Read Books Online and Download eBooks, EPub, PDF, Mobi, Kindle, Text Full Free.
L Dopa Induced Serotonin Dysfunction And Associated Behavioral Indices In A Bilateral Rat Model Of Parkinsons Disease
Download L Dopa Induced Serotonin Dysfunction And Associated Behavioral Indices In A Bilateral Rat Model Of Parkinsons Disease full books in PDF, epub, and Kindle. Read online L Dopa Induced Serotonin Dysfunction And Associated Behavioral Indices In A Bilateral Rat Model Of Parkinsons Disease ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!
Book Synopsis L-DOPA-induced Serotonin Dysfunction and Associated Behavioral Indices in a Bilateral Rat Model of Parkinson's Disease by : Karen Louise Eskow-Jaunarajs
Download or read book L-DOPA-induced Serotonin Dysfunction and Associated Behavioral Indices in a Bilateral Rat Model of Parkinson's Disease written by Karen Louise Eskow-Jaunarajs and published by . This book was released on 2011 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Parkinson’s Disease - Animal Models, Current Therapies and Clinical Trials by : Sarat Chandra Yenisetti
Download or read book Parkinson’s Disease - Animal Models, Current Therapies and Clinical Trials written by Sarat Chandra Yenisetti and published by BoD – Books on Demand. This book was released on 2023-12-20 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite being described about 200 years ago, the pathophysiology of Parkinson’s disease (PD) is not well understood due to its complex etiology and heterogeneity of symptoms and progression. Animal models provide a great opportunity to follow the progression of neurodegeneration and to screen potent therapeutic molecules, knowledge of which can be critical for different levels of clinical trials. Contemporary health technologies are coming in handy to accelerate the pace of developing novel and refined therapeutic strategies for PD. This book, Parkinson’s Disease - Animal Models, Current Therapies and Clinical Trials, provides a comprehensive overview of PD, presenting information on animal models of PD and contemporary therapeutic strategies, health technologies, clinical trials, and their influence on the quality of life of patients with PD.
Book Synopsis Serotonin- and Dopamine-mediated Neurotransmission in the Pathophysiology and Treatment of Parkinson's Disease by : Philippe Huot
Download or read book Serotonin- and Dopamine-mediated Neurotransmission in the Pathophysiology and Treatment of Parkinson's Disease written by Philippe Huot and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis L-dopa and the Serotonergic System by : Branden J. Stansley
Download or read book L-dopa and the Serotonergic System written by Branden J. Stansley and published by . This book was released on 2015 with total page 138 pages. Available in PDF, EPUB and Kindle. Book excerpt: Parkinson's disease (PD) is characterized by a loss of dopamine neurons in the substantia nigra pars compacta, leading to loss of dopamine neurotransmission in the striatum, and subsequent loss of motor control. L-dopa is often administered to recover motor function in PD patients; however, over time the drug efficacy decreases and debilitating side effects such as dyskinesia, mood disorders, and hallucinations occur. The therapeutic effect as well as some of the side effects of L-dopa has been credited to serotonin (5-HT) neurons. To address the mechanisms underlying the side effects of L-dopa, it was hypothesized that L-dopa forms dopamine within 5-HT neurons to produce oxidative stress and cytotoxicity, leading to 5-HT neurotransmitter deficits as well as behavioral impairments in rats. To directly test this hypothesis, initial experiments utilized serotonergic neuronal cell cultures that were incubated with L-dopa. Results illustrated that dopamine production occurred in serotonergic cells after incubation with L-dopa. Furthermore, L-dopa dose-dependently increased reactive oxygen species production and cell death, both of which were attenuated by amino-acid decarboxylase inhibition, MAO inhibition or incubation with antioxidants. The effects of L-dopa on 5-HT neurons in-vivo were also examined. Male rats were treated chronically for 10 days with L-dopa (6 mg/kg; twice daily) and killed 48 hours after the last injection to investigate the effects on 5-HT neuron number in the dorsal raphe nucleus (DRN) and 5-HT content throughout the brain. L-dopa treatment decreased the number of 5-HT neurons significantly in the caudal-dorsal sub-region of the DRN (28% decrease). Co-treatment with the anti-oxidant ascorbate (400 mg/kg) or MAO-B inhibitor deprenyl (2 mg/kg) prevented the L-dopa induced decreases in 5-HT neurons within the DRN. Furthermore, 5-HT tissue content was decreased significantly in the dorsal DRN and prefrontal cortex (PFC) by L-dopa treatment. These L-dopa-induced 5-HT depletions were blocked by ascorbate co-treatment. Chronic L-dopa also caused significant behavioral impairments in rats. Spatial memory recall was impaired, in addition to a potentiated fear response after L-dopa, both of which were prevented by ascorbate co-treatment. Taken together, results presented in this dissertation provide evidence that L-dopa produces 5-HT neuron loss both in vitro and in vivo, as well as in vivo 5-HT neurochemical depletions and behavioral impairments through an oxidative stress mechanism.
Book Synopsis L-Dopa and Parkinsonism by : Manuel Riklan
Download or read book L-Dopa and Parkinsonism written by Manuel Riklan and published by Charles C. Thomas Publisher. This book was released on 1973 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis L-DOPA and Behavior by : Sidney Malitz
Download or read book L-DOPA and Behavior written by Sidney Malitz and published by . This book was released on 1972 with total page 152 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cumulated Index Medicus written by and published by . This book was released on 2000 with total page 1828 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Index Medicus written by and published by . This book was released on 2004 with total page 2098 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
Book Synopsis Neuropsychiatric and Cognitive Changes in Parkinson's Disease and Related Movement Disorders by : Dag Aarsland
Download or read book Neuropsychiatric and Cognitive Changes in Parkinson's Disease and Related Movement Disorders written by Dag Aarsland and published by Cambridge University Press. This book was released on 2013-08-29 with total page 311 pages. Available in PDF, EPUB and Kindle. Book excerpt: A broad and in-depth discussion of the important, but still uninformed, field of behavioral disturbances associated with Parkinson's disease.
Book Synopsis Obsessive-compulsive Disorder by : Christopher Pittenger
Download or read book Obsessive-compulsive Disorder written by Christopher Pittenger and published by Oxford University Press. This book was released on 2017 with total page 777 pages. Available in PDF, EPUB and Kindle. Book excerpt: Obsessive-compulsive disorder (OCD) affects one person in 40 and can cause great suffering. This volume provides the first comprehensive summary of our understanding of this enigmatic condition, summarizing current work ranging from genetics and neurobiology through cognitive psychology, treatment, personal experiences, and societal implications.
Author :National Collaborating Centre for Chronic Conditions (Great Britain) Publisher :Royal College of Physicians ISBN 13 :1860162835 Total Pages :243 pages Book Rating :4.8/5 (61 download)
Book Synopsis Parkinson's Disease by : National Collaborating Centre for Chronic Conditions (Great Britain)
Download or read book Parkinson's Disease written by National Collaborating Centre for Chronic Conditions (Great Britain) and published by Royal College of Physicians. This book was released on 2006 with total page 243 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Deep Brain Stimulation Management by : William J. Marks, Jr
Download or read book Deep Brain Stimulation Management written by William J. Marks, Jr and published by Cambridge University Press. This book was released on 2015-09-03 with total page 251 pages. Available in PDF, EPUB and Kindle. Book excerpt: Essential reference guide for clinicians working with DBS patients, fully revised throughout with new chapters on epilepsy and psychiatric disorders.
Book Synopsis Rehabilitation in Movement Disorders by : Robert Iansek
Download or read book Rehabilitation in Movement Disorders written by Robert Iansek and published by Cambridge University Press. This book was released on 2013-05-23 with total page 263 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides a broad overview of current rehabilitation approaches, emphasizing the need for interdisciplinary management and focussing on deliverable outcomes.
Book Synopsis Sleep Disorders and Sleep Deprivation by : Institute of Medicine
Download or read book Sleep Disorders and Sleep Deprivation written by Institute of Medicine and published by National Academies Press. This book was released on 2006-10-13 with total page 425 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinical practice related to sleep problems and sleep disorders has been expanding rapidly in the last few years, but scientific research is not keeping pace. Sleep apnea, insomnia, and restless legs syndrome are three examples of very common disorders for which we have little biological information. This new book cuts across a variety of medical disciplines such as neurology, pulmonology, pediatrics, internal medicine, psychiatry, psychology, otolaryngology, and nursing, as well as other medical practices with an interest in the management of sleep pathology. This area of research is not limited to very young and old patientsâ€"sleep disorders reach across all ages and ethnicities. Sleep Disorders and Sleep Deprivation presents a structured analysis that explores the following: Improving awareness among the general public and health care professionals. Increasing investment in interdisciplinary somnology and sleep medicine research training and mentoring activities. Validating and developing new and existing technologies for diagnosis and treatment. This book will be of interest to those looking to learn more about the enormous public health burden of sleep disorders and sleep deprivation and the strikingly limited capacity of the health care enterprise to identify and treat the majority of individuals suffering from sleep problems.
Book Synopsis Non-Motor Symptoms of Parkinson's Disease by : K. Ray Chaudhuri
Download or read book Non-Motor Symptoms of Parkinson's Disease written by K. Ray Chaudhuri and published by Oxford University Press, USA. This book was released on 2014 with total page 517 pages. Available in PDF, EPUB and Kindle. Book excerpt: Patients with Parkinson's disease (PD) are known to suffer from motor symptoms of the disease, but they also experience non-motor symptoms (NMS) that are often present before diagnosis or that inevitably emerge with disease progression. The motor symptoms of Parkinson's disease have been extensively researched, and effective clinical tools for their assessment and treatment have been developed and are readily available. In contrast, researchers have only recently begun to focus on the NMS of Parkinson's Disease, which are poorly recognized and inadequately treated by clinicians. The NMS of PD have a significant impact on patient quality of life and mortality and include neuropsychiatric, sleep-related, autonomic, gastrointestinal, and sensory symptoms. While some NMS can be improved with currently available treatments, others may be more refractory and will require research into novel (non-dopaminergic) drug therapies for the future. Edited by members of the UK Parkinson's Disease Non-Motor Group (PD-NMG) and with contributions from international experts, this new edition summarizes the current understanding of NMS symptoms in Parkinson's disease and points the way towards future research.
Book Synopsis Hyperkinetic Movement Disorders by : Alberto Albanese
Download or read book Hyperkinetic Movement Disorders written by Alberto Albanese and published by John Wiley & Sons. This book was released on 2012-03-07 with total page 413 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hyperkinetic movement disorders comprise a range of diseases characterized by unwanted and uncontrollable, or poorly controllable, involuntary movements. The phenomenology of these disorders is quite variable encompassing chorea, tremor, dystonia, myoclonus, tics, other dyskinesias, jerks and shakes. Discerning the underlying condition can be very difficult given the range and variability of symptoms. But recognizing the phenomenology and understanding the pathophysiology are essential to ensure appropriate treatment. Hyperkinetic Movement Disorders provides a clinical pathway for effective diagnosis and management of these disorders. The stellar international cast of authors distils the evidence so you can apply it into your practice. The judicious use of diagnostic criteria algorithms rating scales management guidelines Provides a robust framework for clear patient management. Throughout the text, QR codes* provide smartphone access to case-study videos of hyperkinetic symptoms. Purchase includes an enhanced Wiley Desktop Edition.* This is an interactive digital version featuring: all text and images in fully searchable form integrated videos of presentations View a sample video: www.wiley.com/go/albanese highlighting and note taking facilities book marking linking to additional references Hyperkinetic Movement Disorders provides you with the essential visual and practical tools you need to effectively diagnose and treat your patients. *Full instructions for using QR codes and for downloading your digital Wiley DeskTop Edition are inside the book.
Book Synopsis Movement Disorder Emergencies by : Steven J. Frucht
Download or read book Movement Disorder Emergencies written by Steven J. Frucht and published by Springer Science & Business Media. This book was released on 2008-02-10 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: Movement Disorder Emergencies: Diagnosis and Treatment provides a fresh and unique approach to what is already a high-profile subspecialty area in clinical neurology. The disorders covered in this volume are standard fare in the field but emphasize the urgencies and emergencies that can occur. One of the very attractive features of the field of movement disorders is that diagnosis is often based on unique visible and sometimes audible phenomenological symptoms and signs. Therefore, in this era of highly sophisticated laboratory and radiological diagnostic tools, the diagnosis of many movement disorders is still largely made in the clinic where pattern recognition is key. Crucial to astute clinical diagnosis is broad clinical experience. In short, you have to have seen one to recognize one! Patients with movement disorders nearly always present as outpatients but, as aptly recognized by Drs. Frucht and Fahn, this may include acute manifestations leading to emergency presentations, often in an emergency room setting, where they are very likely to be unrecognized and therefore poorly managed. The authors define an “emergency” movement disorder as one in which failure to promptly diagnose and treat may result in significant morbidity or mortality. However, they also stress the importance of certain “can’t miss” diagnoses such as Wilson’s disease, dopa-responsive dystonia, and Whipple’s disease in which delayed diagnosis in less emergent situations can lead to slowly evolving and often irreversible neurological damage with tragic consequences.
