Local Therapies For Unresectable Primary Hepatocellular Carcinoma

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Local Therapies for Unresectable Primary Hepatocellular Carcinoma

Author : U. S. Department of Health and Human Services
Publisher : CreateSpace
ISBN 13 : 9781491081099
Total Pages : 330 pages
Book Rating : 4.0/5 (81 download)

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Book Synopsis Local Therapies for Unresectable Primary Hepatocellular Carcinoma by : U. S. Department of Health and Human Services

Download or read book Local Therapies for Unresectable Primary Hepatocellular Carcinoma written by U. S. Department of Health and Human Services and published by CreateSpace. This book was released on 2013-07 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comparative effectiveness review evaluates local hepatic therapies for patients with unresectable primary hepatocellular carcinoma (HCC) who are not candidates for surgical resection or liver transplantation. Here we describe the epidemiology and staging of HCC, as well as currently available treatment strategies. We also discuss the current practice guidelines and the impetus for this review. Hepatocellular carcinoma is the most common primary liver tumor. It is the fifth most common cancer and the third leading cause of cancer death worldwide. Overall 5-year survival rates for HCC are less than 10 percent in Europe and the United States. The main etiology of HCC is chronic infection with the hepatitis B and hepatitis C viruses. Approximately 4 million individuals in the United States are chronically infected with hepatitis C virus, and the annual incidence rate of HCC among patients with hepatitis C–related cirrhosis is estimated to be between 2 and 8 percent. Unlike the case with most solid tumors, the incidence of and mortality rate due to HCC are projected to increase worldwide in the next 20 years, primarily due to the dissemination of hepatitis C virus infection.Other causes include cirrhosis due to any cause (e.g., alcohol), hereditary hemochromatosis and iron overload syndromes, nonalcoholic fatty liver disease, obesity, diabetes, and environmental toxins (e.g., aflatoxin, chewing of betel quid, and contaminated water). While there are several causes of HCC, etiology is not an independent prognostic factor for HCC; rather, the underlying cirrhosis impacts prognosis and treatment decisions. In the United States, most cases of HCC occur in patients with cirrhosis.1A small proportion, approximately 5 percent, of all HCC cases in Western countries occur in patients without cirrhosis. For patients with early-stage HCC without underlying cirrhosis, surgical resection is the preferred treatment and offers a high probability of a cure. The Barcelona Clinic Liver Cancer (BCLC) guidelines recommend hepatectomy for patients with a single lesion less than 5 cm in size and mild or no underlying cirrhosis. In contrast, patients with severe cirrhosis are not considered resectable and receive supportive care instead. This report focuses on the approximately 80 percent of patients who are not surgical candidates due to advanced-stage disease at diagnosis, inadequate hepatic reserve to tolerate resection, tumors in unresectable locations, or medical comorbidities that result in a high surgical risk. The following are the Key Questions (KQs) addressed in this review. KQ1. What is the comparative effectiveness of the various liver-directed therapies in patients with HCC who are not otherwise candidates for surgical resection or transplantation with no evidence of extrahepatic disease regarding survival and quality of life? KQ2. What are the comparative harms of the various liver-directed therapies in patients with HCC who are not otherwise candidates for surgical resection or transplantation with no evidence of extrahepatic disease regarding adverse events? KQ3. Are there differences in comparative effectiveness of various liver-directed therapies in patients with HCC who are not otherwise candidates for surgical resection or transplantation for specific patient and tumor characteristics, such as age, gender, disease etiology, and Child-Pugh score?

Local Therapies for Unresectable Primary Hepatocellular Carcinoma

Author : Suzanne Belinson
Publisher :
ISBN 13 :
Total Pages : 324 pages
Book Rating : 4.:/5 (855 download)

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Book Synopsis Local Therapies for Unresectable Primary Hepatocellular Carcinoma by : Suzanne Belinson

Download or read book Local Therapies for Unresectable Primary Hepatocellular Carcinoma written by Suzanne Belinson and published by . This book was released on 2013 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt: OBJECTIVES: To characterize the comparative effectiveness and harms of various local hepatic therapies for patients with unresectable primary hepatocellular carcinoma (HCC) who are not candidates for surgical resection or liver transplantation. Local hepatic therapies include those related to ablation, embolization, and radiotherapy. DATA SOURCES: We searched MEDLINE(r) and Embase(r) from January 2000 to July 2012. We also searched for gray literature in databases with regulatory information, clinical trial registries, abstracts and conference papers, as well as information from manufacturers. REVIEW METHODS: We sought studies reporting two final health outcomes--overall survival and quality of life--and various adverse events related to the different interventions. Data were dually abstracted by a team of four reviewers. A third reviewer resolved conflicts when necessary. We assessed the quality of individual studies and graded the strength of the body of evidence according to prespecified methods. RESULTS: We identified 1,707 articles through the literature search, excluded 1,665 at various stages of screening, and included 42 articles. To these we added 6 hand-searched articles for a total of 48 articles included in this review. Our searches of gray literature sources did not yield any additional published studies. The included literature was comprised of 6 randomized controlled trials (RCTs), 4 nonrandomized comparative studies, 35 case series, and 3 case reports. One RCT was rated as good, three were rated as fair, and two were rated as poor quality. We included 13 local hepatic therapies in this review; however, there was sufficient comparative evidence (three RCTs) to assess only one direct comparison: radiofrequency ablation (RFA) versus percutaneous ethanol injection (PEI)/percutaneous acetic acid injection (PAI). Three-year survival when treated with RFA was superior to that for PEI/PAI for unresectable HCC, with a moderate grade of evidence. Time to progression (TTP) and local recurrence were better for RFA than PEI/PAI, but length of stay (LOS) was longer after RFA than PEI/PAI. Strength of evidence for all other comparisons was rated insufficient. There was a low level of evidence to support longer overall survival following RFA than PEI/PAI for the subgroup of patients with larger lesion size. CONCLUSIONS: Of the 13 interventions included in this report, only 1 comparison had sufficient evidence to receive a rating above insufficient. There was moderate strength of evidence demonstrating better overall survival at 3 years, a low level of evidence supporting improved overall survival for patients with larger lesion sizes, and low strength of evidence for improved TTP and local control for RFA than PEI/PAI for the treatment of unresectable HCC. A low level of evidence also supports a longer LOS following RFA than PEI/PAI. For all other outcomes and comparisons, there is insufficient evidence to permit conclusions on the comparative effectiveness of local hepatic therapies for unresectable HCC. Additional RCTs are necessary for all comparisons. Focusing on comparisons with RFA may allow for the greatest integration of new data with the current body of evidence.

Hepatocellular Carcinoma

Author : Yujin Hoshida
Publisher : Springer
ISBN 13 : 3030215407
Total Pages : 366 pages
Book Rating : 4.0/5 (32 download)

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Book Synopsis Hepatocellular Carcinoma by : Yujin Hoshida

Download or read book Hepatocellular Carcinoma written by Yujin Hoshida and published by Springer. This book was released on 2019-08-05 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive overview of the current limitations and unmet needs in Hepatocellular Carcinoma (HCC) diagnosis, treatment, and prevention. It also provides newly emerging concepts, approaches, and technologies to address challenges. Topics covered include changing landscape of HCC etiologies in association with health disparities, framework of clinical management algorithm, new and experimental modalities of HCC diagnosis and prognostication, multidisciplinary treatment options including rapidly evolving molecular targeted therapies and immune therapies, multi-omics molecular characterization, and clinically relevant experimental models. The book is intended to assist collaboration between the diverse disciplines and facilitate forward and reverse translation between basic and clinical research by providing a comprehensive overview of relevant areas, covering epidemiological trend and population-level patient management strategies, new diagnostic and prognostic tools, recent advances in the standard care and novel therapeutic approaches, and new concepts in pathogenesis and experimental approaches and tools, by experts and opinion leaders in their respective fields. By thoroughly and concisely covering whole aspects of HCC care, Hepatocellular Carcinoma serves as a valuable reference for multidisciplinary readers, and promotes the development of personalized precision care strategies that lead to substantial improvement of disease burden and patient prognosis in HCC.

Encyclopedia of Cancer

Author : Manfred Schwab
Publisher : Springer Science & Business Media
ISBN 13 : 3540368477
Total Pages : 3307 pages
Book Rating : 4.5/5 (43 download)

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Book Synopsis Encyclopedia of Cancer by : Manfred Schwab

Download or read book Encyclopedia of Cancer written by Manfred Schwab and published by Springer Science & Business Media. This book was released on 2008-09-23 with total page 3307 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive encyclopedic reference provides rapid access to focused information on topics of cancer research for clinicians, research scientists and advanced students. Given the overwhelming success of the first edition, which appeared in 2001, and fast development in the different fields of cancer research, it has been decided to publish a second fully revised and expanded edition. With an A-Z format of over 7,000 entries, more than 1,000 contributing authors provide a complete reference to cancer. The merging of different basic and clinical scientific disciplines towards the common goal of fighting cancer makes such a comprehensive reference source all the more timely.

Colorectal Cancer Liver Metastases

Author : Mauro Monteiro Correia
Publisher : Springer Nature
ISBN 13 : 3030254860
Total Pages : 597 pages
Book Rating : 4.0/5 (32 download)

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Book Synopsis Colorectal Cancer Liver Metastases by : Mauro Monteiro Correia

Download or read book Colorectal Cancer Liver Metastases written by Mauro Monteiro Correia and published by Springer Nature. This book was released on 2019-12-28 with total page 597 pages. Available in PDF, EPUB and Kindle. Book excerpt: Colorectal cancer is the third most commonly diagnosed condition in oncology, affecting around 1.23 million individuals per year, according to recent statistics. Of these patients, about 50% will develop liver metastases and approximately 20% will present a stage IV disease at diagnosis. These statistics make colorectal liver metastases (CLM) an issue of major importance in current oncology. The area of CLM is subject to great and continuous advances, as its pathophysiologic mechanisms are better understood and more therapeutic and surgical options are developed. Consequently, all professionals involved with the diagnosis, treatment and follow up of CLM should be kept up to date with the latest advances on the field, to provide high standard medical care to their patients. This book is designed to present the state-of-the-art in CLM management and, in doing so, to review the current evidence on CLM, discussing all important topics in the field. Coverage is broad and comprehensive, encompassing introductory topics (history, definitions, epidemiology, etc.), basic science subjects (molecular biology, genetics, dissemination process, etc.) and practical clinical topics (tumor behavior, diagnosis, drug therapy, radiation therapy, surgery, ablation, multidisciplinary teams, etc.). Although comprehensive on the coverage and selection of topics, each chapter is concise and objective, dissecting topics in a practical and direct format. Evidences and recommendations are included. Chapters display a brief introduction of the common knowledge, go straight to the detailed revision of the most recent years of the literature, and end with practical closing observations. This book is a tool for professionals (general and cancer surgeons, HPB surgeons, clinical oncologists, gastroenterologists and medical residents) and interns who search for a qualified and reader friendly revision on topics concerning Colorectal Cancer Liver Metastases.

Immunotherapy of Hepatocellular Carcinoma

Author : Tim F. Greten
Publisher : Springer
ISBN 13 : 3319649582
Total Pages : 167 pages
Book Rating : 4.3/5 (196 download)

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Book Synopsis Immunotherapy of Hepatocellular Carcinoma by : Tim F. Greten

Download or read book Immunotherapy of Hepatocellular Carcinoma written by Tim F. Greten and published by Springer. This book was released on 2017-10-04 with total page 167 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book we provide insights into liver – cancer and immunology. Experts in the field provide an overview over fundamental immunological questions in liver cancer and tumorimmunology, which form the base for immune based approaches in HCC, which gain increasing interest in the community due to first promising results obtained in early clinical trials. Hepatocellular carcinoma (HCC) is the third most common cause of cancer related death in the United States. Treatment options are limited. Viral hepatitis is one of the major risk factors for HCC, which represents a typical “inflammation-induced” cancer. Immune-based treatment approaches have revolutionized oncology in recent years. Various treatment strategies have received FDA approval including dendritic cell vaccination, for prostate cancer as well as immune checkpoint inhibition targeting the CTLA4 or the PD1/PDL1 axis in melanoma, lung, and kidney cancer. Additionally, cell based therapies (adoptive T cell therapy, CAR T cells and TCR transduced T cells) have demonstrated significant efficacy in patients with B cell malignancies and melanoma. Immune checkpoint inhibitors in particular have generated enormous excitement across the entire field of oncology, providing a significant benefit to a minority of patients.

Liver Malignancies

Author : C. Bartolozzi
Publisher : Springer Science & Business Media
ISBN 13 : 3642586414
Total Pages : 534 pages
Book Rating : 4.6/5 (425 download)

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Book Synopsis Liver Malignancies by : C. Bartolozzi

Download or read book Liver Malignancies written by C. Bartolozzi and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 534 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive and up-to-date overview of the role of diagnostic and interventional radiology in respect of liver malignancies. Following background chapters on anatomy, epidemiology, and clinicopathologic features, each of the diagnostic imaging techniques is carefully appraised, focusing on new developments in equipment and contrast agents. The interventional therapeutic approaches to primary and secondary hepatic malignancies are then discussed in depth, as well as such special topics as liver tumors in children and hepatic transplantation. Written by leading experts from around the world, this will prove to be an indispensable source of information for both clinicians and researchers.

Diagnosis and Treatment of Hepatocellular Carcinoma

Author : Tito Livraghi
Publisher : Greenwich Medical Media
ISBN 13 : 9781900151306
Total Pages : 454 pages
Book Rating : 4.1/5 (513 download)

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Book Synopsis Diagnosis and Treatment of Hepatocellular Carcinoma by : Tito Livraghi

Download or read book Diagnosis and Treatment of Hepatocellular Carcinoma written by Tito Livraghi and published by Greenwich Medical Media. This book was released on 1997-01-01 with total page 454 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book is edited by a multidisciplinary team, with an international group of contributors. After discussing the basic and clinical aspects of HCC the main focus of the book is on diagnosis and therapy. The book is both authoritative and practical, providing expert guidance on the various techniques used in diagnosis, such as ultrasound, CT and MRI and the appropriate therapeutic options, for example, surgical resection, transcatheter therapies and radiofrequency ablation. It is fully illustrated throughout in both colour and black and white.

Hepatocellular Carcinoma

Author : Costin Teodor Streba
Publisher : BoD – Books on Demand
ISBN 13 : 1789842735
Total Pages : 201 pages
Book Rating : 4.7/5 (898 download)

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Book Synopsis Hepatocellular Carcinoma by : Costin Teodor Streba

Download or read book Hepatocellular Carcinoma written by Costin Teodor Streba and published by BoD – Books on Demand. This book was released on 2018-11-28 with total page 201 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hepatocellular carcinoma (HCC) currently ranks as the third most common cause of death. As the primary malignancy of the liver is directly related to an underlying liver condition, its incidence and profile are expected to change soon. While effective prevention programs and antiviral therapies for hepatitis B and C will lower the incidence of HCC, emerging socioeconomic issues will deliver new at-risk populations. Moreover, diagnostic techniques and protocols have undergone significant advancements. Reliance on contrast enhanced ultrasound has been re-evaluated, imaging methods being considered as sufficient diagnostic tools. Molecular characterization remains desirable, since chemotherapeutic agents still have limited applicability. In light of recent diagnostic advancements and novel therapeutic solutions, it is our belief that a comprehensive update on recent paradigm shifts and interesting upcoming developments is highly needed.

Liver-Directed Therapy for Primary and Metastatic Liver Tumors

Author : Mark S. Talamonti
Publisher : Springer Science & Business Media
ISBN 13 : 1475733712
Total Pages : 342 pages
Book Rating : 4.4/5 (757 download)

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Book Synopsis Liver-Directed Therapy for Primary and Metastatic Liver Tumors by : Mark S. Talamonti

Download or read book Liver-Directed Therapy for Primary and Metastatic Liver Tumors written by Mark S. Talamonti and published by Springer Science & Business Media. This book was released on 2013-04-17 with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt: Liver-Directed Therapy for Primary and Metastatic Liver Tumors is a comprehensive examination of tumors of the liver. It provides a unique multi-modality approach to management of all types of primary and secondary liver tumors. The biology of liver cancers, state of the art radiologic imaging and novel, non-surgical interventional strategies are given. There is an in depth analysis of surgical options including transplantation, resection, interstitial ablation techniques and liver-directed chemotherapy for hepatocellular carcinoma, bile duct cancers, and colorectal and neuroendocrine liver metastases. Because of the unique and comprehensive examination of liver tumors, this work is an excellent resource for surgical, transplant and medical oncologists, surgeons, gastroenterologists, and radiologists.

Stereotactic Body Radiation Therapy

Author : Simon S. Lo
Publisher : Springer Science & Business Media
ISBN 13 : 364225604X
Total Pages : 433 pages
Book Rating : 4.6/5 (422 download)

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Book Synopsis Stereotactic Body Radiation Therapy by : Simon S. Lo

Download or read book Stereotactic Body Radiation Therapy written by Simon S. Lo and published by Springer Science & Business Media. This book was released on 2012-08-28 with total page 433 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stereotactic body radiation therapy (SBRT) has emerged as an important innovative treatment for various primary and metastatic cancers. This book provides a comprehensive and up-to-date account of the physical/technological, biological, and clinical aspects of SBRT. It will serve as a detailed resource for this rapidly developing treatment modality. The organ sites covered include lung, liver, spine, pancreas, prostate, adrenal, head and neck, and female reproductive tract. Retrospective studies and prospective clinical trials on SBRT for various organ sites from around the world are examined, and toxicities and normal tissue constraints are discussed. This book features unique insights from world-renowned experts in SBRT from North America, Asia, and Europe. It will be necessary reading for radiation oncologists, radiation oncology residents and fellows, medical physicists, medical physics residents, medical oncologists, surgical oncologists, and cancer scientists.

Cancer Management and Therapy

Author : Amal Hamza
Publisher : BoD – Books on Demand
ISBN 13 : 1789232988
Total Pages : 212 pages
Book Rating : 4.7/5 (892 download)

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Book Synopsis Cancer Management and Therapy by : Amal Hamza

Download or read book Cancer Management and Therapy written by Amal Hamza and published by BoD – Books on Demand. This book was released on 2018-06-20 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt: There are many different types of cancer. Some are very common; others are rare. Having some similar features, each cancer has its own characteristics and symptoms, which vary according to the type of cancer and where it is in the body. The treatment selected may be influenced by the patient's age, concurrent health problems, life expectancy, characteristics of the individual's cancer, the patient's goals of treatment, and the bias of the treating physician. In preparing this book, we have considered and reflected on the concept of the recent advances in cancer management and therapy as well as molecular applications in cancer therapy. The readers can find detailed information about the treatment and management of specific cancers in these book chapters.

Adaptive Radiation Therapy

Author : X. Allen Li
Publisher : CRC Press
ISBN 13 : 1439816352
Total Pages : 404 pages
Book Rating : 4.4/5 (398 download)

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Book Synopsis Adaptive Radiation Therapy by : X. Allen Li

Download or read book Adaptive Radiation Therapy written by X. Allen Li and published by CRC Press. This book was released on 2011-01-27 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: Modern medical imaging and radiation therapy technologies are so complex and computer driven that it is difficult for physicians and technologists to know exactly what is happening at the point-of-care. Medical physicists responsible for filling this gap in knowledge must stay abreast of the latest advances at the intersection of medical imaging an

Laser-induced Interstitial Thermotherapy

Author : Gerhard J. Müller
Publisher : SPIE Press
ISBN 13 : 9780819418593
Total Pages : 572 pages
Book Rating : 4.4/5 (185 download)

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Book Synopsis Laser-induced Interstitial Thermotherapy by : Gerhard J. Müller

Download or read book Laser-induced Interstitial Thermotherapy written by Gerhard J. Müller and published by SPIE Press. This book was released on 1995 with total page 572 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Local Hepatic Therapies for Metastases to the Liver from Unresectable Colorectal Cancer

Author : U. S. Department of Health and Human Services
Publisher : Createspace Independent Pub
ISBN 13 : 9781483955865
Total Pages : 186 pages
Book Rating : 4.9/5 (558 download)

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Book Synopsis Local Hepatic Therapies for Metastases to the Liver from Unresectable Colorectal Cancer by : U. S. Department of Health and Human Services

Download or read book Local Hepatic Therapies for Metastases to the Liver from Unresectable Colorectal Cancer written by U. S. Department of Health and Human Services and published by Createspace Independent Pub. This book was released on 2013-03-25 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report aims to compare the effectiveness and harms of several local hepatic therapies for unresectable colorectal cancer (CRC) metastases to the liver. In this report, we describe CRC and its diagnosis and treatment to orient the reader to the disease. This is followed by a discussion of the treatment of CRC liver metastasis. CRC is the fourth most frequently diagnosed cancer and the second leading cause of cancer death in the United States. It is a cancer that forms in the tissues of the colon and the rectum. Most colorectal cancers are adenocarcinomas, meaning that they are a cancer of the epithelium originating from glandular tissue. Adenocarcinomas develop from adenomas, which are noncancerous tumors in the epithelial tissue. Over time, adenomas can become cancerous. This progression from adenoma to adenocarcinoma occurs through a sequential process of accumulating genetic changes. Although the most common type of CRC is adenocarcinoma, squamous carcinoma and adenosquamous carcinoma have been reported infrequently.An elevated risk of CRC has been associated with obesity, low physical activity, high dietary intake of refined sugars, low dietary intake of fiber, consumption of meat, and consumption of more than two alcoholic drinks per day. A reduction in risk has been linked to the intake of dietary calcium and diets high in fiber and potassium. The objective of this systematic review is to characterize the comparative effectiveness and harms of various local hepatic therapies for liver metastases from unresectable CRC in two distinct patient populations: Patients with unresectable, liver-dominant (i.e., majority of disease located in the liver) metastases who are not eligible for continued systemic chemotherapy because their disease is refractory (i.e., they have experienced disease progression while on therapy); Patients who are candidates for local liver therapies as an adjunct to systemic chemotherapy. There is extensive uncertainty surrounding the optimal use of the various local hepatic therapies. Because of the prevalence of CRC and the high likelihood of metastases, especially to the liver, this topic is important to health care providers, patients, and policymakers. We addressed four Key Questions (KQs) for the two patient populations described above: KQ1. What is the comparative effectiveness of the various liver-directed therapies in patients whose disease is refractory to systemic therapy for unresectable CRC metastases to the liver and who have minimal evidence of extrahepatic disease? KQ2. What are the comparative harms of the various liver-directed therapies in patients whose disease is refractory to systemic therapy for unresectable CRC metastases to the liver and who have minimal evidence of extrahepatic disease? KQ3. What is the comparative effectiveness of the various liver-directed therapies in patients who are candidates for local hepatic therapy as an adjunct to systemic therapy for unresectable CRC metastases to the liver and have no evidence of extrahepatic disease? KQ4. What are the comparative harms of the various liver-directed therapies in patients who are candidates for local hepatic therapy as an adjunct to systemic therapy for unresectable CRC metastases to the liver and have no evidence of extrahepatic disease?

Malignant Liver Tumors

Author : Pierre-Alain Clavien
Publisher : John Wiley & Sons
ISBN 13 : 1444356399
Total Pages : 1039 pages
Book Rating : 4.4/5 (443 download)

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Book Synopsis Malignant Liver Tumors by : Pierre-Alain Clavien

Download or read book Malignant Liver Tumors written by Pierre-Alain Clavien and published by John Wiley & Sons. This book was released on 2011-09-23 with total page 1039 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive and critical review of current and established treatment modalities for malignant liver tumors is designed to help you sort through the proliferation of competitive approaches and choose the best treatment options for your patient. Dr. Clavien and his contributors consider all the options – radiological, surgical, pharmaceutical, and emerging/novel therapies – and help you find the best single or combined therapy. Building on the success of the previous edition, this extremely thorough revision: features a new section on Guidelines for Liver Tumors, where you will find specific strategies for treating common liver malignancies; the guidelines were prepared by the Associate Editors and take into account national and international society guidelines reflects actual practice by taking a multidisciplinary approach, with contributions from international experts who have extensive experience with this patient population achieves comprehensive and balanced coverage by having each chapter reviewed by the Editor, Deputy Editor, two Associate Editors, and at least one external reviewer includes 16 new chapters that cover liver anatomy, histologic changes in the liver, epidemiology and natural history of HCC, CCC and colorectal liver metastases, strategies of liver resection, and economic aspects as well as novel therapies facilitates the kind of daily interaction among hepatologists, hepatic surgeons, medical oncologists, radiotherapists, and interventional radiologists that is essential when treating patients with complex liver malignancies In 44 chapters organized into six major sections, the book covers the full range of liver tumors. The perfect blend of evidence and experience, Malignant Liver Tumors: Current and Emerging Therapies, 3rd Edition, illuminates the path to better patient care.

Hepatobiliary Cancer

Author : Paul H. Sugarbaker
Publisher : Springer Science & Business Media
ISBN 13 : 1461526043
Total Pages : 455 pages
Book Rating : 4.4/5 (615 download)

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Book Synopsis Hepatobiliary Cancer by : Paul H. Sugarbaker

Download or read book Hepatobiliary Cancer written by Paul H. Sugarbaker and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 455 pages. Available in PDF, EPUB and Kindle. Book excerpt: When one deals with cancer, the hepatobiliary malignancies present a chal lenge to the oncologists that can be characterized as a series of unsolved clinical and biological dilemmas. Liver metastases from colorectal and other gastrointestinal malignancies, hepatocellular carcinoma, cholangiocar cinoma, and gall bladder cancer present an array of problems but have two features in common. These are high morbidity and mortality with an overall poor result from treatment. Why is it that hepatobiliary cancer carries with it such a dismal prognosis? First of all, these diseases present, for the most part, in an advanced state. To this point in time the oncologist has had no help from early diagnosis or screening. Only the occasional patient followed by ultrasound or a tumor marker has the disease diagnosed in an asymptomatic state. By the time these diseases become symptomatic, curative treatment options have usually disappeared. Evolution has placed the liver in a protected position in order to avoid injury to the soft parenchyma. As with many other internal organs, the nerve supply is extremely limited. These two anatomic features result in a great lack of early warning signs of cancer.