Jaagsiekte Sheep Retrovirus And Lung Cancer

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Jaagsiekte Sheep Retrovirus and Lung Cancer

Author : Hung Y. Fan
Publisher : Springer Science & Business Media
ISBN 13 : 3642556388
Total Pages : 255 pages
Book Rating : 4.6/5 (425 download)

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Book Synopsis Jaagsiekte Sheep Retrovirus and Lung Cancer by : Hung Y. Fan

Download or read book Jaagsiekte Sheep Retrovirus and Lung Cancer written by Hung Y. Fan and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 255 pages. Available in PDF, EPUB and Kindle. Book excerpt: Retroviruses have been of great importance to biomedical science for the past half century. Initially, studies on oncogenic animal retroviruses provided important insights into molecular processes in carcinogenesis – most notably the existence and mechanisms of action of oncogenes and proto-oncogenes. Moreover, several human diseases are caused by retroviruses, including AIDS, adult T-cell leukemia and the neurological disease HAM/TSP. The topic of this volume is a relatively unknown animal retrovirus, jaagsiekte sheep retrovirus, the causative agent of transmissible lung cancer in sheep –ovine pulmonary adenocarcinoma. The disease was first documented in South Africa in the 1800s, it has a wide geographical distribution, and it is of economic importance in high endemic regions. However, until very recently the nature of the etiologic agent was unclear, and relatively few laboratories actively studied the disease.

Jaagsiekte Sheep Retrovirus and Lung Cancer

Author : Hung Y. Fan
Publisher :
ISBN 13 : 9783642556395
Total Pages : 268 pages
Book Rating : 4.5/5 (563 download)

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Book Synopsis Jaagsiekte Sheep Retrovirus and Lung Cancer by : Hung Y. Fan

Download or read book Jaagsiekte Sheep Retrovirus and Lung Cancer written by Hung Y. Fan and published by . This book was released on 2014-01-15 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Infectious Etiology of Chronic Diseases

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309165911
Total Pages : 234 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis The Infectious Etiology of Chronic Diseases by : Institute of Medicine

Download or read book The Infectious Etiology of Chronic Diseases written by Institute of Medicine and published by National Academies Press. This book was released on 2004-06-16 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, a number of chronic diseases have been linked, in some cases definitively, to an infectious etiology: peptic ulcer disease with Helicobacter pylori, cervical cancer with several human papillomaviruses, Lyme arthritis and neuroborreliosis with Borrelia burgdorferi, AIDS with the human immunodeficiency virus, liver cancer and cirrhosis with hepatitis B and C viruses, to name a few. The proven and suspected roles of microbes does not stop with physical ailments; infections are increasingly being examined as associated causes of or possible contributors to a variety of serious, chronic neuropsychiatric disorders and to developmental problems, especially in children. The Infectious Etiology of Chronic Diseases: Defining the Relationship, Enhancing the Research, and Mitigating the Effects, summarizes a two-day workshop held by the Institute of Medicine's Forum on Microbial Threats to address this rapidly evolving field. Participants explored factors driving infectious etiologies of chronic diseases of prominence, identified difficulties in linking infectious agents with chronic outcomes, and discussed broad-based strategies and research programs to advance the field.

Hyaluronan in Cancer Biology

Author : Robert Stern
Publisher : Academic Press
ISBN 13 : 0080921086
Total Pages : 467 pages
Book Rating : 4.0/5 (89 download)

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Book Synopsis Hyaluronan in Cancer Biology by : Robert Stern

Download or read book Hyaluronan in Cancer Biology written by Robert Stern and published by Academic Press. This book was released on 2009-03-07 with total page 467 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hyaluronan biology is being recognized as an important regulator of cancer progression. Paradoxically, both hyaluronan (HA) and hyaluronidases, the enzymes that eliminate HA, have also been correlated with cancer progression. Hyaluronan, a long-chain polymer of the extracellular matrix, opens up tissue spaces through which cancer cells move and metastasize. It also confers motility upon cells through interactions of cell-surface HA with the cytoskeleton. Embryonic cells in the process of movement and proliferation use the same strategy. It is an example of how cancer cells have commandeered normal cellular processes for their own survival and spread. There are also parallels between cancer and wound healing, cancer occasionally being defined as a wound that does not heal. The growing body of literature regarding this topic has recently progressed from describing the association of hyaluronan and hyaluronidase expression associated with different cancers, to understanding the mechanisms that drive tumor cell activation, proliferation, drug resistance, etc. No one source, however, discusses hyaluronan synthesis and catabolism, as well as the factors that regulate the balance. This book will offer a comprehensive summary and cutting-edge insight into Hyaluronan biology, the role of the HA receptors, the hyaluronidase enzymes that degrade HA, as well as HA synthesis enzymes and their relationship to cancer. Offers a comprehensive summary and cutting-edge insight into Hyaluronan biology, the role of the HA receptors, the hyaluronidase enzymes that degrade HA, as well as HA synthesis enzymes and their relationship to cancer Chapters are written by the leading international authorities on this subject, from laboratories that focus on the investigation of hyaluronan in cancer initiation, progression, and dissemination Focuses on understanding the mechanisms that drive tumor cell activation, proliferation, and drug resistance

The Geographical Distribution of Animal Viral Diseases

Author : Stewart Hal
Publisher : Elsevier
ISBN 13 : 0323147461
Total Pages : 515 pages
Book Rating : 4.3/5 (231 download)

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Book Synopsis The Geographical Distribution of Animal Viral Diseases by : Stewart Hal

Download or read book The Geographical Distribution of Animal Viral Diseases written by Stewart Hal and published by Elsevier. This book was released on 2012-12-02 with total page 515 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Geographical Distribution of Animal Viral Diseases attempts to shed some light on the global distribution of 110 different viral diseases, mainly of livestock and companion animals. The world literature was screened for 110 different viruses, and maps were prepared. These maps delineate the global distribution of pathogenic viruses based on authenticated reports from a variety of reliable sources. Four viruses were categorized as affecting more than one species to a significant degree (astrovirus, rabies, rotaviruses, and Rift Valley fever). The largest number of maps involved viruses that affect humans. Of the 28 viruses a large number were from the California encephalitis group. Ten of the 28 viruses were reported only in the Eastern Hemisphere, 14 only in the Western Hemisphere, and four were worldwide. Birds were the next most frequently affected group with the 15 viruses, followed by pigs with 14 viruses. Overall the vector-borne viruses appear to have much sharper and clear-cut geographical boundaries than the others.

Sheep, Goat, and Cervid Medicine - E-Book

Author : David G. Pugh
Publisher : Elsevier Health Sciences
ISBN 13 : 0323624642
Total Pages : 578 pages
Book Rating : 4.3/5 (236 download)

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Book Synopsis Sheep, Goat, and Cervid Medicine - E-Book by : David G. Pugh

Download or read book Sheep, Goat, and Cervid Medicine - E-Book written by David G. Pugh and published by Elsevier Health Sciences. This book was released on 2020-01-07 with total page 578 pages. Available in PDF, EPUB and Kindle. Book excerpt: NEW! Coverage of cervids has been added to chapters throughout the book, reflecting the growing popularity of deer and elk. NEW! Thorough content updates are made throughout the book and reflect the latest research evidence. NEW! 170 new clinical photos have been added. NEW! Anesthesia and Pain Management chapter includes a new section on pain management strategies, reflecting the emphasis on controlling pain in small ruminants. NEW! Expert Consult website offers an online version of the book, making it easy to search the entire book electronically. NEW! Two new authors are respected and well-known veterinary medicine experts and educators: Dr. Misty Edmondson and Dr. Thomas Passler.

Epidemiology of Lung Cancer

Author : Jonathan M. Samet
Publisher : CRC Press
ISBN 13 : 9780824788537
Total Pages : 568 pages
Book Rating : 4.7/5 (885 download)

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Book Synopsis Epidemiology of Lung Cancer by : Jonathan M. Samet

Download or read book Epidemiology of Lung Cancer written by Jonathan M. Samet and published by CRC Press. This book was released on 1994-03-08 with total page 568 pages. Available in PDF, EPUB and Kindle. Book excerpt: Providing a historical perspective on the etiology of lung cancer, this comprehensive reference presents an in-depth analysis of the epidemiology of cancer of the lung-describing the current understanding of risk factors and the use of epidemiological data to design programs for the control of this leading cause of death worldwide.

Early Events of Jaagsiekte Sheep Retrovirus Infection in the Ovine Lung

Author : Henny Martineau
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (755 download)

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Book Synopsis Early Events of Jaagsiekte Sheep Retrovirus Infection in the Ovine Lung by : Henny Martineau

Download or read book Early Events of Jaagsiekte Sheep Retrovirus Infection in the Ovine Lung written by Henny Martineau and published by . This book was released on 2010 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Identification of Cellular Proteins Important for Jaagsiekte Sheep Retrovirus Transformation

Author : Tom Sih-Yuan Hsu
Publisher :
ISBN 13 : 9781321093933
Total Pages : 174 pages
Book Rating : 4.0/5 (939 download)

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Book Synopsis Identification of Cellular Proteins Important for Jaagsiekte Sheep Retrovirus Transformation by : Tom Sih-Yuan Hsu

Download or read book Identification of Cellular Proteins Important for Jaagsiekte Sheep Retrovirus Transformation written by Tom Sih-Yuan Hsu and published by . This book was released on 2014 with total page 174 pages. Available in PDF, EPUB and Kindle. Book excerpt: Jaagsiekte sheep retrovirus (JSRV) is the etiologic agent of a contagious lung cancer in sheep, ovine pulmonary adenocarcinoma (OPA). The envelope gene (env) also is an oncogene, since it induces cell transformation and tumors on its own. The subject of this thesis was to identify cellular proteins that interact with JSRV Env and to assess their roles in JSRV transformation. A previous yeast two-hybrid screen identified candidate proteins that can interact with the JSRV envelope protein. Two were studied here: Zinc Finger Protein 111 (Zfp111) and Ribonucleotide Reductase subunit 2 (RRM2). For Zfp111, shRNA knockdown of endogenous zfp111 in rat 208F fibroblasts reduced transformation by JSRV Env but not by another viral oncogene v-mos. Env transformation was restored by a knockdown-resistant Zfp111 cDNA, and over-expression of zfp111 increased transformation by Env but not v-mos. Knockdown of zfp111 decreased proliferation rates of Env transformed cells but not untransformed cells. Zfp111 bound to a smaller form of Env (P70env [superscript]; while the Env polyprotein (Pr80env [superscript]) is cytoplasmic, P70env [superscript] is nuclear. P70env [superscript] and Pr80env [superscript] have the same polypeptide backbone, so they differ in glycosylation. Co-expression of Zfp111 with JSRV Env stabilizes both proteins. Selected alanine scanning mutants in the Env cytoplasmic tail (CT) were co-transfected with Zfp111; there was a strong correlation between mutant transformation efficiencies and levels of P70env [superscript] and Zfp111 detected. The results suggested a putative interaction region for Zfp111 in the Env CT. With regard to RRM2, endogenous RRM2 co-localized with Env by re-localization to the plasma membrane in transfected NIH 3T3 cells. In rat 208F cells, RRM2 knockdown decreased Env transformation, but there was also a decrease (significantly less) in v-mos transformation. RRM2 knockdown cells showed a decrease in overall growth rates, which might explain the effect on v-mos transformation. Progress towards tandem affinity purification (TAP) of JSRV Env-associated cellular proteins is also described. JSRV Env with a C-terminal TAP tag (HBH) was generated. The HBH-tagged Env could transform cells, and it could be successfully purified over Ni2+ and streptavidin columns; JSRV Env peptide sequences (SU and TM) were identified in preliminary TAP/MS experiments.

Pathology of Lung Disease

Author : Helmut Popper
Publisher : Springer
ISBN 13 : 366250491X
Total Pages : 708 pages
Book Rating : 4.6/5 (625 download)

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Book Synopsis Pathology of Lung Disease by : Helmut Popper

Download or read book Pathology of Lung Disease written by Helmut Popper and published by Springer. This book was released on 2016-12-22 with total page 708 pages. Available in PDF, EPUB and Kindle. Book excerpt: This well-illustrated textbook covers the full range of lung and pleural diseases from the pathologic standpoint. Both diseases of adults and pediatric lung diseases are presented. The book will serve as an excellent guide to the diagnosis of these diseases, but in addition it explains the disease mechanisms and etiology. Genetics and molecular biology are also discussed whenever necessary for a full understanding. The author is an internationally recognized expert who runs courses on lung and pleural pathology attended by participants from all over the world. In compiling this book, he has drawn on more than 30 years’ experience in the field.

Comparative Oncology

Author : Alecsandru Ioan Baba
Publisher :
ISBN 13 : 9789732714577
Total Pages : 787 pages
Book Rating : 4.7/5 (145 download)

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Book Synopsis Comparative Oncology by : Alecsandru Ioan Baba

Download or read book Comparative Oncology written by Alecsandru Ioan Baba and published by . This book was released on 2007 with total page 787 pages. Available in PDF, EPUB and Kindle. Book excerpt:

International Classification of Diseases for Oncology

Author : April G. Fritz
Publisher : World Health Organization
ISBN 13 : 9789241545341
Total Pages : 252 pages
Book Rating : 4.5/5 (453 download)

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Book Synopsis International Classification of Diseases for Oncology by : April G. Fritz

Download or read book International Classification of Diseases for Oncology written by April G. Fritz and published by World Health Organization. This book was released on 2000 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: This edition of ICD-O, the standard tool for coding diagnoses of neoplasms in tumour and cancer registrars and in pathology laboratories, has been developed by a working party convened by the International Agency for Research on Cancer / WHO. ICD-O is a dual classification with coding systems for both topography and morphology. The book has five main sections. The first provides general instructions for using the coding systems and gives rules for their implementation in tumour registries and pathology laboratories. Section two includes the numerical list of topography codes, which remain unchanged from the previous edition. The numerical list of morphology codes is presented in the next section, which introduces several new terms and includes considerable revisions of the non-Hodgkin lymphoma and leukaemia sections, based on the WHO Classification of Hematopoietic and Lympoid Diseases. The five-digit morphology codes allow identification of a tumour or cell type by histology, behaviour, and grade. Revisions in the morphology section were made in consultation with a large number of experts and were finalised after field-testing in cancer registries around the world. The alphabetical index gives codes for both topography and morphology and includes selected tumour-like lesions and conditions. A guide to differences in morphology codes between the second and third editions is provided in the final section, which includes lists of all new code numbers, new terms and synonyms added to existing code definitions, terms that changed morphology code, terms for conditions now considered malignant, deleted terms, and terms that changed behaviour code.

Papillomaviruses and Human Disease

Author : Kari J. Syrjänen
Publisher : Springer Science & Business Media
ISBN 13 : 3642710972
Total Pages : 527 pages
Book Rating : 4.6/5 (427 download)

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Book Synopsis Papillomaviruses and Human Disease by : Kari J. Syrjänen

Download or read book Papillomaviruses and Human Disease written by Kari J. Syrjänen and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 527 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, papillomaviruses in general and human papillo maviruses in particular have been recognized as possible agents of important diseases, including some forms of human cancer. The purpose of this book is to present a concise panorama of the pre sent status of knowledge of this topic. This knowledge is as impor tant to molecular biologists and virologists as it is to clinicians and pathologists. To bridge the gap among these diverse groups of investigators, we conceived of a book covering a broad spectrum of the basic scientific, clinical, and pathological aspects of diseases associated with papillomaviruses. Although the principal thrust of this book is directed at human papillomaviruses, fundamental knowledge of animal viruses is essential to the current understand ing of the molecular mechanisms of cell transformation. For this reason, a chapter on animal viruses has also been included. Some of the experimental work having to do with the elucidation of transformation and other aspects of interaction between the virus and the cell cannot be based on human papillomaviruses because of a lack of suitable experimental models. Hence, some of the chapters dealing with fundamental aspects of viral molecular biol ogy are based on animal models. We were very fortunate in having persuaded a number of distin guished colleagues to contribute to this work.

Emerging and Reemerging Viral Pathogens

Author : Moulay Mustapha Ennaji
Publisher : Academic Press
ISBN 13 : 0128149671
Total Pages : 388 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Emerging and Reemerging Viral Pathogens by : Moulay Mustapha Ennaji

Download or read book Emerging and Reemerging Viral Pathogens written by Moulay Mustapha Ennaji and published by Academic Press. This book was released on 2019-09-14 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: Emerging and Reemerging Viral Pathogens: Applied Virology Approaches Related to Human, Animal and Environmental Pathogens, Volume Two presents new research information on viruses and their impact on the scientific community. It provides a reference book on certain viruses in humans, animals and vegetal, along with a comprehensive discussion on interspecies interactions. The book then looks at the drug, vaccine and bioinformatical strategies that can be used against these viruses, giving the reader a clear understanding of transmission. The book's end goal is to create awareness that the appearance of newly transmissible pathogens is a global risk that requires shared/adoptable policies for prevention and control. Covers most emerging viral disease in humans, animals and plants Provides the most advanced tools and techniques in molecular virology and the modeling of viruses Creates awareness that the appearance of new transmissible pathogens is a global risk Highlights the need to adopt shared policies for the prevention and control of infectious diseases

Veterinary Oncology

Author : Robert Klopfleisch
Publisher : Springer
ISBN 13 : 3319411241
Total Pages : 311 pages
Book Rating : 4.3/5 (194 download)

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Book Synopsis Veterinary Oncology by : Robert Klopfleisch

Download or read book Veterinary Oncology written by Robert Klopfleisch and published by Springer. This book was released on 2016-10-24 with total page 311 pages. Available in PDF, EPUB and Kindle. Book excerpt: This highly readable textbook provides a comprehensive but concise overview of the principles of oncogenesis in veterinary medicine, discussing selected tumors in domestic animals in detail, and addressing cancer diagnostics and therapy. All chapters are illustrated with histological and radiological images to enhance readers’ understanding. Accordingly, the book is a must-have reference guide for all graduate and advanced undergraduate students in Veterinary Medicine with a special interest in oncology.

Manual on Meat Inspection for Developing Countries

Author : Drago Carl Herenda
Publisher : Food & Agriculture Org.
ISBN 13 : 9789251033043
Total Pages : 388 pages
Book Rating : 4.0/5 (33 download)

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Book Synopsis Manual on Meat Inspection for Developing Countries by : Drago Carl Herenda

Download or read book Manual on Meat Inspection for Developing Countries written by Drago Carl Herenda and published by Food & Agriculture Org.. This book was released on 1994 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Lentivirus Gene Engineering Protocols

Author : Maurizio Federico
Publisher : Springer Science & Business Media
ISBN 13 : 1592593933
Total Pages : 310 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis Lentivirus Gene Engineering Protocols by : Maurizio Federico

Download or read book Lentivirus Gene Engineering Protocols written by Maurizio Federico and published by Springer Science & Business Media. This book was released on 2008-02-03 with total page 310 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cell gene engineering is emerging as a field with outstanding impact, not only in medicine/biology, but also, and perhaps most importantly, in agriculture and in all those food sciences involved in the fight against world hunger. Lentivirus vector-based technologies represent the last frontier in the development of powerful and reliable methods for both in vitro and in vivo gene transfer in eukaryotic animal cells. Although the design of lentivirus vectors is closely reminiscent of those already successfully applied to the construction of oncoretroviral vectors, some unique features, e.g., the ef- ciency in transducing both postmitotic and stem cells, render the use of lentivirus vectors invaluable. It has been a great pleasure to edit Lentivirus Gene Engineering Pro- cols, owing in part to the high level of enthusiasm that the authors dem- strated in contributing to this book. The fact that so many outstanding scientists engaged in lentivirus vector research have provided articles renders it so- thing more than a technical handbook. In addition to detailed descriptions of the most innovative methodologies, the reader may find very informative ov- views concerning both theoretical and practical aspects of the origin and the development of diverse lentivirus vector types. This, in my opinion, rep- sents a unique added value of this volume, which should help our work resist the passage of time, to which books such as this are particularly sensitive.