Isotope Tracers In Metabolic Research

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Isotope Tracers in Metabolic Research

Author : Robert R. Wolfe
Publisher : John Wiley & Sons
ISBN 13 : 9780471462095
Total Pages : 494 pages
Book Rating : 4.4/5 (62 download)

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Book Synopsis Isotope Tracers in Metabolic Research by : Robert R. Wolfe

Download or read book Isotope Tracers in Metabolic Research written by Robert R. Wolfe and published by John Wiley & Sons. This book was released on 2004-10-18 with total page 494 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the past few years, the number of applications of tracers for in vivo biomedical studies has greatly increased. New analytical tools at the genetic and protein levels have spurred this growth, opening the door for a deeper understanding of metabolic events. This in turn promises to yield significant advances in the understanding and treatment of human disease. Now fully revised and expanded, Isotope Tracers in Metabolic Research, Second Edition is the established definitive text on stable and radioactive isotope tracers. In unique, multidisciplinary fashion, it presents comprehensive coverage of new methodological, mathematical, and theoretical approaches. This new Second Edition includes: All-new chapters on nuclear magnetic resonance, mass isotopomer analysis, and methods of protein metabolism analysis A completely updated categorized list of over 750 references Major advances in the development of mass isotopomer and positional isotopomer techniques, noninvasive isotope techniques for studying metabolic pathways, hyphenated techniques, and new tracer techniques The latest developments in quantification of DNA synthesis and mass spectrometry spurred by genome sequencing and proteomics New coverage of mathematical modeling Expanded coverage of microdialysis probes, laboratory procedures, and regulatory issues related to human studies In this complete guide to performing tracer studies, the authors systematically cover tracer selection, modeling considerations, sample derivitization, mass spectrometry analysis, and data interpretation. Problems and discussion questions highlight key points in each chapter. Isotope Tracers in Metabolic Research, Second Edition offers students and researchers a comprehensive, practical resource for utilizing the latest tracer methodologies.

Tracers in Metabolic Research

Author : Robert R. Wolfe
Publisher :
ISBN 13 :
Total Pages : 312 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Tracers in Metabolic Research by : Robert R. Wolfe

Download or read book Tracers in Metabolic Research written by Robert R. Wolfe and published by . This book was released on 1984 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: Methods for studying metabolism. Determination of substrate kinetics. Constant isotope infusion technique. Determination of substrate kinetics. Bolus-injection technique. Determination of substrate oxidation. Bicarbonate kinetics and natural enrichment. Priming the pool. Nonsteady state kinetics. Selection of sites for infusing isotope andj drawing samples. Specific application. Glucose metabolism. Specific application. Urea. Specific application. Fat meltabolism. Amino acids. Whole-body protein turnover. Total body water. Clinical application of stable isotopes. Analytical methods. Instrumentation. Mass spectrometry. Selected ion monitoring. Preparation of samples. Chromatography. Determination of specific radioactivity. Collection of CO2. Isotope ratio mass spectrometry techniques. Gas chromatography-mass spectrometry methods. In vivo approaches. Isotopic tracers. Advantages of stable isotopes. Biological effects. Enzymatic effects. Definition of terms. Influence of uptake on calculation of rate of appearance. Influence of pool size and complexity. Net movement of tracer and tracee. Clearance. Stable versus radioisotopes. Single-pool analysis. Bicarbonate recovery. Natural abundance of 13C. Practical consideration of performing recovery studies. Determining NaH13 CO3 infusion rate. Determining VCO2. Theory of priming dose. Priming secondary pools. Steele equation. In vivo assessment of steele equation. Glucose. Effective volume of distribution. Urea. Arterial versus central venous infusion.

Tracers in Metabolic Research

Author : Robert R. Wolfe
Publisher :
ISBN 13 : 9780471834380
Total Pages : 300 pages
Book Rating : 4.8/5 (343 download)

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Book Synopsis Tracers in Metabolic Research by : Robert R. Wolfe

Download or read book Tracers in Metabolic Research written by Robert R. Wolfe and published by . This book was released on 1984-06 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Tracers in Metabolic Research Radioisotope and Stable Isotope/Mass Spectrometry Methods; Volume 9

Author : RR. Wolfe
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (985 download)

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Book Synopsis Tracers in Metabolic Research Radioisotope and Stable Isotope/Mass Spectrometry Methods; Volume 9 by : RR. Wolfe

Download or read book Tracers in Metabolic Research Radioisotope and Stable Isotope/Mass Spectrometry Methods; Volume 9 written by RR. Wolfe and published by . This book was released on 1984 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Radioactive and Stable Isotope Tracers in Biomedicine

Author : Robert R. Wolfe
Publisher : Wiley-Liss
ISBN 13 : 9780471561316
Total Pages : 480 pages
Book Rating : 4.5/5 (613 download)

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Book Synopsis Radioactive and Stable Isotope Tracers in Biomedicine by : Robert R. Wolfe

Download or read book Radioactive and Stable Isotope Tracers in Biomedicine written by Robert R. Wolfe and published by Wiley-Liss. This book was released on 1992-04-09 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt: An up-to-date, detailed, authoritative overview regarding all aspects of the theory and practice involved in utilizing isotopic tracers for the in vivo study of human metabolic function. Presents specific technical information on performing tracer studies including isotope infusion, analysis and interpretation of data.

High-Throughput Metabolomics

Author : Angelo D'Alessandro
Publisher : Humana
ISBN 13 : 9781493992386
Total Pages : 459 pages
Book Rating : 4.9/5 (923 download)

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Book Synopsis High-Throughput Metabolomics by : Angelo D'Alessandro

Download or read book High-Throughput Metabolomics written by Angelo D'Alessandro and published by Humana. This book was released on 2020-06-06 with total page 459 pages. Available in PDF, EPUB and Kindle. Book excerpt: This detailed volume focuses on recent technological, computational, and biostatistical advances in the field of high-throughput metabolomics. Chapters encompass methods, platforms, and analytical strategies for steady state measurements and metabolic flux analysis with stable isotope-labeled tracers, in biological matrices of clinical relevance and model organisms. Mass spectrometry-based or orthogonal methods are discussed, along with computational and statistical methods to address data sparsity in high-throughput metabolomics approaches. As a part of the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, High-Throughput Metabolomics: Methods and Protocols provides tools that can bring about the next generation of clinical biochemistry in a cost-effective, rigorous fashion, exponentially advancing our capacity to investigate nature while hastening the advent of personalized medicine.

Stable Isotope Ecology

Author : Brian Fry
Publisher : Springer Science & Business Media
ISBN 13 : 0387337458
Total Pages : 318 pages
Book Rating : 4.3/5 (873 download)

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Book Synopsis Stable Isotope Ecology by : Brian Fry

Download or read book Stable Isotope Ecology written by Brian Fry and published by Springer Science & Business Media. This book was released on 2007-01-15 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt: A solid introduction to stable isotopes that can also be used as an instructive review for more experienced researchers and professionals. The book approaches the use of isotopes from the perspective of ecological and biological research, but its concepts can be applied within other disciplines. A novel, step-by-step spreadsheet modeling approach is also presented for circulating tracers in any ecological system, including any favorite system an ecologist might dream up while sitting at a computer. The author’s humorous and lighthearted style painlessly imparts the principles of isotope ecology. The online material contains color illustrations, spreadsheet models, technical appendices, and problems and answers.

Isotopes for Medicine and the Life Sciences

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309176697
Total Pages : 144 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Isotopes for Medicine and the Life Sciences by : Institute of Medicine

Download or read book Isotopes for Medicine and the Life Sciences written by Institute of Medicine and published by National Academies Press. This book was released on 1995-01-27 with total page 144 pages. Available in PDF, EPUB and Kindle. Book excerpt: Radioactive isotopes and enriched stable isotopes are used widely in medicine, agriculture, industry, and science, where their application allows us to perform many tasks more accurately, more simply, less expensively, and more quickly than would otherwise be possible. Indeed, in many casesâ€"for example, biological tracersâ€"there is no alternative. In a stellar example of "technology transfer" that began before the term was popular, the Department of Energy (DOE) and its predecessors has supported the development and application of isotopes and their transfer to the private sector. The DOE is now at an important crossroads: Isotope production has suffered as support for DOE's laboratories has declined. In response to a DOE request, this book is an intensive examination of isotope production and availability, including the education and training of those who will be needed to sustain the flow of radioactive and stable materials from their sources to the laboratories and medical care facilities in which they are used. Chapters include an examination of enriched stable isotopes; reactor and accelerator-produced radionuclides; partnerships among industries, national laboratories, and universities; and national isotope policy.

Tracer Kinetics in Biomedical Research

Author : Claudio Cobelli
Publisher : Springer Science & Business Media
ISBN 13 : 0306468336
Total Pages : 455 pages
Book Rating : 4.3/5 (64 download)

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Book Synopsis Tracer Kinetics in Biomedical Research by : Claudio Cobelli

Download or read book Tracer Kinetics in Biomedical Research written by Claudio Cobelli and published by Springer Science & Business Media. This book was released on 2007-05-08 with total page 455 pages. Available in PDF, EPUB and Kindle. Book excerpt: 1. Introduction. 2. Fundamentals of Tracer Kinetics. 3. The Noncompartmental Model of Multipool Systems. 4. The Compartmental Model. 5. Identifiability of the Tracer Model. 6. Using the Tracer Model to Estimate Kinetic Parameters. 7. Compartmental Versus Noncompartmental Kinetic Parameters. 8. Parameter Estimation: Some Fundamentals of Regression Analysis. 9. Parameter Estimation in Noncompartmental Models. 10. Parameter Estimation in Compartmental Models. 11. Precursor-Product Models. Appendices. Index.

Metabolic Analysis Using Stable Isotopes

Author :
Publisher : Academic Press
ISBN 13 : 0128025344
Total Pages : 424 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Metabolic Analysis Using Stable Isotopes by :

Download or read book Metabolic Analysis Using Stable Isotopes written by and published by Academic Press. This book was released on 2015-09-21 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metabolic Analysis Using Stable Isotopes, the newest volume in Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods in metabolic analysis using stable isotopes. Continues the legacy of this premier serial with quality chapters on metabolic analysis using stable isotopes Represents the newest volume in Methods in Enzymology, providing a premier serial with quality chapters authored by leaders in the field Ideal reference for those interested in the study of metabolism, metabolic tracing, isotopic labeling, and lipogenesis

Translational Research Methods in Diabetes, Obesity, and Nonalcoholic Fatty Liver Disease

Author : Andrew J. Krentz
Publisher : Springer
ISBN 13 : 3030117480
Total Pages : 556 pages
Book Rating : 4.0/5 (31 download)

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Book Synopsis Translational Research Methods in Diabetes, Obesity, and Nonalcoholic Fatty Liver Disease by : Andrew J. Krentz

Download or read book Translational Research Methods in Diabetes, Obesity, and Nonalcoholic Fatty Liver Disease written by Andrew J. Krentz and published by Springer. This book was released on 2019-04-02 with total page 556 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book aims to aid the selection of the most appropriate methods for use in early phase (1 and 2) clinical studies of new drugs for diabetes, obesity, non-alcoholic fatty liver disease (NAFLD) and related cardiometabolic disorders. Clinical research methods to assess the pharmacokinetics and pharmacodynamics of new diabetes drugs, e.g. the euglycemic clamp technique, have become well-established in proof-of-mechanism studies. However, selection of the most appropriate techniques is by no means straightforward. Moreover, the application of such methods must conform to the regulatory requirements for new drugs. This book discusses the need for new pharmacotherapies for diabetes, obesity and NAFLD and the molecular targets of drugs currently in development. Emerging technologies including functional imaging, circulating biomarkers and omics are considered together with practical and ethical issues pertaining to early phase clinical trials in subjects with cardiometabolic disorders. Translational Research Methods in Diabetes, Obesity, and Non-Alcoholic Fatty Liver Disease is of interest to biomedical scientists, pharmacologists, academics involved in metabolic research and clinicians practicing in these specialties.

Isotope Tracers in Catchment Hydrology

Author : C. Kendall
Publisher : Elsevier
ISBN 13 : 008092915X
Total Pages : 870 pages
Book Rating : 4.0/5 (89 download)

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Book Synopsis Isotope Tracers in Catchment Hydrology by : C. Kendall

Download or read book Isotope Tracers in Catchment Hydrology written by C. Kendall and published by Elsevier. This book was released on 2012-12-02 with total page 870 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book represents a new "earth systems" approach to catchments that encompasses the physical and biogeochemical interactions that control the hydrology and biogeochemistry of the system. The text provides a comprehensive treatment of the fundamentals of catchment hydrology, principles of isotope geochemistry, and the isotope variability in the hydrologic cycle -- but the main focus of the book is on case studies in isotope hydrology and isotope geochemistry that explore the applications of isotope techniques for investigating modern environmental problems. Isotope Tracers in Catchment Hydrology is the first synthesis of physical hydrology and isotope geochemistry with catchment focus, and is a valuable reference for professionals and students alike in the fields of hydrology, hydrochemistry, and environmental science. This important interdisciplinary text provides extensive guidelines for the application of isotope techniques for all investigatores facing the challenge of protecting precious water, soil, and ecological resources from the ever-increasing problems associated with population growth and environmental change, including those from urban development and agricultural land uses.

Tools and Applications of Biochemical Engineering Science

Author : K. Schügerl
Publisher : Springer
ISBN 13 : 3540457364
Total Pages : 286 pages
Book Rating : 4.5/5 (44 download)

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Book Synopsis Tools and Applications of Biochemical Engineering Science by : K. Schügerl

Download or read book Tools and Applications of Biochemical Engineering Science written by K. Schügerl and published by Springer. This book was released on 2003-07-01 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: This special volume "Tools and Applications of Biochemical Engineering Science" is dedicated to Professor Wolf-Dieter Deckwer on the occasion of his 60th bir- day. It was a great pleasure for me to act together with Professor Karl Schtigerl as volume editor and to present here a collection of 11 outstanding review articles written mainly by former students, associates, colleagues and friends of Wolf- Dieter Deckwer. The title of this special volume well reflects the research interests and sci- tific pursuit of Wolf-Dieter Deckwer during his more than 20 years’ work in the area of biochemical engineering, particularly during the last 15 years when he was the head of the Biochemical Engineering Division of GBF (German Nat- nal Research Center for Biotechnology). He has decisively pushed the devel- ment not only of "software tools" ranging from analytical means and mathe- tical models for monitoring and understanding cellular processes to gene expression systems for designing microorganisms, but also of "hardware tools" such as computer control systems, bioreaction and separation devices for eff- tively producing a variety of bioproducts on semi-production scale. New developments in some of these important tools in biochemical engineering are reviewed in articles included in this volume. Wolf-Dieter Deckwer was among the leading biochemical engineers who timely pointed out the necessity of applying these tools in an integrated manner for bioprocess development. By establishing "Integrated Bioprocess Development" as one of the GBF main - search topics as early as 1990 he also actively promoted this idea.

Metabolic Engineering

Author : Sang Yup Lee
Publisher : John Wiley & Sons
ISBN 13 : 352782345X
Total Pages : 1075 pages
Book Rating : 4.5/5 (278 download)

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Book Synopsis Metabolic Engineering by : Sang Yup Lee

Download or read book Metabolic Engineering written by Sang Yup Lee and published by John Wiley & Sons. This book was released on 2021-06-02 with total page 1075 pages. Available in PDF, EPUB and Kindle. Book excerpt: Learn more about foundational and advanced topics in metabolic engineering in this comprehensive resource edited by leaders in the field Metabolic Engineering: Concepts and Applications delivers a one-stop resource for readers seeking a complete description of the concepts, models, and applications of metabolic engineering. This guide offers practical insights into the metabolic engineering of major cell lines, including E. Coli, Bacillus and Yarrowia Lipolytica, and organisms, including human, animal, and plant). The distinguished editors also offer readers resources on microbiome engineering and the use of metabolic engineering in bioremediation. Written in two parts, Metabolic Engineering begins with the essential models and strategies of the field, like Flux Balance Analysis, Quantitative Flux Analysis, and Proteome Constrained Models. It also provides an overview of topics like Pathway Design, Metabolomics, and Genome Editing of Bacteria and Eukarya. The second part contains insightful descriptions of the practical applications of metabolic engineering, including specific examples that shed light on the topics within. In addition to subjects like the metabolic engineering of animals, humans, and plants, you’ll learn more about: Metabolic engineering concepts and a historical perspective on their development The different modes of analysis, including flux balance analysis and quantitative flux analysis An illuminating and complete discussion of the thermodynamics of metabolic pathways The Genome architecture of E. coli, as well as genome editing of both bacteria and eukarya An in-depth treatment of the application of metabolic engineering techniques to organisms including corynebacterial, bacillus, and pseudomonas, and more Perfect for students of biotechnology, bioengineers, and biotechnologists, Metabolic Engineering: Concepts and Applications also has a place on the bookshelves of research institutes, biotechnological institutes and industry labs, and university libraries. It's comprehensive treatment of all relevant metabolic engineering concepts, models, and applications will be of use to practicing biotechnologists and bioengineers who wish to solidify their understanding of the field.

Isotopic Tracers in Biology

Author : Martin D. Kamen
Publisher : Elsevier
ISBN 13 : 1483274330
Total Pages : 491 pages
Book Rating : 4.4/5 (832 download)

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Book Synopsis Isotopic Tracers in Biology by : Martin D. Kamen

Download or read book Isotopic Tracers in Biology written by Martin D. Kamen and published by Elsevier. This book was released on 2013-10-22 with total page 491 pages. Available in PDF, EPUB and Kindle. Book excerpt: Isotopic Tracers in Biology: An Introduction to Tracer Methodology, Third Edition focuses on stable isotopes, structures, composition, and reactions of nitrogen and oxygen, and radioactive tracers. The book first takes a look at atomic nuclei, radioactivity, and the production of radioactive isotopes and radiation characteristics of tracer atoms. Topics include nuclear reactions, general properties of nuclei, radioactivity, target techniques and radiochemistry, and beta and gamma radiations. The text also discusses isotopic assay, radiation hazards, procedures related with sample preparation for radioactive assay, and combustion of labeled materials. The manuscript examines the biochemical, physiological, and medical aspects of tracer methodology, as well as biochemical applications, value of tracer methods for biology, intermediary metabolism, and applications to clinical research. The text also ponders on the isotopes of hydrogen, carbon, oxygen, nitrogen, phosphorus, and sulfur. Concerns include assay of deuterium and tritium, short-lived and heavy stable carbon, and oxygen, nitrogen, sulfur, and phosphorus isotopes. The publication is a dependable reference for readers interested in isotopic tracers.

Using Geochemical Data

Author : Hugh Rollinson
Publisher : Cambridge University Press
ISBN 13 : 1108803822
Total Pages : 359 pages
Book Rating : 4.1/5 (88 download)

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Book Synopsis Using Geochemical Data by : Hugh Rollinson

Download or read book Using Geochemical Data written by Hugh Rollinson and published by Cambridge University Press. This book was released on 2021-05-06 with total page 359 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook is a complete rewrite, and expansion of Hugh Rollinson's highly successful 1993 book Using Geochemical Data: Evaluation, Presentation, Interpretation. Rollinson and Pease's new book covers the explosion in geochemical thinking over the past three decades, as new instruments and techniques have come online. It provides a comprehensive overview of how modern geochemical data are used in the understanding of geological and petrological processes. It covers major element, trace element, and radiogenic and stable isotope geochemistry. It explains the potential of many geochemical techniques, provides examples of their application, and emphasizes how to interpret the resulting data. Additional topics covered include the critical statistical analysis of geochemical data, current geochemical techniques, effective display of geochemical data, and the application of data in problem solving and identifying petrogenetic processes within a geological context. It will be invaluable for all graduate students, researchers, and professionals using geochemical techniques.

Practical Inductively Coupled Plasma Spectroscopy

Author : John R. Dean
Publisher : John Wiley & Sons
ISBN 13 : 0470093501
Total Pages : 208 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Practical Inductively Coupled Plasma Spectroscopy by : John R. Dean

Download or read book Practical Inductively Coupled Plasma Spectroscopy written by John R. Dean and published by John Wiley & Sons. This book was released on 2005-08-05 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book provides an up-to-date account of inductively coupled plasmas and their use in atomic emission spectroscopy and mass spectrometry. Specific applications of the use of these techniques are highlighted including applications in environmental, food and industrial analysis. It is written in a distance learning / open learning style; suitable for self study applications. It contains contain self-assessment and discussion questions, worked examples and case studies that allow the reader to test their understanding of the presented material.