Read Books Online and Download eBooks, EPub, PDF, Mobi, Kindle, Text Full Free.
Download Investigating Type I Collagen Self Assembly Processes And End Products full books in PDF, epub, and Kindle. Read online Investigating Type I Collagen Self Assembly Processes And End Products ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!
Author : Calvin Chia-Hung Cheng
Publisher :
ISBN 13 : 9780494856604
Total Pages : pages
Book Rating : 4.8/5 (566 download)
Download or read book Investigating Type I Collagen Self-Assembly Processes and End Products written by Calvin Chia-Hung Cheng and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Darren Anderson
Publisher :
ISBN 13 : 9780494157466
Total Pages : 698 pages
Book Rating : 4.1/5 (574 download)
Download or read book Collagen Self-assembly written by Darren Anderson and published by . This book was released on 2006 with total page 698 pages. Available in PDF, EPUB and Kindle. Book excerpt: Collagen is the major structural protein in mammals, and forms the basis of a variety of tissues essential for animal life, including bone, skin, teeth, cornea, tendon, and others. It self-assembles---both in vivo and in vitro---into a variety of biologically important structures, and this self-assembly process is highly dependent on solution pH, ionic strength, and the concentration of the collagen monomer. Kinetic studies demonstrating these dependencies are presented for the formation of the most important aggregate, native type collagen. The cold dissociation of collagen that does not contain complete non-helical telopeptide regions is also demonstrated. Based on these studies, five different types of collagen intermediates are identified and a partially hierarchical fibrillogenesis mechanism is proposed, along with a detailed kinetic model. In order to further understand collagen fibrillogenesis at a molecular level, a previously predicted structure of the collagen monomer is completely relaxed using condensed phase molecular dynamics simulations. For validation purposes, several experimentally solved model collagen structures are simulated in the same way, and the simulation results agree with the crystal structures to within the experimental error. Therefore, a structure of the collagen monomer is proposed that comprises the most complete model currently developed. This model forms the basis for two sets of simulations aimed at explaining the formation of several of the polymorphisms of collagen. First, a three-dimensional analysis of the interactions between collagen monomers in fibrillar aggregates is presented, including hydrophobic-hydrophobic and electrostatic interactions. An examination of these interactions as a function of overlap between monomers demonstrates the origin of the topological regularity in native type collagen. Second, a detailed molecular model for formation of segmental long spacing crystallites of collagen is presented, involving bridging of in-register collagen monomers by nucleotide triphosphate moieties at colocalized acidic and basic residues. The proposed model is confirmed using molecular mechanics and dynamics simulations.
Author : Matthew Freeman Paige
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (133 download)
Download or read book Assembly Mechanisms of Type I Collagen Aggregates written by Matthew Freeman Paige and published by . This book was released on 2000 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The solution-phase association of biological molecules to form aggregates has been studied from a variety of perspectives, such as the flocculation of polymers, association of colloids and the aggregation of proteins. The latter subject has been the target of particular attention, mainly because of its importance in biomedical applications as well as its implication in diseases such as spongiform encephalopathies and Alzheimer's disease. Investigating protein aggregation at a fundamental level, however, is often complicated by the poorly defined structures of the aggregation products formed, as well as by the difficulty in working with biological systems. In this thesis, studies of Type-I collagen, a rod-like protein which can undergo 'in vitro' aggregation into highly-ordered protein structures, have been carried out with a view towards determining the mechanisms by which protein aggregates form. Two particular aggregate structures have been investigated. The first, a block-like aggregate called segmental long spacing collagen, was formed by the addition of nucleotide triphosphates to collagen monomers. By analyzing aggregate structures, formation kinetics and growth thermodynamics, it was concluded that these aggregates form via a hierarchical growth mechanism involving the formation of a stable intermediate and subsequent fusion of these intermediates. The second form of aggregate investigated was a fibril referred to as fibrous long spacing collagen. In this case, particular insight was made into elucidating the structure of these fibrils using the atomic force microscope. Results obtained again suggest that this aggregate forms via a hierarchical mechanism, first forming stable 'protofibrils', which then merge in a complex manner to produce the final structure. In the final Part of this thesis, the capabilities of the atomic force microscope in performing imaging of dynamic, biological processes in real time was examined, and was used to image the enzymatic digestion of collagen fibrils by the protein collagenase. The utility of the atomic force microscopy for 'in situ' investigation of complex processes such as collagen formation is discussed with a view towards applying this technique to future work.
Author : Chuan Xu
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (131 download)
Download or read book Nanostructure and Nanomechanics of Collagen Self-Assemblies written by Chuan Xu and published by . This book was released on 2014 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This thesis outlines the development and application of methods for characterization of nanostructured biomaterials, specifically, collagen. Collagen is the most abundant protein in the human body and plays an important structural role. Therefore, research on the structural and mechanical properties of this protein is beneficial for disease treatment and health improvement, including the development of new materials for bioengineering. These newly developed techniques and methods demonstrated their merit in this research. They can potentially find the way to applications in broader areas, e.g. bio-engineering, medical science, nano technology and industry. A novel method called minimum indentation, which I developed, extracts the mechanical properties of superficial layers or nanometer scale objects in a sample with high precision. This is a true surface measurement with a detection depth of less than 10 nanometers. During sample testing, an atomic force microscope (AFM) tip jumps to contact with the sample surface when the tip-sample attractive force gradient increases and exceeds the cantilever spring constant. The jump-to-contact distance is determined by the sample mechanical properties and tip-sample surface adhesion. Hence proper interpretation of the jump-to-contact phenomenon yields sample surface mechanical properties. I present different models to suit for hydrophilic and hydrophobic surfaces. The minimum indentation method requires a different treatment in the presence of strong capillary effects. I develop this in the context of a study of segment-longspacing collagen crystallites (SLS). A combination of morphological and nanomechanical data yields a more complete picture of SLS nanostructure, including proposed growth mechanism and internal structure. Nanoidentation and persistence length are different methods to access complementary mechanical information. I apply them to investigate the fibrillogenosis of type I and type II collagens, demonstrating distinct growth stages and structure transition phenomena. Type I collagen fibrils are much longer than type II collagen fibrils and present different internal structures, with consequently different mechanical properties.
Author : Colin Michael Yoder
Publisher :
ISBN 13 :
Total Pages : 100 pages
Book Rating : 4.:/5 (122 download)
Download or read book Self Assembly of Type IV Collagen on PTFE written by Colin Michael Yoder and published by . This book was released on 2006 with total page 100 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Vincent Rotello
Publisher : John Wiley & Sons
ISBN 13 : 0470384042
Total Pages : 492 pages
Book Rating : 4.4/5 (73 download)
Download or read book Molecular Recognition and Polymers written by Vincent Rotello and published by John Wiley & Sons. This book was released on 2008-09-15 with total page 492 pages. Available in PDF, EPUB and Kindle. Book excerpt: State-of-the-art techniques for tapping the vast potential of polymers The use of specific non-covalent interactions to control polymer structure and properties is a rapidly emerging field with applications in diverse disciplines. Molecular Recognition and Polymers covers the fundamental aspects and applications of molecular recognition—in the creation of novel polymeric materials for use in drug delivery, sensors, tissue engineering, molecular imprinting, and other areas. This reference begins by explaining the fundamentals of supramolecular polymers; it progresses to cover polymer formation and self-assembly with a wide variety of examples, and then includes discussions of biomolecular recognition using polymers. With chapters contributed by the foremost experts in their fields, this resource: Provides an integrated resource for supramolecular chemistry, polymer science, and interfacial science Covers advanced, state-of-the-art techniques used in the design and characterization of non-covalent interactions in polymers Illustrates how to tailor the properties of polymeric materials for various applications Stand-alone chapters address specific applications independently for easy reference. This is a premier resource for graduate students and researchers in polymer chemistry, supramolecular chemistry, materials science, and physical organic chemistry.
Author : Jennifer J. McManus
Publisher : Humana
ISBN 13 : 9781493996803
Total Pages : 266 pages
Book Rating : 4.9/5 (968 download)
Download or read book Protein Self-Assembly written by Jennifer J. McManus and published by Humana. This book was released on 2020-08-08 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume explores experimental and computational approaches to measuring the most widely studied protein assemblies, including condensed liquid phases, aggregates, and crystals. The chapters in this book are organized into three parts: Part One looks at the techniques used to measure protein-protein interactions and equilibrium protein phases in dilute and concentrated protein solutions; Part Two describes methods to measure kinetics of aggregation and to characterize the assembled state; and Part Three details several different computational approaches that are currently used to help researchers understand protein self-assembly. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Thorough and cutting-edge, Protein Self-Assembly: Methods and Protocols is a valuable resource for researchers who are interested in learning more about this developing field.
Author : Gary Wnek
Publisher : CRC Press
ISBN 13 : 1498761437
Total Pages : 3145 pages
Book Rating : 4.4/5 (987 download)
Download or read book Encyclopedia of Biomaterials and Biomedical Engineering written by Gary Wnek and published by CRC Press. This book was released on 2008-05-28 with total page 3145 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by more than 400 subject experts representing diverse academic and applied domains, this multidisciplinary resource surveys the vanguard of biomaterials and biomedical engineering technologies utilizing biomaterials that lead to quality-of-life improvements. Building on traditional engineering principles, it serves to bridge advances in materials science, life sciences, nanotechnology, and cell biology to innovations in solving medical problems with applications in tissue engineering, prosthetics, drug delivery, biosensors, and medical devices. In nearly 300 entries, this four-volume Encyclopedia of Biomaterials and Biomedical Engineering, Second Edition, covers: essential topics integral to tissue engineering research: bioreactors, scaffolding materials and fabrication, tissue mechanics, cellular interaction, and development of major tissues and organs being attempted by researchers worldwide; artificial lungs and muscles, bio-artificial livers, and corneal, dental, inner ear, and total hip implants; tissue engineering of blood vessels, heart valves, ligaments, microvascular networks, skeletal muscle, and skin; bone remodeling, bone cement, and bioabsorbable bone plates and screws; controlled drug delivery, insulin delivery, and transdermal and ocular implant-based drug delivery; endovascular stent grafts, vascular grafts, and xenografts; 3-D medical imaging, electrical impedance imaging, and intravascular ultrasound; biomedical, protein adsorption, and in vivo cardiovascular modeling; polymer foams, biofunctional and conductive polymers, and electroactive polymeric materials; blood–material interactions, the bone–implant interface, host reactions, and foreign body responses and much more.
Author : Peter M. Royce
Publisher : John Wiley & Sons
ISBN 13 : 0471461172
Total Pages : 1201 pages
Book Rating : 4.4/5 (714 download)
Download or read book Connective Tissue and Its Heritable Disorders written by Peter M. Royce and published by John Wiley & Sons. This book was released on 2003-04-14 with total page 1201 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Second Edition of Connective Tissue and Its Heritable Disorders: Molecular, Genetic, and Medical Aspects is the definitive reference text in its field, with over 40% more pages on the nature, diagnosis, and treatment of disease than its predecessor. Collecting new research on disorders detailed in the first edition as well as on those previously excluded, editors Peter Royce and Beat Steinmann provide the most up-to-date clinical and scientific information for medical specialists treating affected individuals. Features of this revised and updated volume include detailed reviews of the clinical diagnosis, mode of inheritance, risk of recurrence, and prenatal diagnosis of each inherited connective tissue disorder; a thorough description of the morphology of connective tissues; a completely updated and revised section on the biology of the extracellular matrix; and the addition of syndromes such as craniosyntosis, and disorders of sulfate metabolism.
Author : Morten Karsdal
Publisher : Academic Press
ISBN 13 : 0128098996
Total Pages : 274 pages
Book Rating : 4.1/5 (28 download)
Download or read book Biochemistry of Collagens, Laminins and Elastin written by Morten Karsdal and published by Academic Press. This book was released on 2016-07-29 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biochemistry of Collagens, Laminins, and Elastin: Structure, Function, and Biomarkers provides a comprehensive introduction to collagen and structural proteins. Type I collagen is one of the most abundant molecules in the body, playing essential roles in different tissues, particularly bone and skin. A key aspect of type I collagen is its post-translational modifications which are essential for correct synthesis and structural integrity of collagens, for tissue-specific functionality, as well as for application as biomarkers of different pathologies. This volume summarizes current data on key structural proteins (collagens, laminins and elastin), reviews how these molecules affect pathologies, and describes selected modifications of proteins that result in altered signaling properties of the original extracellular matrix component. Further, it discusses the novel concept that an increasing number of components of the ECM harbor cryptic signaling functions that may be viewed as endocrine functions. Additionally, it highlights how this knowledge can be exploited to modulate fibrotic disease. - Provides a comprehensive introduction to collagen and structural proteins - Provides insight into emerging analytical technologies that can detect biomarkers of extracellular matrix degradation - Includes a chapter dedicated to the biomarkers of structural proteins - Contains insights into the biochemical interactions and changes to structural composition of proteins in disease states
Author : Peter Fratzl
Publisher : Springer Science & Business Media
ISBN 13 : 0387739068
Total Pages : 516 pages
Book Rating : 4.3/5 (877 download)
Download or read book Collagen written by Peter Fratzl and published by Springer Science & Business Media. This book was released on 2008-05-10 with total page 516 pages. Available in PDF, EPUB and Kindle. Book excerpt: Not only does this book provide a comprehensive review of current research advances in collagen structure and mechanics, it also explores this biological macromolecule’s many applications in biomaterials and tissue engineering. Readers gain an understanding of the structure and mechanical behavior of type I collagen and collagen-based tissues in vertebrates across all length scales, from the molecular (nano) to the organ (macro) level.
Author : Helena S. Azevedo
Publisher : Woodhead Publishing
ISBN 13 : 0081020120
Total Pages : 614 pages
Book Rating : 4.0/5 (81 download)
Download or read book Self-assembling Biomaterials written by Helena S. Azevedo and published by Woodhead Publishing. This book was released on 2018-04-17 with total page 614 pages. Available in PDF, EPUB and Kindle. Book excerpt: Self-assembling biomaterials: molecular design, characterization and application in biology and medicine provides a comprehensive coverage on an emerging area of biomaterials science, spanning from conceptual designs to advanced characterization tools and applications of self-assembling biomaterials, and compiling the recent developments in the field. Molecular self-assembly, the autonomous organization of molecules, is ubiquitous in living organisms and intrinsic to biological structures and function. Not surprisingly, the exciting field of engineering artificial self-assembling biomaterials often finds inspiration in Biology. More important, materials that self-assemble speak the language of life and can be designed to seamlessly integrate with the biological environment, offering unique engineering opportunities in bionanotechnology. The book is divided in five parts, comprising design of molecular building blocks for self-assembly; exclusive features of self-assembling biomaterials; specific methods and techniques to predict, investigate and characterize self-assembly and formed assemblies; different approaches for controlling self-assembly across multiple length scales and the nano/micro/macroscopic properties of biomaterials; diverse range of applications in biomedicine, including drug delivery, theranostics, cell culture and tissue regeneration. Written by researchers working in self-assembling biomaterials, it addresses a specific need within the Biomaterials scientific community. - Explores both theoretical and practical aspects of self-assembly in biomaterials - Includes a dedicated section on characterization techniques, specific for self-assembling biomaterials - Examines the use of dynamic self-assembling biomaterials
Author : Eugene J. Kucharz
Publisher : Springer Science & Business Media
ISBN 13 : 3642761976
Total Pages : 429 pages
Book Rating : 4.6/5 (427 download)
Download or read book The Collagens: Biochemistry and Pathophysiology written by Eugene J. Kucharz and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 429 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes every manner in which collagen is involved in normal anddisease-altered states of the various organs and systems. In the first part of the book the biochemical aspects of collagens are reviewed, including their structure, heterogeneity, syntheses, and degradation. The main part focuses on the involvement of collagen in bone, cartilage, tendon, muscle, heart, vessels, lungs, liver, skin, eye, ear, teeth, periodontal tissues, kidneys and reproductive, hemopoietic,and nervous systems. The influence of radiation and nutrition on collagen, the role of collagen in neoplasms, the hormonal control of its metabolism, immunobiology and the pharmacology of collagen are also described. The most important feature of the book is the comprehensive review of the medical aspects of collagen, from those known in detail to those only hypothesized including hereditary disorders affecting collagen and so-called collagen diseases. Each chapter reviewsknown or possible mechanisms of collagen involvement and changes in indices of collagen which can be measured in clinical practice to monitor these phenomena. The fact that collagen is involved into the pathophysiology of almost all organs and body systems means that physicians in almost all branches of medicine will find this book of great interest.
Author :
Publisher :
ISBN 13 :
Total Pages : 704 pages
Book Rating : 4.3/5 (555 download)
Download or read book Investigative Ophthalmology & Visual Science written by and published by . This book was released on 1995-10 with total page 704 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher :
ISBN 13 : 9780815332183
Total Pages : 0 pages
Book Rating : 4.3/5 (321 download)
Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher :
ISBN 13 :
Total Pages : 1828 pages
Book Rating : 4.3/5 (243 download)
Download or read book Cumulated Index Medicus written by and published by . This book was released on 2000 with total page 1828 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : F. Raquel Maia
Publisher : Springer Nature
ISBN 13 : 3031563638
Total Pages : 1322 pages
Book Rating : 4.0/5 (315 download)
Download or read book Handbook of the Extracellular Matrix written by F. Raquel Maia and published by Springer Nature. This book was released on with total page 1322 pages. Available in PDF, EPUB and Kindle. Book excerpt:
