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Author : Peter L. Pedersen
Publisher :
ISBN 13 :
Total Pages : 5 pages
Book Rating : 4.:/5 (793 download)
Download or read book Ion Motive ATPases. I. Ubiquity, Properties, and Significance to Cell Function written by Peter L. Pedersen and published by . This book was released on 1987 with total page 5 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Sajal Chakraborti
Publisher : Springer
ISBN 13 : 3319247808
Total Pages : 582 pages
Book Rating : 4.3/5 (192 download)
Download or read book Regulation of Ca2+-ATPases,V-ATPases and F-ATPases written by Sajal Chakraborti and published by Springer. This book was released on 2015-12-10 with total page 582 pages. Available in PDF, EPUB and Kindle. Book excerpt: The biological membranes of cellular organization enfold an important group of membrane proteins called the ATPases, which are not only versatile in maintaining chemical gradient and electrical potential across the membrane but also bring metabolites necessary for cell metabolism and drive out toxins, waste products and solutes that otherwise can curb cell functions. ATPases are distributed virtually in all live forms starting from unicellular to multicellular and also in viruses. There are different types of ATPases, which differ in function and structure and in the type of ions they transport. The three main types of the ion pump ATPase family are: (i) P-type ATPases that transport different ions across membranes and Ca2+ATPases belongs to this catagory (ii) F-type ATPase in mitochondria, chloroplasts and bacterial plasma membranes produce ATP using the proton gradient; and (iii) V-type ATPase catalyzes ATP hydrolysis to transport solutes and maintains acidic pH in organelles like lysosomes. Genetic defects in either of the ATPases cause several diseases and a number of researches have demonstrated the involvement of the members of ATPases in the cell pathology and diseases, thereby penetrating exciting new areas of our understanding. In this book, the authors summarize recent knowledge about the molecular mechanisms associated with Ca2+-ATPase, V-ATPase and F-ATPase in intracellular and extracellular Ca2+ transport, mitochondrial ATP synthase, vesicular H+ transport, and lysosomal pH regulation. This book thereby bridges the gap between fundamental research and biomedical and pharmaceutical applications. The book provides an informative resource to improve ATPase research and modern therapeutic approaches toward different life threatening diseases that are associated with dysregulation of the ATPases.
Author : A.G. Lee
Publisher : Elsevier
ISBN 13 : 0080527701
Total Pages : 441 pages
Book Rating : 4.0/5 (85 download)
Download or read book ATPases written by A.G. Lee and published by Elsevier. This book was released on 1996-12-17 with total page 441 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume 5 of Biomembranes covers an important group of membrane proteins, the ATPases. The P-type ATPases couple the hydrolysis of ATP to the movement of ions across a membrane and are characterized by the formation of a phosphoyrlated intermediate. Included are the plasma membrane and muscle sarcoplasmic reticulum Ca2+ -ATPases, the (Na+ -K+) -ATPase, the gastric (H+ -K+) -ATPase, the plasma membrane H+ -ATPase of fungi and plants, the Mg2+ - transport ATPase, the Salmonella typhimurium, and the K+ -ATPase of Escherichia coli, KdpB. The other important classes of ATPase in eukaryotic systems are the vacuolar H+ -ATPases and the F0F1 ATP synthase, and, in bacteria, the anion-translocating ATPases, responsible for resistance to arsenicals and antimonials, and the (Na+ -Mg2+) -ATPase of Acholeplasma. Finally, eukaryotic systems contain a variety of ectonucleotidases important, for example, in hydrolysis of extracellular ATP released as a cotransmitter from cholinergic and adrenergic nerve terminals. Volume 5 of Biomembranes explores structure-function relationships for these mebrane-bound ATPases.
Author : Edward Bittar
Publisher : Elsevier
ISBN 13 : 0080528732
Total Pages : 361 pages
Book Rating : 4.0/5 (85 download)
Download or read book Cell Chemistry and Physiology: Part III written by Edward Bittar and published by Elsevier. This book was released on 1996-06-17 with total page 361 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first section of this volume consists of five chapters to the nature of membrane transport systems. A chapter on secondary active glucose transport has been omitted because this topic is slated to appear in the Nephrobiology module. Chapter 6 deals with oxidase control of plasma membrane proton transport, while chapter 7 addresses the question of how cell volume is regulated. Although we chose not to have a separate chapter covering additional co-transport systems namely, Na+ -K+ -2CI-, KCI, -HCO-3, as well as CI- -HCO-3 exchange and K+ and CI- movements through channels, the role of each in cell volume regulation is emphasized in Chapter 7. Instead of devoting an entire section to the thermodynamics of metabolism, we thought it desirable to have the subjects of medical imaging and NMR of cell metabolism discussed in some detail in two chapters. These are followed by a chapter on the thermodynamic instrument - the calorimeter. Calrimetry allows the measurement of net changes of heat in cells, tissues, organs and whole body. As will be recognized, heat dissipation does not arise only from chemical reactions but also from interactions between macromolecules and conformational changes in protein complexes and mass Ca2+ movement such as that occurring in contracting skeletal muscle. The last chapter provides an account of equilibrium and non-equilibrium thermodynamics and the enthalpy balance method. It reveals that calometric measurements are useful in studies of clinical and toxicological problems.
Author :
Publisher : Academic Press
ISBN 13 : 0080585388
Total Pages : 365 pages
Book Rating : 4.0/5 (85 download)
Download or read book Cellular and Molecular Approaches to Fish Ionic Regulation written by and published by Academic Press. This book was released on 1995-07-17 with total page 365 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many physiological processes are regulated by the movement of ions into and out of organs, tissues, and cells. During the past decade, a variety of new techniques and approaches have contributed to a deeper understanding of the myriad influences ions have on the function and structure of organisms. From respiration and excretion to neurological control and metabolic processing, ions and their regulation occupy a central role in physiology of fish as well as other organisms. Comprehensive update of ionic regulation in fish Focuses on wide variety of organ systems and the influence of ions on organ system function Contributions from an international group
Author : A. Kleinzeller
Publisher : Newnes
ISBN 13 : 0444598197
Total Pages : 374 pages
Book Rating : 4.4/5 (445 download)
Download or read book Exploring the Cell Membrane: Conceptual Developments written by A. Kleinzeller and published by Newnes. This book was released on 2012-12-02 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt: The suggestion for this collection of essays originated in part from a course given to graduate students at the University of Pennsylvania School of Medicine. In sections of this course, the conceptual developments in the fields of membrane transport and cellular respiration were traced to illustrate general aspects of the development of ideas in a scientific field. Discussions with peers on the topic also greatly enhanced the development of the project as it is reflected in this book. The volume reflects the breadth and scope of this rapidly developing field, and is an excellent treatise of a historical evaluation of how this field has developed.
Author : Harold L. Drake
Publisher : Springer Science & Business Media
ISBN 13 : 146151777X
Total Pages : 660 pages
Book Rating : 4.4/5 (615 download)
Download or read book Acetogenesis written by Harold L. Drake and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 660 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first volume to provide comprehensive coverage of acetogenesis. Leading experts present state-of-the-art research, investigating the structure and function relationship of key acetogenic processes, including synthesis of ATP, the conservation of energy, and intersecting metabolic pathways. It explores the interactions between acetogenic bacteria and the flow of matter and energy, giving the reader an integrated perspective on acetogens and the environment. It presents landmark advances in the biochemistry, phylogeny, and molecular biology of acetogens, with lucid explanations of background material, making this volume accessible to newcomers to the subject. It discusses diverse functions of acetogenesis in soils, and gastrointestinal tracts, as well as current and potential commercial and environmental applications. This volume will serve as a broad and in-depth review of basic and emerging issues in acetogenesis for microbiologists, molecular biologists, biochemists, and ecologists, and as a stimulus for future research.
Author : Donald. Grierson
Publisher : Springer Science & Business Media
ISBN 13 : 1461536669
Total Pages : 241 pages
Book Rating : 4.4/5 (615 download)
Download or read book Plant Molecular Biology written by Donald. Grierson and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 241 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the preface to the first edition ofthis book, we expressed a conviction that there was a need for a short book that highlighted important advances in the new discipline of plant molecular biology. The rapid development of this topic has been brought about by the recognition of the unique properties of plants in the study of growth and development together with the application of recombinant DNA techniques to tackle these problems. Plant cells contain DNA in nuclei, plastids and mitochondria, and so offer the unique challenge of studying the interaction of three separate genetic systems in a single organism. The molecular approach has provided, in recent years, a wealth of important information about how plants function, and how they interact with bacteria, fungi and viruses. Furthermore, plant development involves the regulation of gene expression in response to intern al and external signals, and plant molecular biology has provided a fundamental insight into how this development is regulated. This is not only of considerable scientific interest, but also has important implications for the production of plants and plant products in agriculture, horticulture and the food industries.
Author : Hirotoshi Morii
Publisher : Springer Science & Business Media
ISBN 13 : 1447106679
Total Pages : 824 pages
Book Rating : 4.4/5 (471 download)
Download or read book Calcium in Internal Medicine written by Hirotoshi Morii and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 824 pages. Available in PDF, EPUB and Kindle. Book excerpt: Calcium plays an enormous and varied role in living systems now widely appreciated by clinicians. Calcium in Internal Medicine demonstrates the physiological significance of calcium in clinical medicine and discusses the abnormal calcium metabolism in disorders such as renal failure, hypertension, atherosclerosis and osteoporosis. Hirotoshi Morii (Editor) linked the clinical use of vitamin D analogues in bone diseases, Yoshiki Nishizawa (Editor) researched the connection between calcium metabolism and atherosclerosis and Shaul G. Massry (Editor) was the first to systematize the importance of excess PTH in chronic renal failure. In addition to these areas, Calcium in Internal Medicine covers basic physiology, pathophysiology, nutritional requirements and the role of calcium in the development and treatment of other various diseases. The importance of calcium and its regulatory systems is brought together in one publication providing a useful reference tool for internists, rheumatologists and endocrinologists.
Author : J.P. Andersen
Publisher : Elsevier
ISBN 13 : 0080877079
Total Pages : 273 pages
Book Rating : 4.0/5 (88 download)
Download or read book Ion Pumps, Part A written by J.P. Andersen and published by Elsevier. This book was released on 1997-11-19 with total page 273 pages. Available in PDF, EPUB and Kindle. Book excerpt: Both eukaryotic and prokaryotic cells depend strongly on the function of ion pumps present in their membranes. The term ion pump, synonymous with active ion-transport system, refers to a membrane-associated protein that translocates ions uphill against an electrochemical potential gradient. Primary ion pumps utilize energy derived from chemical reactions or from the absorption of light, while secondary ion pumps derive the energy for uphill movement of one ionic species from the downhill movement of another species. In the present volume, various aspects of ion pump structure, mechanism, and regulation are treated using mostly the ion-transporting ATPases as examples. One chapter has been devoted to a secondary ion pump, the Na+-Ca2+ exchanger, not only because of the vital role played by this transport system in regulation of cardiac contractility, but also because it exemplifies the interesting mechanistic and structural similarities between primary and secondary pumps.
Author : Lorenza González-Mariscal
Publisher : Springer Science & Business Media
ISBN 13 : 0387366733
Total Pages : 235 pages
Book Rating : 4.3/5 (873 download)
Download or read book Tight Junctions written by Lorenza González-Mariscal and published by Springer Science & Business Media. This book was released on 2007-02-26 with total page 235 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides state-of-the-art insight into Tight Junctions (TJs), the intersection of epithelial and endothelial cells in various tissues. Opening with an analysis of the evolutionary development of a transporting epithelium in early metazoans, the book describes current understanding of TJ structure and function information, including evidence supporting the presence of ion channels within TJs. Also deals with TJs of central nervous system myelin and at the blood brain barrier.
Author : M. P. Blaustein
Publisher : Springer Science & Business Media
ISBN 13 : 3540475478
Total Pages : 267 pages
Book Rating : 4.5/5 (44 download)
Download or read book Reviews of Physiology, Biochemistry and Pharmacology written by M. P. Blaustein and published by Springer Science & Business Media. This book was released on 2006-04-11 with total page 267 pages. Available in PDF, EPUB and Kindle. Book excerpt: P.J. Pearson, P.M. Vanhoutte: Vasodilator and Vasoconstrictor Substances Produced by the Endothelium. L. Dux: Muscle Relaxation and Sarcoplasmic Reticulum Function in Different Muscle Types. C.C. Ashley, P.J. Griffith, T.J. Lea, I.P. Mulligan, R.e. Palmer, and S.J. Simnett: Barnacle Muscle: Ca2+ Activation and Mechanics.
Author : Ralph A. Bradshaw
Publisher : Academic Press
ISBN 13 : 0080533574
Total Pages : 2560 pages
Book Rating : 4.0/5 (85 download)
Download or read book Handbook of Cell Signaling, Three-Volume Set written by Ralph A. Bradshaw and published by Academic Press. This book was released on 2003-12-02 with total page 2560 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Handbook of Cell Signaling is a comprehensive work covering all aspects of intracellular signal processing, including extra/intracellular membrane receptors, signal transduction, gene expression/translation, and cellular/organotypic signal responses. The subject matter has been divided into five main parts (each of which is headed by a recognized expert in the field): * Initiation: Extracellular and Membrane Events * Transmission: Effectors and Cytosolic Events * Nuclear Responses: Gene Expression and Translation * Events in Intracellular Compartments * Cell-Cell and Cell-Matrix Interactions Covered in extensive detail, these areas will appeal to a broad, cross-disciplinary audience interested in the structure, biochemistry, molecular biology and pathology of cellular effectors. Tabular and well-illustrated, the Handbook will serve as an in-depth reference for this complex and evolving field. Tabular and well illustrated, the Handbook will serve as an in-depth reference for this complex and evolving field! * Contains approximately 470 articles * Provides well-organized sections on each essential area in signaling * Includes discussion on everything from ligand/receptor interactions to organ/organism responses * Extremely user-friendly
Author : E. Kenneth Weir
Publisher : Springer Science & Business Media
ISBN 13 : 1461523974
Total Pages : 345 pages
Book Rating : 4.4/5 (615 download)
Download or read book Ion Flux in Pulmonary Vascular Control written by E. Kenneth Weir and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 345 pages. Available in PDF, EPUB and Kindle. Book excerpt: 6 Ions can pass through a single membrane channel at a rate of 10 ions/second. Over the last decade the ability to measure ion flux so precisely and to document the opening and closing of individual ion channels has provided a powerful tool to those working on smooth muscle physiology and vascular reactivity. The use of potassium channel blockers by Tom Lloyd in the 1960s and calcium channel blockers by Ivan McMurtry in the 1970s indicated the importance of ion flux in regulating pulmonary vascular tone. Recent advances in technology. principally the patch-clamp technique and fluorescent ion-sensitive dyes. now permit a more detailed description of physiologic mechanisms. This volume arises from the Sixth Grover Conference on the Pulmonary Circulation. a NATO Advanced Research Workshop. held in Colorado in October 1992. A group of international sCientists who are leaders in the field of ion flux focused their attention on the problems of the pulmonary vasculature. The chapters in this book describe the present state of knowledge of the movement and storage of ions in vascular endothelial and smooth muscle cells. Those who are not familiar with the techniques of patch clamping and calcium imaging will find an introduction to these methods in the chapters by Leblanc and Wan and Archer et al. The role of potassium channels in oxygen sensing illustrates the rapid progress which the study of ion currents has made possible.
Author : John H. Byrne
Publisher : Academic Press
ISBN 13 : 0123982677
Total Pages : 692 pages
Book Rating : 4.1/5 (239 download)
Download or read book From Molecules to Networks written by John H. Byrne and published by Academic Press. This book was released on 2014-05-23 with total page 692 pages. Available in PDF, EPUB and Kindle. Book excerpt: An understanding of the nervous system at virtually any level of analysis requires an understanding of its basic building block, the neuron. The third edition of From Molecules to Networks provides the solid foundation of the morphological, biochemical, and biophysical properties of nerve cells. In keeping with previous editions, the unique content focus on cellular and molecular neurobiology and related computational neuroscience is maintained and enhanced. All chapters have been thoroughly revised for this third edition to reflect the significant advances of the past five years. The new edition expands on the network aspects of cellular neurobiology by adding new coverage of specific research methods (e.g., patch-clamp electrophysiology, including applications for ion channel function and transmitter release; ligand binding; structural methods such as x-ray crystallography). Written and edited by leading experts in the field, the third edition completely and comprehensively updates all chapters of this unique textbook and insures that all references to primary research represent the latest results. The first treatment of cellular and molecular neuroscience that includes an introduction to mathematical modeling and simulation approaches 80% updated and new content New Chapter on "Biophysics of Voltage-Gated Ion Channels" New Chapter on "Synaptic Plasticity" Includes a chapter on the Neurobiology of Disease Highly referenced, comprehensive and quantitative Full color, professional graphics throughout All graphics are available in electronic version for teaching purposes
Author : Sigrid A. Langhans
Publisher : Frontiers Media SA
ISBN 13 : 2889457117
Total Pages : 265 pages
Book Rating : 4.8/5 (894 download)
Download or read book P-type ATPases in Health and Disease written by Sigrid A. Langhans and published by Frontiers Media SA. This book was released on 2019-01-11 with total page 265 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Edward Bittar
Publisher : Elsevier
ISBN 13 : 0080528740
Total Pages : 415 pages
Book Rating : 4.0/5 (85 download)
Download or read book Cell Chemistry and Physiology: Part II written by Edward Bittar and published by Elsevier. This book was released on 1996-05-14 with total page 415 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume illustrates the extent to which the traditional distinction between biochemical and physiological processes is being obliterated by molecular biology. It can hardly be doubted that the revolution in cell and molecular biology is leading to core knowledge that provides an outline of the integrative and reductionist approach. We view this as the beginning of a new era, that of the integration of learning. As in the preceding volumes, the choice of topics has been deliberate not only because of the need to keep the volume within reasonable bounds but also because of the need to avoid information over-load. Several relevant topics are dealt with in other modules; for example, the role of G proteins in transmembrane signalling is covered in the Membranes and Cell Signalling module (i.e., Volume 7). Omissions are of course inevitable but they are minor. A case in point is the subject of phosphatases, the treatment of which does not take into account calcineurin. One of the key functions of this Ca2+ -activated protein phosphatase that is also regulated by calmodulin is to desphosphorylate voltage-dependent Ca2+ channels. The mere recognition of such omissions before or after consulting textbooks and journals should be a spur to a more complete discussion by the student of the subject in a small group teaching setting.
