Le Suivi Des Fournisseurs De Matieres Premieres Dans Lindustrie Pharmaceutique

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When People Come First

Author : João Biehl
Publisher : Princeton University Press
ISBN 13 : 0691157391
Total Pages : 454 pages
Book Rating : 4.6/5 (911 download)

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Book Synopsis When People Come First by : João Biehl

Download or read book When People Come First written by João Biehl and published by Princeton University Press. This book was released on 2013-07-07 with total page 454 pages. Available in PDF, EPUB and Kindle. Book excerpt: A people-centered approach to global health When People Come First critically assesses the expanding field of global health. It brings together an international and interdisciplinary group of scholars to address the medical, social, political, and economic dimensions of the global health enterprise through vivid case studies and bold conceptual work. The book demonstrates the crucial role of ethnography as an empirical lantern in global health, arguing for a more comprehensive, people-centered approach. Topics include the limits of technological quick fixes in disease control, the moral economy of global health science, the unexpected effects of massive treatment rollouts in resource-poor contexts, and how right-to-health activism coalesces with the increased influence of the pharmaceutical industry on health care. The contributors explore the altered landscapes left behind after programs scale up, break down, or move on. We learn that disease is really never just one thing, technology delivery does not equate with care, and biology and technology interact in ways we cannot always predict. The most effective solutions may well be found in people themselves, who consistently exceed the projections of experts and the medical-scientific, political, and humanitarian frameworks in which they are cast. When People Come First sets a new research agenda in global health and social theory and challenges us to rethink the relationships between care, rights, health, and economic futures.

Dealmaking

Author : Richard Razgaitis
Publisher : John Wiley & Sons
ISBN 13 : 0471452017
Total Pages : 308 pages
Book Rating : 4.4/5 (714 download)

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Book Synopsis Dealmaking by : Richard Razgaitis

Download or read book Dealmaking written by Richard Razgaitis and published by John Wiley & Sons. This book was released on 2004-04-16 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt: Applying practical tools to the volatile process of negotiating Prognosticators apply Monte Carlo Analysis (MCA) to determine the likelihood and significance of a complete range of future outcomes; Real Options Analysis (ROA) can then be employed to develop pricing structures, or options, for such outcomes. Richard Razgaitis' Dealmaking shows readers how to apply these powerful valuation tools to a variety of business processes, such as pricing, negotiating, or living with a "deal," be it a technology license, and R&D partnership, or an outright sales agreement. Dealmaking distinguishes itself from other negotiating guides not only by treating negotiations as an increasingly common situation, but also by presenting a tool-based approach that creates flexible, practical valuation models. This forward-thinking guide includes a variety of checklists, case studies, and a CD-ROM with the appropriate software. Richard Razgaitis (Bloomsbury, NJ) is a Managing Director at InteCap, Inc. He has over twenty-five years of experience working with the development, commercialization, and strategic management of technology, seventeen of which have been spent in the commercialization of intellectual property.

Innovate Bristol

Author : Sven Boermeester
Publisher :
ISBN 13 : 9781949677072
Total Pages : pages
Book Rating : 4.6/5 (77 download)

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Book Synopsis Innovate Bristol by : Sven Boermeester

Download or read book Innovate Bristol written by Sven Boermeester and published by . This book was released on 2019-12 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Innovate Bristol highlights and celebrates those companies and individuals that are actively working at building a better tomorrow for all. Innovation Ecosystems thrive through the involvement and support of companies and individuals from all industries, which is why the Innovate series not only focuses on the innovators but also those people whom the Innovation Ecosystem, would not be able to thrive without.

Faecal Sludge Management

Author : Linda Strande
Publisher : IWA Publishing
ISBN 13 : 1780404735
Total Pages : 428 pages
Book Rating : 4.7/5 (84 download)

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Book Synopsis Faecal Sludge Management by : Linda Strande

Download or read book Faecal Sludge Management written by Linda Strande and published by IWA Publishing. This book was released on 2014-08-15 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is estimated that literally billions of residents in urban and peri-urban areas of Africa, Asia, and Latin America are served by onsite sanitation systems (e.g. various types of latrines and septic tanks). Until recently, the management of faecal sludge from these onsite systems has been grossly neglected, partially as a result of them being considered temporary solutions until sewer-based systems could be implemented. However, the perception of onsite or decentralized sanitation technologies for urban areas is gradually changing, and is increasingly being considered as long-term, sustainable options in urban areas, especially in low- and middle-income countries that lack sewer infrastructures. This is the first book dedicated to faecal sludge management. It compiles the current state of knowledge of the rapidly evolving field of faecal sludge management, and presents an integrated approach that includes technology, management, and planning based on Sandecs 20 years of experience in the field. Faecal Sludge Management: Systems Approach for Implementation and Operation addresses the organization of the entire faecal sludge management service chain, from the collection and transport of sludge, and the current state of knowledge of treatment options, to the final end use or disposal of treated sludge. The book also presents important factors to consider when evaluating and upscaling new treatment technology options. The book is designed for undergraduate and graduate students, and engineers and practitioners in the field who have some basic knowledge of environmental and/or wastewater engineering.

Making Medicines in Africa

Author : Maureen Mackintosh
Publisher : Springer
ISBN 13 : 1137546476
Total Pages : 353 pages
Book Rating : 4.1/5 (375 download)

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Book Synopsis Making Medicines in Africa by : Maureen Mackintosh

Download or read book Making Medicines in Africa written by Maureen Mackintosh and published by Springer. This book was released on 2016-02-03 with total page 353 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is open access under a CC-BY license. The importance of the pharmaceutical industry in Sub-Saharan Africa, its claim to policy priority, is rooted in the vast unmet health needs of the sub-continent. Making Medicines in Africa is a collective endeavour, by a group of contributors with a strong African and more broadly Southern presence, to find ways to link technological development, investment and industrial growth in pharmaceuticals to improve access to essential good quality medicines, as part of moving towards universal access to competent health care in Africa. The authors aim to shift the emphasis in international debate and initiatives towards sustained Africa-based and African-led initiatives to tackle this huge challenge. Without the technological, industrial, intellectual, organisational and research-related capabilities associated with competent pharmaceutical production, and without policies that pull the industrial sectors towards serving local health needs, the African sub-continent cannot generate the resources to tackle its populations' needs and demands. Research for this book has been selected as one of the 20 best examples of the impact of UK research on development. See http://www.ukcds.org.uk/the-global-impact-of-uk-research for further details.

What is the Code of Conduct for Responsible Fisheries?

Author : Food and Agriculture Organization of the United Nations
Publisher : Food & Agriculture Org.
ISBN 13 : 9789251045411
Total Pages : 20 pages
Book Rating : 4.0/5 (454 download)

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Book Synopsis What is the Code of Conduct for Responsible Fisheries? by : Food and Agriculture Organization of the United Nations

Download or read book What is the Code of Conduct for Responsible Fisheries? written by Food and Agriculture Organization of the United Nations and published by Food & Agriculture Org.. This book was released on 2001 with total page 20 pages. Available in PDF, EPUB and Kindle. Book excerpt: The actual Code of conduct is also available (1996) (ISBN 9251038341).

2nd Pan-African Symposium on the Sustainable Use of Natural Resources in Africa

Author : Bihini won wa Musiti
Publisher : IUCN
ISBN 13 : 2831706904
Total Pages : 344 pages
Book Rating : 4.8/5 (317 download)

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Book Synopsis 2nd Pan-African Symposium on the Sustainable Use of Natural Resources in Africa by : Bihini won wa Musiti

Download or read book 2nd Pan-African Symposium on the Sustainable Use of Natural Resources in Africa written by Bihini won wa Musiti and published by IUCN. This book was released on 2003 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: This bilingual publication results from a four-day symposium aimed at capturing the general directions and analytical issues that characterize approaches to sustainable use in Africa. The papers included in this work are organized under four major headings: modes of use, devolution, scale issues and external issues. Authors explore these themes through the use of case studies and the description of specific regional experiences. External issues are further explored in a series of commissioned policy papers which have also been included.

South-South Cooperation Beyond the Myths

Author : Isaline Bergamaschi
Publisher : Springer
ISBN 13 : 1137539690
Total Pages : 342 pages
Book Rating : 4.1/5 (375 download)

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Book Synopsis South-South Cooperation Beyond the Myths by : Isaline Bergamaschi

Download or read book South-South Cooperation Beyond the Myths written by Isaline Bergamaschi and published by Springer. This book was released on 2017-03-14 with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book, which brings together scholars from the developed and developing world, explores one of the most salient features of contemporary international relations: South-South cooperation. It builds on existing empirical evidence and offers a comparative analytical framework to critically analyse the aid policies and programmes of ten rising donors from the global South. Amongst these are several BRICS (Brazil, India, China and South Africa) but also a number of less studied countries, including Cuba, Venezuela, the United Arab Emirates, Colombia, Turkey, and Korea. The chapters trace the ideas, identities and actors that shape contemporary South-South cooperation, and also explore potential differences and points of convergence with traditional North-South aid. This thought-provoking edited collection will appeal to students and scholars of international relations, international political economy, development, economics, area studies and business. /div

Aquaculture Development

Author : Food and Agriculture Organization of the United Nations
Publisher : Food & Agriculture Org.
ISBN 13 : 9789251039717
Total Pages : 52 pages
Book Rating : 4.0/5 (397 download)

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Book Synopsis Aquaculture Development by : Food and Agriculture Organization of the United Nations

Download or read book Aquaculture Development written by Food and Agriculture Organization of the United Nations and published by Food & Agriculture Org.. This book was released on 1997 with total page 52 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides annotations to the Principles of Article 9 of the Code of Conduct for Responsible Fisheries. These annotations are meant to serve as general guidance, and should be taken as suggestions or observations intended to assist those interested in identifying their own criteria and options for actions, as well as partners for collaboration, in support of sustainable aquaculture development.

3D Printing of Pharmaceuticals

Author : Abdul W. Basit
Publisher : Springer
ISBN 13 : 3319907557
Total Pages : 246 pages
Book Rating : 4.3/5 (199 download)

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Book Synopsis 3D Printing of Pharmaceuticals by : Abdul W. Basit

Download or read book 3D Printing of Pharmaceuticals written by Abdul W. Basit and published by Springer. This book was released on 2018-08-06 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: 3D printing is forecast to revolutionise the pharmaceutical sector, changing the face of medicine development, manufacture and use. Potential applications range from pre-clinical drug development and dosage form design through to the fabrication of functionalised implants and regenerative medicine. Within clinical pharmacy practice, printing technologies may finally lead to the concept of personalised medicines becoming a reality. This volume aims to be the definitive resource for anyone thinking of developing or using 3D printing technologies in the pharmaceutical sector, with a strong focus on the translation of printing technologies to a clinical setting. This text brings together leading experts to provide extensive information on an array of 3D printing techniques, reviewing the current printing technologies in the pharmaceutical manufacturing supply chain, in particular, highlighting the state-of-the-art applications in medicine and discussing modern drug product manufacture from a regulatory perspective. This book is a highly valuable resource for a range of demographics, including academic researchers and the pharmaceutical industry, providing a comprehensive inventory detailing the current and future applications of 3D printing in pharmaceuticals. Abdul W. Basit is Professor of Pharmaceutics at the UCL School of Pharmacy, University College London. Abdul’s research sits at the interface between pharmaceutical science and gastroenterology, forging links between basic science and clinical outcomes. He leads a large and multidisciplinary research group, and the goal of his work is to further the understanding of gastrointestinal physiology by fundamental research. So far, this knowledge has been translated into the design of new technologies and improved disease treatments, many of which are currently in late-stage clinical trials. He has published over 350 papers, book chapters and abstracts and delivered more than 250 invited research presentations. Abdul is also a serial entrepreneur and has filed 25 patents and founded 3 pharmaceutical companies (Kuecept, Intract Pharma, FabRx). Abdul is a frequent speaker at international conferences, serves as a consultant to many pharmaceutical companies and is on the advisory boards of scientific journals, healthcare organisations and charitable bodies. He is the European Editor of the International Journal of Pharmaceutics. Abdul was the recipient of the Young Investigator Award in Pharmaceutics and Pharmaceutical Technology from the American Association of Pharmaceutical Scientists (AAPS) and is the only non-North American scientist to receive this award. He was also the recipient of the Academy of Pharmaceutical Sciences (APS) award. Simon Gaisford holds a Chair in Pharmaceutics and is Head of the Department of Pharmaceutics at the UCL School of Pharmacy, University College London. He has published 110 papers, 8 book chapters and 4 authored books. His research is focused on novel technologies for manufacturing medicines, particularly using ink-jet printing and 3D printing, and he is an expert in the physico-chemical characterisation of compounds and formulations with thermal methods and calorimetry.

Social Lives of Medicines

Author : Susan Reynolds Whyte
Publisher : Cambridge University Press
ISBN 13 : 9780521804691
Total Pages : 212 pages
Book Rating : 4.8/5 (46 download)

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Book Synopsis Social Lives of Medicines by : Susan Reynolds Whyte

Download or read book Social Lives of Medicines written by Susan Reynolds Whyte and published by Cambridge University Press. This book was released on 2002 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt: Medicines are the core of treatment in biomedicine, as in many other medical traditions. As material things, they have social as well as pharmacological lives, with people and between people. They are tokens of healing and hope, as well as valuable commodities. Each chapter of this book shows drugs in the hands of particular actors: mothers in Manila, villagers in Burkina Faso, women in the Netherlands, consumers in London, market traders in Cameroon, pharmacists in Mexico, injectionists in Uganda, doctors in Sri Lanka, industrialists in India, and policymakers in Geneva. Each example is used to explore a different problem in the study of medicines, such as social efficacy, experiences of control, skepticism and cultural politics, commodification of health, the attraction of technology and the marketing of images and values. The book shows how anthropologists deal with the sociality of medicines, through their ethnography, their theorizing, and their uses of knowledge.

Open Government

Author : Daniel Lathrop
Publisher : "O'Reilly Media, Inc."
ISBN 13 : 1449388809
Total Pages : 434 pages
Book Rating : 4.4/5 (493 download)

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Book Synopsis Open Government by : Daniel Lathrop

Download or read book Open Government written by Daniel Lathrop and published by "O'Reilly Media, Inc.". This book was released on 2010-02-08 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt: In a world where web services can make real-time data accessible to anyone, how can the government leverage this openness to improve its operations and increase citizen participation and awareness? Through a collection of essays and case studies, leading visionaries and practitioners both inside and outside of government share their ideas on how to achieve and direct this emerging world of online collaboration, transparency, and participation. Contributions and topics include: Beth Simone Noveck, U.S. Deputy Chief Technology Officer for open government, "The Single Point of Failure" Jerry Brito, senior research fellow at the Mercatus Center at George Mason University, "All Your Data Are Belong to Us: Liberating Government Data" Aaron Swartz, cofounder of reddit.com, OpenLibrary.org, and BoldProgressives.org, "When Is Transparency Useful?" Ellen S. Miller, executive director of the Sunlight Foundation, "Disrupting Washington's Golden Rule" Carl Malamud, founder of Public.Resource.Org, "By the People" Douglas Schuler, president of the Public Sphere Project, "Online Deliberation and Civic Intelligence" Howard Dierking, program manager on Microsoft's MSDN and TechNet Web platform team, "Engineering Good Government" Matthew Burton, Web entrepreneur and former intelligence analyst at the Defense Intelligence Agency, "A Peace Corps for Programmers" Gary D. Bass and Sean Moulton, OMB Watch, "Bringing the Web 2.0 Revolution to Government" Tim O'Reilly, founder and CEO of O'Reilly Media, "Defining Government 2.0: Lessons Learned from the Success of Computer Platforms" Open Government editors: Daniel Lathrop is a former investigative projects reporter with the Seattle Post Intelligencer who's covered politics in Washington state, Iowa, Florida, and Washington D.C. He's a specialist in campaign finance and "computer-assisted reporting" -- the practice of using data analysis to report the news. Laurel Ruma is the Gov 2.0 Evangelist at O'Reilly Media. She is also co-chair for the Gov 2.0 Expo.

Single-Use Technology in Biopharmaceutical Manufacture

Author : Regine Eibl
Publisher : John Wiley & Sons
ISBN 13 : 1119477786
Total Pages : 367 pages
Book Rating : 4.1/5 (194 download)

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Book Synopsis Single-Use Technology in Biopharmaceutical Manufacture by : Regine Eibl

Download or read book Single-Use Technology in Biopharmaceutical Manufacture written by Regine Eibl and published by John Wiley & Sons. This book was released on 2019-07-18 with total page 367 pages. Available in PDF, EPUB and Kindle. Book excerpt: Authoritative guide to the principles, characteristics, engineering aspects, economics, and applications of disposables in the manufacture of biopharmaceuticals The revised and updated second edition of Single-Use Technology in Biopharmaceutical Manufacture offers a comprehensive examination of the most-commonly used disposables in the manufacture of biopharmaceuticals. The authors—noted experts on the topic—provide the essential information on the principles, characteristics, engineering aspects, economics, and applications. This authoritative guide contains the basic knowledge and information about disposable equipment. The author also discusses biopharmaceuticals’ applications through the lens of case studies that clearly illustrate the role of manufacturing, quality assurance, and environmental influences. This updated second edition revises existing information with recent developments that have taken place since the first edition was published. The book also presents the latest advances in the field of single-use technology and explores topics including applying single-use devices for microorganisms, human mesenchymal stem cells, and T-cells. This important book: • Contains an updated and end-to-end view of the development and manufacturing of single-use biologics • Helps in the identification of appropriate disposables and relevant vendors • Offers illustrative case studies that examine manufacturing, quality assurance, and environmental influences • Includes updated coverage on cross-functional/transversal dependencies, significant improvements made by suppliers, and the successful application of the single-use technologies Written for biopharmaceutical manufacturers, process developers, and biological and chemical engineers, Single-Use Technology in Biopharmaceutical Manufacture, 2nd Edition provides the information needed for professionals to come to an easier decision for or against disposable alternatives and to choose the appropriate system.

Consuming Habits

Author : Jordan Goodman
Publisher : Routledge
ISBN 13 : 1134093632
Total Pages : 305 pages
Book Rating : 4.1/5 (34 download)

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Book Synopsis Consuming Habits by : Jordan Goodman

Download or read book Consuming Habits written by Jordan Goodman and published by Routledge. This book was released on 2014-04-08 with total page 305 pages. Available in PDF, EPUB and Kindle. Book excerpt: Covering a wide range of substances, this new edition has been extensively updated, with an updated bibliography and two new chapters on cannabis and khat. Consuming Habits is the perfect companion for all those interested in how different cultures have defined drugs across the ages.

The Life-Cycle of Pharmaceuticals in the Environment

Author : B.M. Peake
Publisher : Elsevier
ISBN 13 : 190881845X
Total Pages : 272 pages
Book Rating : 4.9/5 (88 download)

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Book Synopsis The Life-Cycle of Pharmaceuticals in the Environment by : B.M. Peake

Download or read book The Life-Cycle of Pharmaceuticals in the Environment written by B.M. Peake and published by Elsevier. This book was released on 2015-11-13 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Life-Cycle of Pharmaceuticals in the Environment identifies pathways of entry of pharmaceuticals into the environment, beginning with the role of global prescribing and disposal practices. The book then discusses typical levels of common pharmaceuticals and how they can be determined in natural waters such as raw and treated sewage, and in potable water. In addition, sections examine methods currently available to degrade pharmaceuticals in natural waters and some of their ecotoxicological impacts, along with future considerations and the growing concept of product stewardship. - Encompasses the full lifecycle of common pharmaceuticals, from prescription and dispensing practices to their occurrence in a range of different types of natural waters and their environmental impact - Explores the role of the healthcare system and its affect on users - Beneficial for environmental engineers involved in the design and operation of appropriate degradation technologies of the pharmaceutical prescription and disposal practices

OECD Science, Technology and Industry Scoreboard 2001

Author : Organisation for Economic Co-operation and Development
Publisher : Organisation for Economic Co-operation and Development
ISBN 13 :
Total Pages : 220 pages
Book Rating : 4.:/5 (31 download)

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Book Synopsis OECD Science, Technology and Industry Scoreboard 2001 by : Organisation for Economic Co-operation and Development

Download or read book OECD Science, Technology and Industry Scoreboard 2001 written by Organisation for Economic Co-operation and Development and published by Organisation for Economic Co-operation and Development. This book was released on 2001-10-04 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: Are OECD countries becoming more knowledge-based? Are they embracing the information economy? To what extent are innovation, science, technology and economies becoming global? What are the new growth industries and occupations? With over 160 indicators, 60% of them new to this edition, the volume provides a comprehensive picture of countries’ performance in the areas of science, technology and industry. It uses an improved classification of technology and knowledge-intensive industries. New indicators address emerging policy issues: international mobility of human capital, relative innovative performance as measured by patent families, skills in the information economy, diffusion of the Internet and electronic commerce. Resources devoted to innovation in emerging areas such as biotechnology, environment, health and information and communication technologies are measured for the first time. A new section on the information economy relies on the latest data from official sources. With the essential findings presented in bullet points and methodological notes on indicators and data sources, this publication combines statistical rigour with easy access and readability. An electronic version makes individual sections, an elaborate data appendix and links to the databases readily available. The electronic version also gives users “clickable” access to the data used in charts and figures. AREAS COVERED: New resources for the knowledge-based economy - Human capital and international mobility - R&D performance - Role of government and business in R&D and innovation - Science and innovation performance - Resources and infrastructure for the information economy - Diffusion of Internet technologies and electronic commerce - Contribution of the information and communication technologies to economic performance - International trade - Foreign direct investment - Strategic alliances and cross-border, mergers and acquisitions - Internationalisation of science and technology - Industrial structure and productivity growth - Technology and knowledge-intensive industries and their performance. FURTHER READING: OECD Science, Technology and Industry Outlook 2000; OECD Information Technology Outlook 2000; OECD Communications Outlook 2001; A New Economy: Beyond the Hype, 2001 (OECD ); OECD Main Science and Technology Indicators 2001/1 and STI Working Papers series available at http://www.oecd.org/dsti/sti/stat-ana/index.htm.

Dying for Growth

Author : Jim Yong Kim
Publisher :
ISBN 13 :
Total Pages : 736 pages
Book Rating : 4.4/5 (91 download)

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Book Synopsis Dying for Growth by : Jim Yong Kim

Download or read book Dying for Growth written by Jim Yong Kim and published by . This book was released on 2000 with total page 736 pages. Available in PDF, EPUB and Kindle. Book excerpt: Is economic growth killing the poor? The Institute for Health and Social Justice brings us the answers in Dying for Growth. An extraordinary collection of fourteen hard-hitting case studies from Haiti to the US, Dying for Growth exposes the interests behind a system that consigns a fifth of the world's population to live (and die) on less than a dollar a day. Rooted in the lives of people waging heart-wrenching struggles against a new, systemic form of poverty, these studies don't just document inequality -- they pinpoint its underlying causes.Looking at the effects of international restructuring strategies on the poor, the increasing control trans-national corporations exert over world health, and the impact of U.S. drug policy on global inequality, Dying for Growth debunks the myths of global capitalism, including: Myth: Throwing loans at developing nations will cure poverty.Fact: As shown in Sickness Amidst Recovery: Public Debt and Private Suffering in a Peruvian Shanty Town, loans can make things worse.Myth: Getting rid of big government automatically improves the standard of living.Fact: Cutting services can lead to calamity, as detailed in Neoliberal Economic Policy, State Desertion and the Russian Health Crisis. Myth: The free market is a panacea.Fact: There's nothing liberating about modern capitalism, as demonstrated in 'Todo Bajo Control': The Costs of 'Free' Trade to Mexican Maquiladora Workers.Dying for Growth concludes with an extensive section on alternatives to standard models. Included is a chapter on health and revolution in Cuba, The Threat of a Good Example, and a plan for action, Pragmatic Solidarity: What You Can Do.With passionrarely found in works of comparable analytic rigor, Dying for Growth tells the stories of people trapped in the machine of growth, and compels readers to recognize that the problem of inequality is not one of insufficient resources, nor even of inefficiency -- the problem is power.