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Author : Bengt Samuelsson
Publisher : Lippincott Williams & Wilkins
ISBN 13 : 9780890047415
Total Pages : 365 pages
Book Rating : 4.0/5 (474 download)
Download or read book Leukotrienes and Other Lipoxygenase Products written by Bengt Samuelsson and published by Lippincott Williams & Wilkins. This book was released on 1982 with total page 365 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Stanley Crooke
Publisher : Academic Press
ISBN 13 : 0323156533
Total Pages : 313 pages
Book Rating : 4.3/5 (231 download)
Download or read book Lipoxygenases and Their Products written by Stanley Crooke and published by Academic Press. This book was released on 2012-12-02 with total page 313 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lipoxygenases and Their Products provides a cogent summary of the advances in understanding lipoxygenases and their products, emphasizing their pharmacology and pathophysiology; regulation and structure; physiological role; and receptors and receptor antagonists. This text also reviews the literature where specific receptor antagonists (as opposed to enzymatic inhibitors) have been used to characterize the pharmacologic action and the pathophysiologic roles of some of lipoxygenase products of arachidonic acid metabolism. This book is organized into 11 chapters and begins with an overview of the biochemical, pharmacological, and pathophysiological aspects of 5-lipoxygenase products of arachidonic acid metabolism in the respiratory, cardiovascular, renal, gastrointestinal, and central nervous systems. The discussion then shifts to human 5-lipoxygenase, emphasizing this enzyme purification, stimulatory factors, and membrane translocation. The reader is methodically introduced to 5-lipoxygenase activity in rats and pigs; the potential and therapeutic value of 5-lipoxygenase inhibitors; the distribution of 15-lipoxygenase in cells or tissues; and products formed through the 15-lipoxygenase pathway. This book also considers lipoxins and third-generation peptidoleukotriene receptor antagonists, and then concludes with a summary of the physiological and pathophysiological effects of leukotrienes and lipoxins in a variety of organs. This book is of interest to scientists interested in arachidonic acid and its metabolites, to scientists engaged in drug discovery-and-development activities in academia and the pharmaceutical industry, and to clinicians interested in diseases associated with leukotrienes and related products.
Author : G. Velo
Publisher : Springer Science & Business Media
ISBN 13 : 1468478419
Total Pages : 390 pages
Book Rating : 4.4/5 (684 download)
Download or read book Drugs Affecting Leukotrienes and Other Eicosanoid Pathways written by G. Velo and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Z. Kmiec
Publisher : Springer Science & Business Media
ISBN 13 : 3642565530
Total Pages : 154 pages
Book Rating : 4.6/5 (425 download)
Download or read book Cooperation of Liver Cells in Health and Disease written by Z. Kmiec and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 154 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is only during the last decade that the functions of sinusoidal endothelial cells, Kupffer cells, hepatic stellate cells, pit cells and other intrahepatic lymphocytes have been better understood. The development of methods for isolation and co-culturing various types of liver cells has established that they communicate and cooperate via secretion of various intercellular mediators. This monograph summarizes multiple data that suggest the important role of cellular cross-talk for the functions of both normal and diseased liver. Special features of the book include concise presentation of the majority of detailed data in 19 tables. Original schemes allow for the clear illustration of complicated intercellular relationships. This is the first ever presentation of the newly emerging field of liver biology, which is important for hepatic function in health and disease and opens new avenues for therapeutic interventions.
Author : Jeffrey Drazen
Publisher : CRC Press
ISBN 13 : 0824746368
Total Pages : 520 pages
Book Rating : 4.8/5 (247 download)
Download or read book Five-Lipoxygenase Products in Asthma written by Jeffrey Drazen and published by CRC Press. This book was released on 2016-04-19 with total page 520 pages. Available in PDF, EPUB and Kindle. Book excerpt: Five-Lipoxygenase Products in Asthma offers an authoritative examination of the biochemistry, basic pharmacology, and clinical pharmacology of the leukotrienes with special emphasis on their role in asthma. A critical reference for every asthma researcher and clinician, Five-Lipoxygenase Products in Asthma highlights agents and products
Download or read book Regulation of Cellular Activities by Leukotrienes and Other Lipoxygenase Products of Arachidonic Acid written by and published by . This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Edwin N. Frankel
Publisher : Elsevier
ISBN 13 : 085709792X
Total Pages : 487 pages
Book Rating : 4.8/5 (57 download)
Download or read book Lipid Oxidation written by Edwin N. Frankel and published by Elsevier. This book was released on 2014-01-23 with total page 487 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this second edition, Edwin Frankel has updated and extended his now well-known book Lipid oxidation which has come to be regarded as the standard work on the subject since the publication of the first edition seven years previously. His main objective is to develop the background necessary for a better understanding of what factors should be considered, and what methods and lipid systems should be employed, to achieve suitable evaluation and control of lipid oxidation in complex foods and biological systems. The oxidation of unsaturated fatty acids is one of the most fundamental reactions in lipid chemistry. When unsaturated lipids are exposed to air, the complex, volatile oxidation compounds that are formed cause rancidity. This decreases the quality of foods that contain natural lipid components as well as foods in which oils are used as ingredients. Furthermore, products of lipid oxidation have been implicated in many vital biological reactions, and evidence has accumulated to show that free radicals and reactive oxygen species participate in tissue injuries and in degenerative disease. Although there have been many significant advances in this challenging field, many important problems remain unsolved. This second edition of Lipid oxidation follows the example of the first edition in offering a summary of the many unsolved problems that need further research. The need to understand lipid oxidation is greater than ever with the increased interest in long-chain polyunsaturated fatty acids, the reformulation of oils to avoid hydrogenation and trans fatty acids, and the enormous attention given to natural phenolic antioxidants, including flavonoids and other phytochemicals.
Author : Conference on Regulation of Cellular Activities by Leukotrienes and Other Lipoxygenase Products of Arachidonic Acid (1983, Santa Ynez, Calif.)
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (612 download)
Download or read book Proceedings of a Conference on Conference on Regulation of Cellular Activities by Leukotrienes and Other Lipoxygenase Products of Arachidonic Acid written by Conference on Regulation of Cellular Activities by Leukotrienes and Other Lipoxygenase Products of Arachidonic Acid (1983, Santa Ynez, Calif.) and published by . This book was released on 1984 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Joshua Rokach
Publisher : Elsevier Publishing Company
ISBN 13 :
Total Pages : 560 pages
Book Rating : 4.3/5 (91 download)
Download or read book Leukotrienes and Lipoxygenases written by Joshua Rokach and published by Elsevier Publishing Company. This book was released on 1989 with total page 560 pages. Available in PDF, EPUB and Kindle. Book excerpt: Important advances have been made in the chemistry and biochemistry of the leukotrienes mainly as a result of the development of new biophysical and biochemical methodologies. The extraordinary effort of many scientists and the interactions of many scientific disciplines has created a vast amount of data and information and, with it, the need for a book addressing all aspects of this multidisciplinary field. This book has been written to respond to that need. It comprises six chapters which together provide a cohesive interdisciplinary coverage of the field, from the organic, analytical aspect to the biological sciences. Among the many subjects covered are many aspects of the leukotriene field which have not been covered in detail before, i.e. the numerous methodologies employed in the detection, localization and quantitation of lipoxygenase products; the role of leukotrienes in human disease states; leukotriene antagonists and lipoxygenase inhibitors, and potential therapeutic agents. The book brings together a wide variety of material to give a valuable overview of this important subject.
Author : Zvi Naor
Publisher :
ISBN 13 : 9780881672367
Total Pages : 436 pages
Book Rating : 4.6/5 (723 download)
Download or read book Leukotrienes and Prostanoids in Health and Disease written by Zvi Naor and published by . This book was released on 1986 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Edward J. Goetzl
Publisher :
ISBN 13 :
Total Pages : 6 pages
Book Rating : 4.:/5 (251 download)
Download or read book Proceedings of a Conference on Regulation of Cellular Activities by Leukotrienes and Other Lipoxygenase Products of Arachidonic Acid written by Edward J. Goetzl and published by . This book was released on 1984 with total page 6 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Lawrence Chakrin
Publisher : Elsevier
ISBN 13 : 032315607X
Total Pages : 321 pages
Book Rating : 4.3/5 (231 download)
Download or read book The Leukotrienes written by Lawrence Chakrin and published by Elsevier. This book was released on 2012-12-02 with total page 321 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Leukotrienes, Chemistry and Biology discusses the significant scientific progress of leukotrienes, from the discovery of slow-reacting substance to the chemical identification of a mixture of leukotrienes. Composed of 11 chapters, the book presents an enormous increase in research on the chemistry and biology of these and related substances, especially as they relate to the etiology of allergic and inflammatory diseases. After briefly discussing the continuing perspectives on the leukotriene biology, the book describes the structure, synthesis, formation, and biological actions of leukotrienes. This is followed by a discussion on arachidonic metabolism for the development of therapeutic agents specifically designed to either inhibit the synthesis or antagonize the effects of the leukotrienes. The book also looks into the biochemical and pharmacologic control of the synthesis and actions of leukotrienes. The information is considered in the context of the specific enzymes in the pathway that may be affected by any given agent. The in vivo studies on the pulmonary mechanical effect of leukotrienes, the pharmacologic activity of leukotriene receptors, and the antagonistic property of peptidoleukotrienes as an approach to allergic disease treatment are considered in the concluding chapters of the book. This book will be of value to scientists and researchers interested in hypersensitivity reactions, inflammation, and allergic diseases.
Author : I B C Business Publishing Limited
Publisher :
ISBN 13 : 9781852710309
Total Pages : 140 pages
Book Rating : 4.7/5 (13 download)
Download or read book Drugs Affecting Leukotrienes and Lipoxygenase Products written by I B C Business Publishing Limited and published by . This book was released on 1988 with total page 140 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Royal College of Surgeons of England, Institute of
Publisher :
ISBN 13 : 9780835770811
Total Pages : 367 pages
Book Rating : 4.7/5 (78 download)
Download or read book Leukotrienes and Other Lipoxygenase Products written by Royal College of Surgeons of England, Institute of and published by . This book was released on with total page 367 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : William E.M. Lands
Publisher : Springer Science & Business Media
ISBN 13 : 9780898387179
Total Pages : 468 pages
Book Rating : 4.3/5 (871 download)
Download or read book Biochemistry of Arachidonic Acid Metabolism written by William E.M. Lands and published by Springer Science & Business Media. This book was released on 1985-04-30 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt: Prostaglandins, Leukotrienes, and Cancer is a multi-volume series that will focus on an emerging area of cancer research. In 1968, R.H. Williams first reported that elevated prostaglandin levels are present in human medullary car cinoma. Since that time, the concept that arachidonic acid metabolites may be in volved in cancer has expanded to include every aspect of the disease from cell transformation through metastasis. Prostaglandins and leukotrienes are generic terms used to describe a family of bioactive lipids produced from unsaturated fatty acids (principally from arachidonic acid) via the cyclooxygenase and lipoxygenase pathways, respec tively. Cyclooxygenase products consist of diverse products such as prosta glandin E, (POE,), prostacyclin (POI2) and thromboxane A2 (TXA2), whereas lipoxygenase products consist of hydroperoxy fatty acids and mono-, di- and tri-hydroxy acids including leukotrienes. The precursor fatty acids for the cyclooxygenase and lip oxygenase pathways are present in cellular phospholipids. This finding established an important control point in their biosynthesis-the release of substrate. This occurs in response to numerous stimuli that act at the cell surface. Dr. Bengt Samuelsson's extensive study of the metabolism of pros taglandins indicated that they are rapidly inactivated on a single pass through pulmonary circulation. Thus, they cannot act as circulating hormones and appear to be made on demand in or in the vicinity of target tissues leading to the concept that prostaglandins are local hormones or autocoids.
Author : Gianni Marone
Publisher : Academic Press
ISBN 13 : 0080535852
Total Pages : 738 pages
Book Rating : 4.0/5 (85 download)
Download or read book Mast Cells and Basophils written by Gianni Marone and published by Academic Press. This book was released on 2000-05-25 with total page 738 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mast Cells and Basophils will be essential reading for immunologists, biochemists and medical researchers. Detailed chapters cover all aspects of mast cell and basophil research, from cell development, proteases, histamine, cysteinyl leukotrienes, physiology and pathology to the role of these cells in health and disease. Chapters also discuss the clinical implications of histamine receptor antagonists.
Author :
Publisher :
ISBN 13 :
Total Pages : 440 pages
Book Rating : 4.E/5 ( download)
Download or read book Advances in Prostaglandin, Thromboxane, and Leukotriene Research written by and published by . This book was released on 1986 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt:
