric John Dadey
Download or read book Development of a Series of Novel Nanoparticles with Applications in Drug Delivery and Magnetic Resonance Imaging written by Eric John Dadey and published by . This book was released on 1992 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Quantitative in Vivo Drug Delivery Research Using Magnetic Resonance by : Xin Liu
Download or read book Quantitative in Vivo Drug Delivery Research Using Magnetic Resonance written by Xin Liu and published by . This book was released on 2011 with total page 118 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Magnetic Resonance Imaging for Drug Delivery by : Brett Zain Fite
Download or read book Magnetic Resonance Imaging for Drug Delivery written by Brett Zain Fite and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Magnetic resonance imaging (MRI) is a versatile imaging modality that can be a powerful tool for developing and improving drug delivery strategies. High field ([greater than or equal to]7T), small bore MR systems are increasingly available for preclinical research, and high field human systems are becoming available as well, thus promising easier translation of high field MR techniques to human medicine. The increased signal to noise at high field can be allocated to improving spatial resolution, which allows for earlier detection of both primary and metastatic neoplasias. Moreover, resolving smaller lesions also permits us to more fully characterize the development process of disease, such as the progression of permeability of metastatic brain lesions, which is an important consideration when choosing an appropriate therapeutic course. In addition to the general benefit of higher signal to noise at higher field, some methods, such as MR thermometry (via the proton resonance frequency shift), and more generally, any imaging method that attempts to resolve differences in resonance frequency/chemical shift, also benefit from the increased spectral separation, in absolute terms, at higher field strengths. Here, we examine MRI methods for improving drug delivery strategies including using real time MR thermometry in a closed loop with an MR compatible focused ultrasound system to provide a consistent acoustic dose in vivo. Further, we examine the use of paramagnetic micelles as a way to track the disposition of these small drug delivery vehicles, comparing peptide targeted to untargeted versions. We then extend our examination to the detection and characterization of small brain metastases followed by the imaging the vascular volume both for registration with PET images and estimation of the arterial input function as a step in pharmacokinetic modeling of vascular permeability. Finally, we examine displacement imaging techniques and successfully program and implement displacement imaging sequences for two purposes: adaptive focusing of an ultrasound beam without heating, and obtaining the shear modulus for evaluating tissue stiffness.
Book Synopsis Encyclopedia of Pharmaceutical Technology by : James Swarbrick
Download or read book Encyclopedia of Pharmaceutical Technology written by James Swarbrick and published by CRC Press. This book was released on 1994-05-12 with total page 560 pages. Available in PDF, EPUB and Kindle. Book excerpt: Now complete in 17 volumes, the Encyclopedia of Pharmaceutical Technology presents authoritative and contemporary articles on all aspects of drug development, dosage forms, manufacturing, and regulation-enabling the specialist and novice alike to keep abreast of developments in this rapidly evolving and highly competitive field. A dependable reference tool and a solid investment for years to come--maintaining currency through its supplements [Volume 18/Supplement 1: Published November, 1998] The Encyclopedia contains interdisciplinary contributions in a wide array of subjects, including Drugs decomposition metabolism pharmaceutical incompatibilities pharmacokinetics physicochemical properties preformulation stability Drug Delivery Systems and Devices-Development and Manufacture analysis and controls bioavailability use of computerization formulation and processing alternatives national and international registration packaging patents process validation scale-up safety and efficacy stability standards Post-Production and Practical Considerations governmental/industrial/professional organizations legal aspects national and international agencies patent life of drugs patient compliance ...and much, much more!
Book Synopsis NMR in Pharmaceutical Science by : Jeremy R. Everett
Download or read book NMR in Pharmaceutical Science written by Jeremy R. Everett and published by John Wiley & Sons. This book was released on 2015-08-20 with total page 504 pages. Available in PDF, EPUB and Kindle. Book excerpt: NMR in Pharmaceutical Sciences is intended to be a comprehensive source of information for the many individuals that utilize MR in studies of relevance to the pharmaceutical sector. The book is intended to educate and inform those who develop and apply MR approaches within the wider pharmaceutical environment, emphasizing the toolbox that is available to spectroscopists and radiologists. This book is structured on the key processes in drug discovery, development and manufacture, but underpinned by an understanding of fundamental NMR principles and the unique contribution that NMR (including MRI) can provide. After an introductory chapter, which constitutes an overview, the content is organised into five sections. The first section is on the basics of NMR theory and relevant experimental methods. The rest follow a sequence based on the chronology of drug discovery and development, firstly 'Idea to Lead' then 'Lead to Drug Candidate', followed by 'Clinical Development', and finally 'Drug Manufacture'. The thirty one chapters cover a vast range of topics from analytical chemistry, including aspects involved in regulatory matters and in the prevention of fraud, to clinical imaging studies. Whilst this comprehensive volume will be essential reading for many scientists based in pharmaceutical and related industries, it should also be of considerable value to a much wider range of academic scientists whose research is related to the various aspects of pharmaceutical R&D; for them it will supply vital understanding of pharmaceutical industrial concerns and the basis of key decision making processes. About eMagRes Handbooks eMagRes (formerly the Encyclopedia of Magnetic Resonance) publishes a wide range of online articles on all aspects of magnetic resonance in physics, chemistry, biology and medicine. The existence of this large number of articles, written by experts in various fields, is enabling the publication of a series of eMagRes Handbooks on specific areas of NMR and MRI. The chapters of each of these handbooks will comprise a carefully chosen selection of eMagRes articles. In consultation with the eMagRes Editorial Board, the eMagRes handbooks are coherently planned in advance by specially-selected Editors, and new articles are written to give appropriate complete coverage. The handbooks are intended to be of value and interest to research students, postdoctoral fellows and other researchers learning about the scientific area in question and undertaking relevant experiments, whether in academia or industry. Have the content of this handbook and the complete content of eMagRes at your fingertips! Visit: www.wileyonlinelibrary.com/ref/eMagRes
Book Synopsis MRI Visualization and Mathematical Modeling of Local Drug Delivery by : Morgan Giers
Download or read book MRI Visualization and Mathematical Modeling of Local Drug Delivery written by Morgan Giers and published by . This book was released on 2013 with total page 168 pages. Available in PDF, EPUB and Kindle. Book excerpt: Controlled release formulations for local, in vivo drug delivery are of growing interest to device manufacturers, research scientists, and clinicians; however, most research characterizing controlled release formulations occurs in vitro because the spatial and temporal distribution of drug delivery is difficult to measure in vivo. In this work, in vivo magnetic resonance imaging (MRI) of local drug delivery is performed to visualize and quantify the time resolved distribution of MRI contrast agents. I find it is possible to visualize contrast agent distributions in near real time from local delivery vehicles using MRI. Three dimensional T1 maps are processed to produce in vivo concentration maps of contrast agent for individual animal models. The method for obtaining concentration maps is analyzed to estimate errors introduced at various steps in the process. The method is used to evaluate different controlled release vehicles, vehicle placement, and type of surgical wound in rabbits as a model for antimicrobial delivery to orthopaedic infection sites. I are able to see differences between all these factors; however, all images show that contrast agent remains fairly local to the wound site and do not distribute to tissues far from the implant in therapeutic concentrations. I also produce a mathematical model that investigates important mechanisms in the transport of antimicrobials in a wound environment. It is determined from both the images and the mathematical model that antimicrobial distribution in an orthopaedic wounds is dependent on both diffusive and convective mechanisms. Furthermore, I began development of MRI visible therapeutic agents to examine active drug distributions. I hypothesize that this work can be developed into a non-invasive, patient specific, clinical tool to evaluate the success of interventional procedures using local drug delivery vehicles.
Book Synopsis Drug Delivery Nanoparticles Formulation and Characterization by : Yashwant Pathak
Download or read book Drug Delivery Nanoparticles Formulation and Characterization written by Yashwant Pathak and published by CRC Press. This book was released on 2016-04-19 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: Exploring fundamental concepts, Drug Delivery Nanoparticles Formulation and Characterization presents key aspects of nanoparticulate system development for various therapeutic applications and provides advanced methods used to file for regulatory approval.This comprehensive guide features:Process Analytical Techniques (PAT) used in manufacturing Na
Book Synopsis Drug Delivery Approaches and Nanosystems, Volume 2 by : Raj K. Keservani
Download or read book Drug Delivery Approaches and Nanosystems, Volume 2 written by Raj K. Keservani and published by CRC Press. This book was released on 2017-11-15 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is a thorough presentation of the state-of-the-art research and developments in drug delivery systems using nanotechnology and its applications. The second of this two-volume set, it addresses the applications of nanotechnology or nano-sized materials in the medical field and the real-world challenges and complexities of current drug delivery methodologies and techniques. This volume includes 11 chapters that focus on the targeting facet of drug delivery systems. Targeting is a focused maneuver to achieve the specified goals, including achieving the desired result and reaching the specific location. Targeting has now been successfully achieved for several diseases/disorders; however, its role is noteworthy in cancer treatment where chemotherapy is a main course of approach. Nanotechnology-based products have great potential by virtue of their inherent features. This edited book provides a detailed application of nanotechnology in drug delivery systems in health care. The book discusses general principles of drug targeting, material of construction and technological concerns of nanoparticles, and different drug delivery systems and their preparation. Taken together, the informative chapters will provide researchers and scientists as well as faculty and students with valuable research on the effective use of new approaches in advanced drug delivery nanosystems. Volume 1 of the two-volume series is subtitled Novel Drug Carriers. The volumes are available separately or as a set.
Book Synopsis Targeting of Drugs 6 by : Gregory Gregoriadis
Download or read book Targeting of Drugs 6 written by Gregory Gregoriadis and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proceedings of a NATO ASI held in Cape Sounion Beach, Greece, June 24-July 5, 1997
Book Synopsis Drug Delivery Approaches and Nanosystems, Two-Volume Set by : Raj K. Keservani
Download or read book Drug Delivery Approaches and Nanosystems, Two-Volume Set written by Raj K. Keservani and published by CRC Press. This book was released on 2020-02-10 with total page 858 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new two-volume set, Drug Delivery Approaches and Nanosystems, Volume 1: Novel Drug Carriers and Volume 2: Drug Targeting Aspects of Nanotechnology presents a comprehensive look at the state-of-the-art research and developments in drug delivery systems using nanotechnology and its applications. Many methods of drug delivery systems have been used, but very few of them have been validated for medical use. A major reason for the above situation, the editors believe, is due to the gap between academia and research, and the gap between academic research and real-time clinical applications and needs. These volumes address that gap. Volume 1 addresses the ubiquitous applications of nanotechnology or nano-sized materials in the medical field and the real-world challenges and complexities of current drug delivery methodologies and techniques, while Volume 2 focuses on drug targeting aspects of nanotechnology. Together they provide a thorough review of the applications of nanotechnology or nano-sized materials in the medical field and the real-world challenges and complexities of current drug delivery methodologies and techniques. These two volumes will provide a plethora of real-world information for the application of drug delivery approaches via nanotechnology that will be valuable to scientists and researchers as well as faculty and students. The volumes are available separately or together as a set.
Book Synopsis Magnetic Resonance and Its Applications by : Vladimir I. Chizhik
Download or read book Magnetic Resonance and Its Applications written by Vladimir I. Chizhik and published by Springer. This book was released on 2016-09-03 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book is devoted to the description of the fundamentals in the area of magnetic resonance. The book covers two domains: radiospectroscopy and quantum radioelectronics. Radiospectroscopy comprises nuclear magnetic resonance , electron paramagnetic resonance, nuclear quadrupolar resonance, and some other phenomena. The radiospectroscopic methods are widely used for obtaining the information on internal (nano, micro and macro) structure of objects. Quantum radioelectronics, which was developed on the basis of radiospectroscopic methods, deals with processes in quantum amplifiers, generators and magnetometers. We do not know analogues of the book presented. The book implies a few levels of the general consideration of phenomena, that can be useful for different groups of readers (students, PhD students, scientists from other scientific branches: physics, chemistry, physical chemistry, biochemistry, biology and medicine).
Book Synopsis Excipient Applications in Formulation Design and Drug Delivery by : Ajit S Narang
Download or read book Excipient Applications in Formulation Design and Drug Delivery written by Ajit S Narang and published by Springer. This book was released on 2015-10-07 with total page 700 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, emerging trends in the design and development of drug products have indicated ever greater need for integrated characterization of excipients and in-depth understanding of their roles in drug delivery applications. This book presents a concise summary of relevant scientific and mechanistic information that can aid the use of excipients in formulation design and drug delivery applications. Each chapter is contributed by chosen experts in their respective fields, which affords truly in-depth perspective into a spectrum of excipient-focused topics. This book captures current subjects of interest – with the most up to date research updates – in the field of pharmaceutical excipients. This includes areas of interest to the biopharmaceutical industry users, students, educators, excipient manufacturers, and regulatory bodies alike.
Book Synopsis Silk-based Drug Delivery Systems by : Elia Bari
Download or read book Silk-based Drug Delivery Systems written by Elia Bari and published by Royal Society of Chemistry. This book was released on 2020-10-07 with total page 243 pages. Available in PDF, EPUB and Kindle. Book excerpt: Covering spider silk and silk worm cocoons, the editors elucidate the extraction, structure and properties of silk sericin and silk fibroin.
Book Synopsis A Magnetic Resonance Microscopy Study of Transdermal Drug Delivery Using Electric Fields and Chemical Penetration Enhancers by : John B. Caban
Download or read book A Magnetic Resonance Microscopy Study of Transdermal Drug Delivery Using Electric Fields and Chemical Penetration Enhancers written by John B. Caban and published by . This book was released on 2000 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt:
