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Isolated Lung Perfusion With Gemcitabine For The Treatment Of Pulmonary Metastases
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Book Synopsis Lung Metastases and Isolated Lung Perfusion by : P. Van Schil
Download or read book Lung Metastases and Isolated Lung Perfusion written by P. Van Schil and published by Nova Publishers. This book was released on 2007 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt: Surgical resection of lung metastases is a widely accepted procedure but long-term results are disappointing with a 5-year survival rate of approximately 40%. The main prognostic factor is complete resection and a better survival is reported in patients with a single metastasis and a disease-free survival of more than 3 years. Re-operations are feasible but often patients become inoperable due to insufficient pulmonary reserve and new treatment modalities are looked for. Intravenous (iv) chemotherapy has no major impact on survival due to systemic side-effects when high doses are given. As isolated limb and liver perfusion, isolated lung perfusion (ILuP) has the advantage of selectively delivering an agent into the lung while diverting the venous effluent. This allows the drug to be given in a significantly higher dose compared to iv therapy, while drug levels in the other organs are kept low enough to avoid major complications. ILuP has been shown to be very effective for the treatment of lung metastases in animal models. Phase I clinical studies to determine dose-limiting toxicity and maximum tolerated dose have recently been reported. The principal aim of this book is to discuss the current treatment of lung metastases and the possible contribution of ILuP.
Book Synopsis Pulmonary Metastasectomy, An Issue of Thoracic Surgery Clinics of North America by : Mark W. Onaitis
Download or read book Pulmonary Metastasectomy, An Issue of Thoracic Surgery Clinics of North America written by Mark W. Onaitis and published by Elsevier Health Sciences. This book was released on 2016-03-09 with total page 145 pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of Thoracic Surgery Clinics of North America focuses on Pulmonary Metastasectomy. Articles will include: Biology of Pulmonary Metastases; Preoperative Evaluations and Indications for Metastasectomy; Open Approaches to Pulmonary Metastases: Thoracotomy and Sternotomy; Ablative Approaches for Pulmonary Metastases: RFA, microwave, SBRT; Role of Lymphadenectomy with Pulmonary Metastasectomy; Results of Pulmonary Resection: Colorectal Carcinoma; Results of Pulmonary Resection: Sarcoma and Germ Cell Tumors; Isolated Lung Perfusion; Immunotherapy; Medical Management of Pulmonary Metastases: Is There a Role for Surgery?; Thoracoscopic Management of Pulmonary Metastases; Results of Pulmonary Resection: Other Epithelial Malignancies; Thoracoscopic Lung Suffusion; and more!
Book Synopsis Handbook of Anticancer Pharmacokinetics and Pharmacodynamics by : Michelle A. Rudek
Download or read book Handbook of Anticancer Pharmacokinetics and Pharmacodynamics written by Michelle A. Rudek and published by Springer Science & Business Media. This book was released on 2014-01-10 with total page 828 pages. Available in PDF, EPUB and Kindle. Book excerpt: There are many steps on the road from discovery of an anticancer drug to securing its final approval by the Food and Drug Administration. In this thoroughly updated and expanded second edition of the Handbook of Anticancer Pharmacokinetics and Pharmacodynamics, leading investigators synthesize an invaluable overview of the experimental and clinical processes of anticancer drug development, creating a single indispensable reference that covers all the steps from the identification of cancer-specific molecular targets to screening techniques and the development and validation of bioanalytical methods to clinical trial design and all phases of clinical trials. The authors have included new material on phase 0 trials in oncology, organ dysfunction trials, drug formulations and their impact on anticancer drug PK/PD including strategies to improve drug delivery, pharmacogenomics and cancer therapy, high throughput platforms in drug metabolism and transport pharmacogenetics, imaging in drug development and nanotechnology in cancer. Authoritative and up-to-date, Handbook of Anticancer Pharmacokinetics and Pharmacodynamics, 2nd Edition provides in one comprehensive and highly practical volume a detailed step-by-step guide to the successful design and approval of anticancer drugs. Road map to anticancer drug development from discovery to NDA submission Discussion of molecular targets and preclinical screening Development and validation of bioanalytical methods Chapters on clinical trial design and phase 0, I, II, III clinical trials Pharmacokinetics, pharmacodynamics, pharmacogenomics, and pharmacogenetics of anticancer agents Review of the drug development process from both laboratory and clinical perspectives New technological advances in imaging, high throughput platforms, and nanotechnology in anticancer drug development
Book Synopsis Cardiothoracic Surgery Review by : Kenneth L. Franco
Download or read book Cardiothoracic Surgery Review written by Kenneth L. Franco and published by Lippincott Williams & Wilkins. This book was released on 2012-01-05 with total page 4752 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cardiothoracic Surgery Review covers all of the core knowledge necessary to pass the cardiothoracic boards or the cardiothoracic recertification exam. Each topic presents core information in two-to-four pages and concludes with a brief list of the most important references. The topics cover all areas in cardiothoracic surgery, including cardiac surgery, pediatric cardiac surgery, and thoracic surgery. Included with the book is a companion website featuring the fully searchable text and over 60 procedural videos. This topic-based review is ideal for anyone needing to rapidly reference an up-to-date knowledge base in cardiothoracic surgery, including cardiothoracic fellows, practitioners studying for recertification, and surgical nurses.
Book Synopsis Shields' General Thoracic Surgery by : Joseph LoCicero
Download or read book Shields' General Thoracic Surgery written by Joseph LoCicero and published by Lippincott Williams & Wilkins. This book was released on 2018-06-19 with total page 2512 pages. Available in PDF, EPUB and Kindle. Book excerpt: Publisher's Note: Products purchased from 3rd Party sellers are not guaranteed by the Publisher for quality, authenticity, or access to any online entitlements included with the product. The gold standard thoracic surgery reference for 45 years, Shields’ General Thoracic Surgery remains your #1 resource for comprehensive coverage of both open and endoscopic surgical techniques, with commentary from more than 150 global experts in the field. This two-volume masterwork covers all facets of thoracic disease, enhanced with dynamic audio and visual content, colorful graphics, and an authoritative analysis of the world’s literature and electronic data – making this 8th Edition the most extensive and concise collection of practical, complete information available for today’s busy clinician.
Book Synopsis Induction Chemotherapy by : Karl Reinhard Aigner
Download or read book Induction Chemotherapy written by Karl Reinhard Aigner and published by Springer. This book was released on 2016-05-27 with total page 501 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the full range of management techniques and practices used in induction chemotherapy – both systemic and locoregional - by experienced international groups within one accessible volume. It provides the latest information on the pioneering and cutting-edge practices employed in different institutions and documents the advantages of integrated treatment schedules. All those responsible for treating patients with locally advanced cancers may find new, interesting aspects of locoregional cancer management and will find this book to be an invaluable source of up-to-date information. Throughout the world, induction chemotherapy is being used as part of an integrated plan of management for locally advanced, solid tumors, while systemic chemotherapy is most commonly used to shrink primarily non-operable tumors. In cases of poorly or nonresponsive tumors, attempts have been made to administer chemotherapeutics via the arterial route in order to achieve higher localized drug exposure and response rates. Such therapies are being practiced worldwide in independent, remote departments in universities, teaching hospitals and clinical schools. Frequently, however, these teams remain relatively unaware of the work being done in other institutions, which may slow further progress.
Book Synopsis Locoregional Tumor Therapy by : Eric Van Cutsem
Download or read book Locoregional Tumor Therapy written by Eric Van Cutsem and published by Springer. This book was released on 2014-11-10 with total page 163 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent years have witnessed a renaissance in the use of locoregional tumor therapy as part of a multimodal therapeutic approach to a variety of solid tumors, and attempts are underway to define its value in the overall therapeutic strategy for individual tumor entities. This flourishing of interest in locoregional tumor therapy derives from a series of important new developments concerning methodology, drug treatments, and instrumentation. The resulting approaches include not only optimized locoregional chemotherapy and chemoembolization for hepatocellular carcinoma and other tumors, but also other “targeted” therapies such as stereotactic radiosurgery, radiofrequency ablation, intra-arterial administration of radiopharmaceuticals, and complex new methods of chemoembolization of liver metastases involving the use of multiagent chemotherapy in combination with targeted drugs, drug-eluting beads/microspheres, or nanoparticles. In addition, intraperitoneal and intrapleural therapies, e.g., cytoreduction plus hyperthermic intraperitoneal chemotherapy, are now a standard element of the strategy for a range of tumors. It is vital that practitioners have the necessary expertise in the use of these locoregional treatment methods and understand how to combine them optimally with modern systemic therapies. With that goal in mind, this book presents, in condensed form, the clinical results achieved using various locoregional tumor therapies. In so doing, it will allow the reader to rapidly retrieve the information on indications and effectiveness that is required for optimal integration of these highly effective therapies into modern, yet more complex treatment strategies.
Book Synopsis General Thoracic Surgery by : Thomas W. Shields
Download or read book General Thoracic Surgery written by Thomas W. Shields and published by Lippincott Williams & Wilkins. This book was released on 2005 with total page 1572 pages. Available in PDF, EPUB and Kindle. Book excerpt: The leading comprehensive reference on thoracic surgery is now in its Sixth Edition. Coverage of surgical oncology has been expanded. This edition also features state-of-the-art video-assisted procedures, new chapters on tracheostomy, and new techniques for lung cancer and paraesophageal hernia. Organized by anatomic region, this two-volume work offers comprehensive guidelines on surgical management of all adult and pediatric conditions. Coverage includes detailed information on diagnostic procedures, preoperative assessment, postoperative care, and relevant basic science and physiology. More than 2,000 images, drawings, and photographs complement the text.
Book Synopsis DeVita, Hellman, and Rosenberg's Cancer by : Vincent T. DeVita
Download or read book DeVita, Hellman, and Rosenberg's Cancer written by Vincent T. DeVita and published by Lippincott Williams & Wilkins. This book was released on 2008 with total page 1748 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presenting comprehensive, cutting-edge information on the science of oncology and the multimodality treatment of every cancer type, this eighth edition--now in full color--contains more than 40 brand-new chapters, and more than 70 chapters have been rewritten by new contributing authors.
Book Synopsis Multimodality Imaging and Intervention in Oncology by : Emanuele Neri
Download or read book Multimodality Imaging and Intervention in Oncology written by Emanuele Neri and published by Springer Nature. This book was released on 2024-01-27 with total page 594 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides the reader with a focused review of multimodality imaging strategies (radiology and molecular imaging) in staging and re-staging the major types of cancer (i.e. thyroid, breast, colon-rectum, lung, prostate, pancreas, liver, head and neck, and hematological cancer), including rare neoplasms. In addition to presenting the possible diagnostic pathways for all oncologic diseases, the book identifies those interventions currently available in clinical practice (these being a branch of interventional radiology), while also examining and detailing molecular radiotherapy strategies. The work has an interdisciplinary appeal and, thanks to its highly informative and cutting-edge coverage, professionals as well as advanced students and residents in radiology, oncology and surgery will find it of particular interest.
Download or read book Cumulated Index Medicus written by and published by . This book was released on 1997 with total page 1856 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Index Medicus written by and published by . This book was released on 2004 with total page 2068 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
Book Synopsis Innovations in Thoracic Surgery, An Issue of Thoracic Surgery Clinics of North America by : Kazuhiro Yasufuku
Download or read book Innovations in Thoracic Surgery, An Issue of Thoracic Surgery Clinics of North America written by Kazuhiro Yasufuku and published by Elsevier Health Sciences. This book was released on 2016-05-27 with total page 129 pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of Thoracic Surgery Clinics of North America focuses on Innovations in Thoracic Surgery. Articles will include: Advances in Image Guided Thoracic Surgery; Evolving Applications of Extracorporeal Membrane Oxygenation (ECMO) in Thoracic Surgery; Novel Technologies for Isolated Lung Perfusion – Beyond Lung Transplant; Peroral Endoscopic Myotomy (POEM) for Achalasia; Bioengineered Organs: Dream or a Reality?; Credentialing for New Technology; Endoscopic Resection and Ablation for Early Stage Esophageal Cancer; Novel Technologies in Bronchoscopic Lung Volume Reduction; Advances in Uniportal Video-Assisted Thoracoscopic Surgery: Pushing the Envelope; Guided Bronchoscopy for Peripheral Pulmonary Nodules; Nanotechnology: Applications in Thoracic Surgery?; Present and Future Application of Energy Devices in Thoracic Surgery; and more!
Book Synopsis Extreme Hepatic Surgery and Other Strategies by : Eduardo de Santibañes
Download or read book Extreme Hepatic Surgery and Other Strategies written by Eduardo de Santibañes and published by Springer. This book was released on 2017-07-26 with total page 383 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the diagnoses; staging and management of patients with colorectal liver metastases initially considered unresectable and portrays the different strategies to increase resectability along with their tactics and tricks. Colorectal carcinoma is the third most commonly diagnosed cancer in the world and according to recent cancer statistics around 1.23 million patients are diagnosed each year. Of these patients, approximately 50% will develop liver metastases during the course of their disease and around 15-25% are found to have stage IV disease at diagnosis. Liver resection has been recognized as the treatment of choice for these patients, offering overall 5-year survival rates of up to 50-60% and the only hope for cure. However, at diagnosis only 10-20% of these patients are possibly amenable to surgical resection with curative intent. The possibility to achieve an R0 resection is many times limited by the amount and quality of the future liver remnant (FLR), being posthepatectomy liver failure (PHLF) the most feared and severe complication after major liver resections. With the years, diverse strategies have been developed with the intention to increase resectability by increasing the future liver remnant and/or reducing tumor size, e.g. ALPPS. Along with these techniques, associated surgeries are developed including multivisceral resections, which broadens even more the resectability for patients.
Book Synopsis Regional Chemotherapy by : Maurie Markman
Download or read book Regional Chemotherapy written by Maurie Markman and published by Springer Science & Business Media. This book was released on 2000-01-02 with total page 363 pages. Available in PDF, EPUB and Kindle. Book excerpt: Maurie Markman and a panel of distinguished clinicians and leading clinical investigators comprehensively review the current status of regional antineoplastic drug delivery in the management of malignant disease. These authorities present a critical analysis of both the rationale and limitations of regional therapy and discuss potential clinical trials designed to explain the effectiveness of this method of therapy in special settings. Their presentations describe many exciting and innovative strategies for using regional drug delivery in anticancer therapy, including coverage of such areas of special interest as colorectal, skin, lung, pancreatic, ovarian, and gastrointestinal cancers. Comprehensive and authoritative, Regional Chemotherapy: Clinical Research and Practice offers surgical and medical oncologists and clinical cancer investigators a gold-standard review of the current role and future development of this increasingly powerful weapon in the battle against cancer.
Download or read book Bone Cancer written by Dominique Heymann and published by Academic Press. This book was released on 2021-09-23 with total page 1080 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bone Cancer: Bone Sarcomas and Bone Metastases - From Bench to Bedside, Third Edition comprehensively investigates key discoveries in the field of bone biology. New aspects of bone cancer biology are treated in new chapters covering exosomes, autophagy, and metabolism. These have led to the development of entirely new areas for investigation, such as therapies which combine surgery and biological approaches. The Third Edition expands on the original overview of bone cancer development (physiology and pathophysiology), with 40% new material. Each chapter has been written by internationally recognized specialists on the bone cancer microenvironment, bone metastases, osteoclast biology in bone cancer, proteomics, bone niche, circulating tumor cells, and clinical trials. Given the global prevalence of breast and prostate cancers, knowledge of bone biology has become essential for everyone within the medical and cancer research communities. Bone Cancer: Bone Sarcomas and Bone Metastases - From Bench to Bedside continues to offer the only translational reference to cover all aspects of primary bone cancer and bone metastases. This revision opens the door to myeloma with two short chapters dedicated to this bone-associated disease. - Covers the broad field of bone sarcomas and bone metastases from basic research to clinical approaches - Presents comprehensive and translational overview of biological and clinical aspects of bone cancers, discussing pathophysiology from genetic and molecular levels using the most recent evidence - Provides a common language for cancer researchers, bone biologists, oncologists, and radiologists to discuss bone tumors and how bone cancer metastases affects each major organ system - Offers insights to research clinicians (oncologists and radiologists) into understanding the molecular basis of bone cancer, leading to more well-informed diagnoses and treatment of tumors and metastases - Offers insights to bone biologists into how clinical observations and practices can feed back into the research cycle and, therefore, can contribute to the development of more targeted genomic and proteomic assays
Book Synopsis Soft Tissue Sarcomas by : Raphael E. Pollock
Download or read book Soft Tissue Sarcomas written by Raphael E. Pollock and published by PMPH-USA. This book was released on 2002 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: Part of the acclaimed ACS Atlas of Clinical Oncology series, this book offers an expert overview of soft tissue sarcomas. It discusses diagn osis and staging, surgical approaches, radiation therapy, chemotherapy, pediatric sarcomas, and much more. Topics covered include epidemiolo gy, inherited syndromes, biopsy and surgical techniques, external beam irradiation, brachytherapy, intraoperative radiation therapy, neoadju vant therapy, adjuvant therapy, regional perfusion, pain syndromes, an d rehabilitation.
