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Intracellular Pathogens In Membrane Interactions And Vacuole Biogenesis
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Author :Jean-Pierre Gorvel Publisher :Springer Science & Business Media ISBN 13 :9780306478338 Total Pages :328 pages Book Rating :4.4/5 (783 download)
Book Synopsis Intracellular Pathogens in Membrane Interactions and Vacuole Biogenesis by : Jean-Pierre Gorvel
Download or read book Intracellular Pathogens in Membrane Interactions and Vacuole Biogenesis written by Jean-Pierre Gorvel and published by Springer Science & Business Media. This book was released on 2004-01-31 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides information on the molecular interactions between host cell organelles and pathogens, which have developed strategies to survive within infected cells. Chapters are grouped into five sections: I. Endocytosis and phagocytosis. Collectively, the chapters of this section review basic knowledge regarding intracellular organelles are involved in membrane interactions with pathogen-containing vacuoles. II. Professional and non-professional phagocytes. Here the authors describe the major differences between the two host cell types, which can be infected by microorganisms. III. Maturation pathways of bacteria-containing vacuoles. Molecular interactions between vacuoles and intracellular organelles leading to the search of the Holy Grail, the replication niche, are described. IV. Host response. Host cells are able to react against intruders and eventually mount host responses. In these chapters the various types of host response mechanisms against intracellular intruders are reviewed. V. Co-evolution. In these final chapters, the question is addressed of whether knowledge of bacteria-host cell interactions will be acquired fast enough to find the necessary tools for controlling microorganism development.
Book Synopsis Vacuolar Compartments by : David G. Robinson
Download or read book Vacuolar Compartments written by David G. Robinson and published by CRC PressI Llc. This book was released on 2000 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research into plant vacuoles has, over the last 5 years, been injected with new data which have already radically changed our concept of the vacuolar compartment in plant cells. In fact, we should no longer speak of the vacuole, but rather of vacuolar compartments. This is a revolutionary change in the way in which the plant cell has traditionally been presented in the biological literature. Vacuolar Compartments is a timely volume that provides a broad overview of our current understanding of the roles of vacuolar compartments in plant cells. Chapters focus on individual function of plant vacuoles and the tonoplast machinery that supports them. Additional chapters present up-to-date information on the identity of different vacuole types and the traffic of proteins to them. The book also provides a basis for comparing the plant system to vacuoles in other organisms. The present challenge is to understand how the separate organelles in the system are generated and maintained by the cell, and to explain at a biochemical level the functions of each vacuole type and the mechanisms by which they are achieved. Vacuolar Compartments is the first book to provide this perspective.
Book Synopsis Intracellular Pathogens in Membrane Interactions and Vacuoles by : Jean-Pierre Gorvel
Download or read book Intracellular Pathogens in Membrane Interactions and Vacuoles written by Jean-Pierre Gorvel and published by . This book was released on 2003-01-01 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Trafficking Inside Cells by : Nava Segev
Download or read book Trafficking Inside Cells written by Nava Segev and published by Springer Science & Business Media. This book was released on 2010-05-30 with total page 459 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers the past, present and future of the intra-cellular trafficking field, which has made a quantum leap in the last few decades. It details how the field has developed and evolved as well as examines future directions.
Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Membrane Biogenesis by : Jos A.F. Op den Kamp
Download or read book Membrane Biogenesis written by Jos A.F. Op den Kamp and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 474 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many individual aspects of the dynamics and assembly of biological membranes have been studied in great detail. Cell biological approaches, advanced genetics, biophysics and biochemistry have greatly contributed to an increase in our knowledge in this field.lt is obvious however, that the three major membrane constituents - lipids, proteins and carbohydrates- are studied, in most cases separately and that a coherent overview of the various aspects of membrane biogenesis is not readily available. The NATO Advanced Study Institute on "New Perspectives in the Dynamics of Assembly of Biomembranes" intended to provide such an overview: it was set up to teach students and specialists the achievements obtained in the various research areas and to try and integrate the numerous aspects of membrane assembly into a coherent framework. The articles in here reflect this. Statting with detailed contributions on phospholipid structure, dynamics, organization and biogenesis, an up to date overview of the basic, lipidic backbone of biomembranes is given. Extensive progress is made in the research on membrane protein biosynthesis. In particular the post- and co-translational modification processes of proteins, the mechanisms of protein translocation and the sorting mechanisms which are necessary to direct proteins to their final, intra - or extracellular destination have been characterized in detail. Modern genetic approaches were indispensable in this research area: gene cloning, hybrid protein construction, site directed mutagenesis and sequencing techniques elucidated many functional aspects of specific nucleic acid and amino acid sequences.
Book Synopsis Cellular Microbiology by : Pascale Cossart
Download or read book Cellular Microbiology written by Pascale Cossart and published by . This book was released on 2005 with total page 642 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive examination of this burgeoning area of important research.
Book Synopsis Trained Immunity-based Vaccines by : Jose Luis Subiza
Download or read book Trained Immunity-based Vaccines written by Jose Luis Subiza and published by Frontiers Media SA. This book was released on 2021-08-25 with total page 195 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dr. Jose Luis Subiza is the founder and CEO of Inmunotek SL. The other Topic Editors declare no competing interests with regard to the Research Topic subject.
Book Synopsis Endocytosis in Plants by : Jozef Šamaj
Download or read book Endocytosis in Plants written by Jozef Šamaj and published by Springer Science & Business Media. This book was released on 2012-10-02 with total page 337 pages. Available in PDF, EPUB and Kindle. Book excerpt: Endocytosis is a fundamental cellular process by means of which cells internalize extracellular and plasma membrane cargos for recycling or degradation. It is important for the establishment and maintenance of cell polarity, subcellular signaling and uptake of nutrients into specialized cells, but also for plant cell interactions with pathogenic and symbiotic microbes. Endocytosis starts by vesicle formation at the plasma membrane and progresses through early and late endosomal compartments. In these endosomes cargo is sorted and it is either recycled back to the plasma membrane, or degraded in the lytic vacuole. This book presents an overview of our current knowledge of endocytosis in plants with a main focus on the key molecules undergoing and regulating endocytosis. It also provides up to date methodological approaches as well as principles of protein, structural lipid, sugar and microbe internalization in plant cells. The individual chapters describe clathrin-mediated and fluid-phase endocytosis, as well as flotillin-mediated endocytosis and internalization of microbes. The book was written for a broad spectrum of readers including students, teachers and researchers.
Book Synopsis The Mononuclear Phagocyte System in Infectious Disease by : Geanncarlo Lugo-Villarino
Download or read book The Mononuclear Phagocyte System in Infectious Disease written by Geanncarlo Lugo-Villarino and published by Frontiers Media SA. This book was released on 2019-10-04 with total page 790 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Mononuclear Phagocyte System (MPS) of vertebrates is composed of monocytes, macrophages and dendritic cells. Together, they form part of the first line of immune defense against a variety of pathogens (bacteria, fungi, parasites and viruses), and thus play an important role in maintaining organism homeostasis. The mode of transmission, type of replication and mechanism of disease-causing differ significantly for each pathogen, eliciting a unique immune response in the host. Within this context, the MPS acts as both the sentinel and tailor of the immune system. As sentinels, MPS cells are found in blood and within tissues throughout the body to patrol against pathogenic insult. The strategy to detect 'microbial non-self' relies on MPS to recognize conserved microbial products known as 'pathogen-associated molecular pattern' (PAMPs). PAMPs recognition represents a checkpoint in the response to pathogens and relies on conserved 'pattern recognition receptors' (PRRs). Upon PRR engagement, MPS mount a cell-autonomous attack that includes the internalization and compartmentalization of intracellular pathogens into toxic compartments that promote destruction. In parallel, MPS cells launch an inflammatory response composed of a cellular arm and soluble factors to control extracellular pathogens. In cases when innate immunity fails to eliminate the invading microbe, MPS serves as a tailor to generate adaptive immunity for pathogen eradication and generation of "memory" cells, thus ensuring enhanced protection against re-infection. Indeed, MPS cell functions comprise the capture, process, migration and delivery of antigenic information to lymphoid organs, where type-1 immunity is tailored against intracellular microbes and type-2 immunity against extracellular pathogens. However, this potent adaptive immunity is also a double-edge sword that can cause aberrant inflammatory disorders, like autoimmunity or chronic inflammation. For this reason, MPS also tailors tolerance immunity against unwanted inflammation. Successful clearance of the microbe results in its destruction and proper collection of debris, resolution of inflammation and tissue healing for which MPS is essential. Reciprocally, as part of the evolutionary process taking place in all organisms, microbes evolved strategies to circumvent the actions bestowed by MPS cells. Multiple pathogens modulate the differentiation, maturation and activation programs of the MPS, as an efficient strategy to avoid a dedicated immune response. Among the most common evasion strategies are the subversion of phagocytosis, inhibition of PRR-mediated immunity, resistance to intracellular killing by reactive oxygen and nitrogen species, restriction of phagosome maturation, modulation of cellular metabolism and nutrient acquisition, regulation of cell death and autophagy, and modulation of pro-inflammatory responses and hijacking of tolerance mechanisms, among others. The tenet of this eBook is that a better understanding of MPS in infection will yield insights for development of therapeutics to enhance antimicrobial processes or dampen detrimental inflammation for the host's benefit. We believe that contributions to this topic will serve as a platform for discussion and debate about relevant issues and themes in this field. Our aim is to bring expert junior and senior scientists to address recent progress, highlight critical knowledge gaps, foment scientific exchange, and establish conceptual frameworks for future MPS investigation in the context of infectious disease.
Book Synopsis Cytoskeleton by : Jose C. Jimenez-Lopez
Download or read book Cytoskeleton written by Jose C. Jimenez-Lopez and published by BoD – Books on Demand. This book was released on 2017-05-17 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: The cytoskeleton is a highly dynamic intracellular platform constituted by a three-dimensional network of proteins responsible for key cellular roles as structure and shape, cell growth and development, and offering to the cell with "motility" that being the ability of the entire cell to move and for material to be moved within the cell in a regulated fashion (vesicle trafficking). The present edition of Cytoskeleton provides new insights into the structure-functional features, dynamics, and cytoskeleton's relationship to diseases. The authors' contribution in this book will be of substantial importance to a wide audience such as clinicians, researches, educators, and students interested in getting updated knowledge about molecular basis of cytoskeleton, such as regulation of cell vital processes by actin-binding proteins as cell morphogenesis, motility, their implications in cell signaling, as well as strategies for clinical trial and alternative therapies based in multitargeting molecules to tackle diseases, that is, cancer.
Book Synopsis Bacteria and Intracellularity by : Pascale Cossart
Download or read book Bacteria and Intracellularity written by Pascale Cossart and published by John Wiley & Sons. This book was released on 2019-12-24 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bacteria and Intracellularity clearly demonstrates that cellular microbiology as a field has reached maturity, extending beyond the strictly cellular level to infections of various organs and tissues. Decades of intense investigation into host-bacterial pathogen interactions have highlighted common concepts in intracellularity but also very diverse mechanisms underlying the various infections produced by bacteria. This book offers a wide-ranging look at the latest studies, including: foodborne pathogens, including how, when, and where bacteria interact with the gut and its microbiota infections of the urogenital tract, endothelial barriers, and the nervous system major advances in work with Mycobacterium tuberculosis and M. leprae subcellular microbiology, including metabolism of infected cells, nuclear biology, and microRNAs endosymbionts, in particular the latest work with Wolbachia and its effect on insect transmission of viral pathogens research into cell autonomous defense pathways that has led to major insights into immunology and innate immunity the latest developments in technology, for the next steps in the study of intracellularity All facets of cellular physiology, within the entire scope of cells and host tissues, can be targeted by pathogens. This book offers to researchers, students, and laboratorians a valuable overview of the state of current research into the cellular microbiology of host-pathogen interactions.
Download or read book Cumulated Index Medicus written by and published by . This book was released on 1997 with total page 1860 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Organelle Contact Sites by : Mitsuo Tagaya
Download or read book Organelle Contact Sites written by Mitsuo Tagaya and published by Springer. This book was released on 2017-08-16 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides the first comprehensive coverage of the quickly evolving research field of membrane contact sites (MCS). A total of 16 chapters explain their organization and role and unveil the significance of MCS for various diseases. MCS, the intracellular structures where organellar membranes come in close contact with one another, mediate the exchange of proteins, lipids, and ions. Via these functions, MCS are critical for the survival and the growth of the cell. Owing to that central role in the functioning of cells, MCS dysfunctions lead to important defects of human physiology, influence viral and bacterial infection, and cause disease such as inflammation, type II diabetes, neurodegenerative disorders, and cancer. To approach such a multifaceted topic, this volume assembles a series of chapters dealing with the full array of research about MCS and their respective roles for diseases. Most chapters also introduce the history and the state of the art of MCS research, which will initiate discussion points for the respective types of MCS for years to come. This work will appeal to all cell biologists as well as researchers on diseases that are impacted by MCS dysfunction. Additionally, it will stimulate graduate students and postdocs who will energize, drive, and develop the research field in the near future.
Book Synopsis Brucella:Molecular & Cell Biol by : Ignacio Lopez-Goni
Download or read book Brucella:Molecular & Cell Biol written by Ignacio Lopez-Goni and published by Taylor & Francis. This book was released on 2005-11-08 with total page 447 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book opens with chapters that focus on the development of molecular diagnostic tools and these are followed by chapters on genetic evolution and its relationship to pathogenicity. Other topics include Brucella comparative genomics and proteomics, analysis of the structure, biosynthesis and biology of glucans and lipopolysaccharides, pathogenicity, approaches to vaccine development, bacterium-host interactions, immune response, and much more. Essential reading for everyone with an interest in Brucella and brucellosis and recommended reading for the wider body of scientists with an interest in microbial diagnostics, microbial pathogenesis, cellular microbiology and immunology, and vaccine development.
Download or read book OMICS written by Debmalya Barh and published by CRC Press. This book was released on 2016-04-19 with total page 609 pages. Available in PDF, EPUB and Kindle. Book excerpt: A reflection of the explosion of research and development in this field, OMICS: Biomedical Perspectives and Applications explores applications of omics in bioinformatics, cancer research and therapy, diabetes research, plant science, molecular biology, and neurosciences. A select editorial panel of experts discusses their cutting edge omics researc
Book Synopsis Salmonella host-pathogen interactions by : John S. Gunn
Download or read book Salmonella host-pathogen interactions written by John S. Gunn and published by Frontiers Media SA. This book was released on 2011-11-01 with total page 79 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Research Topic provides updated information on several important areas of Salmonella host cell interaction. Articles begin on topics outside of the host cell, examining the transit to and interaction with the epithelium, including pattern recognition. Once inside the host cell, topics of manuscripts include examination of the Salmonella-containing vacuole, its ability to resist intracellular killing, and the bacterial gene induction within the host cells responsible for survival. Finally, knowledge concerning carriage in and transmission from the infected host are discussed.This Research Topic provides updated information on several important areas of Salmonella host cell interaction. Articles begin on topics outside of the host cell, examining the transit to and interaction with the epithelium, including pattern recognition. Once inside the host cell, topics of manuscripts include examination of the Salmonella-containing vacuole, its ability to resist intracellular killing, and the bacterial gene induction within the host cells responsible for survival. Finally, knowledge concerning carriage in and transmission from the infected host are discussed.
