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Ion Channels Of Excitable Cells
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Book Synopsis Ionic Channels of Excitable Membranes by : Bertil Hille
Download or read book Ionic Channels of Excitable Membranes written by Bertil Hille and published by Sinauer Associates, Incorporated. This book was released on 1992 with total page 632 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new, fully revised and expanded edition of Ionic Channels of Excitable Membranes includes new chapters on fast chemical synapses, modulation through G protein coupled receptors and second messenger systems, molecules cloning, site directed mutagenesis, and cell biology. It begins with the classical biophysical work of Hodgkin and Huxley and then weaves a description of the known ionic channels together with their biological functions. The book continues by developing the physical and molecular principles needed for explaining permeation, gating, pharmacological modification, and molecular diversity, and ends with a discussion of channel evolution. Ionic Channels of Excitable Membranes is written to be accessible and interesting to biological and physical scientists of all kinds.
Book Synopsis Ion Channels of Excitable Cells by : Toshio Narahashi
Download or read book Ion Channels of Excitable Cells written by Toshio Narahashi and published by Academic Press. This book was released on 2013-10-22 with total page 402 pages. Available in PDF, EPUB and Kindle. Book excerpt: Because of the highly significant and widely recognized roles of ion channels in physiology, pathophysiology, pharmacology, and toxicology, the term ion channel has now become a household word in the biomedical sciences. This volume covers preparations and techniques for the study of various ion channels. Both voltage-gated and ligand-gated ion channels of neurons, axons, and cardiac and smooth muscles are covered. It includes not only patch clamp techniques but molecular biology and imaging techniques as well. Comprehensive protocols included for the study of: Ion channels using patch-clamp, molecular biology, and imaging techniques Role of ion channels in physiology, pathophysiology, pharmacology, and toxicology Specific ion channels of specific tissues
Book Synopsis Molecular Biology of The Cell by : Bruce Alberts
Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Calcium Entry Channels in Non-Excitable Cells by : Juliusz Ashot Kozak
Download or read book Calcium Entry Channels in Non-Excitable Cells written by Juliusz Ashot Kozak and published by CRC Press. This book was released on 2017-07-14 with total page 343 pages. Available in PDF, EPUB and Kindle. Book excerpt: Calcium Entry Channels in Non-Excitable Cells focuses on methods of investigating the structure and function of non-voltage gated calcium channels. Each chapter presents important discoveries in calcium entry pathways, specifically dealing with the molecular identification of store-operated calcium channels which were reviewed by earlier volumes in the Methods in Signal Transduction series. Crystallographic and pharmacological approaches to the study of calcium channels of epithelial cells are also discussed. Calcium ion is a messenger in most cell types. Whereas voltage gated calcium channels have been studied extensively, the non-voltage gated calcium entry channel genes have only been identified relatively recently. The book will fill this important niche.
Book Synopsis Handbook of Ion Channels by : Jie Zheng
Download or read book Handbook of Ion Channels written by Jie Zheng and published by CRC Press. This book was released on 2015-02-25 with total page 682 pages. Available in PDF, EPUB and Kindle. Book excerpt: The New Benchmark for Understanding the Latest Developments of Ion ChannelsIon channels control the electrical properties of neurons and cardiac cells, mediate the detection and response to sensory stimuli, and regulate the response to physical stimuli. They can often interact with the cellular environment due to their location at the surface of ce
Book Synopsis Ionic Channels of Excitable Membranes by : Bertil Hille
Download or read book Ionic Channels of Excitable Membranes written by Bertil Hille and published by Sinauer Associates, Incorporated. This book was released on 1984 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: Discusses the classic biophysical work of Hodgkin and Huxley, weaves a description of the known ionic channels together with their biological functions, and then develops the physical and molecular principles needed for explaining permeation, gating, pharmacological modification, molecular diversity, and channel evolution. Includes new chapters on fast chemical synapses, modulation through G protein- coupled receptors and second messenger systems, molecular cloning, site-directed mutagenesis, and cell biology. Annotation copyrighted by Book News, Inc., Portland, OR
Book Synopsis Methods in Neurosciences: Ion channels of excitable cells by : P. Michael Conn
Download or read book Methods in Neurosciences: Ion channels of excitable cells written by P. Michael Conn and published by . This book was released on 1989 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Ion Channels written by David J. Aidley and published by Cambridge University Press. This book was released on 1996-08-13 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ion channels are crucial components of living cells. Situated in the cell's membranes. they allow particular ions to pass from one side of the membrane to the other. In recent years the patch clamp technique has allowed the activity of individual channels to be measured, and recombinant DNA technology has led to fascinating detail on their structure. Together, these technical advances have produced a great flowering of knowledge and understanding about the subject, itself leading to further breakthroughs in science and medicine. Ion Channels provides an introduction to this scientific endeavour. It emphasises the molecular structure of channels as determined by gene cloning technology. This knowledge illuminates discussions of the permeability and selectivity of channels, their gating and modulation, their responses to drugs and toxins and the human diseases caused when they do not function properly.
Book Synopsis The Physiology of Excitable Cells by : David J. Aidley
Download or read book The Physiology of Excitable Cells written by David J. Aidley and published by Cambridge University Press. This book was released on 1998-09-03 with total page 496 pages. Available in PDF, EPUB and Kindle. Book excerpt: The fourth edition of this highly successful text has been extensively revised and restructured to take account of the many recent advances in the subject and bring it right up to date. The classic observations of recent years can now be interpreted with the powerful new techniques of molecular biology. Consequently there is much new material throughout the book, including many new illustrations and extensive references to recent work. Its essential philosophy remains the same, though: fundamental concepts are clearly explained, and key experiments are examined in some detail. This textbook will be used by students of physiology, neuroscience, cell biology and biophysics. Specializing undergraduates and graduates as well as lecturers and researchers will find the text thorough and clearly written.
Download or read book Ion Channels written by T. Narahashi and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 347 pages. Available in PDF, EPUB and Kindle. Book excerpt: A wealth of information has been accumulated about the function of ion channels of excitable cells since the extensive and pioneering voltage clamp studies by Hodgkin, Huxley, and Katz 36 years ago. The study of ion chan nels has now reached a stage at which a quantum jump in progress is antici pated. There are many good reasons for this. Patch clamp techniques origi nally developed by Neher and Sakmann 12 years ago have made it possible to study the function of ion channels in a variety of cells. Membrane ionic currents can now be recorded practically from many types of cells using the whole-cell patch clamp technique. The opening and closing of individual ion channels can be analyzed using the single-channel patch clamp method. Techniques have also been developed to incorporate purified ion channels into lipid bilayers to reconstitute an "excitable membrane. " Advanced tech niques developed in molecular biology, genetics, and immunology, such as gene cloning and the use of monoclonal antibodies, are now being applied to the study of ion channels. A variety of drugs have now been found or are suspected to interact with ion channels to exert therapeutic effects. In addition to the classical exam ples, as represented by local anesthetics, many other drugs, including cal cium antagonists, psychoactive drugs, cardiac drugs, and anticonvulsants, shown to alter ion channel function. For certain pesticides such as have been pyrethroids and DDT, sodium channels are clearly the major target site.
Book Synopsis Ion Channels and Disease by : Frances M. Ashcroft
Download or read book Ion Channels and Disease written by Frances M. Ashcroft and published by Academic Press. This book was released on 1999-10-20 with total page 505 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ion channels are membrane proteins that act as gated pathways for the movement of ions across cell membranes. They play essential roles in the physiology of all cells. In recent years, an ever-increasing number of human and animal diseases have been found to result from defects in ion channel function. Most of these diseases arise from mutations in the genes encoding ion channel proteins, and they are now referred to as the channelopathies. Ion Channels and Disease provides an informative and up-to-date account of our present understanding of ion channels and the molecular basis of ion channel diseases. It includes a basic introduction to the relevant aspects of molecular biology and biophysics and a brief description of the principal methods used to study channelopathies. For each channel, the relationship between its molecular structure and its functional properties is discussed and ways in which genetic mutations produce the disease phenotype are considered. This book is intended for research workers and clinicians, as well as graduates and advanced undergraduates. The text is clear and lively and assumes little knowledge, yet it takes the reader to frontiers of what is currently known about this most exciting and medically important area of physiology. Introduces the relevant aspects of molecular biology and biophysics Describes the principal methods used to study channelopathies Considers single classes of ion channels with summaries of the physiological role, subunit composition, molecular structure and chromosomal location, plus the relationship between channel structure and function Looks at those diseases associated with defective channel structures and regulation, including mutations affecting channel function and to what extent this change in channel function can account for the clinical phenotype
Book Synopsis Voltage Gated Sodium Channels by : Peter C. Ruben
Download or read book Voltage Gated Sodium Channels written by Peter C. Ruben and published by Springer Science & Business Media. This book was released on 2014-04-15 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: A number of techniques to study ion channels have been developed since the electrical basis of excitability was first discovered. Ion channel biophysicists have at their disposal a rich and ever-growing array of instruments and reagents to explore the biophysical and structural basis of sodium channel behavior. Armed with these tools, researchers have made increasingly dramatic discoveries about sodium channels, culminating most recently in crystal structures of voltage-gated sodium channels from bacteria. These structures, along with those from other channels, give unprecedented insight into the structural basis of sodium channel function. This volume of the Handbook of Experimental Pharmacology will explore sodium channels from the perspectives of their biophysical behavior, their structure, the drugs and toxins with which they are known to interact, acquired and inherited diseases that affect sodium channels and the techniques with which their biophysical and structural properties are studied.
Book Synopsis Cellular Biophysics and Modeling by : Greg Conradi Smith
Download or read book Cellular Biophysics and Modeling written by Greg Conradi Smith and published by Cambridge University Press. This book was released on 2019-03-14 with total page 395 pages. Available in PDF, EPUB and Kindle. Book excerpt: What every neuroscientist should know about the mathematical modeling of excitable cells, presented at an introductory level.
Book Synopsis Structure and Function in Excitable Cells by : Donald Cheng
Download or read book Structure and Function in Excitable Cells written by Donald Cheng and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 495 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a collection of up-to-date research reviews dealing with various aspects of the structure and function of excitable cells. Its overall objective is to further the search for a better understanding of the mechanism of excitation on a structural and physicochemical basis. The chapters are written by active investigators from a variety of disciplines, repre senting many different points of view. Their complementary fields of expertise give this book the rare feature of extraordinary breadth. Excitability is a fundamental property of many biological systems. The mechanisms by which nerve impulses are initiated and propagated, and by which rhythmical activities are produced in nerve, muscle, and cardiac cells, can be fully elucidated only when the process of excitation is derived from fundamental principles applied to known structural forms, at both the macroscopic and the molecular level. The problems of excitation are complex, requiring knowledge of many aspects of cells, including their morphology, elec trobiology, chemical physics, and biochemistry.
Download or read book Ion Channels written by James N. C. Kew and published by . This book was released on 2010 with total page 586 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ion channels are intimately involved in the everyday physiological functions that enable us to live a full and varied life. When disease strikes, malfunction of ion channels or their dependent is often involved, either as the cause or the effect of the illness. Thus, billions of dollars have been, and still are being, invested in research to understand the physiological and pathophysiological functions of ion channels in an attempt to develop novel therapeutic treatments for a wide range of diseases. This book provides a comprehensive overview of ion channel structure and function. It comprises two major parts. Part one is an introductory overview of the ion channel superfamily and the generic aspects of ion channel function. This part also reviews the methodologies by which ion channel function can be studied from the perspective of performing detailed biophysical characterization through to the deployment of high throughput approaches for identifying novel ion channel ligands. Part two of the book provides an in-depth review of the individual ion channel subfamilies and, as such, is subdivided into four broad sections: Voltage-Gated Ion Channels, Extracellular Ligand-Gated Ion Channels, Intracellular Ligand-Gated Ion Channels, and Polymodal-Gated Ion Channels, with each chapter focused on specific family members. These chapters have been written by world leading experts and provide a detailed overview of the structure, biophysics, localization, pharmacology, physiology, and disease relevance of each particular ion channel subfamily. Reviewing both the basic principles of ion channel function and providing a detailed up-to-date review of the phsyiological and pharmacological aspects of individual ion channel sub-families, this book constitutes both an excellent introduction to the field for non-specialists, as well as a highly valuable reference text for experienced researchers already working in the ion channel area.
Book Synopsis Ion Channels in Health and Sickness by : Fatima Shad Kaneez
Download or read book Ion Channels in Health and Sickness written by Fatima Shad Kaneez and published by BoD – Books on Demand. This book was released on 2018-10-10 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ion channels are proteins that make pores in the membranes of excitable cells present both in the brain and the body. These cells are not only responsible for converting chemical and mechanical stimuli into the electrical signals but are also liable for monitoring vital functions. All our activities, from the blinking of our eyes to the beating of our heart and all our senses from smell to sight, touch, taste and hearing are regulated by the ion channels. This book will take us on an expedition describing the role of ion channels in congenital and acquired diseases and the challenges and limitations scientist are facing in the development of drugs targeting these membrane proteins.
Book Synopsis Mg2+ and Excitable Membranes by : Piergiorgio Strata
Download or read book Mg2+ and Excitable Membranes written by Piergiorgio Strata and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 153 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume presents the most recent research findings on the key role played by Mg2+ in the regulation of ion channels in excitable tissue. Contributions describe the multiple actions exerted by Mg2+ on the different types on ion channels controlling nerve and cardiac cell activity. Recent developments in the detection of single ion channel activity provide important insights into the mechanisms of action of Mg2+ at the channel level.
