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Intramembrane Cleaving Proteases I Clips
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Book Synopsis Intramembrane-Cleaving Proteases (I-CLiPs) by : Nigel M. Hooper
Download or read book Intramembrane-Cleaving Proteases (I-CLiPs) written by Nigel M. Hooper and published by Springer Science & Business Media. This book was released on 2007-06-21 with total page 147 pages. Available in PDF, EPUB and Kindle. Book excerpt: Authors Nigel M. Hooper and Otto von Guericke, world leaders in protease research, have written the first book that focuses on recent data stemming from the structural determination of intramembrane-cleaving proteases (I-CLiPs). You get the latest findings concerning the various roles that these proteases play in biology and in the course of diseases such as Alzheimer’s and viral infection.
Book Synopsis Symposium on Regulated Intramembrane Proteolysis by :
Download or read book Symposium on Regulated Intramembrane Proteolysis written by and published by . This book was released on 2007 with total page 5 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Enzymology at the Membrane Interface: Intramembrane Proteases by :
Download or read book Enzymology at the Membrane Interface: Intramembrane Proteases written by and published by Academic Press. This book was released on 2017-01-05 with total page 496 pages. Available in PDF, EPUB and Kindle. Book excerpt: Enzymology at the Membrane Interface: Intramembrane Proteases, Volume 584, the latest release in the Methods in Enzymology series, covers a subset of enzymes that work in the environment of the biological cell membrane. This field, called interfacial enzymology, involves a special series of experimental approaches for the isolation and study of these enzymes. - Covers a subset of enzymes that work in the environment of the biological cell membrane - Offers a series of experimental approaches for the isolation and study of enzymes
Book Synopsis Functional Analysis of the Intramembrane Cleaving Proteases Signal Peptide Peptidase-like (SPPL) 2a and 2b by : Torben Mentrup
Download or read book Functional Analysis of the Intramembrane Cleaving Proteases Signal Peptide Peptidase-like (SPPL) 2a and 2b written by Torben Mentrup and published by . This book was released on 2016 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Molecular Interactions and Mechanisms of Intramembrane-cleaving Aspartyl Proteases by : Stephen Hsueh-Jeng Lu
Download or read book The Molecular Interactions and Mechanisms of Intramembrane-cleaving Aspartyl Proteases written by Stephen Hsueh-Jeng Lu and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Strategies and Tools for Modulating Pathologic Protein Self-Assembly in Proteinopathies by : Gal Bitan
Download or read book Strategies and Tools for Modulating Pathologic Protein Self-Assembly in Proteinopathies written by Gal Bitan and published by Frontiers Media SA. This book was released on 2022-08-16 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Handbook of Proteolytic Enzymes by : Alan J. Barrett
Download or read book Handbook of Proteolytic Enzymes written by Alan J. Barrett and published by Academic Press. This book was released on 2012-10-30 with total page 4097 pages. Available in PDF, EPUB and Kindle. Book excerpt: Extensively revised and updated, the new edition of the highly regarded Handbook of Proteolytic Enzymes is an essential reference for biochemists, biotechnologists and molecular biologists. Edited by world-renowned experts in the field, this comprehensive work provides detailed information on all known proteolytic enzymes to date. This two-volume set unveils new developments on proteolytic enzymes which are being investigatedin pharmaceutical research for such diseases as HIV, Hepatitis C, and the common cold. Volume I covers aspartic and metallo petidases while Volume II examines peptidases of cysteine, serine, threonine and unknown catalytic type. A CD-ROM accompanies the book containing fully searchable text, specialised scissile bond searches, 3-D color structures and much more. - The only comprehensive book on proteolytic enzymes - Includes 671 chapters, each written by experts in their field, on proteolytic enzymes from all groups of living organisms and the viruses, including those that are currently major targets of pharmaceutical research - Accompanying CD-ROM provides fully searchable text, 2D structures of peptidases in color and links directly to PubMed and MEROPS databases - Each chapter describes in detail the enzyme name, its history, activity and specificity, structural chemistry, preparation, biological aspects and distinguishing features - Over 1000 peptidases included
Book Synopsis Pathophysiological Aspects of Proteases by : Sajal Chakraborti
Download or read book Pathophysiological Aspects of Proteases written by Sajal Chakraborti and published by Springer. This book was released on 2017-11-15 with total page 668 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive overview of the multifaceted field of protease in the cellular environment and focuses on the recently elucidated functions of complex proteolytic systems in physiology and pathophysiology. Given the breadth and depth of information covered in the respective contributions, the book will be immensely useful for researchers working to identify targets for drug development. Multidisciplinary in scope, the book bridges the gap between fundamental and translational research, with applications in the biomedical and pharmaceutical industry, making it a thought-provoking read for basic and applied scientists engaged in biomedical research. Proteases represent one of the largest and most diverse families of enzymes known, and we now know that they are involved in every aspect of a given organism’s life functions. Under physiological conditions, proteases are regulated by their endogenous inhibitors. However, when the activity of proteases is not correctly regulated, disease processes such as tumour progression, vascular remodelling, atherosclerotic plaque progression, ulcer, rheumatoid arthritis, Alzheimer’s disease and inflammation can result. Many infective microorganisms require proteases for replication or use them as virulence factors, which has facilitated the development of protease-targeted therapies for a variety of parasitic diseases.
Book Synopsis Presenilins and Nicastrin are Components of the -Secretease Complex Involved in APP and Notch Processing by : An Herreman
Download or read book Presenilins and Nicastrin are Components of the -Secretease Complex Involved in APP and Notch Processing written by An Herreman and published by Leuven University Press. This book was released on 2003-12 with total page 110 pages. Available in PDF, EPUB and Kindle. Book excerpt: "This is a Ph.D. dissertation. Dementia is a major cause of disability and mortality. The most frequent type of dementia is Alzheimer's disease, accounting for about 70% of all dementia cases. Worldwide, about 20 million people suffer from Alzheimer's disease. With the increasing number of elderly in the world, Alzheimer's disease represents more and more a major health problem with an enormous impact on individuals, families, the health care system, and the society. Therefore, it is imperative that we understand the etiologies, the risk factors and the pathogenic mechanisms involved in Alzheimer's disease in order to develop effective treatments that ameliorate or even prevent this illness."
Book Synopsis Proteases in Physiology and Pathology by : Sajal Chakraborti
Download or read book Proteases in Physiology and Pathology written by Sajal Chakraborti and published by Springer. This book was released on 2017-09-14 with total page 619 pages. Available in PDF, EPUB and Kindle. Book excerpt: Using a multidisciplinary approach, this book describes the biochemical mechanisms associated with dysregulation of proteases and the resulting pathophysiological consequences. It highlights the role and regulation of different types of proteases as well as their synthetic and endogenous inhibitors. The role of proteases was initially thought to be limited to general metabolic digestion. However, we now know that the role of protein breakdown is much more complex, and proteases have multiple functions: they are coupled to turnover and can affect protein composition, function and synthesis. In addition to eliminating abnormal proteins, breakdown has many modulatory functions, including activating and inactivating enzymes, modulating membrane function, altering receptor channel properties, affecting transcription and cell cycles and forming active peptides. The ubiquity of proteases in nature makes them an important target for drug development. This in-depth, comprehensive is a valuable resource for researchers involved in identifying new targets for drug development. With its multidisciplinary scope, it bridges the gap between fundamental and translational research in the biomedical and pharmaceutical industries, making it thought-provoking reading for scientists in the field.
Book Synopsis Neurodegenerative Diseases by : Uday Kishore
Download or read book Neurodegenerative Diseases written by Uday Kishore and published by BoD – Books on Demand. This book was released on 2013-05-15 with total page 642 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book highlights the pathophysiological complexities of the mechanisms and factors that are likely to be involved in a range of neuroinflammatory and neurodegenerative diseases including Alzheimer's disease, other Dementia, Parkinson Diseases and Multiple Sclerosis. The spectrum of diverse factors involved in neurodegeneration, such as protein aggregation, oxidative stress, caspases and secretase, regulators, cholesterol, zinc, microglia, astrocytes, oligodendrocytes, etc, have been discussed in the context of disease progression. In addition, novel approaches to therapeutic interventions have also been presented. It is hoped that students, scientists and clinicians shall find this very informative book immensely useful and thought-provoking.
Book Synopsis Bacterial Signaling by : Reinhard Krämer
Download or read book Bacterial Signaling written by Reinhard Krämer and published by John Wiley & Sons. This book was released on 2009-12-09 with total page 513 pages. Available in PDF, EPUB and Kindle. Book excerpt: Providing a comprehensive insight into cellular signaling processes in bacteria with a special focus on biotechnological implications, this is the first book to cover intercellular as well as intracellular signaling and its relevance for biofilm formation, host pathogen interactions, symbiotic relationships, and photo- and chemotaxis. In addition, it deals in detail with principal bacterial signaling mechanisms -- making this a valuable resource for all advanced students in microbiology. Dr. Krämer is a world-renowned expert in intracellular signaling and its implications for biotechnology processes, while Dr. Jung is an expert on intercellular signaling and its relevance for biomedicine and agriculture.
Book Synopsis Proteases in Human Diseases by : Sajal Chakraborti
Download or read book Proteases in Human Diseases written by Sajal Chakraborti and published by Springer. This book was released on 2017-07-13 with total page 516 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book bridges the gap between fundamental research and biomedical and pharmacological applications on proteases. It represents a comprehensive overview of the multifaceted field of proteases in cellular environment and highlights the recently elucidated functions of complex proteolytic systems in different diseases. Several established investigators have elucidated the crucial role of proteases in biological processes, including how proteolytic function and regulation can be combined to develop new strategies of therapeutic interventions. Proteases form one of the largest and most diverse families of enzymes known. It is now clear that proteases are involved in every aspect of life functions of an organism. Under physiological conditions, proteases are regulated by their endogenous inhibitors; however, when the activity of proteases is not regulated appropriately, disease processes can result in. So, there is absolute need for a stringent control of proteolytic activities in cells and tissues. Dysregulation of proteases may cause derangement of cellular signalling network resulting in different pathophysiological conditions such as vascular remodelling, atherosclerotic plaque progression, ulcer and rheumatoid arthritis, Alzheimer disease, cancer metastasis, tumor progression and inflammation. Additionally, many infective microorganisms require proteases for replication or use proteases as virulence factors, which have facilitated the development of protease-targeted therapies for a variety of parasitic diseases.
Book Synopsis Alzheimer's Disease by : Jolanta Dorszewska
Download or read book Alzheimer's Disease written by Jolanta Dorszewska and published by BoD – Books on Demand. This book was released on 2018-07-18 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt: Alzheimer's disease was discovered over 100 years ago and still belongs to incurable neurological diseases; its pharmacotherapy is considered to be ineffective. This book presents contemporary views on the genetic, biochemical, and immunological determinants of this disease. This book also concerns the issue of Alzheimer's disease prevention through lifestyle and physical activity. Moreover, it describes the therapies used in Alzheimer's disease to slow the progression of the disease and delay its onset. Subsequently, the authors discuss experimental and clinical trials used now and in the near future. We hope that this book will help the readers to understand the complex mechanism leading to the development of Alzheimer's disease and indicate effective ways to prevent this disorder.
Book Synopsis A-Beta Metabolism and Alzheimer's Disease by : Takaomi Comings Saido
Download or read book A-Beta Metabolism and Alzheimer's Disease written by Takaomi Comings Saido and published by CRC Press. This book was released on 2003-02-18 with total page 179 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides information regarding three major aspects of Aβ metabolism: generation from its precursor, degradation within the brain, and transport out of the brain. It is useful for graduate students, post-doctoral fellows, and scientists both in this and other disciplines.
Book Synopsis Structural and Functional Repercussions of Loss of Function and Clinical Mutants of Presenilin by : Omar Nyabi
Download or read book Structural and Functional Repercussions of Loss of Function and Clinical Mutants of Presenilin written by Omar Nyabi and published by Leuven University Press. This book was released on 2005 with total page 122 pages. Available in PDF, EPUB and Kindle. Book excerpt: Alzheimer's disease is a major health problem. The disease is clinically characterized by the progressive mental decline of the patients and pathologically by the accumulation of amyloid plaques and tangles and neurodegenerative changes in the brain. The cause of the disease remains unclear but in some cases, genetic (missense) mutations in the Amyloid Precursor Protein (APP) and in the Presenilin genes (PS1 & PS2) are sufficient to initiate the whole disease cascade. All these mutations cause in essence an increase in the generation or a change of the characteristics of the AB peptide making it more prone to produce amyloid plaques. The AB peptide is generated from the APP protein and the question how Presenilin influences APP processing and AB production is the main topic of our work.
Author :Wolfgang Schumann (Prof. Dr. rer. nat.) Publisher :John Wiley & Sons ISBN 13 :9783527304967 Total Pages :462 pages Book Rating :4.3/5 (49 download)
Book Synopsis Dynamics of the Bacterial Chromosome by : Wolfgang Schumann (Prof. Dr. rer. nat.)
Download or read book Dynamics of the Bacterial Chromosome written by Wolfgang Schumann (Prof. Dr. rer. nat.) and published by John Wiley & Sons. This book was released on 2006-07-31 with total page 462 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an unique overview on bacterial genetics, bacterial genome projects and gene technology and its applications in biological and biomedical research and medicine. The author guides the reader up the front in research within the different fields of bacterial genetics, based mainly on results received with Escherichia coli and Bacillus subtilis.
