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Low Energy Accelerator Based Neutron Sources For Neutron Capture Therapy
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Author :Wolfgang A.G. Sauerwein Publisher :Springer Science & Business Media ISBN 13 :3642313345 Total Pages :545 pages Book Rating :4.6/5 (423 download)
Book Synopsis Neutron Capture Therapy by : Wolfgang A.G. Sauerwein
Download or read book Neutron Capture Therapy written by Wolfgang A.G. Sauerwein and published by Springer Science & Business Media. This book was released on 2012-11-05 with total page 545 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neutron capture therapy (NCT) is based on the ability of the non-radioactive isotope boron-10 to capture thermal neutrons with very high probability and immediately to release heavy particles with a path length of one cell diameter, which in principle allows for tumor cell-selective high-LET particle radiotherapy. This book provides a comprehensive summary of the progress made in NCT in recent years. Individual sections cover all important aspects, including neutron sources, boron chemistry, drugs for NCT, dosimetry, and radiation biology. The use of NCT in a variety of malignancies and also some non-malignant diseases is extensively discussed. NCT is clearly shown to be a promising modality at the threshold of wider clinical application. All of the chapters are written by experienced specialists in language that will be readily understood by all participating disciplines.
Book Synopsis Cancer Neutron Capture Therapy by : Y. Mishima
Download or read book Cancer Neutron Capture Therapy written by Y. Mishima and published by Springer. This book was released on 2013-05-17 with total page 920 pages. Available in PDF, EPUB and Kindle. Book excerpt: There are many human cancers which actively synthesize specific characteristic proteins such as melanomas, thyroid cancer and squamous cell carcinoma. Many cancer researchers have of course tried to utilize this specific activity as a key for the selective treatment of cancers. In the past for example, the molecular hybrid compound of DOPA, a substrate of melanin, and nitrogen mustard N-oxide hydrochloride, a ctyotoxic anti-tumor drug, was synthesized as Melphalan and used to treat malignant melanoma. A major problem arose though in that it was soon found to be highly suppressive toward bone marrow and quite toxic while not being remarkably effective. Thus, malignant melanoma could not be cured by it. Such failure led us to develop a novel bimodal therapeutic system which includes the use of non-toxic potentially cytocidal chemicals which selectively accumulate within the cancer cells and which are converted by a controllable modality into an actively cytocidal element in situ. We can now non-surgically cure malignant melanoma and glioblastoma with our selective cancer treatment, neutron capture therapy (NCT); as can be found in this volume. Included are 124 papers on the latest breaking developments discussed at the Sixth International Symposium on NCT for Cancer held in Kobe during the late autumn of 1994.
Book Synopsis Photoneutron Sources by : B. W. Sargent
Download or read book Photoneutron Sources written by B. W. Sargent and published by . This book was released on 1946 with total page 8 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Neutron Generators for Analytical Purposes by : International Atomic Energy Agency
Download or read book Neutron Generators for Analytical Purposes written by International Atomic Energy Agency and published by IAEA Radiation Technology Repo. This book was released on 2012 with total page 145 pages. Available in PDF, EPUB and Kindle. Book excerpt: This publication addresses recent developments in neutron generator (NG) technology. It presents information on compact instruments with high neutron yield to be used for neutron activation analysis (NAA) and prompt gamma neutron activation analysis in combination with high count rate spectrometers. Traditional NGs have been shown to be effective for applications including borehole logging, homeland security, nuclear medicine and the on-line analysis of aluminium, coal and cement. Pulsed fast thermal neutron analysis, as well as tagged and timed neutron analysis, are additional techniques which can be applied using NG. Furthermore, NG can effectively be used for elemental analysis and is also effective for analysis of hidden materials by neutron radiography. Useful guidelines for developing NG based research laboratories are also provided in this publication.
Book Synopsis Boron And Gadolinium Neutron Capture Therapy For Cancer Treatment by : Narayan S Hosmane
Download or read book Boron And Gadolinium Neutron Capture Therapy For Cancer Treatment written by Narayan S Hosmane and published by World Scientific. This book was released on 2012-03-07 with total page 271 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book focuses on two concurrent experimental therapies in cancer treatment known as boron neutron capture therapy (BNCT) and gadolinium neutron capture therapy (GdNCT) using a variety of boron- and gadolinium-based compounds. Some of the gadolinium compounds serve the dual purpose as being MRI contrast agents and GdNCT agents. The book describes why BNCT & GdNCT were not at the forefront of the clinical trials during the past seven to eight decades since the discovery of neutrons by John Chadwick in 1932 and how the latest development in the synthesis of target boron- and gadolinium-based drugs has turned the area into the hottest one worthy of further investigation with the new clinical trials in the USA and elsewhere.
Book Synopsis Microdosimetry by : Lennart Lindborg
Download or read book Microdosimetry written by Lennart Lindborg and published by CRC Press. This book was released on 2017-07-06 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt: Experimental microdosimetry deals with the measurement of charged particle energy deposition in tissue equivalent volumes, ranging in size from nanometres to micrometres. Microdosimetry is employed to improve our understanding of the relationship between radiation energy deposition, the resulting biological effects, and the appropriate quantities to be used in characterizing and quantifying radiation quality. Although many reviews and contributions to the field have been published over the past fifty years, this new book is the first to provide a single, up to date, and easily accessible account of experimental microdosimetry. This book is designed to be used in medical, radiation, and health physics courses and by Master’s and PhD students. In addition to serving as an introductory text to the field for graduate students, this book will also be of interest as a teaching and reference resource for graduate supervisors and established researchers. Drs. Lennart Lindborg and Anthony Waker have spent a life-time career in experimental microdosimetry research in academic, industrial and regulatory environments and have observed the development of the field from its early days as a recognized discipline; they bring to this book particular knowledge and experience in the design, construction, operation and use of tissue equivalent gas ionization counters and chambers.
Book Synopsis Frontiers in Neutron Capture Therapy by : M. Frederick Hawthorne
Download or read book Frontiers in Neutron Capture Therapy written by M. Frederick Hawthorne and published by Springer. This book was released on 2013-11-11 with total page 1389 pages. Available in PDF, EPUB and Kindle. Book excerpt: Frontiers in Neutron Capture Therapy contains current research results originally presented at the Eighth International Symposium on Neutron Capture Therapy for Cancer in La Jolla, CA. This comprehensive collection of peer-reviewed manuscripts is showcased in two volumes covering all aspects of the development of this multidisciplinary approach to cancer therapy. Volume I of this work includes clinical results and current progress in treatment planning, neutron sources and dosimetry, while Volume II presents the synthesis, pharmacology and tissue-targeting design of boron compounds, including work on preclinical dosimetry and radiobiology. Intended for researchers and clinicians involved with or interested in new modes of cancer therapy, this volume will also serve as a useful guideline for scientists, students, and practitioners in the field.
Book Synopsis Intense Neutron Sources by : U.S. Atomic Energy Commission
Download or read book Intense Neutron Sources written by U.S. Atomic Energy Commission and published by . This book was released on 1966 with total page 856 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :International Atomic Energy Agency Publisher :International Atomic Energy Agency ISBN 13 :9789201450104 Total Pages :108 pages Book Rating :4.4/5 (51 download)
Book Synopsis Applications of Research Reactors by : International Atomic Energy Agency
Download or read book Applications of Research Reactors written by International Atomic Energy Agency and published by International Atomic Energy Agency. This book was released on 2014 with total page 108 pages. Available in PDF, EPUB and Kindle. Book excerpt: This publication is a comprehensive study that reviews the current situation in a great number of applications of research reactors. It revises the contents of IAEA TECDOC-1234, The Applications of Research Reactors, giving detailed updates on each field of research reactor uses worldwide. Reactors of all sizes and capabilities can benefit from the sharing of current practices and research enabled via this updated version, which describes the requirements for practicing methods as diverse as neutron activation analysis, education and training, neutron scattering and neutron imaging, silicon doping and radioisotope production, material/fuel irradiation and testing, and some others. Many underutilised research reactors can learn how to diversify their technical capabilities, staff and potential commercial partners and users seeking research reactor services and products. The content of the publication has also been strengthened in terms of current issues facing the vast majority of research reactors by including sections describing user and customer relations as well as strategic planning considerations.
Book Synopsis Handbook of Spallation Research by : Detlef Filges
Download or read book Handbook of Spallation Research written by Detlef Filges and published by Wiley-VCH. This book was released on 2010-02-01 with total page 787 pages. Available in PDF, EPUB and Kindle. Book excerpt: This detailed and comprehensive reference to spallation -- from the foundations to the latest applications is the only work of its kind and is written by two internationally renowned researchers. Clearly divided into three parts, it begins with the basic principles, while the second part describes the proton-nucleus and proton-matter experiments so-called thin and thick target experiments in terms of secondary particle production as hadrons, pions, muons, photons, electrons, light and intermediate masses, isotope production, heating and energy deposition and materials damage. Many of the experiments are associated with studies, investigations and the construction of spallation neutron sources since 1975 with emphasis on the most recent developments. The final part on technology and applications describes the various engineering problems associated with high intensity neutron spallation sources, ATW's, the needed accelerator systems, material and neutron issues, and high energy neutron source shielding aspects. A must-have for engineers and physicists working in or entering this field.
Book Synopsis Advances in Neutron Capture Therapy by : R.F. Barth
Download or read book Advances in Neutron Capture Therapy written by R.F. Barth and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 776 pages. Available in PDF, EPUB and Kindle. Book excerpt: Binary systems for the treatment of cancer potentially are among the most attractive of the new therapeutic modalities that currently are under investigation. The basicconcept is to selectivelydestroy malignantcells whileconcomitantlysparing normal tissue. Neutron capture therapy (NCT) is the binary system that has been the subject of the Fifth International Symposium on Neutron Capture Therapy, which was held September13-17, 1992, in Columbus, Ohio, undertheauspicesoftheInternational Society for Neutron Capture Therapy. Its objective was to bring together researchers from throughout the world and to provide a forum at which they could present the latest advances in the development of Neutron capture therapy. Neutron capture therapy has largely, but not exclusively, focused on the use of boron-10 as the target nuclide. Boron neutron capture therapy (BNCT) is based on the nuclear reaction that occurs when the stable isotope, boron-10, absorbs low-energy non ionizing thermal neutrons to yield alphaparticles and recoiling lithium-7 nuclei. The size and energy of these high linear energy transfer (LET) particles result in their being confined largely to the cells in which the capture reaction occurs. For BNCT to be successful, a sufficient numberof I~atoms mustbe localized within neoplastic cells, and enough thermal neutrons must be delivered and absorbed by the I~ to produce a lethal 1~(n,QVLi reaction. Two major problems must be surmounted.
Book Synopsis Photon, Electron, Proton, and Neutron Interaction Data for Body Tissues by :
Download or read book Photon, Electron, Proton, and Neutron Interaction Data for Body Tissues written by and published by International Commission on Radiation. This book was released on 1992-01-01 with total page 207 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Proton Therapy Physics by : Harald Paganetti
Download or read book Proton Therapy Physics written by Harald Paganetti and published by CRC Press. This book was released on 2016-04-19 with total page 691 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proton Therapy Physics goes beyond current books on proton therapy to provide an in-depth overview of the physics aspects of this radiation therapy modality, eliminating the need to dig through information scattered in the medical physics literature. After tracing the history of proton therapy, the book summarizes the atomic and nuclear physics background necessary for understanding proton interactions with tissue. It describes the physics of proton accelerators, the parameters of clinical proton beams, and the mechanisms to generate a conformal dose distribution in a patient. The text then covers detector systems and measuring techniques for reference dosimetry, outlines basic quality assurance and commissioning guidelines, and gives examples of Monte Carlo simulations in proton therapy. The book moves on to discussions of treatment planning for single- and multiple-field uniform doses, dose calculation concepts and algorithms, and precision and uncertainties for nonmoving and moving targets. It also examines computerized treatment plan optimization, methods for in vivo dose or beam range verification, the safety of patients and operating personnel, and the biological implications of using protons from a physics perspective. The final chapter illustrates the use of risk models for common tissue complications in treatment optimization. Along with exploring quality assurance issues and biological considerations, this practical guide collects the latest clinical studies on the use of protons in treatment planning and radiation monitoring. Suitable for both newcomers in medical physics and more seasoned specialists in radiation oncology, the book helps readers understand the uncertainties and limitations of precisely shaped dose distribution.
Book Synopsis RF Linear Accelerators by : Thomas P. Wangler
Download or read book RF Linear Accelerators written by Thomas P. Wangler and published by John Wiley & Sons. This book was released on 2008-03-03 with total page 476 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dieses einschlägige Lehrbuch, entwickelt auf der Grundlage der Ausbildung an der US Particle Accelerator School, schließt eine Lücke in der verfügbaren Literatur zum Thema Hochfrequenz-Linearbeschleuniger, kurz RF-Linac. Nach einer Erläuterung der naturwissenschaftlichen Grundlagen und der neuesten technologischen Eckdaten stellt diese zweite Auflage neueste RF-Linacs, spezialisierte Systeme, Systeme mit Supraleitern und verschiedene Spezialverfahren vor. Übungsaufgaben an den Kapitelenden erleichtern das Einprägen und das Nacharbeiten von Vorlesungen.
Book Synopsis Proton Radiotherapy Accelerators by : Waldemar H Scharf
Download or read book Proton Radiotherapy Accelerators written by Waldemar H Scharf and published by World Scientific. This book was released on 2001-08-17 with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hadronic radiotherapy uses particle beams to treat tumors located near critical body structures and tumors that respond poorly to conventional photon and electron beam radiotherapy. Initial research in hadronic radiotherapy was performed using accelerators built for physics research. The good results of the proton and ion therapy programs have enhanced the tendency to use protontherapy as a routine method. There are about 20 working protontherapy facilities (first, second and third generation) and more than 30 centers are planned.This book presents the first comprehensive overview of the field with a discussion on the fundamental basis of particle physics and radiobiology, as well as review of clinical and technical specifications and designs for proton radiotherapy. In particular, the current designs of proton and heavy ion accelerators, beam delivery systems, gantries, beam monitoring and dosimetry systems, control and safety systems, patient positioning and immobilization devices, and ancillary treatment facilities are widely discussed.
Book Synopsis Advances in Neutron Capture Therapy by : A.H. Soloway
Download or read book Advances in Neutron Capture Therapy written by A.H. Soloway and published by Springer Science & Business Media. This book was released on 1993 with total page 872 pages. Available in PDF, EPUB and Kindle. Book excerpt: Binary systems for the treatment of cancer potentially are among the most attractive of the new therapeutic modalities that currently are under investigation. The basicconcept is to selectivelydestroy malignantcells whileconcomitantlysparing normal tissue. Neutron capture therapy (NCT) is the binary system that has been the subject of the Fifth International Symposium on Neutron Capture Therapy, which was held September13-17, 1992, in Columbus, Ohio, undertheauspicesoftheInternational Society for Neutron Capture Therapy. Its objective was to bring together researchers from throughout the world and to provide a forum at which they could present the latest advances in the development of Neutron capture therapy. Neutron capture therapy has largely, but not exclusively, focused on the use of boron-10 as the target nuclide. Boron neutron capture therapy (BNCT) is based on the nuclear reaction that occurs when the stable isotope, boron-10, absorbs low-energy non ionizing thermal neutrons to yield alphaparticles and recoiling lithium-7 nuclei. The size and energy of these high linear energy transfer (LET) particles result in their being confined largely to the cells in which the capture reaction occurs. For BNCT to be successful, a sufficient numberof I~atoms mustbe localized within neoplastic cells, and enough thermal neutrons must be delivered and absorbed by the I~ to produce a lethal 1~(n,QVLi reaction. Two major problems must be surmounted.
Book Synopsis Topics in Dosimetry and Treatment Planning for Neutron Capture Therapy by : Robert G. Zamenhof
Download or read book Topics in Dosimetry and Treatment Planning for Neutron Capture Therapy written by Robert G. Zamenhof and published by . This book was released on 1994 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt:
