Ions Cell Proliferation And Cancer

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Ions, Cell Proliferation, and Cancer

Author : Alton L. Boynton
Publisher : Academic Press
ISBN 13 : 1483277488
Total Pages : 572 pages
Book Rating : 4.4/5 (832 download)

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Book Synopsis Ions, Cell Proliferation, and Cancer by : Alton L. Boynton

Download or read book Ions, Cell Proliferation, and Cancer written by Alton L. Boynton and published by Academic Press. This book was released on 2013-09-17 with total page 572 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ions, Cell Proliferation, and Cancer present the credibility of ions as specific regulators of cell proliferation. This book provides an understanding of the control of cell proliferation and the deregulated proliferation of cancer cells. Organized into three sections encompassing 32 chapters, this book begins with an overview of the important role that ions in animal cells play in a variety of fundamental processes associated with essential cell functions. This text then examines the relationship between ionic events and cellular production, specifically in mammalian cell systems. Other chapters consider the development of atomic absorption spectrophotometry as a method for measuring inorganic cations. This book discusses as well the two widely applicable methods for measuring free concentrations of ions inside cells. The final chapter deals with magnesium ion as the most abundant divalent action in living cells. This book is a valuable resource for animal cell biologists, molecular biologists, and research workers.

Ion Channel Signalling in Cancer: From Molecular Mechanisms to Therapeutics

Author : Elena Adinolfi
Publisher : Frontiers Media SA
ISBN 13 : 2889711242
Total Pages : 261 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Ion Channel Signalling in Cancer: From Molecular Mechanisms to Therapeutics by : Elena Adinolfi

Download or read book Ion Channel Signalling in Cancer: From Molecular Mechanisms to Therapeutics written by Elena Adinolfi and published by Frontiers Media SA. This book was released on 2021-08-02 with total page 261 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Transportome Malfunction in the Cancer Spectrum

Author : Christian Stock
Publisher : Springer Nature
ISBN 13 : 3030909204
Total Pages : 432 pages
Book Rating : 4.0/5 (39 download)

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Book Synopsis Transportome Malfunction in the Cancer Spectrum by : Christian Stock

Download or read book Transportome Malfunction in the Cancer Spectrum written by Christian Stock and published by Springer Nature. This book was released on 2022-01-01 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first of three volumes in the "Ion Channels & Transporters in Tumor Biology" collection, which discusses the function of ion transport proteins in cellular and systemic homeostasis. The authors highlight the role of the so-called transportome, which is defined by the entirety of ion transporters and ion channels. Thereby, readers will get a better understanding of the impact dysregulated ion transport has on the whole spectrum of cancer types. Cancers display deficiencies in several, sometimes interdependent members of the transportome. Clinicians will be interested in the fact that controlled expression of ion transport proteins dramatically impacts the life span of cancer patients, as shown in recent studies. These observations offer a promising outlook for biomedical scientists, as members of the transportome could be the tumor markers of tomorrow - both for diagnostic and therapeutic purposes. As part of a three-volume collection, this book will fascinate members of the active research community, as well as clinicians from the cancer field.

Targets of Cancer Diagnosis and Treatment

Author : Christian Stock
Publisher : Springer Nature
ISBN 13 : 3031039947
Total Pages : 280 pages
Book Rating : 4.0/5 (31 download)

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Book Synopsis Targets of Cancer Diagnosis and Treatment by : Christian Stock

Download or read book Targets of Cancer Diagnosis and Treatment written by Christian Stock and published by Springer Nature. This book was released on 2022-05-05 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: This third and final volume in the "Ion Transport in Tumor Biology" collection presents novel diagnostic and therapeutic approaches in cancer based on the exploitation of ion transport proteins. The authors critically examine several transportome members, particularly Na+, K+, Ca2+, and Cl- channels, as well as organic solute carriers regarding their suitability as therapeutic targets. Synergistic effects resulting from the combined use of classical cytostatics with ion transport-inhibiting drugs are pointed out, and the capability of bispecific antibodies to function as anticancer drugs is discussed. As readers will also learn, the use of ion channel inhibitors could improve the outcome of radiotherapy because the development of radio-resistance during radiotherapeutic treatment often correlates with increases in the expression levels and conductance of ion channels. The translational topics of this volume form a bridge between biochemical research and therapeutic application. As part of a three-volume collection, this book will fascinate members of the active research community, as well as clinicians in the cancer field.

Ion Channels in Cancer

Author :
Publisher : Elsevier
ISBN 13 : 0443188831
Total Pages : 248 pages
Book Rating : 4.4/5 (431 download)

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Book Synopsis Ion Channels in Cancer by :

Download or read book Ion Channels in Cancer written by and published by Elsevier. This book was released on 2023-11-24 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ion Channels in Cancer, Volume 92 in the Current Topics in Membranes series, highlights advances in the field, including chapters on the Interplay of calcium and potassium signals in cell cycle and cancer, Non-conducting functions of ion channels in cancer and neurological disease, Sodium channels and progression of solid tumors, The Elusive Nav1.7: From Pain to Cancer, Signaling Pathways in cancer: Channels Interactome as a novel therapeutic target, Ion channels in cancer drugs resistance, CLIC1: A potential therapeutic target for malignant glioma, Beyond the Building Blocks: Amino Acids as modulators of ion channels and transporters, and Activation of potassium channels unveils tumor vulnerability. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in Current Topics in Membranes Updated release includes the latest information on Ion Channels in Cancer

From Malignant Transformation to Metastasis

Author : Christian Stock
Publisher : Springer Nature
ISBN 13 : 3030998002
Total Pages : 188 pages
Book Rating : 4.0/5 (39 download)

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Book Synopsis From Malignant Transformation to Metastasis by : Christian Stock

Download or read book From Malignant Transformation to Metastasis written by Christian Stock and published by Springer Nature. This book was released on 2022-04-24 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: This second book of the three-volume collection "Ion Transport in Tumor Biology" helps readers gain comprehensive knowledge of the pathophysiology of cancer. The authors highlight that ion transport proteins, channels and transporters - collectively referred to as the transportome - are significantly involved in the development and progression of cancer. Nearly 90% of malignant tumor diseases originate from epithelial cells, the function of which, for the most part, is based on the transportome. This volume focuses on molecular principles by showing that dysregulated expression and/or function of ion transporters have been correlated with malignancy in the vast majority of tumor diseases. Within the story of the various chapters, the authors line out various malfunctions of the transportome and where they can be found at different stages of the metastatic cascade. The authors describe how the interactions between the tumor cells' transportome and the environment reinforce mesenchymal behaviour of cancer cells and contribute to their uncontrolled proliferation, migration, invasion, intra- and extravasation up to the formation of metastases. As part of a three-volume collection, this book will fascinate members of the active research community, as well as clinicians from the cancer field.

Breast Cancer

Author : Phuc Van Pham
Publisher : BoD – Books on Demand
ISBN 13 : 9535129996
Total Pages : 570 pages
Book Rating : 4.5/5 (351 download)

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Book Synopsis Breast Cancer by : Phuc Van Pham

Download or read book Breast Cancer written by Phuc Van Pham and published by BoD – Books on Demand. This book was released on 2017-04-05 with total page 570 pages. Available in PDF, EPUB and Kindle. Book excerpt: Breast Cancer - From Biology to Medicine thoroughly examines breast cancer from basic definitions, to cellular and molecular biology, to diagnosis and treatment. This book also has some additional focus on preclinical and clinical results in diagnosis and treatment of breast cancer. The book begins with introduction on epidemiology and pathophysiology of breast cancer in Section 1. In Section 2, the subsequent chapters introduce molecular and cellular biology of breast cancer with some particular signaling pathways, the gene expression, as well as the gene methylation and genomic imprinting, especially the existence of breast cancer stem cells. In Section 3, some new diagnostic methods and updated therapies from surgery, chemotherapy, hormone therapy, immunotherapy, radiotherapy, and some complementary therapies are discussed. This book provides a succinct yet comprehensive overview of breast cancer for advanced students, graduate students, and researchers as well as those working with breast cancer in a clinical setting.

Hormones Growth Factors & Oncogenes

Author : Enrique Pimentel
Publisher : CRC Press
ISBN 13 : 9780849353468
Total Pages : 274 pages
Book Rating : 4.3/5 (534 download)

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Book Synopsis Hormones Growth Factors & Oncogenes by : Enrique Pimentel

Download or read book Hormones Growth Factors & Oncogenes written by Enrique Pimentel and published by CRC Press. This book was released on 1987-06-30 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text examines the hormones and peptide growth factors involved in the regulation of metabolism, growth and differentiation in metazoan organisms and proto-oncogene expression. Investigates protein products of some proto-oncogenes for involvement in the transductional and post-transductional and mechanisms of hormones and peptide growth factors.

Autophagy and Cancer

Author : Hong-Gang Wang
Publisher : Springer Science & Business Media
ISBN 13 : 1461465613
Total Pages : 267 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis Autophagy and Cancer by : Hong-Gang Wang

Download or read book Autophagy and Cancer written by Hong-Gang Wang and published by Springer Science & Business Media. This book was released on 2013-03-30 with total page 267 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the explosion of information on autophagy in cancer, this is an opportune time to speed the efforts to translate our current knowledge about autophagy regulation into better understanding of its role in cancer. This book will cover the latest advances in this area from the basics, such as the molecular machinery for autophagy induction and regulation, up to the current areas of interest such as modulation of autophagy and drug discovery for cancer prevention and treatment. The text will include an explanation on how autophagy can function in both oncogenesis and tumor suppression and a description of its function in tumor development and tumor suppression through its roles in cell survival, cell death, cell growth as well as its influences on inflammation, immunity, DNA damage, oxidative stress, tumor microenvironment, etc. The remaining chapters will cover topics on autophagy and cancer therapy. These pages will serve as a description on how the pro-survival function of autophagy may help cancer cells resist chemotherapy and radiation treatment as well as how the pro-death functions of autophagy may enhance cell death in response to cancer therapy, and how to target autophagy for cancer prevention and therapy − what to target and how to target it.

The Heterogeneity of Cancer Metabolism

Author : Anne Le
Publisher : Springer
ISBN 13 : 331977736X
Total Pages : 186 pages
Book Rating : 4.3/5 (197 download)

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Book Synopsis The Heterogeneity of Cancer Metabolism by : Anne Le

Download or read book The Heterogeneity of Cancer Metabolism written by Anne Le and published by Springer. This book was released on 2018-06-26 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer therapeutic strategies.

Control of Animal Cell Proliferation

Author : Alton L. Boynton
Publisher : Elsevier
ISBN 13 : 1483277410
Total Pages : 576 pages
Book Rating : 4.4/5 (832 download)

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Book Synopsis Control of Animal Cell Proliferation by : Alton L. Boynton

Download or read book Control of Animal Cell Proliferation written by Alton L. Boynton and published by Elsevier. This book was released on 2013-09-24 with total page 576 pages. Available in PDF, EPUB and Kindle. Book excerpt: Control of Animal Cell Proliferation, Volume I presents how animals regulate their proliferation activity and how cells become proliferatively autonomous resulting in malignant behavior. This book provides an understanding of mechanisms that control animal cell proliferation. Organized into five parts encompassing 17 chapters, this volume begins with an overview of the efforts to elucidate he genetic alterations that lead normal cells to become cancer cells, which have been aided considerably by the investigation of acute retroviruses. This text then examines the factors involved in growth control. Other chapters describe in detail the biology and biochemistry of epidermal growth factor (EGF), which have been elucidated through the study of cultured human fibroblasts. This book discusses as well the protein kinases with specificity for tyrosine. The final chapter deals with regulation of initiation of eukaryotic protein synthesis by phosphorylation. This book is a valuable resource for scientists as well as cellular and molecular biologists.

Influence of Tumor Development on the Host

Author : L.A. Liotta
Publisher : Springer Science & Business Media
ISBN 13 : 940092528X
Total Pages : 250 pages
Book Rating : 4.4/5 (9 download)

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Book Synopsis Influence of Tumor Development on the Host by : L.A. Liotta

Download or read book Influence of Tumor Development on the Host written by L.A. Liotta and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent experimental evidence has made it increasingly clear In particular, this volume reviews the discrete steps involved that the properties of invasive, malignant cells during tumor in metastatic invasion: the interaction of invasive tumor cells development substantially impact on the host. This is under with extracellular matrices, the basement membrane, attach scored by a variety of biochemical properties of tumor cells ment to extracellular matrices, local proteolytic degradation during their differentiation and metastatic dissemination. of matrices, and the locomotion of invasive tumor cells These properties can be analyzed at different stages of tumor through such areas of localized degradation. The critical growth and progression and this volume explores the role of the cell surface in secondary tumor formation is characteristics of primary tumors as well as the shared reviewed as are important advances in the molecular biology characteristics of both primary and secondary tumors. of metastasis initiation and maintenance. Recent advances The primary tumor comes into existence following in the role of DNA methylation in the generation of tumor preneoplastic biochemical and cellular events that ultimate cell heterogeneity and tumor progression are also critically ly result in malignant transformation. Various aspects of summarized. Chapters in this volume also review molecular metabolism, predetermined by nutritional status, often play aspects of metastatic progression, and the use of the tech a basic role. Obesity, for example, is cancer-promoting. Cell nologies of DNA transfection and somatic cell fusion in the surface carbohydrates, cytoskeletal proteins, glycoproteins, exploration of molecular aspects of metastatic progression.

Translational Research in Cancer

Author : Sivapatham Sundaresan
Publisher :
ISBN 13 : 9781838805357
Total Pages : pages
Book Rating : 4.8/5 (53 download)

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Book Synopsis Translational Research in Cancer by : Sivapatham Sundaresan

Download or read book Translational Research in Cancer written by Sivapatham Sundaresan and published by . This book was released on 2021 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Water and Ions in Biological Systems

Author : Alberte Pullman
Publisher : Springer Science & Business Media
ISBN 13 : 1489904247
Total Pages : 793 pages
Book Rating : 4.4/5 (899 download)

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Book Synopsis Water and Ions in Biological Systems by : Alberte Pullman

Download or read book Water and Ions in Biological Systems written by Alberte Pullman and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 793 pages. Available in PDF, EPUB and Kindle. Book excerpt: As the First International Conference on Water and Ions in Biological Systems (Bucharest, June 25-27, 1980) was appreciated as a success, a second one was organized in the fall of the year 1982 under the sponsorship of the United Nations Educational, Scientific and Cultural Organization (UNESCO), the Romanian Academy of Medical Sciences, the Romanian Biophysical Society (Union of Societies for Medical Sciences in the Socialist Republic of Romania) and in co operation with the International Union for Pure and Applied Bio physics (IUPAB). The responsibility for the scientific program and organization of the Second Conference on Water fell on an International Scientific Committee which included Prof. J. Tigyi (Pees), President of the UNESCO Expert Committee on Biophysics, Prof. K. Wuthrich, Secretary General of IUPAB and Prof. H. Eisenberg, (member of the IUPAB Council) under the guidance of an Executive Board whose members were Prof. J. Jaz (representative of UNESCO), Prof. B. Pullman (Vice President of IUPAB) and Prof. V. Vasilescu (President of the Romanian Biophysical Society). The Meeting was attended by more than 250 specialists including 150 Romanian participants and others from Bulgaria, Czechoslovakia, England, the Federal Republic of Germany, the German Democratic Republic, Greece, Hungary, India, Israel, Italy, Japan, the Netherlands, Nigeria, Poland, Sweden, Switzerland, USSR, USA, Venezuela, Yugoslavia. The proceedings of the Conference took place in the Medical Faculty of Bucharest. The theoretical and practical importance of the Meeting was pointed out by the speakers, among whom were Prof.

Ion Channels in Health and Disease

Author : Geoffrey S. Pitt
Publisher : Academic Press
ISBN 13 : 0128020172
Total Pages : 392 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Ion Channels in Health and Disease by : Geoffrey S. Pitt

Download or read book Ion Channels in Health and Disease written by Geoffrey S. Pitt and published by Academic Press. This book was released on 2016-10-04 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ion Channels in Health and Disease provides key insight to allow researchers to generate discoveries across disease states. A single resource that integrates disparate areas of biology and disease ion channel biology, this publication includes cross-referencing for disease, channels, and tissues. Offers a broad view of research of interest to early and experienced researchers across biological and biomedical research. Provides an overview of fundamental concepts in ion channels research to link defects in human disease Written in an accessible manner, without jargon Provides a helpful, easy cross-reference for diseases, channels, and tissues

Protein Targeting, Transport, and Translocation

Author : Ross Dalbey
Publisher : Elsevier
ISBN 13 : 9780080480503
Total Pages : 336 pages
Book Rating : 4.4/5 (85 download)

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Book Synopsis Protein Targeting, Transport, and Translocation by : Ross Dalbey

Download or read book Protein Targeting, Transport, and Translocation written by Ross Dalbey and published by Elsevier. This book was released on 2002-04-09 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein Targeting, Transport, and Translocation presents an in-depth overview on the topic of protein synthesis, covering all areas of protein science, including protein targeting, secretion, folding, assembly, structure, localization, quality control, degradation, and antigen presentation. Chapters also include sections on the history of the field as well as summary panels for quick reference. Numerous color illustrations complement the presentation of material. This book is an essential reference for anyone in biochemistry and protein science, as well as an excellent textbook for advanced students in these and related fields. Basic principles and techniques Targeting adn sorting sequences Protein export in bacteria Membrane protein integration into ER and bacterial membranes Protein translocation across the ER Disulfide bond formation in prokaryotes and eukaryotes Quality control in the export pathway Import of proteins into organelles The secretory pathway Vesicular transport Spectacular color throughout

Biomedical Applications of Microprobe Analysis

Author : Peter Ingram
Publisher : Academic Press
ISBN 13 : 9780080524566
Total Pages : 545 pages
Book Rating : 4.5/5 (245 download)

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Book Synopsis Biomedical Applications of Microprobe Analysis by : Peter Ingram

Download or read book Biomedical Applications of Microprobe Analysis written by Peter Ingram and published by Academic Press. This book was released on 1999-10-29 with total page 545 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomedical Applications of Microprobe Analysis is a combination reference/laboratory manual for the use of microprobe analysis in both clinical diagnostic and research settings. Also called microchemical microscopy, microprobe analysis uses high-energy bombardment of cells and tissue, in combination with high resolution EM or confocal microscopy to provide a profile of the ion, metal, and mineral concentrations present in a sample. This allows insight into the physiology and pathophysiology of a wide variety of cells and tissues. This book describes methods for obtaining detailed information about the identity and composition of particles too small to be seen with the naked eye and describes how this information can be useful in diagnostic and biomedical research. Up-to-date review of electron microprobe analysis Detailed descriptions of sample preparation techniques Recent technologies including confocal microscopy, infrared microspectroscopy, and laser raman spectroscopy Over 100 illustrations with numerous specific applications Contributions by world-renowned experts in the field Brief summary of highlights precedes each chapter