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Intestinal Hedgehog Signaling In Tumors And Inflammation
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Book Synopsis Intestinal Hedgehog Signaling in Tumors and Inflammation by :
Download or read book Intestinal Hedgehog Signaling in Tumors and Inflammation written by and published by . This book was released on 2015 with total page 162 pages. Available in PDF, EPUB and Kindle. Book excerpt: "In this thesis we investigated the role of Hedgehog signaling in tumors and inflammation. By using an inducible Indian Hedgehog (Ihh) knockout mouse we show that Ihh signals via the mesenchyme to the proliferating cells in the crypt to attenuate proliferation. Despite its anti-proliferative role in intestinal homeostasis, we show that Ihh is mandatory for Apc mutant adenoma formation in mice. It seems that tumor epithelial cells need to secrete Ihh in order to maintain an intestinal stromal phenotype that is required for adenoma development. In the next study, we used mouse models where we can either activate or inactivate the Hedgehog pathway conditionally. Analysis of gene arrays of colons from these mice show that Hedgehog regulates the expression of the Interferon response target genes. This finding can explain why Ihh mutant mice are more prone to develop a more severe colitis. The next question is how Hedgehog regulates the interferon response? This question touches upon an issue that has been in the field for years; what cell is the Hedgehog target cell in the intestine? We exclude that the Hedgehog target cell is a myeloid cell and show by characterization of known mesenchymal markers that the Hedgehog target cell is a stromal cell. Furthermore, we show that Hedgehog's effect on the expression of the Interferon response mediated genes, including chemokines seems to act via the stromal cells. Together, this thesis gives us more insight in the role of Hedgehog in homeostasis, inflammation and adenoma formation."--Samenvatting auteur.
Book Synopsis Signal Transduction in Cancer by : David A. Frank
Download or read book Signal Transduction in Cancer written by David A. Frank and published by Springer Science & Business Media. This book was released on 2002-12-31 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the most exciting areas of cancer research now is the development of agents which can target signal transduction pathways that are activated inappropriately in malignant cells. The understanding of the molecular abnormalities which distinguish malignant cells from their normal counterparts has grown tremendously. This volume summarizes the current research on the role that signal transduction pathways play in the pathogenesis of cancer and how this knowledge may be used to develop the next generation of more effective and less toxic anticancer agents. Series Editor comments: "The biologic behavior of both normal and cancer cells is determined by critical signal transduction pathways. This text provides a comprehensive review of the field. Leading investigators discuss key molecules that may prove to be important diagnostic and/or therapeutic targets."
Book Synopsis Liver Growth and Repair by : A. Strain
Download or read book Liver Growth and Repair written by A. Strain and published by Springer Science & Business Media. This book was released on 1997-12-31 with total page 1320 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nelson Fausto The Greek myth of Prometheus with its picture of a vulture feasting on its chained victimhas traditionallyprovided a visualimageofliverregeneration. Itis apowerful and frightening representationbut ifone were to substitute the vulture by a surgeon and Prometheus by a patient laying on a properly prepared operating table, the outcomeoftheprocedurewould not differ significantlyfrom that describedbyGreek poets. Yet few of us who work in the field have stopped long enough to ask where this myth originated. Did the poet observe a case of liver regeneration in a human being? Was it brilliant intuition or perhaps, literally, just a 'gut feeling' of a poet looking for good rhymes that led to the prediction that livers grow when part of the tissueisremoved? Thisbookdoesnotattemptto solve these historical issues. Itdoes, instead, cover in detail some of the major modem themes of research on liver regen eration, injury and repair. As indicated in Dr. N. Bucher's chapter, the modem phase ofexperimental studies on liver regeneration started in 1931 with the publication by Higgins and Anderson of a method to perform a two-thirds resection of the liver of a rat. The technique described has 3 remarkable features: 1) it is highly reproducible, resulting in the removal of 68% of the liver, 2) it has minimal if any mortality, and 3) it consists only of blood vessel ligation and does not involve cutting through or wounding hepatic tissue.
Book Synopsis Intestinal Tumorigenesis by : Vincent W. Yang
Download or read book Intestinal Tumorigenesis written by Vincent W. Yang and published by Springer. This book was released on 2015-09-19 with total page 451 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume includes the information necessary to understand recent critical advances in the mechanisms of intestinal tumorigenesis and to comprehend the complexity of the process. The volume aims to entice new researchers to participate in relevant studies, and to provide a forum for discussion within the scientific community to shape future research in this field. Discoveries in intestinal tumorigenesis lead to further understanding of mechanisms involved in colon cancer. Additionally, advancements in techniques and methods open the doors for new approaches to better define the molecular and organismal mechanisms of intestinal tumorigenesis. Chapters are authored by widely published authorities in the field. Each year, there are close to 150,000 new cases of colorectal cancer, which results in approximately 50,000 deaths per year in the United States; these figures render colorectal cancer a significant health concern. Studies attempting to understand the mechanisms of development and progression of colorectal cancer have been ongoing for decades and each year brings new discoveries yielding a better comprehension of the underlying processes at work.
Download or read book Intestinal Stem Cell Niche written by and published by Academic Press. This book was released on 2018-04-24 with total page 150 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Stem Cells and Their Niches addresses stem cells during development, homeostasis, and disease/injury of the respective organs, presenting new developments in the field, including new data on disease and clinical applications. Video content illustrates such areas as protocols, transplantation techniques, and work with mice. Explores not only reviews of research, but also shares methods, protocols, and transplantation techniques Contains video content to illustrate such areas as protocols, transplantation techniques, and work with mice Each volume concentrates on one organ, making this a unique publication
Book Synopsis Inflammation and Cancer by : Bharat B. Aggarwal
Download or read book Inflammation and Cancer written by Bharat B. Aggarwal and published by Springer. This book was released on 2014-05-12 with total page 489 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume examines in detail the role of chronic inflammatory processes in the development of several types of cancer. Leading experts describe the latest results of molecular and cellular research on infection, cancer-related inflammation and tumorigenesis. Further, the clinical significance of these findings in preventing cancer progression and approaches to treating the diseases are discussed. Individual chapters cover cancer of the lung, colon, breast, brain, head and neck, pancreas, prostate, bladder, kidney, liver, cervix and skin as well as gastric cancer, sarcoma, lymphoma, leukemia and multiple myeloma.
Book Synopsis Intestinal Homeostasis and Disease: A Complex Partnership between Immune Cells, Non-Immune Cells and the Microbiome by : Marcela A. Hermoso
Download or read book Intestinal Homeostasis and Disease: A Complex Partnership between Immune Cells, Non-Immune Cells and the Microbiome written by Marcela A. Hermoso and published by Frontiers Media SA. This book was released on 2020-01-20 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :Janusz A. Z. Jankowski Publisher :Springer Science & Business Media ISBN 13 :3642035035 Total Pages :201 pages Book Rating :4.6/5 (42 download)
Book Synopsis Inflammation and Gastrointestinal Cancers by : Janusz A. Z. Jankowski
Download or read book Inflammation and Gastrointestinal Cancers written by Janusz A. Z. Jankowski and published by Springer Science & Business Media. This book was released on 2011-08-08 with total page 201 pages. Available in PDF, EPUB and Kindle. Book excerpt: Inflammation in gastrointestinal mucosa can remodel the topography of the overlying epithelium. If such inflammation is chronic, it has fundamental clinical consequences, the principal of which is premalignant metaplasia throughout the alimentary tract. Furthermore, mucosal inflammation, even if subtle, is the single most common pathway for GI cancer. This book discusses all aspects of the relation between inflammation and GI cancer, from the basic science through to the translational science which is helping in the optimization of clinical management strategies. Among the topics considered are the impact of inherited syndromes; the roles of acid reflux, H. pylori, inflammatory bowel disease, and primary sclerosing cholangitis; screening strategies; targeted drug therapies; genetics; and the use of endoscopic methods. The authors are the best in their field, and this book is designed for the enthusiastic student as well as the professional in GI science and medicine.
Book Synopsis Intestinal Dysbiosis in Inflammatory Diseases by : Gislane Lelis Vilela de Oliveira
Download or read book Intestinal Dysbiosis in Inflammatory Diseases written by Gislane Lelis Vilela de Oliveira and published by Frontiers Media SA. This book was released on 2021-09-29 with total page 331 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dr. Fasano holds stocks in Alba Therapeutics and receives financial support from Takeda Pharmaceuticals. Dr. Taneja receives financial support from Elysium Health and Evelo Biosciences. The other Topic Editors declare no competing interests with regards to the Research Topic subject.
Book Synopsis Targeting Signaling Pathways in Solid Tumors Part A by :
Download or read book Targeting Signaling Pathways in Solid Tumors Part A written by and published by Elsevier. This book was released on 2024-04-23 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: Targeting Signaling Pathways in Solid Tumors, Part A, Volume 385 in the International Review of Cell and Molecular Biology series, highlights new advances in the field, with this new volume presenting interesting chapters on topics such as Drugging the Undruggable: Advances in Targeting KRAS Signaling in Solid Tumors, Emerging Trends in Gastrointestinal Cancers: Targeting Developmental Pathways in their Carcinogenesis and Tumor Progression, Importance of targeting various cell signaling pathways in solid cancers, Targeting signaling pathways in cancer stem cells: a potential approach for developing novel anticancer therapeutics, Factors affecting heterogeneity in breast cancer microenvironment: A narrative review, and much more. Additional sections cover Exploring TLR Signaling Pathways as Promising Targets in Cervical Cancer: The Road Less Travelled Provides the latest information on cancer research Offers outstanding and original reviews on a range of cancer research topics Serves as an indispensable reference for researchers and students alike
Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Physiology of the Gastrointestinal Tract by : Hamid M. Said
Download or read book Physiology of the Gastrointestinal Tract written by Hamid M. Said and published by Academic Press. This book was released on 2018-03-08 with total page 1752 pages. Available in PDF, EPUB and Kindle. Book excerpt: Physiology of the Gastrointestinal Tract, Sixth Edition, a Two-Volume set, covers the study of the mechanical, physical and biochemical functions of the GI Tract by linking clinical disease and disorder, thus bridging the gap between clinical and laboratory medicine while also covering breakthroughs in gastroenterology, such as the brain-gut axis and microbiome. Additionally, information is provided at the organism level, including animal models of gastrointestinal disorders and therapeutic possibilities. The book covers a wide range of conditions, from food allergies, constipation, chronic liver disease and IBS, also exploring emerging techniques to diagnose and normalize functions of the GI tract. As a highly referenced book, this is a useful resource for gastroenterologists, physiologists, internists, professional researchers and instructors teaching courses for clinical and research students. - Discusses the multiple processes governing gastrointestinal function - Presents new information on the brain-gut axis and microbiome - Edited by preeminent scientists in the field - Includes coverage of issues, such as food allergies, constipation, chronic liver disease, IBS, Crohn's disease, and more
Book Synopsis Reprogramming Stromal Cells in Chronic Inflammation and Cancer by : Ioannis S. Pateras
Download or read book Reprogramming Stromal Cells in Chronic Inflammation and Cancer written by Ioannis S. Pateras and published by Frontiers Media SA. This book was released on 2022-01-05 with total page 116 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Mitochondria as Targets for Phytochemicals in Cancer Prevention and Therapy by : Dhyan Chandra
Download or read book Mitochondria as Targets for Phytochemicals in Cancer Prevention and Therapy written by Dhyan Chandra and published by Springer Science & Business Media. This book was released on 2013-12-11 with total page 267 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book highlights the importance of phytochemicals and mitochondria in cancer prevention and therapy. Recent scientific discoveries have identified that naturally occurring biologically active compounds (i.e. phytochemicals) target multiple steps of tumorigenesis leading to the inhibition or delay in cancer progression. Mitochondria, organelles within a cell, are a critical target for phytochemicals in regulating the initiation, promotion, and progression of cancer. The book is divided into three parts to better communicate the important findings related to phytochemicals and mitochondria in cancer research. The first part describes updates on environmental and genetic factors causing cancer initiation and progression, the role of mitochondria function in regulating the process of tumorigenesis, and the role of mitochondria in regulating cell death such as apoptosis, autophagy, and necroptosis. The second part focuses on the elucidation of key target proteins that could be exploited for cancer prevention, an the role of phytochemicals in cancer prevention, updates on basic research related to phytochemicals action critical for cancer prevention, and updates on translational knowledge on cancer prevention by phytochemicals. The third part provides updates on phytochemicals targeting mitochondria for cancer therapy, an overview of action of phytochemicals on cancer stem cells, updates on the role of microRNA in phytochemicals-based therapy of cancer, and updates on phytochemicals-based translation research on therapy for metastatic cancer.
Book Synopsis Advances in the Molecular Mechanisms in Gastrointestinal Tumorigenesis and Treatment by : Ruowen Zhang
Download or read book Advances in the Molecular Mechanisms in Gastrointestinal Tumorigenesis and Treatment written by Ruowen Zhang and published by Frontiers Media SA. This book was released on 2024-09-20 with total page 499 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gastrointestinal (GI) cancer, the group of cancers that affect the gastrointestinal tract and other organs that are contained within the digestive system, including the esophagus, pancreas, stomach, colon, rectum, anus, liver, biliary system and small intestine, is the most common malignant diseases with high mortality rates, leading to a substantial burden on public health and healthcare systems around the world. Diverse subtypes of GI cancer impressively exhibit similar characteristics like high frequency oncogenic mutation burden, early metastatic potency, chemo-resistance and immunotherapeutic tolerance indicating a possible unique tumorigenic mechanism.
Book Synopsis Cancer Stem Cells by : Stanley Shostak
Download or read book Cancer Stem Cells written by Stanley Shostak and published by BoD – Books on Demand. This book was released on 2011-08-01 with total page 634 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the last thirty years, the foremost inspiration for research on metastasis, cancer recurrence, and increased resistance to chemo- and radiotherapy has been the notion of cancer stem cells.The twenty-eight chapters assembled in Cancer Stem Cells - The Cutting Edge summarize the work of cancer researchers and oncologists at leading universities and hospitals around the world on every aspect of cancer stem cells, from theory and models to specific applications (glioma), from laboratory research on signal pathways to clinical trials of bio-therapies using a host of devices, from solutions to laboratory problems to speculation on cancers' stem cells' evolution. Cancer stem cells may or may not be a subset of slowly dividing cancer cells that both disseminate cancers and defy oncotoxic drugs and radiation directed at rapidly dividing bulk cancer cells, but research on cancer stem cells has paid dividends for cancer prevention, detection, targeted treatment, and improved prognosis.
Book Synopsis Energy Balance and Gastrointestinal Cancer by : Sanford D. Markowitz
Download or read book Energy Balance and Gastrointestinal Cancer written by Sanford D. Markowitz and published by Springer Science & Business Media. This book was released on 2012-03-09 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: The gastrointestinal track provides one of the distinct systems where multiple malignancies, including adenocarcinoma of the pancreas, esophagus and colon are each associated with obesity. This unique association is covered in this volume of Energy Balance and Cancer from the epidemiologic, biologic and potential etiologic viewpoint. The focus on possible dietary contribution as well as the role of exercise in prevention and therapy is presented in both animal model and patient based studies. Special focus is provided also on the role of genetic mutations and inflammatory pathways as drivers of these obesity related gastrointestinal malignancies. Overall, this volume on Energy Balance and Gastrointestinal Malignancies should be valuable to Epidemiologists, Gastroenterologists and Oncologists, as well as to students and researchers from multiple disciplines interested in understanding and disrupting the association between obesity and cancer.
