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Investigation Of The Link Between Prolactin Mammary Gland Development And Carcinogenesis By Transcript Profiling
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Book Synopsis Investigation of the Link Between Prolactin, Mammary Gland Development and Carcinogenesis by Transcript Profiling by :
Download or read book Investigation of the Link Between Prolactin, Mammary Gland Development and Carcinogenesis by Transcript Profiling written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mammary lobuloalveolar development during pregnancy is controlled by the endocrine action of prolactin, estrogen and progesterone, but currently little is known of the transcriptional events that occur in response to these hormones. This study examines the transcriptional response of the mammary gland to the direct action of prolactin. Mammary tissue recombination experiments demonstrated that lobuloalveolar development is dependent upon the presence of prolactin receptors in mammary epithelium but not the stroma. Comparison of transcript profiles derived from recombined glands with and without epithelial prolactin receptors, from glands without epithelium, and from SCp2 cells treated with and without prolactin, allowed a small set of epithelial-specific prolactin-modulated transcripts to be identified. This included the epithelial specific Ets transcription factor Elf5. Elf5 expression decreased in Prlr(+/- ) mammary glands but there was no change in Prlr expression in Elf5(+/- ) mammary glands, indicate that ElfS acts downstream of prolactin. The expression of milk protein genes decreased in both Prlr(+/- ) and Elf5(+/- ) mammary glands, consistent with a role for Elf5 in mediating prolactin-induced epithelial differentiation, however, the expression of a number of growth factors decreased in Prlr(+/- ) mammary glands but increased in Elf5(+/- ) mammary glands. Thus prolactin induces the expression of Elf5, which performs a pivotal role in mediating the switch from prolactin induced epithelial cell proliferation to differentiation within the mammary gland during pregnancy.
Book Synopsis Investigation of the Link Between Prolactin and Mammary Gland Development by Transcript Profiling by : Jessica Harris (Ph. D.)
Download or read book Investigation of the Link Between Prolactin and Mammary Gland Development by Transcript Profiling written by Jessica Harris (Ph. D.) and published by . This book was released on 2004 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Investigation of the Role of Prolactin in Mammary Gland Development and Carcinogenesis by : Samantha Richelle Oakes
Download or read book Investigation of the Role of Prolactin in Mammary Gland Development and Carcinogenesis written by Samantha Richelle Oakes and published by . This book was released on 2006 with total page 682 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Investigation of the Role of the Mitogenic Neuropeptide Galanin in Mammary Gland Development and Carcinogenesis by :
Download or read book Investigation of the Role of the Mitogenic Neuropeptide Galanin in Mammary Gland Development and Carcinogenesis written by and published by . This book was released on 2002 with total page 77 pages. Available in PDF, EPUB and Kindle. Book excerpt: Null mutation of the galanin gene produced lactational failure following pregnancy. Galanin and galanin receptor 2 (GALR2) are expressed in the mammary gland and are differentially regulated during mammopoiesis. Mammary transplantation experiments demonstrated galanin does not act via autocrine or paracrine mechanisms in the mammary gland. Galanin knockout mice have decreased levels of secreted prolactin and were also found to have an increased ratio of phosphorylated to unmodified prolactin. Unmodified prolactin rescued the lactation failure and treatment of wildtype mice with a molecular mimic of phosphorylated prolactin inhibited lactation and alveolar differentiation. In addition treatment of whole mammary gland explants with galanin resulted in a 3.8 fold increase in the number of lobuloalveoli demonstrating that galanin also has a direct endocrine action on the mammary gland. Investigation of signalling mechanisms showed that galanin activated the Jak/Stat pathway while prolactin activated the Jak/Stat and MAPK pathways. Galanin was a potent inducer of milk protein gene expression. Transcript profiling revealed the synergist activity of galanin and prolactin. These data identify several novel functions of galanin during mammary gland.
Book Synopsis Stress and Breast Cancer by : Cary L. Cooper
Download or read book Stress and Breast Cancer written by Cary L. Cooper and published by . This book was released on 1988 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years interest has increased in the links between stress and breast cancer, reflecting the growing concern at the continuing increase in the disease. This book brings together leading researchers in the field to review the evidence available.
Book Synopsis Hormone Action by : Bert W. O'Malley
Download or read book Hormone Action written by Bert W. O'Malley and published by . This book was released on 1974 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hormone assays; Hormone receptors; Evaluation of biological effects of hormones; Purification and synthesis of hormones.
Book Synopsis Second Harmonic Generation Imaging by : Francesco S. Pavone
Download or read book Second Harmonic Generation Imaging written by Francesco S. Pavone and published by Taylor & Francis. This book was released on 2016-04-19 with total page 465 pages. Available in PDF, EPUB and Kindle. Book excerpt: Second-harmonic generation (SHG) microscopy has shown great promise for imaging live cells and tissues, with applications in basic science, medical research, and tissue engineering. Second Harmonic Generation Imaging offers a complete guide to this optical modality, from basic principles, instrumentation, methods, and image analysis to biomedical a
Download or read book The Pituitary written by Shlomo Melmed and published by Academic Press. This book was released on 2010-12-09 with total page 745 pages. Available in PDF, EPUB and Kindle. Book excerpt: The pituitary, albeit a small gland, is known as the "master gland" of the endocrine system and contributes to a wide spectrum of disorders, diseases, and syndromes. Since the publication of the second edition of The Pituitary, in 2002, there have been major advances in the molecular biology research of pituitary hormone production and action and there is now a better understanding of the pathogenesis of pituitary tumors and clinical syndromes resulting in perturbation of pituitary function. There have also been major advances in the clinical management of pituitary disorders. Medical researchers and practitioners now better understand the morbidity and mortality associated with pituitary hormone hyposecretion and hypersecretion. Newly developed drugs, and improved methods of delivering established drugs, are allowing better medical management of acromegaly and prolactinoma. These developments have improved the worldwide consensus around the definition of a "cure" for pituitary disease, especially hormone hypersecretion, and hence will improve the success or lack of success of various forms of therapy. It is therefore time for a new edition of The Pituitary. The third edition will continue to be divided into sections that summarize normal hypothalamic-pituitary development and function, hypothalamic-pituitary failure, and pituitary tumors; additional sections will describe pituitary disease in systemic disorders and diagnostic procedures, including imaging, assessment of the eyes, and biochemical testing. The first chapter will be completely new – placing a much greater emphasis on physiology and pathogenesis. Two new chapters will be added on the Radiation and Non-surgical Management of the Pituitary and Other Pituitary Lesions. Other chapters will be completely updated and many new author teams will be invited. The second edition published in 2002 and there have been incredible changes in both the research and clinical aspects of the pituitary over the past 8 years – from new advances in growth hormones to pituitary tumor therapy. Presents a comprehensive, translational source of information about the pituitary in one reference work Pituitary experts (from all areas of research and practice) take readers from the bench research (cellular and molecular mechanism), through genomic and proteomic analysis, all the way to clinical analysis (histopathology and imaging) and new therapeutic approaches Clear presentation by endocrine researchers of the cellular and molecular mechanisms underlying pituitary hormones and growth factors as well as new techniques used in detecting lesions (within the organ) and other systemic disorders Clear presentation by endocrinologists and neuroendocrine surgeons of how imaging, assessment of the eyes, and biochemical testing can lead to new therapeutic approaches
Author :International association for breast cancer research. congress Publisher :IOS Press ISBN 13 :9781586036690 Total Pages :90 pages Book Rating :4.0/5 (366 download)
Book Synopsis The 25th Congress of the International Association for Breast Cancer Research by : International association for breast cancer research. congress
Download or read book The 25th Congress of the International Association for Breast Cancer Research written by International association for breast cancer research. congress and published by IOS Press. This book was released on 2006 with total page 90 pages. Available in PDF, EPUB and Kindle. Book excerpt: Talks about the theme 'Personalized Breast Cancer Therapy', which covers a number of areas of general interest to breast cancer researchers including sessions on pathology and molecular profiling of breast tumors, signal transduction, receptors and hormones, tumor microenvironment, cancer stem cells and clinical therapeutics.
Book Synopsis Intercellular Signalling in the Mammary Gland by : C.H. Knight
Download or read book Intercellular Signalling in the Mammary Gland written by C.H. Knight and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: All being done, we went to Mrs Shipmans, who is a great butter-woman; and I did see there the most of milke and cream, and the cleanest, that I ever saw in my life (29 May 1661). Among others, Sir Wm. Petty did tell me that in good earnest, he hath in his will left such parts of his estate to him that could invent such and such things -as among others, that could discover truly the way of milk coming into the breasts of a woman ... (22 March 1665). My wife tells me that she hears that my poor aunt James hath had her breast cut off here in tow- her breast having long been out of order (5 May 1665). From the Diary of Samuel Pepys, published as The Shorter Pepys (edited by R. Latham), Penguin Books (1987) The long-standing ultimate importance of research on the mammary gland is illustrated by the importance attached to cows' milk for human consumption, to human lactation and to breast cancer by Samuel Pepys and his contemporaries in the middle of the 17th century. Research has tended to develop in isolation in these three areas of continuing contemporary importance largely because in most countries, the underlying science of agricultural productivity is funded separately from the underlying science of human health and welfare.
Book Synopsis Advances in Immunohistochemistry by : Ronald A. DeLellis
Download or read book Advances in Immunohistochemistry written by Ronald A. DeLellis and published by . This book was released on 1988 with total page 516 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Biology of the Mammary Gland by : John A. Mol
Download or read book Biology of the Mammary Gland written by John A. Mol and published by Springer Science & Business Media. This book was released on 2006-04-11 with total page 309 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proceedings of the European Cooperation in the Field of Scientific and Technical Research (COST 825) Symposium on Mammary Gland Biology, held September 16-18, 1999, in Tours, France. It is difficult to overstate the evolutionary and functional significance of mammary tissue in biology. Substantial progress has been made by researchers in various disciplines, particularly over the last fifteen years, towards realizing the potential of this tissue to yield powerful experimental models for morphogenesis and tissue development; for cellular differentiation; for the biosynthesis and secretion of proteins, lipids, small molecules and inorganic salts; and for the coordination and regulation of these processes. More recently, the possibility of exploiting the secretory epithelial cells of mammary tissue as `cell factories' has become a reality and the recombinant production by lactating animals of an increasing number of proteins, valuable both in the pharmaceutical and `nutraceutical' fields, is in progress or under development. Also in this sphere of agricultural production, genetic as well as nutritional technologies are under investigation and exploitation to optimize milk composition for various end-uses - for instance in food process and manufacture. The possibilities of deriving health benefit from the bioactive properties of some of the minor constituents of milk are emerging to counter the highly-publicized negative health impact of excessive consumption of saturated animal fats. In human nutrition and medicine, the mammary gland is both a source of nutrition to the neonate and a potential health threat to the adult female - breast cancer remains the major single cause of female mortality in most developed countries. This volume provides a unique glimpse into our understanding, at the cutting edge of a variety of disciplines, of this versatile and extraordinary tissue, at the birth of the twenty-first century.
Download or read book Toxicological Profile for Lead written by and published by . This book was released on 2007 with total page 584 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The gestating and lactating sow by : Chantal Farmer
Download or read book The gestating and lactating sow written by Chantal Farmer and published by BRILL. This book was released on 2023-09-04 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt: The last book on the lactating sow was published over 15 years ago. This new book brings us up to date in current knowledge on the gestating and lactating sow. It covers new and important topics such as conditioning of gilts for optimal reproductive performance, feeding high fibre diets to gestating sows and providing various fat sources in gestation and lactation. It also describes the several key success factors to group-housing systems in gestation, which is a must due to the current move towards group-housing. The new concept of transition feeding for sows is discussed, as well as the factors involved in mammary development of gilts and sows, both of which are instrumental for maximum colostrum and/or milk yields. The impact of the human-animal interactions on sow welfare and performance is discussed with focus on new handling practices that could be developed to overbalance the negative interactions inherent to pig management systems. Updates on must-have topics, such as amino acid and energy requirements of sows, colostrum and milk yield and composition, and sow health are also provided. The subjects covered in this book will assist animal scientists, nutritionists, veterinarians and swine producers in learning the most recent information on relevant and current topics affecting sow production, and in knowing which areas are in need of further research efforts.
Book Synopsis The Endocrine System by : Joy Hinson
Download or read book The Endocrine System written by Joy Hinson and published by Churchill Livingstone. This book was released on 2010 with total page 185 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is an integrated textbook on the musculoskeletal system, covering the anatomy, physiology and biochemistry of the system, all presented in a clinically relevant context appropriate for the first two years of the medical student course. One of the seven volumes in the Systems of the Body series. Concise text covers the core anatomy, physiology and biochemistry in an integrated manner as required by system- and problem-based medical courses. The basic science is presented in the clinical context in a way appropriate for the early part of the medical course. There is a linked website providing self-assessment material ideal for examination preparation.
Book Synopsis Mechanisms of Differentiation by : Paul B. Fisher
Download or read book Mechanisms of Differentiation written by Paul B. Fisher and published by CRC Press. This book was released on 1990-09-20 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: Significant recent advances in cell culture technology now permit a detailed biochemical and molecular analysis of differentiation in both normal and tumor cells. These studies are important in attempting to understand the complex factors involved in normal growth and development, as well as the abnormalities associated with carcinogenesis. Mechanisms of Differentiation, Volumes I and II, is comprised of review chapters addressing various topics of current interest in this important area of research. Topics discussed include genes controlling differentiation, changes in gene expression during differentiation, induction of differentiation, induction of differentiation as a mode of action of chemotherapeutic agents, and the effect of cell shape, growth factors and differentiation modulating agents on the differentiated cell phenotype. Mechanisms of Differentiation is valuable to researchers involved in differentiation and development, carcinogenesis, cell biology, chemotherapy, and immunology.
Book Synopsis Recent Advances in Prolactin Research by : Maria Diakonova, PhD
Download or read book Recent Advances in Prolactin Research written by Maria Diakonova, PhD and published by Springer. This book was released on 2014-12-03 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent Advances in Prolactin Research summarizes the current knowledge of prolactin (PRL), PRL receptor, PRL-dependent signaling pathways, the role of PRL in oncogenesis and PRL crosstalk with other oncogenic factors. The chapters are written by experts in these fields and focus on identifying and reviewing timely experimental findings that provide new insights into the expanding role of PRL in the pathophysiology associated with a variety of human conditions. Prolactin is a peptide hormone that is best known for its role in lactation. Prolactin also has an influence on hematopoiesis and angiogenesis, and is involved in the regulation of blood clotting through several pathways. Although PRL was discovered more than 80 years ago, the understanding of PRL signaling and its relationship to various pathologies is still very incomplete. PRL is not only a pituitary hormone with an important role in reproduction, but PRL also acts as a cytokine, modulating a wide variety of physiological processes. For example, data gathered during the last decade have demonstrated that locally produced PRL acts as the autocrine/paracrine factor and plays a contributory role during breast oncogenesis. In fact, the scientific and clinical communities have suggested that the manipulation of the PRL axis may lead to the successful treatment of breast cancer. However, recent work has demonstrated that the role of the PRL axis is much more complex than first envisaged.
