Liquid Biopsy

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Atlas of Liquid Biopsy

Author : Ludmilla Thomé Domingos Chinen
Publisher : Springer Nature
ISBN 13 : 3030698793
Total Pages : 208 pages
Book Rating : 4.0/5 (36 download)

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Book Synopsis Atlas of Liquid Biopsy by : Ludmilla Thomé Domingos Chinen

Download or read book Atlas of Liquid Biopsy written by Ludmilla Thomé Domingos Chinen and published by Springer Nature. This book was released on 2021-05-31 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a wealth of images and extensive information on circulating tumor cells (CTCs) and other cells usually observed in blood from patients with cancer, such as giant macrophages, and circulating tumor microemboli (CTM). The field of “liquid biopsy” began with the analysis of CTCs in the early 2000s. In the beginning, molecular techniques were developed to detect these cells in the blood. However, it has since become clear that CTCs initially require a cytopathological analysis to be detected without false positive and negative results. After detection, molecular analysis can be subsequently performed. Cancer is an important cause of mortality, especially when detected in late stages. Even with all the advances that have been made in its treatment, cancer is still challenging, as many patients do not respond to any therapy. Many health agencies have considered early diagnosis as a feasible tool. In this context, it is of the utmost importance to know the morphology and characteristics of CTCs to determine a correct diagnosis. Currently much of the scientific community is committed to expanding our knowledge of CTCs, and this work makes a valuable contribution, presenting hundreds of cell images from patients with various types of cancer, in many different stages of disease, and after receiving various treatments. The Atlas of Liquid Biopsy: Circulating Tumor Cells and Other Rare Cells in Cancer Patients’ Blood is an essential reference guide for all physicians, biologists, biomedics, and professionals working at clinical and research laboratories, hospitals and research centers.

Hepatocellular Carcinoma

Author : Yujin Hoshida
Publisher : Springer
ISBN 13 : 3030215407
Total Pages : 366 pages
Book Rating : 4.0/5 (32 download)

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Book Synopsis Hepatocellular Carcinoma by : Yujin Hoshida

Download or read book Hepatocellular Carcinoma written by Yujin Hoshida and published by Springer. This book was released on 2019-08-05 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive overview of the current limitations and unmet needs in Hepatocellular Carcinoma (HCC) diagnosis, treatment, and prevention. It also provides newly emerging concepts, approaches, and technologies to address challenges. Topics covered include changing landscape of HCC etiologies in association with health disparities, framework of clinical management algorithm, new and experimental modalities of HCC diagnosis and prognostication, multidisciplinary treatment options including rapidly evolving molecular targeted therapies and immune therapies, multi-omics molecular characterization, and clinically relevant experimental models. The book is intended to assist collaboration between the diverse disciplines and facilitate forward and reverse translation between basic and clinical research by providing a comprehensive overview of relevant areas, covering epidemiological trend and population-level patient management strategies, new diagnostic and prognostic tools, recent advances in the standard care and novel therapeutic approaches, and new concepts in pathogenesis and experimental approaches and tools, by experts and opinion leaders in their respective fields. By thoroughly and concisely covering whole aspects of HCC care, Hepatocellular Carcinoma serves as a valuable reference for multidisciplinary readers, and promotes the development of personalized precision care strategies that lead to substantial improvement of disease burden and patient prognosis in HCC.

Liquid Biopsy in Urogenital Cancers and its Clinical Utility

Author : Seyed Mohammad Kazem Aghamir
Publisher : Academic Press
ISBN 13 : 0323983979
Total Pages : 210 pages
Book Rating : 4.3/5 (239 download)

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Book Synopsis Liquid Biopsy in Urogenital Cancers and its Clinical Utility by : Seyed Mohammad Kazem Aghamir

Download or read book Liquid Biopsy in Urogenital Cancers and its Clinical Utility written by Seyed Mohammad Kazem Aghamir and published by Academic Press. This book was released on 2022-01-30 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt: Liquid Biopsy in Urogenital Cancers and Their Clinical Utility presents updated information on liquid biopsy techniques and their utility for diagnosing urological cancers. As a promising and recent diagnostic method, these techniques can be used for identifying tumors at initial stage, thus greatly improving treatment outcomes and survivorship. Chapters provide an overview of liquid biopsy as a new tool for diagnosis, monitoring and personalized medicine in urogenital cancers and explain its applicability in different cancer types, including bladder, prostate, kidney and testis tumors, female genital tract and pediatric urogenital tumors. This is a valuable resource for cancer researchers, oncologists, graduate students, urologists and biomedical researchers who need to understand more about liquid biopsy and its use for urogenital cancers. Presents an overview on liquid biopsy techniques and their applications in cancer diagnosis Explains how to extract circulating tumor DNA, RNA and circulating tumor cells and extracellular vehicles from blood samples to identify the urology cancers, including testis, prostate, bladder and kidney Includes several images and schematic diagrams that illustrate content and facilitate its comprehension

Liquid Biopsy

Author : Ilze Strumfa
Publisher : BoD – Books on Demand
ISBN 13 : 183881129X
Total Pages : 160 pages
Book Rating : 4.8/5 (388 download)

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Book Synopsis Liquid Biopsy by : Ilze Strumfa

Download or read book Liquid Biopsy written by Ilze Strumfa and published by BoD – Books on Demand. This book was released on 2019-07-10 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reliable diagnosis is the cornerstone, starting point, and prerequisite of successful treatment. Therefore, development of innovative diagnostic technologies represents a hot topic in medical research. Liquid biopsy is a novel, minimally invasive laboratory evaluation concept for diagnostic, prognostic, and predictive testing, as well as dynamic monitoring of treatment or disease course. To achieve these goals, a multitude of specific, targeted tests can be performed to detect free nucleic acids, exosomes, microRNAs, tumor-educated platelets, and whole cells of tumor or fetal origin in different biological fluids, including blood, urine, cerebrospinal fluid, and others. Although tissue biopsy has long been considered the gold standard of diagnostics, especially regarding malignant tumors, liquid biopsy has the advantages of a non-invasive approach and thus low risk of complications. It is technically feasible even in serious general status or if tumors or metastases are not easily accessible using conventional tissue biopsy. The testing is fast, exact, and can be repeated to ensure real-time follow-up. In contrast to classic tumor markers, liquid biopsy is distinguished by high specificity at genomic, proteomic, and cellular levels. It is expected to equal and exceed the diagnostic value of tissue biopsy. The field of liquid biopsies is developing rapidly regarding the selection of targets, technological improvements, and quality assessment. This book, written by a global team of recognized scientists, comprises state-of-the-art reviews on the current knowledge and advances in the technologies and software for liquid biopsy. Examples of practical application of liquid biopsy to evaluate thyroid cancer, multiple myeloma, etc. are discussed as well. The book is intended to serve as a reference for scientists and clinicians interested in the development and practical implementation of liquid biopsy.

Liquid Biopsies in Solid Tumors

Author : Massimo Cristofanilli
Publisher : Humana
ISBN 13 : 9783319845302
Total Pages : 161 pages
Book Rating : 4.8/5 (453 download)

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Book Synopsis Liquid Biopsies in Solid Tumors by : Massimo Cristofanilli

Download or read book Liquid Biopsies in Solid Tumors written by Massimo Cristofanilli and published by Humana. This book was released on 2018-05-08 with total page 161 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume, with chapters written by experts in the field of cancerous tumors, details the key factors associated with liquid biopsies in solid tumors: blood-based diagnostics; circulating tumor cells; enumeration and molecular analysis (association with breast cancer); epithelialmesenchymal transition; detection and monitoring; circulating-free tumor DNA; CTCs and ctDNA; and the exosome. The field of blood-based diagnostics is rapidly evolving demonstrating the possibility of real-time molecular analysis of cancer cells and their phenotype and genotype. Circulating Tumor Cell (CTCs) have demonstrated prognostic and predictive value in advanced cancer and represents a source of tumor cells for transcriptome and genomic analysis. Most recently, the detection of genomic abnormalities in the peripheral blood by sensitive and selective PCR methods (liquid biopsy) opened to the option of a comprehensive blood-based tumor analysis. Similar information can be obtained by analysis of exosome, a natural packaging and messaging system being explored in advanced malignancies. The final frontier is the evaluation of immune cells determinant of innate and adaptive immunity.

Tumor Liquid Biopsies

Author : Florence Schaffner
Publisher : Springer Nature
ISBN 13 : 3030264394
Total Pages : 365 pages
Book Rating : 4.0/5 (32 download)

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Book Synopsis Tumor Liquid Biopsies by : Florence Schaffner

Download or read book Tumor Liquid Biopsies written by Florence Schaffner and published by Springer Nature. This book was released on 2019-10-11 with total page 365 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a comprehensive guide to the techniques, clinical applications, and benefits of the different forms of liquid biopsy employed in patients with a variety of tumor types, including lung, breast and colorectal cancer. Offering detailed explanations, it discusses the how changes in tumors can be tracked using these cutting-edge technologies, which enable the detection and analysis of diverse circulating biomarkers: tumor cells, tumor DNA, tumor RNA (free or in exosomes), and fluid biomarkers identifiable by means of targeted proteomics. The use of such advanced technologies is enabling us to tackle questions and problems in a way that was not possible just a few years ago. We now have at our disposal an effective means of overcoming the problem of intratumor heterogeneity, which has limited the value of conventional biopsy approaches. As a consequence, oncology practice is about to change radically, toward truly personalized precision medicine. This book provides both clinicians and researchers with a thorough and up-to-date overview of progress in the field.

Liquid Biopsies in Solid Tumors

Author : Massimo Cristofanilli
Publisher : Humana Press
ISBN 13 : 331950956X
Total Pages : 161 pages
Book Rating : 4.3/5 (195 download)

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Book Synopsis Liquid Biopsies in Solid Tumors by : Massimo Cristofanilli

Download or read book Liquid Biopsies in Solid Tumors written by Massimo Cristofanilli and published by Humana Press. This book was released on 2017-03-25 with total page 161 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume, with chapters written by experts in the field of cancerous tumors, details the key factors associated with liquid biopsies in solid tumors: blood-based diagnostics; circulating tumor cells; enumeration and molecular analysis (association with breast cancer); epithelialmesenchymal transition; detection and monitoring; circulating-free tumor DNA; CTCs and ctDNA; and the exosome. The field of blood-based diagnostics is rapidly evolving demonstrating the possibility of real-time molecular analysis of cancer cells and their phenotype and genotype. Circulating Tumor Cell (CTCs) have demonstrated prognostic and predictive value in advanced cancer and represents a source of tumor cells for transcriptome and genomic analysis. Most recently, the detection of genomic abnormalities in the peripheral blood by sensitive and selective PCR methods (liquid biopsy) opened to the option of a comprehensive blood-based tumor analysis. Similar information can be obtained by analysis of exosome, a natural packaging and messaging system being explored in advanced malignancies. The final frontier is the evaluation of immune cells determinant of innate and adaptive immunity.

Clinical Molecular Diagnostics

Author : Shiyang Pan
Publisher : Springer Nature
ISBN 13 : 9811610371
Total Pages : 889 pages
Book Rating : 4.8/5 (116 download)

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Book Synopsis Clinical Molecular Diagnostics by : Shiyang Pan

Download or read book Clinical Molecular Diagnostics written by Shiyang Pan and published by Springer Nature. This book was released on 2021-07-08 with total page 889 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers the discovery of molecular biomarkers, the development of laboratory testing techniques and their clinical applications, focusing on basic research to clinical practice. It introduces new and crucial knowledge and ethics of clinical molecular diagnosis. This book emphasizes the applications of clinical molecular diagnostic test on health management, especially from different diseased organs. It lets readers to understand and realize precision healthcare.

Precision Cancer Medicine

Author : Sameek Roychowdhury
Publisher : Springer Nature
ISBN 13 : 3030236374
Total Pages : 196 pages
Book Rating : 4.0/5 (32 download)

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Book Synopsis Precision Cancer Medicine by : Sameek Roychowdhury

Download or read book Precision Cancer Medicine written by Sameek Roychowdhury and published by Springer Nature. This book was released on 2020-01-02 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genomic sequencing technologies have augmented the classification of cancer beyond tissue of origin and towards a molecular taxonomy of cancer. This has created opportunities to guide treatment decisions for individual patients with cancer based on their cancer’s unique molecular characteristics, also known as precision cancer medicine. The purpose of this text will be to describe the contribution and need for multiple disciplines working together to deliver precision cancer medicine. This entails a multi-disciplinary approach across fields including molecular pathology, computational biology, clinical oncology, cancer biology, drug development, genetics, immunology, and bioethics. Thus, we have outlined a current text on each of these fields as they work together to overcome various challenges and create opportunities to deliver precision cancer medicine. As trainees and junior faculty enter their respective fields, this text will provide a framework for understanding the role and responsibility for each specialist to contribute to this team science approach.

Liquid Biopsy as a Tool for Precision Oncology: New Challenges to Assess Clinical Response

Author : Gloria Ravegnini
Publisher : Frontiers Media SA
ISBN 13 : 2889662020
Total Pages : 78 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis Liquid Biopsy as a Tool for Precision Oncology: New Challenges to Assess Clinical Response by : Gloria Ravegnini

Download or read book Liquid Biopsy as a Tool for Precision Oncology: New Challenges to Assess Clinical Response written by Gloria Ravegnini and published by Frontiers Media SA. This book was released on 2020-12-10 with total page 78 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Liquid Biopsy in Cancer Patients

Author : Antonio Russo
Publisher : Humana Press
ISBN 13 : 3319556614
Total Pages : 214 pages
Book Rating : 4.3/5 (195 download)

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Book Synopsis Liquid Biopsy in Cancer Patients by : Antonio Russo

Download or read book Liquid Biopsy in Cancer Patients written by Antonio Russo and published by Humana Press. This book was released on 2017-07-26 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text is designed to provide readers with a useful and comprehensive resource and state-of-the-art overview about the new, growing and fast-expanding field of “liquid biopsy” for the management of cancer patients. The liquid biopsy represents an important turning point in oncology since it provides a tool for a serial monitoring of disease. Liquid biopsy is our “hand lens” to follow molecular changes that characterize tumor development and progression. The book provide a unique and valuable resource on the clinical relevance of liquid biopsy as well as on the technical aspects of liquid biopsy analysis. All invited authors are recognized experts in their field. Liquid Biopsy in Cancer Patients: The Hand Lens for Tumor Evolution is targeted to resident and fellows physicians, medical oncologists, molecular biologists and biotechnologists.

Precision Medicine for Investigators, Practitioners and Providers

Author : Joel Faintuch
Publisher : Academic Press
ISBN 13 : 0128191791
Total Pages : 640 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Precision Medicine for Investigators, Practitioners and Providers by : Joel Faintuch

Download or read book Precision Medicine for Investigators, Practitioners and Providers written by Joel Faintuch and published by Academic Press. This book was released on 2019-11-16 with total page 640 pages. Available in PDF, EPUB and Kindle. Book excerpt: Precision Medicine for Investigators, Practitioners and Providers addresses the needs of investigators by covering the topic as an umbrella concept, from new drug trials to wearable diagnostic devices, and from pediatrics to psychiatry in a manner that is up-to-date and authoritative. Sections include broad coverage of concerning disease groups and ancillary information about techniques, resources and consequences. Moreover, each chapter follows a structured blueprint, so that multiple, essential items are not overlooked. Instead of simply concentrating on a limited number of extensive and pedantic coverages, scholarly diagrams are also included. Provides a three-pronged approach to precision medicine that is focused on investigators, practitioners and healthcare providers Covers disease groups and ancillary information about techniques, resources and consequences Follows a structured blueprint, ensuring essential chapters items are not overlooked

Liquid Biopsy

Author : Antonio Russo
Publisher : Academic Press
ISBN 13 : 0128227117
Total Pages : 252 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Liquid Biopsy by : Antonio Russo

Download or read book Liquid Biopsy written by Antonio Russo and published by Academic Press. This book was released on 2022-11-03 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: Liquid Biopsy: New Challenges in the era of Immunotherapy and Precision Oncology aims to describe links between cancer, precision oncology, and liquid biopsy, focusing on their participation to immunotherapy management. The book provides updated information on the main applications of liquid biopsy and immunotherapy as well as interesting aspects useful for planning basic and translational research activities. It helps readers understand the central aspects of precision medicine in oncology, including the use of new generation technologies for translational and diagnostic settings and the main clinical trials in this area that may be useful during their research.The book is a valuable source for cancer researchers, oncologists and other members of the medical and biomedical field who are interested in learning more about recent developments in liquid biopsy and its relationship with precision medicine and immunotherapy. Presents a “highlights section in every chapter to help readers summarize the main aspects discussed Encompasses case reports to guide the reader on applying what they read in their clinical practice Includes several tables and figures specially created for the book to illustrate the meaning of what is expressed in the text

Less Medicine, More Health

Author : Dr. H. Gilbert Welch
Publisher : Beacon Press
ISBN 13 : 0807077585
Total Pages : 242 pages
Book Rating : 4.8/5 (7 download)

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Book Synopsis Less Medicine, More Health by : Dr. H. Gilbert Welch

Download or read book Less Medicine, More Health written by Dr. H. Gilbert Welch and published by Beacon Press. This book was released on 2016-03-01 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: A nationally recognized expert describes seven widespread assumptions that encourage excessive, ineffective, and sometimes harmful medical care—for readers of Overdiagnosed and Malcolm Gladwell You might think the biggest problem in medical care is that it costs too much. Or that health insurance is too expensive, too uneven, too complicated—and gives you too many forms to fill out. But the central problem is that too much medical care has too little value. Dr. H. Gilbert Welch is worried about too much medical care. He doesn’t deny that some people get too little medical care—rather that the conventional concern about “too little” needs to be balanced with a concern about “too much”: too many people being made to worry about diseases they don’t have and are at only average risk to get; too many people being tested and exposed to the harmful effects of the testing process; too many people being subjected to treatments they don’t need or can’t benefit from. The American public has been sold the idea that seeking medical care is one of the most important steps to maintain wellness. Surprisingly, medical care is not, in fact, well correlated with good health. More medicine does not equal more health; in reality the opposite may be true. In Less Medicine, More Health, Dr. Welch pushes against established wisdom and suggests that medical care can be too aggressive. Drawing on his twenty-five years of medical practice and research, he notes that while economics and lawyers contribute to the excesses of American medicine, the problem is essentially created when the general public clings to these powerful assumptions about the value of tests and treatments—a number of which are just plain wrong. By telling fascinating (and occasionally amusing) stories backed by reliable data, Dr. Welch challenges patients and the health-care establishment to rethink some very fundamental practices. His provocative prescriptions hold the potential to save money and, more important, improve health outcomes for us all.

Critical Issues in Head and Neck Oncology

Author : Jan B. Vermorken
Publisher : Springer Nature
ISBN 13 : 3031231759
Total Pages : 361 pages
Book Rating : 4.0/5 (312 download)

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Book Synopsis Critical Issues in Head and Neck Oncology by : Jan B. Vermorken

Download or read book Critical Issues in Head and Neck Oncology written by Jan B. Vermorken and published by Springer Nature. This book was released on 2023-03-27 with total page 361 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is an open access book. With a wealth of exciting data emerging in this rapidly evolving field this book will review the state-of-the-art knowledge with emphasis on multidisciplinary decision and management of head and neck cancer. The book provides significant detail on a wide range of topics including: the role of new targets for treatment, immunotherapy, resistance mechanisms, standardizing molecular profiling programs, and new methods to guide therapeutic approaches. In addition different disease situations are addressed including different treatment approaches in primary disease and in recurrent and/or metastatic disease as well as new developments in pathology, surgery and reconstruction techniques, new systemic therapies in salivary gland cancer, and supportive care and follow-up. All disciplines involved in the treatment of head & neck cancer are covered with a focus on translation into daily practice. The 8th-THNO is designed for medical oncologists, head and neck surgeons, radiation oncologists, otolaryngologists, and other medical professionals involved in the treatment of patients with head and neck cancer.

Two Faces of Evil: Cancer and Neurodegeneration

Author : Thomas Curran
Publisher : Springer Science & Business Media
ISBN 13 : 3642166024
Total Pages : 171 pages
Book Rating : 4.6/5 (421 download)

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Book Synopsis Two Faces of Evil: Cancer and Neurodegeneration by : Thomas Curran

Download or read book Two Faces of Evil: Cancer and Neurodegeneration written by Thomas Curran and published by Springer Science & Business Media. This book was released on 2010-12-16 with total page 171 pages. Available in PDF, EPUB and Kindle. Book excerpt: Homeostasis involves a delicate interplay between generative and degenerative processes to maintain a stable internal environment. In biological systems, equilibrium is established and controlled through a series of negative feedback mechanisms driven by a range of signal transduction processes. Failures in these complex communication pathways result in instability leading to disease. Cancer represents a state of imbalance caused by an excess of cell proliferation. In contrast, neurodegeneration is a consequence of excessive cell loss in the nervous system. Both of these disorders exhort profound tolls on humanity and they have been subject to a great deal of research designed to ameliorate this suffering. For the most part, the topics have been viewed as distinct and rarely do opportunities arise for transdisciplinary discussions among experts in both fields. However, cancer and neurodegeneration represent yin-yang counterpoints in the regulation of cell growth, and it is reasonable to hypothesize that key regulatory events mediated by oncogenes and tumor suppressor genes in cancer may also affect neurodegenerative processes

Tumor Immunology and Immunotherapy – Molecular Methods

Author :
Publisher : Academic Press
ISBN 13 : 0128186720
Total Pages : 554 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Tumor Immunology and Immunotherapy – Molecular Methods by :

Download or read book Tumor Immunology and Immunotherapy – Molecular Methods written by and published by Academic Press. This book was released on 2019-11-13 with total page 554 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tumor Immunology and Immunotherapy – Molecular Methods, Volume 629, the latest release in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Chapters in this release include Droplet digital PCR for measuring circulating tumor-derived DNA, Detection and quantification of cytosolic DNA, Methods to detect endogenous dsRNA induction and recognition, Quantification of eIF2alpha phosphorylation during immunogenic cell death, Assessment of annexin A1 release during immunogenic cell death, Luciferase-assisted detection of extracellular ATP in the course of ICD, The P2X7 receptor: structure and function, and much more. Contains the authority of authors who are leaders in their field Provides a comprehensive source on new methods and research in enzymology