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Author : Julia L. Gregory
Publisher :
ISBN 13 :
Total Pages : 173 pages
Book Rating : 4.:/5 (277 download)
Download or read book Macrophage Migration Inhibitory Factor and Leukocyte Recruitment written by Julia L. Gregory and published by . This book was released on 2006 with total page 173 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Alberta Y. Hoi
Publisher :
ISBN 13 :
Total Pages : 416 pages
Book Rating : 4.:/5 (854 download)
Download or read book The Role of Macrophage Migration Inhibitory Factor in the Pathogenesis of Systemic Lupus Erythematosus written by Alberta Y. Hoi and published by . This book was released on 2010 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: Using a murine model, MIF expression was examined in target organs of lupus-prone MRL/lpr mice. MIF was highly expressed in kidneys of MRL/lpr mice. There was an age-dependent increase in renal MIF expression, and the time course paralleled the reported up-regulation of other key inflammatory cytokines and chemokines. Similarly, MIF expression was significantly higher in skin lesions of MRL/lpr mice, compared to non-diseased skin. Studies to address the functional contribution of MIF in the MRL/lpr lupus-prone model were performed using two approaches: MIF inhibition and genetic deletion of MIF. A Melbourne-based drug discovery and development company, Cortical, provided access to a small molecule MIF antagonist, known as COR100140. A pilot study using COR100140 in MRL/lpr mice was performed and a trend towards reduction of proteinuria was observed. In studies presented in Chapter 5, the functional contribution of MIF in murine lupus was definitively tested by the generation of MIF-deficient MRL/lpr mice. The disease phenotype in these MIF-/- MRL/lpr mice was compared to lettermate MIF+/+ MRL/lpr mice. MIF-deficient MRL/lpr lupus-prone mice had less severe renal and skin disease and, most importantly, significantly prolonged survival. This was associated with reduced renal expression of monocyte-selective chemokine MCP-1, leading to reduced renal macrophage infiltration, and near-complete protection from glomerular crescent formation and sclerosis. Intriguingly, MIF deficiency was not associated with significant alteration in immunological abnormalities in these mice including development of autoantibodies, indicating a downstream 'effector' role for MIF independent of the autoimmune lesion. The therapeutic potential of MIF inhibition was further investigated by studying the efficacy of long-term COR100140 treatment, which did not reduce disease severity in MRL/lpr mice. The relationship between MIF and glucocorticoids were also explored but the addition of COR100140 to low dose dexamethasone did not confer any further benefit in reducing disease severity, compared to dexamethasone alone. Finally the emerging role for MIF in regulating leukocyte trafficking was studied using intravital microscopy of dermal post-capillary venules in MRL/lpr mice. Lower rates of leukocyte adhesion were found in MIF-/- MRL/lpr mice suggesting MIF may have a role in promoting leukocyte-endothelial interaction in the microvasculature of lupus affected organs. The studies produced in this thesis demonstrate that MIF has an important effector role in the pathogenesis of SLE. While results indicate that MIF does not contribute to development of autoimmunity, it promotes tissue injury by its effect on leukocyte recruitment. Therapeutic antagonism of MIF shoud be explored further in future studies.
Author :
Publisher : ScholarlyEditions
ISBN 13 : 1464969167
Total Pages : 38 pages
Book Rating : 4.4/5 (649 download)
Download or read book Leukocyte Migration-Inhibitory Factors: Advances in Research and Application: 2011 Edition written by and published by ScholarlyEditions. This book was released on 2012-02-14 with total page 38 pages. Available in PDF, EPUB and Kindle. Book excerpt: Leukocyte Migration-Inhibitory Factors: Advances in Research and Application: 2011 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Leukocyte Migration-Inhibitory Factors in a compact format. The editors have built Leukocyte Migration-Inhibitory Factors: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Leukocyte Migration-Inhibitory Factors in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Leukocyte Migration-Inhibitory Factors: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Download or read book Macrophage Migration Inhibitory Factor is Required for Recruitment of Scar‐associated Macrophages During Liver Fibrosis written by and published by . This book was released on 2014 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher : ScholarlyEditions
ISBN 13 : 1481614398
Total Pages : 54 pages
Book Rating : 4.4/5 (816 download)
Download or read book Leukocyte Migration-Inhibitory Factors—Advances in Research and Application: 2012 Edition written by and published by ScholarlyEditions. This book was released on 2012-12-26 with total page 54 pages. Available in PDF, EPUB and Kindle. Book excerpt: Leukocyte Migration-Inhibitory Factors—Advances in Research and Application: 2012 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Leukocyte Migration-Inhibitory Factors in a concise format. The editors have built Leukocyte Migration-Inhibitory Factors—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Leukocyte Migration-Inhibitory Factors in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Leukocyte Migration-Inhibitory Factors—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Author : Klaus Ley
Publisher : Frontiers Media SA
ISBN 13 : 2889194302
Total Pages : 109 pages
Book Rating : 4.8/5 (891 download)
Download or read book Arrest chemokines written by Klaus Ley and published by Frontiers Media SA. This book was released on 2015-05-20 with total page 109 pages. Available in PDF, EPUB and Kindle. Book excerpt: Arrest chemokines are a small group of chemokines that promote leukocyte arrest from rolling by triggering rapid integrin activation. Arrest chemokines have been described for neutrophils, monocytes, eosinophils, naïve lymphocytes and effector memory T cells. Most arrest chemokines are immobilized on the endothelial surface by binding to heparin sulfate proteoglycans. Whether soluble chemokines can promote integrin activation and arrest is controversial (Alon-Gerszten). Many aspects of the signaling pathway from the GPCR chemokine receptor to integrin activation are the subject of active investigation. Leukocyte adhesion deficiency III is a human disease in which chemokine-triggered integrin activation is defective because of a mutation in the cytoskeletal protein kindlin-3. About 10 different such mutations have been described. The defects seen in patients with LAD-III elucidate the importance of rapid integrin activation for host defense in humans. We welcome reports that help clarifying this crucial first step in the process of leukocyte transendothelial migration.
Author : Tobili Y. Sam-Yellowe
Publisher : Springer Nature
ISBN 13 : 3030646866
Total Pages : 461 pages
Book Rating : 4.0/5 (36 download)
Download or read book Immunology: Overview and Laboratory Manual written by Tobili Y. Sam-Yellowe and published by Springer Nature. This book was released on 2021-08-01 with total page 461 pages. Available in PDF, EPUB and Kindle. Book excerpt: A two-in-one text providing teaching lab students with an overview of immunology as well as a lab manual complete with current standard exercises. Section I of this book provides an overview of the immune system and immunity, and includes review questions, problem sets, case studies, inquiry-based questions, and more to provide students with a strong foundation in the field. Section II consists of twenty-two lab exercises focused on key concepts in immunology, such as antibody production, cell separation, cell function, immunoassays, Th1/Th2 cytokine detection, cell and tissue culture methods, and cell and molecular biology techniques. Appendices include safety information, suggested links and readings, and standard discipline processes, protocols, and instructions.
Author :
Publisher : ScholarlyEditions
ISBN 13 : 1481689371
Total Pages : 40 pages
Book Rating : 4.4/5 (816 download)
Download or read book Leukocyte Migration-Inhibitory Factors—Advances in Research and Application: 2013 Edition written by and published by ScholarlyEditions. This book was released on 2013-06-21 with total page 40 pages. Available in PDF, EPUB and Kindle. Book excerpt: Leukocyte Migration-Inhibitory Factors—Advances in Research and Application: 2013 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about ZZZAdditional Research in a compact format. The editors have built Leukocyte Migration-Inhibitory Factors—Advances in Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about ZZZAdditional Research in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Leukocyte Migration-Inhibitory Factors—Advances in Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Author : Aaron P. Kithcart
Publisher :
ISBN 13 :
Total Pages : 139 pages
Book Rating : 4.:/5 (518 download)
Download or read book Macrophage Migration Inhibitor Factor written by Aaron P. Kithcart and published by . This book was released on 2009 with total page 139 pages. Available in PDF, EPUB and Kindle. Book excerpt: Abstract: Multiple sclerosis represents one the most common and complex syndromes of the family of autoimmune diseases. Affecting more than 2.4 million worldwide in the second and third decades of life, it is the primary cause of non-traumatic disability in the United States. Sensory and motor neuron loss follows the demyelination of axons in the brain and spinal cord after autoreactive T lymphocytes gain access to the central nervous system and mediate an inflammatory reaction. Thus, most current therapies in multiple sclerosis seek to suppress the immune system in order to slow progression. Several cytokines have been shown to be involved in the pathogenesis of autoimmune diseases, including multiple sclerosis. We have focused on macrophage migration inhibitory factor, a ubiquitously expressed proinflammatory cytokine that has been described in a number of syndromes. Utilizing an MIF knockout model of EAE in the C57Bl/6 strain of mice, we show that MIF is required for susceptibility to EAE. MIF knockout mice are protected with a decreased incidence of disease and lower clinical scores. Additionally, we show that an inhibitor of MIF is therapeutic during ongoing disease. Administration of an MIF inhibitor reduced clinical scores. We propose several mechanisms of MIF that mediate inflammation. First, MIF inhibits the expansion of CD4+CD25+Foxp3+ regulatory T lymphocytes. This population of cells is found in higher numbers after immunization in MIF knockout and inhibitor-treated mice. CD4+CD25+Foxp+ regulatory T lymphocytes are protective during EAE through contact inhibition with autoreactive lymphocytes and the production of IL-10. Second, we propose that MIF mediates leukocyte migration into the brain and spinal cord. We show that MIF knockout mice have profoundly reduced inflammation and the administration of an inhibitor of MIF prevents new migration into the brain. Furthermore, MIF knockout recipient mice were universally protected following adoptive transfer of autoreactive lymphocytes. Finally, MIF regulates the synthesis of testosterone. MIF knockout mice have a four fold higher level of testosterone than wild type mice. Testosterone is an immunosuppressive hormone, and gonadectomy of MIF knockout mice greatly increased the incidence of EAE. We propose that MIF mediates inflammation via different mechanisms depending on the timing of disease. Inhibition of testosterone in naive mice enhances susceptibility to disease. Later changes during inflammation, including inhibition of regulatory T cell differentiation and facilitation of migration into peripheral tissues allows the progression of disease. We propose that targeting MIF during multiple sclerosis could be therapeutic through novel regulation of multiple aspects of inflammation.
Author : Mark Aaron Barnes (Jr)
Publisher :
ISBN 13 :
Total Pages : 134 pages
Book Rating : 4.:/5 (11 download)
Download or read book Macrophage Migration Inhibitory Factor and Liver Disease written by Mark Aaron Barnes (Jr) and published by . This book was released on 2014 with total page 134 pages. Available in PDF, EPUB and Kindle. Book excerpt: Macrophage migration inhibitory factor (MIF) exhibits both cytokine and chemotactic properties and is expressed by many cell types, including hepatocytes and nonparenchymal cells. Excessive alcohol abuse can lead to alcoholic liver disease (ALD), which has multiple stages of pathogenesis including hepatic steatosis and hepatic fibrosis. During steatohepatitis, several precipitating events, including triglyceride accumulation in the liver, hepatocyte damage and leukocyte infiltration, lead to further pathogenesis of ALD. Hepatic fibrosis is dependent on interactions between hepatocytes, hepatic stellate cells (HSC) and leukocytes. Recruitment of monocytes to the liver is a key contributor to hepatic fibrosis. Due to MIF's chemotactic properties, we hypothesized that MIF would be a key contributor to ALD pathogenesis. Female C57BL/6 or MIF-/- mice were fed an ethanol-containing liquid diet or pair-fed control diet for 25 days. Expression of MIF messenger RNA was induced after 25 days of ethanol feeding. After chronic ethanol feeding, chemokine expression and monocyte recruitment was increased in wild-type mice, but not MIF-/- mice. In a model of12liver fibrosis, female C57BL/6 or MIF-/- mice were challenged with carbon tetrachloride (CCI4). Expression of mRNA for MIF, as well as plasma MIF content, were increased in female wild-type mice in response to an acute dose of CCI4. a Smooth muscle actin (aSMA) mRNA and protein, indicators of HSC activation, were increased in liver of wild-type after chronic CCI4 challenge. This response was dampened in MIF-/- mice. Despite lower activation of HSC, MIF deficient mice developed similar fibrosis after CCI4 exposure when compared to wild-type mice. Inflammatory scar-associated macrophages (SAMs) were recruited to the liver from the periphery in response to chronic CCI4 in wild-type and MIF-/- mice, but later converted to a restorative SAM phenotype during fibrosis resolution. Fewer inflammatory and restorative monocytes were recruited in MIF-/- mice compared to wild-type mice. Fewer restorative macrophages were associated with lower MMP13 enzymatic activity in MIF-deficient mice. Taken together, these data indicate that MIF is an important mediator of chemokine production and leukocyte infiltration in the liver during ethanol feeding. However, during resolution of hepatic fibrosis, MIF is a key mediator for recruiting SAMs, which are critical for extracellular matrix degradation.
Author : James Harris
Publisher : Humana
ISBN 13 : 9781493999385
Total Pages : 265 pages
Book Rating : 4.9/5 (993 download)
Download or read book Macrophage Migration Inhibitory Factor written by James Harris and published by Humana. This book was released on 2020-12-03 with total page 265 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume looks at--and discusses the techniques of--a range of areas in biology in which macrophage migration inhibitory factor (MIF) is studied. Topics covered in this book include methods to quantify MIF in cell supernatants and human samples, using ELISA and western blot; detection and analysis of intracellular MIF using flow cytometry; genotyping of human MIF polymorphisms, detection of MIF expression in a marine invertebrate using rapid amplification of cDNA RACE; studying the MIF receptor CD74 in tissues using immunohistochemistry; and studying MIF in models of disease such as asthma, Plasmodium infection, and gout. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and practical, Macrophage Migration Inhibitory Factor: Methods and Protocols is a valuable resource that will help researchers gain a new understanding of MIF biology in health and disease.
Author : Richard Bucala
Publisher : World Scientific
ISBN 13 : 9814475459
Total Pages : 330 pages
Book Rating : 4.8/5 (144 download)
Download or read book Mif: A Most Interesting Factor written by Richard Bucala and published by World Scientific. This book was released on 2007-07-27 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, researchers have identified a pivotal, upstream role for macrophage migration inhibitory factor (MIF) in the innate immune response. This pioneering book describes this renaissance of knowledge in the biology of MIF. Topics covered include MIF's molecular mechanism of action, its counterregulatory action on the immunosuppressive properties of glucocorticoids, its role in the production of proinflammatory mediators as shown in cell-based and animal studies; and its central role in human inflammation. Human genetic studies have identified allelic forms of the MIF gene, and high-expression alleles have been associated with rheumatoid arthritis, asthma severity, sarcoidosis, atopy, inflammatory bowel disease, and other inflammatory and infectious maladies. The book also discusses the role of MIF as a therapeutic target. Unique structural features of the protein, such as an intrinsic catalytic activity and the recent discovery of its cell surface receptor, offer attractive opportunities for therapeutic intervention. Such approaches are presently in clinical development.
Author : D. Neil Granger
Publisher : Morgan & Claypool Publishers
ISBN 13 : 1615041656
Total Pages : 99 pages
Book Rating : 4.6/5 (15 download)
Download or read book Inflammation and the Microcirculation written by D. Neil Granger and published by Morgan & Claypool Publishers. This book was released on 2010 with total page 99 pages. Available in PDF, EPUB and Kindle. Book excerpt: The microcirculation is highly responsive to, and a vital participant in, the inflammatory response. All segments of the microvasculature (arterioles, capillaries, and venules) exhibit characteristic phenotypic changes during inflammation that appear to be directed toward enhancing the delivery of inflammatory cells to the injured/infected tissue, isolating the region from healthy tissue and the systemic circulation, and setting the stage for tissue repair and regeneration. The best characterized responses of the microcirculation to inflammation include impaired vasomotor function, reduced capillary perfusion, adhesion of leukocytes and platelets, activation of the coagulation cascade, and enhanced thrombosis, increased vascular permeability, and an increase in the rate of proliferation of blood and lymphatic vessels. A variety of cells that normally circulate in blood (leukocytes, platelets) or reside within the vessel wall (endothelial cells, pericytes) or in the perivascular space (mast cells, macrophages) are activated in response to inflammation. The activation products and chemical mediators released from these cells act through different well-characterized signaling pathways to induce the phenotypic changes in microvessel function that accompany inflammation. Drugs that target a specific microvascular response to inflammation, such as leukocyte-endothelial cell adhesion or angiogenesis, have shown promise in both the preclinical and clinical studies of inflammatory disease. Future research efforts in this area will likely identify new avenues for therapeutic intervention in inflammation. Table of Contents: Introduction / Historical Perspectives / Anatomical Considerations / Impaired Vasomotor Responses / Capillary Perfusion / Angiogenesis / Leukocyte-Endothelial Cell Adhesion / Platelet-Vessel Wall Interactions / Coagulation and Thrombosis / Endothelial Barrier Dysfunction / Epilogue / References
Download or read book Macrophage Migration Inhibitory Factor Drives Neutrophil Accumulation by Facilitating IL‐1β Production in a Murine Model of Acute Gout written by and published by . This book was released on 2016 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Richard Bucala
Publisher : World Scientific
ISBN 13 : 9814335355
Total Pages : 399 pages
Book Rating : 4.8/5 (143 download)
Download or read book The MIF Handbook written by Richard Bucala and published by World Scientific. This book was released on 2012 with total page 399 pages. Available in PDF, EPUB and Kindle. Book excerpt: The role of the cytokine, macrophage migration inhibitory factor (MIF), in the immune response and in the immunopathogenesis of different inflammatory, autoimmune, and infectious disorders is now well established. The aim of this handbook is to provide an authoritative volume covering all aspects of MIF, from basic molecular biology to structure-function relationships, pathophysiology, genetics, and drug development. Recent studies continue to broaden considerably the role of MIF in both normal physiology and pathology, which range from such diverse areas as oncogenesis, cardiac physiology, and neurodevelopment. MIF's molecular mechanism of action in these contexts is becoming increasingly understood and the role of variant MIF alleles in different conditions continues to be defined. Unique structural features of the protein, such as an intrinsic catalytic activity, and the continuing elucidation of its receptor-dependent mechanism of action offer attractive opportunities for therapeutic intervention. This volume will provide a comprehensive synthesis of the state of the art of MIF science.
Author : Bharat B. Aggarwal
Publisher : Springer
ISBN 13 : 3034808372
Total Pages : 489 pages
Book Rating : 4.0/5 (348 download)
Download or read book Inflammation and Cancer written by Bharat B. Aggarwal and published by Springer. This book was released on 2014-05-12 with total page 489 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume examines in detail the role of chronic inflammatory processes in the development of several types of cancer. Leading experts describe the latest results of molecular and cellular research on infection, cancer-related inflammation and tumorigenesis. Further, the clinical significance of these findings in preventing cancer progression and approaches to treating the diseases are discussed. Individual chapters cover cancer of the lung, colon, breast, brain, head and neck, pancreas, prostate, bladder, kidney, liver, cervix and skin as well as gastric cancer, sarcoma, lymphoma, leukemia and multiple myeloma.
Author :
Publisher : ScholarlyEditions
ISBN 13 : 1481677160
Total Pages : 42 pages
Book Rating : 4.4/5 (816 download)
Download or read book Leukocyte Migration-Inhibitory Factors—Advances in Research and Application: 2013 Edition written by and published by ScholarlyEditions. This book was released on 2013-06-21 with total page 42 pages. Available in PDF, EPUB and Kindle. Book excerpt: Leukocyte Migration-Inhibitory Factors—Advances in Research and Application: 2013 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about ZZZAdditional Research in a compact format. The editors have built Leukocyte Migration-Inhibitory Factors—Advances in Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about ZZZAdditional Research in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Leukocyte Migration-Inhibitory Factors—Advances in Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
