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Investigation Of Peripheral And Central Neuro Immune Interactions In The Pharmacological Intervention Of Chronic Pain Treatment
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Book Synopsis Investigation of Peripheral and Central Neuro-immune Interactions in the Pharmacological Intervention of Chronic Pain Treatment by : Thao Nguyen
Download or read book Investigation of Peripheral and Central Neuro-immune Interactions in the Pharmacological Intervention of Chronic Pain Treatment written by Thao Nguyen and published by . This book was released on 2008 with total page 198 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Pain and Neuroimmune Interactions by : Nayef E. Saadé
Download or read book Pain and Neuroimmune Interactions written by Nayef E. Saadé and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: For those of us involved in research on the neural mechanisms that relate tissue damage to pain. it is becoming more evident that the sensation of pain and suffering could be considered as part of a mechanism that involves not only sizeable areas in the brain but also simultaneous activations of the immune and the endocrine systems as well. A consensus is growing among specialists in the field that pain involves the sharing of molecular mechanisms between the nervous, immune and endocrine systems that can interact at peripheral and, ultimately, central levels. Furthermore, chronic pain could then be looked upon as a corollary of the imbalance in the cross talk between these systems, which could lead to new treatment strategies. The aim of this book is not to deal with acute pain that serves as an alarm signal, but to attempt to explain the molecular mechanisms of chronic pains considered as a multifactorial syndrome or disease.
Author :National Academies of Sciences, Engineering, and Medicine Publisher :National Academies Press ISBN 13 :0309459575 Total Pages :483 pages Book Rating :4.3/5 (94 download)
Book Synopsis Pain Management and the Opioid Epidemic by : National Academies of Sciences, Engineering, and Medicine
Download or read book Pain Management and the Opioid Epidemic written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2017-09-28 with total page 483 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug overdose, driven largely by overdose related to the use of opioids, is now the leading cause of unintentional injury death in the United States. The ongoing opioid crisis lies at the intersection of two public health challenges: reducing the burden of suffering from pain and containing the rising toll of the harms that can arise from the use of opioid medications. Chronic pain and opioid use disorder both represent complex human conditions affecting millions of Americans and causing untold disability and loss of function. In the context of the growing opioid problem, the U.S. Food and Drug Administration (FDA) launched an Opioids Action Plan in early 2016. As part of this plan, the FDA asked the National Academies of Sciences, Engineering, and Medicine to convene a committee to update the state of the science on pain research, care, and education and to identify actions the FDA and others can take to respond to the opioid epidemic, with a particular focus on informing FDA's development of a formal method for incorporating individual and societal considerations into its risk-benefit framework for opioid approval and monitoring.
Book Synopsis Peripheral Receptor Targets for Analgesia by : Brian E. Cairns
Download or read book Peripheral Receptor Targets for Analgesia written by Brian E. Cairns and published by John Wiley & Sons. This book was released on 2009-09-01 with total page 566 pages. Available in PDF, EPUB and Kindle. Book excerpt: A unique reference on peripheral pain receptor mechanisms While considerable advances have been made on pharmacotherapies for many chronic disease states, options available to treat chronic pain have remained relatively unchanged for decades. However, utilizing the receptors involved in peripheral pain transduction mechanisms offers a significant opportunity to create novel therapies for pain. A comprehensive review of peripheral pain mechanisms, Peripheral Receptor Targets for Analgesia: Novel Approaches to Pain Management provides a unique resource that brings together a body of knowledge that was previously widely dispersed. As such, it gives readers a framework for further basic and clinical studies on potential receptor targets, as well as the development of improved topical analgesics. Coverage includes: The latest discoveries by leading researchers relating to the function of various ion channels and receptors in the peripheral nervous system Novel delivery techniques An appendix listing currently available topical analgesic medications A Foreword by Professor Lars Arendt-Nielsen of the Center for Sensory-Motor Interaction (SMI) at Aalborg University An unmatched resource for improving drug therapies and making pain management more efficient, Peripheral Receptor Targets for Analgesia supplies pharmaceutical scientists, pharmacologists, neuroscientists, and graduate and upper-level undergraduate students with a comprehensive, up-to-date reference.
Book Synopsis Novel Neuroimmune Interactions in the Context of Neuropathic Pain and Anti-inflammatory Modulation with Transforming Growth Factor-[beta]1 by : Estefania Echeverry Castano
Download or read book Novel Neuroimmune Interactions in the Context of Neuropathic Pain and Anti-inflammatory Modulation with Transforming Growth Factor-[beta]1 written by Estefania Echeverry Castano and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: "Neuropathic pain is a debilitating problem affecting millions of people worldwide. This condition affects the quality of life and bears a substantial economic burden on society. Current drug treatments are often inadequate to treat this type of chronic pain, as they provide limited relief and are often accompanied with many undesired and difficult to manage side effects. It is imperative thus, to find new treatments that target alternative mechanisms from the currently approved drugs.The pathogenesis of neuropathic pain is very complex and involves structural, physiological and pharmacological changes throughout the neural axis (from the site of peripheral nerve injury to the spinal cord/brain). While a neuron-centric view has dominated the literature for decades and the way we approach neuropathic pain treatment, recent work has uncovered extensive neuroimmune interactions as substrates of this condition. Interactions between the immune and nervous systems occur at multiple levels, where different types of immune/glial cells and immune-derived substances are implicated in various stages of the pathogenesis. The four experimental chapters contained in this dissertation are in line with this recent recognition of the importance of neuroimmune mechanisms in neuropathic pain. In the work presented here, we sought to unravel novel neuroinflammatory mechanisms driving the aberrant pain condition in both the spinal cord and the peripheral nerve as well as to investigate the role of a potent anti-inflammatory cytokine, TGF-[beta]1, as a potential modulator of these mechanisms. Several important mechanisms have been observed: A) Modulation of the central and peripheral inflammatory reaction with TGF-[beta]1 significantly delays and attenuates mechanical allodynia and thermal hyperalgesia via immunosuppressive actions on glial cells (Chapter 2) and macrophages (Chapter 3). In the spinal cord TGF-[beta]1 inhibits microglial proliferation, astrocytic activation and release of pro-inflammatory cytokines and exerts neuroprotective effects resulting in a decrease in the production of MCP-1. At the site of the injury, exposure to TGF-[beta]1 reduces the number of macrophages, which release pro-inflammatory mediators, and modulates different populations of T-cells. B) In chapter 4 we demonstrate that sciatic nerve injury-induced neuropathic pain is associated with an increased permeability of the blood spinal cord barrier (BSCB). We observed that the spinal inflammatory reaction triggered by nerve injury is a key player in modulating this BSCB impairment. We identified MCP-1 as an endogenous trigger of BSCB leakage, which could be reversed using anti-inflammatory molecules TGF-[beta]1 and IL-10. C) Selective depletion of microglia with MAC-1-saporin results in impairment of mechanical and thermal hypersensitivities at both acute and chronic stages following nerve injury suggesting an important and persistent contribution of microglia in the pathogenesis of neuropathic pain. These results expand our understanding of the neuro-inflammatory mechanisms of neuropathic pain as well as propose that immunosuppression or blockade of the reciprocal signalling pathways between neuronal and non-neuronal cells offer new opportunities for disease modification and more successful management of pain. " --
Book Synopsis Mind over Matter - Regulation of Peripheral Inflammation by the CNS by : Michael Schäfer
Download or read book Mind over Matter - Regulation of Peripheral Inflammation by the CNS written by Michael Schäfer and published by Springer. This book was released on 2012-12-06 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: Several new developments in the field of neuroimmunology with focus on the brain-to-immune system communication have been the incentive for this PIR volume. It covers topics such as brain-immune interactions, the impact of stress on the immune response, pain and immunosuppression, the modulation of inflammation and pain by the sympathetic nervous system, consequences of nerve injury for the immune system, neuronal mechanisms of immune cell recruitment, and the modulation of the immune response by corticotropin-releasing hormone or adenosine. The authors are a unique group of scientists who are all interested in brain-to-immune interactions; however, each from a different perspective. The volume will serve both neurobiologists and immunologists to understand the influence of the central nervous system on peripheral inflammation. Many aspects of this book will also be stimulating for researchers in the pain field.
Book Synopsis Peripheral Receptor Targets for Analgesia by : Brian E. Cairns
Download or read book Peripheral Receptor Targets for Analgesia written by Brian E. Cairns and published by Wiley. This book was released on 2009-08-07 with total page 549 pages. Available in PDF, EPUB and Kindle. Book excerpt: A unique reference on peripheral pain receptor mechanisms While considerable advances have been made on pharmacotherapies for many chronic disease states, options available to treat chronic pain have remained relatively unchanged for decades. However, utilizing the receptors involved in peripheral pain transduction mechanisms offers a significant opportunity to create novel therapies for pain. A comprehensive review of peripheral pain mechanisms, Peripheral Receptor Targets for Analgesia: Novel Approaches to Pain Management provides a unique resource that brings together a body of knowledge that was previously widely dispersed. As such, it gives readers a framework for further basic and clinical studies on potential receptor targets, as well as the development of improved topical analgesics. Coverage includes: The latest discoveries by leading researchers relating to the function of various ion channels and receptors in the peripheral nervous system Novel delivery techniques An appendix listing currently available topical analgesic medications A Foreword by Professor Lars Arendt-Nielsen of the Center for Sensory-Motor Interaction (SMI) at Aalborg University An unmatched resource for improving drug therapies and making pain management more efficient, Peripheral Receptor Targets for Analgesia supplies pharmaceutical scientists, pharmacologists, neuroscientists, and graduate and upper-level undergraduate students with a comprehensive, up-to-date reference.
Book Synopsis Neuroimmune Interactions in Pain by : Ru-Rong Ji
Download or read book Neuroimmune Interactions in Pain written by Ru-Rong Ji and published by . This book was released on 2023 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: As lifespans increase, more people around the world find themselves victims of chronic pain. In spite of this, treatment options continue to be severely limited. Anti-inflammatory drugs can only do so much, while painkillers like opioids have led to crippling addictions and fatal overdoses. The subject of the book is the role of immune cells, including glial cells, and neuroimmune interactions in chronic pain. The book begins by examining the preclinical and clinical evidence supporting the involvement of non-neuronal cells in chronic pain. It discusses the interactions between non-neuronal cells and neurons in the regulation of chronic pain. It then presents the implications of these findings, including promising and emerging treatments such as specialized pro-resolving mediators (SPMs, such as resolvins and protectins), immune cell therapy, and complementary and alternative medicine, as well as neuromodulation and regenerative medicine, which may prove to be the turning point for hundreds of millions of patients world-wide who struggle to escape from the shadow of chronic pain. The book presents ground-breaking research that will alter current perspectives on chronic pain.
Book Synopsis Immune and Glial Regulation of Pain by : Joyce A. De Leo
Download or read book Immune and Glial Regulation of Pain written by Joyce A. De Leo and published by . This book was released on 2007 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Review of immune and glial factors within the peripheral and central nervous systems that relate to chronic pain states. Discussion of novel immune and glial targets for clinical pain control that may yield new analgesic drugs"--Provided by publisher.
Book Synopsis Novel Aspects of Pain Management by : Jana Sawynok
Download or read book Novel Aspects of Pain Management written by Jana Sawynok and published by Wiley-Liss. This book was released on 1999-08-11 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: Of related interest . . . Neuronal Nicotinic Receptors Pharmacology and Therapeutic Opportunities Edited by Stephen P. Arneric and Jorge D. Brioni Providing a comprehensive review of nicotinic receptors, this reference examines all aspects-from the molecular level to clinical applications. The editors cover the emerging molecular biological advances in the cloning of nAChRs, as well as the localization and regulation of these receptors, and the role these receptors have in central nervous system (CNS) disorder functions. Additionally, examined areas include in vivo pharmacology, and the therapeutic opportunities existing for agents that selectively interact with these receptors to treat CNS disorders. 1999 (0-471-24743-X) 440 pp. Purinergic Approaches in Experimental Therapeutics Edited by Kenneth A. Jacobson and Michael F. Jarvis Purinergic receptors are a type of neuroreceptor that has been found to have unique therapeutic potential as a chemical compound in the treatment of many neurological disorders such as Alzheimer's disease, chronic pain, Parkinson's disease, stroke, thrombosis, bladder function, stress, and cancer. This book covers the molecular pharmacology, medicinal chemistry, and experimental therapeutics of purinergic compounds. 1997 (0-471-14071-6) 600 pp.
Book Synopsis Cytokines and Pain by : L.R. Watkins
Download or read book Cytokines and Pain written by L.R. Watkins and published by Springer. This book was released on 2013-03-08 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: Within the past few years, it has become recognized that the immune system communicates to the brain. Substances released from activated immune cells (cytokines) stimulate peripheral nerves, thereby signaling the brain and spinal cord that infection/inflammation has occurred. Additionally, peripheral infection/inflammation leads to de novo synthesis and release of cytokines within the brain and spinal cord. Thus, cytokines effect neural activation both peripherally and centrally. Through this communication pathway, cytokines such as interleukin-1, interleukin-6 and tumor necrosis factor markedly alter brain function, physiology and behavior. One important but underrecognized aspect of this communication is the dramatic impact that immune activation has on pain modulation. The purpose of this book is to examine, for the first time, immune-to-brain communication from the viewpoint of its effect on pain processing. It is aimed both at the basic scientist and health care providers, in order to clarify the major role that substances released by immune cells play in pain modulation. This book contains chapters contributed by all of the major laboratories focused on understanding how cytokines modulate pain. These chapters provide a unique vantage point from which to examine this question, as the summarized work ranges from evolutionary approaches across diverse species, to the basics of the immune response, to the effect of cytokines on peripheral and central nervous system sites, to therapeutic potential in humans.
Download or read book Neuroimaging of Pain written by Luca Saba and published by Springer. This book was released on 2017-06-08 with total page 509 pages. Available in PDF, EPUB and Kindle. Book excerpt: Authored by world renowned scientists, this book expertly reviews all the imaging techniques and exciting new methods for the analysis of the pain, including novel tracers, biomarker, metabolomic and gene-array profiling, together with cellular, genetic, and molecular approaches. Recent advances in human brain imaging techniques have allowed a better understand of the functional connectivity in pain pathways, as well as the functional and anatomical alterations that occur in chronic pain patients. Modern imaging techniques have permitted rapid progress in the understanding of networks in the brain related to pain processing and those related to different types of pain modulation. Neuroimaging of Pain is designed to be a valuable resource for radiologists, neuroradiologists, neurologists and neuroscientists, working in hospitals and universities from junior trainees to consultants.
Book Synopsis NEUROINFLAMMATORY MECHANISMS OF CENTRAL SENSITIZATION ARE MEDIATED BY TNF- AND IL1-DRIVEN PATHWAYS IN A PASSIVE TRANSFER-TRAUMA MOUSE MODEL OF COMPLEX REGIONAL PAIN SYNDROME (CRPS) by : Nikolett Szentes
Download or read book NEUROINFLAMMATORY MECHANISMS OF CENTRAL SENSITIZATION ARE MEDIATED BY TNF- AND IL1-DRIVEN PATHWAYS IN A PASSIVE TRANSFER-TRAUMA MOUSE MODEL OF COMPLEX REGIONAL PAIN SYNDROME (CRPS) written by Nikolett Szentes and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuroinflammatory mechanisms of central sensitization are mediated by TNF- and IL1-driven pathways in a passive transfer-trauma mouse model of Complex Regional Pain Syndrome (CRPS) Nikolett Szentes1, Krisztina Pohu00f3czky1,2, Valu00e9ria Tu00e9kus1, Bu00e1lint Botz1, u00c1gnes Kemu00e9ny1,3, Tamu00e1s Kiss1, Zsuzsanna Ku00f6rnyei5, Krisztina Tu00f3th5, Serena Sensi6, Jenny Hawkes6, u00c1du00e1m Du00e9nes5, Andreas Goebel6,7, Zsuzsanna Helyes1,4[1] University of Pu00e9cs, Medical School, Department of Pharmacology and Pharmacotherapy & Ju00e1nos Szentu00e1gothai Research Centre, Centre for Neuroscience[2] University of Pu00e9cs, Faculty of Pharmacy, Department of Pharmacology[3] University of Pu00e9cs, Medical School, Department of Medical Biology[4] PharmInVivo Ltd., Pu00e9cs, Hungary[5] Momentum Laboratory of Neuroimmunology, Institute of Experimental Medicine, Hungary[6] Department of Translational Medicine, University of Liverpool[7] The Walton Centre NHS Foundation Trust, LiverpoolBackgroundComplex Regional Pain Syndrome (CRPS) is a severe chronic pain condition accompanied by hypersensitivity, swelling and autonomic dysfunctions after a small injury. The ethiology is unknown, but immune response against sensory nerve-derived antigens and complex neuro-immune interactions are involved. The therapy is unsatisfactory, therefore, there is need to explore the pathophysiological mechanisms and identify drug targets.MethodsFemale C57Bl/6 mice were treated daily with purified serum-IgG from CRPS patients or healthy volunteers following plantar skin-muscle incision. We determined the mechanonociceptive threshold, edeme, myeloperoxidase activity, inflammatory cytokines, microglia and astrocyte markers in pain-related brain regions. Fractalkin receptor (CX3CR1) gene-deficient mice were used to investigate microglia activation mechanisms. The effects of the interleukin 1 (IL-1) receptor antagonist anakinra, the inhibitor of its signaling Janus kinase tofacitinib, or the soluble tumor necrosis factor (TNF) receptor etanercept were investigated by 7-13-day experiments.ResultsSignificantly greater mechanical hyperalgesia and paw edema developed after incision in CRPS IgG-treated mice accompanied by a significant increase of astrocyte and microglia markers. Myeloperoxidase activity increased in the early phase but inflammatory cytokine concentrations did not change. CX3CR1 gene deficiency, as well as anakinra, tofacitinib and etanercept treatments significantly reduced CRPS IgG-induced hyperalgesia and increase neuroinflammation. Anakinra treatment decreased myeloperoxidase activity and glia activation.ConclusionsAutoantibody-induced neuroinflammation and central sensitization plays a crucial role in persistent CRPS-related pain. Glia activation is a key factor of this process via CX3CR1, IL-1- and TNF-signalling, through the JAK pathway. Blocking these receptors or inhibiting the signal transduction may represent new therapeutic perspectives.Support: National Brain Research Program (2017-1.2.1-NKP-2017-00002); GINOP-2.3.2-15-2016-00050 u201ePEPSYSu201d; EFOP-3.6.1-16-2016-00004, NTP-NFTu00d6-18-B-0454.
Book Synopsis Sickle Cell Pain by : Samir K. Ballas
Download or read book Sickle Cell Pain written by Samir K. Ballas and published by Lippincott Williams & Wilkins. This book was released on 2015-06-01 with total page 1004 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sickle Cell Pain is a panoramic, in-depth exploration of every scientific, human, and social dimension of this cruel disease. This comprehensive, definitive work is unique in that it is the only book devoted to sickle cell pain, as opposed to general aspects of the disease. The 752-page book links sickle cell pain to basic, clinical, and translational research, addressing various aspects of sickle pain from molecular biology to the psychosocial aspects of the disease. Supplemented with patient narratives, case studies, and visual art, Sickle Cell Pain’s scientific rigor extends through its discussion of analgesic pharmacology, including abuse-deterrent formulations. The book also addresses in great detail inequities in access to care, stereotyping and stigmatization of patients, the implications of rapidly evolving models of care, and recent legislation and litigation and their consequences.
Book Synopsis Relieving Pain in America by : Institute of Medicine
Download or read book Relieving Pain in America written by Institute of Medicine and published by National Academies Press. This book was released on 2011-10-26 with total page 383 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chronic pain costs the nation up to $635 billion each year in medical treatment and lost productivity. The 2010 Patient Protection and Affordable Care Act required the Department of Health and Human Services (HHS) to enlist the Institute of Medicine (IOM) in examining pain as a public health problem. In this report, the IOM offers a blueprint for action in transforming prevention, care, education, and research, with the goal of providing relief for people with pain in America. To reach the vast multitude of people with various types of pain, the nation must adopt a population-level prevention and management strategy. The IOM recommends that HHS develop a comprehensive plan with specific goals, actions, and timeframes. Better data are needed to help shape efforts, especially on the groups of people currently underdiagnosed and undertreated, and the IOM encourages federal and state agencies and private organizations to accelerate the collection of data on pain incidence, prevalence, and treatments. Because pain varies from patient to patient, healthcare providers should increasingly aim at tailoring pain care to each person's experience, and self-management of pain should be promoted. In addition, because there are major gaps in knowledge about pain across health care and society alike, the IOM recommends that federal agencies and other stakeholders redesign education programs to bridge these gaps. Pain is a major driver for visits to physicians, a major reason for taking medications, a major cause of disability, and a key factor in quality of life and productivity. Given the burden of pain in human lives, dollars, and social consequences, relieving pain should be a national priority.
Book Synopsis Case Studies in Pain Management by : Alan David Kaye
Download or read book Case Studies in Pain Management written by Alan David Kaye and published by Cambridge University Press. This book was released on 2014-10-16 with total page 547 pages. Available in PDF, EPUB and Kindle. Book excerpt: Edited by internationally recognized pain experts, this book offers 73 clinically relevant cases, accompanied by discussion in a question-and-answer format.
Book Synopsis Neuroimmune Interactions in Pain by : Ru-Rong Ji
Download or read book Neuroimmune Interactions in Pain written by Ru-Rong Ji and published by Springer Nature. This book was released on 2023-05-05 with total page 365 pages. Available in PDF, EPUB and Kindle. Book excerpt: As lifespans increase, more people around the world find themselves victims of chronic pain. In spite of this, treatment options continue to be severely limited. Anti-inflammatory drugs can only do so much, while painkillers like opioids have led to crippling addictions and fatal overdoses. The subject of the book is the role of immune cells, including glial cells, and neuroimmune interactions in chronic pain. The book begins by examining the preclinical and clinical evidence supporting the involvement of non-neuronal cells in chronic pain. It discusses the interactions between non-neuronal cells and neurons in the regulation of chronic pain. It then presents the implications of these findings, including promising and emerging treatments such as specialized pro-resolving mediators (SPMs, such as resolvins and protectins), immune cell therapy, and complementary and alternative medicine, as well as neuromodulation and regenerative medicine, which may prove to be the turning point for hundreds of millions of patients world-wide who struggle to escape from the shadow of chronic pain. The book presents ground-breaking research that will alter current perspectives on chronic pain.
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