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Book Synopsis Molecular and Cellular Insights to Ion Channel Biology by : Robert A. Maue
Download or read book Molecular and Cellular Insights to Ion Channel Biology written by Robert A. Maue and published by Gulf Professional Publishing. This book was released on 2004 with total page 510 pages. Available in PDF, EPUB and Kindle. Book excerpt: Annotation Contains fresh perspectives and up-to-date view points from international experts Illustrates the diverse array of techniques applied to ion channel research Represents a valuable resource to both the beginner and expert researcher, with over 2500 references and more than 100 figures and tables.
Download or read book EDHF written by Michel Feletou and published by CRC Press. This book was released on 2005-11-02 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: The advances made in vascular biology in the last 25 years have considerably changed the perception that one could have of the endothelial cells. Once considered as a diffusion barrier preventing the access of the blood cells to the vascular matrix, the endothelium is now recognized as playing a major role in the control of blood fluidity, platelet aggregation, and vascular tone, but also in immunology, inflammation, angiogenesis, and for serving as a metabolizing and an endocrine organ. -- from the preface Cardiovascular diseases, so prevalent in the Western world during the twentieth century, could well become the scourge of the twenty-first century in emerging countries as well as the West. Endothelial dysfunction linked to an imbalance in the synthesis and/or release of contracting and relaxing factors is often evoked to explain the initiation of the cardiovascular pathology or its development and perpetuation. Two decades ago, when nitric oxide was demonstrated to mediate endothelium-dependent relaxations, the vascular world seemed convinced that nitric oxide was the ultimate and sole explanation for such relaxations. However not everyone agreed. EDHF: The Complete Story is the work of two leading researchers who did not accept that simple conclusion, but instead continued to search, along with others, for a deeper understanding of the ways in which endothelial cells communicate with the underlying smooth muscle to signal it to hyperpolarize. Now with most, if not all, of those ways, uncovered, the authors offer this summary as way of bringing closure to the quest. This monograph reports on the work of many researchers. It summarizes the significant recent discoveries concerning endothelium-dependent hyperpolarizations, which are likely to play a much more important role in cardiovascular physiology and pathology than was originally foreseen Extensively illustrated with original diagrams and schematics that summarize the different steps of endothelium-dependent hyperpolarization, the text is designed for vascular biologists, and cardiologists, as well as graduate students looking to gain an understanding of the intimate functioning of the blood vessel wall.
Book Synopsis Calcium Channel Pharmacology by : Stefan I. McDonough
Download or read book Calcium Channel Pharmacology written by Stefan I. McDonough and published by Springer Science & Business Media. This book was released on 2011-06-28 with total page 427 pages. Available in PDF, EPUB and Kindle. Book excerpt: Voltage-gated calcium channels are critical regulators of cytoplasmic levels of calcium, the universal signaling ion. As such, calcium channels trigger a wide range of cellular functions, from muscle contraction to neurotransmitter secretion, and are important players in human disease. Prominent in the nervous, cardiovascular, and endocrine systems, members of the calcium channel family are targets for existing antihypertensive and anticonvulsant drugs. In addition, they are emerging targets for drugs to treat an extraordinarily diverse group of disorders, including pain, cerebral ischemia, cardiac arrhythmia, and migraine. This book reviews the compounds that target individual calcium channel subtypes and the cellular and behavioral functions governed by each different channel. It contains information for basic scientists using calcium channel antagonists as experimental tools, for behavioralists studying animal models of human disease, and for pharmaceutical scientists interested in creating the next generation of calcium channel-targeted drugs. Several factors make an entire book on calcium channel pharmacology timely.
Book Synopsis The Journal of Biological Chemistry by :
Download or read book The Journal of Biological Chemistry written by and published by . This book was released on 2001 with total page 940 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vols. 3-140 include the society's Proceedings, 1907-41
Book Synopsis Signal Transduction and the Gasotransmitters by : Rui Wang
Download or read book Signal Transduction and the Gasotransmitters written by Rui Wang and published by Springer Science & Business Media. This book was released on 2004-06-11 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gasotransmitters-principally nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S)-are endogenous signaling molecules that play a significant role in the biomedical, clinical, and health sciences, as well as in population health studies. In Signal Transduction and the Gasotransmitters: NO, CO, and H2S in Biology and Medicine, a panel of distinguished researchers and clinicians review the biological and biomedical aspects of gasotransmitters, emphasizing their signaling transduction mechanisms in general, and ion channel regulation in particular. The authors discuss the endogeneous metabolism and regulation of gasotransmitters, their toxicological profiles and biological actions, and their interactions in terms of their production and effects. The physiological roles of NO, CO, and H2S in the regulation of the cardiovascular, neuronal, and gastrointestinal systems, as well as of cell metabolism, are also reviewed, along with the interaction of the gastrotransmitters with KATP,KCa voltage-gated Ca2+, voltage-gated Na+, and cyclic nucleotide-gated ion channels. Included in the array of different mechanisms for the interaction of NO, CO, and H2S are channel phosphorylation, S-nitrosylation, carboxylation, sulfuration, and altered cellular redox status. The authors also offer guidance and suggestions for exploring and further characterizing other still unknown gasotransmitters. Authoritative and comprehensive, Signal Transduction and the Gasotransmitters: NO, CO, and H2S in Biology and Medicine offers clinical scientists and physicians not only a deeper understanding, but also a cutting-edge review, of the critically important field of gasotransmitter biology and medicine.
Download or read book Index Medicus written by and published by . This book was released on 2002-07 with total page 1896 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
Book Synopsis Gene Family Targeted Molecular Design by : Karen Lackey
Download or read book Gene Family Targeted Molecular Design written by Karen Lackey and published by John Wiley & Sons. This book was released on 2008-12-01 with total page 382 pages. Available in PDF, EPUB and Kindle. Book excerpt: As research progresses and information continues to proliferate in the field of molecular design for therapeutic use, there is a need for a reference that brings current theory and proven practice together in a how-to volume. This reference guides scientists new to the field on how to design small molecules that interact with critical protein targets. The chapters condense useful material into a manageable format which is carefully organized and presented. It offers an essential resource for a variety of chemists in academia, and the biotech and pharmaceutical industries, as well as professionals in complementary fields.
Book Synopsis Diabetes Mellitus by : Derek LeRoith
Download or read book Diabetes Mellitus written by Derek LeRoith and published by Lippincott Williams & Wilkins. This book was released on 2004 with total page 1608 pages. Available in PDF, EPUB and Kindle. Book excerpt: Thoroughly revised and updated, this Third Edition encompasses the most recent advances in molecular and cellular research and describes the newest therapeutic modalities for type 1 and type 2 diabetes mellitus. Chapters by leading experts integrate the latest basic science and clinical research on diabetes mellitus and its complications. The text is divided into ten major sections, including extensive sections on therapeutics, diabetes during pregnancy, and complications. New chapters cover stem cell therapy for type 1 diabetes; genetics and treatment of obesity; new therapies to promote insulin action; vasculopathy; islet cell protocols; triglycerides in muscle; hypoglycemia in the adult; and the Diabetes Prevention Program.
Book Synopsis Signaling at the Cell Surface in the Circulatory and Ventilatory Systems by : Marc Thiriet
Download or read book Signaling at the Cell Surface in the Circulatory and Ventilatory Systems written by Marc Thiriet and published by Springer Science & Business Media. This book was released on 2011-12-14 with total page 988 pages. Available in PDF, EPUB and Kindle. Book excerpt: The volumes in this authoritative series present a multidisciplinary approach to modeling and simulation of flows in the cardiovascular and ventilatory systems, especially multiscale modeling and coupled simulations. The cardiovascular and respiratory systems are tightly coupled, as their primary function is to supply oxygen to and remove carbon dioxide from the body's cells. Because physiological conduits have deformable and reactive walls, macroscopic flow behavior and prediction must be coupled to nano- and microscopic events in a corrector scheme of regulated mechanisms when the vessel lumen caliber varies markedly. Therefore, investigation of flows of blood and air in physiological conduits requires an understanding of the biology, chemistry, and physics of these systems together with the mathematical tools to describe their functioning. Volume 3 is devoted to the set of mediators of the cell surface, especially ion and molecular carriers and catalytic receptors that, once liganded and activated, initiate signal transduction pathways. Intracellular cascades of chemical reactions trigger the release of substances stored in cellular organelles and/or gene transcription and protein synthesis. Primary mediators are included in models of regulated cellular processes, but multiple secondary signaling components are discarded to allow simple, representative modeling and to manage their inverse problems.
Book Synopsis Red Cell Membrane Transport in Health and Disease by : Ingolf Bernhardt
Download or read book Red Cell Membrane Transport in Health and Disease written by Ingolf Bernhardt and published by Springer Science & Business Media. This book was released on 2013-04-17 with total page 761 pages. Available in PDF, EPUB and Kindle. Book excerpt: 51 worldwide leading experts in the field of erythrocyte research contributed to this first book on transport processes in red blood cells. It explains the latest findings on the basis of well-established principles, in an accessibly structured and carefully organized compilation.
Download or read book Cumulated Index Medicus written by and published by . This book was released on 1999 with total page 1776 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Chemical Abstracts written by and published by . This book was released on 2002 with total page 2710 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Physiology of the Gastrointestinal Tract, Two Volume Set by : Hamid M. Said
Download or read book Physiology of the Gastrointestinal Tract, Two Volume Set written by Hamid M. Said and published by Academic Press. This book was released on 2012-07-04 with total page 2250 pages. Available in PDF, EPUB and Kindle. Book excerpt: Physiology of the Gastrointestinal Tract, Fifth Edition — winner of a 2013 Highly Commended BMA Medical Book Award for Internal Medicine — covers the study of the mechanical, physical, and biochemical functions of the GI Tract while linking the clinical disease or disorder, bridging the gap between clinical and laboratory medicine. The gastrointestinal system is responsible for the breakdown and absorption of various foods and liquids needed to sustain life. Other diseases and disorders treated by clinicians in this area include: food allergies, constipation, chronic liver disease and cirrhosis, gallstones, gastritis, GERD, hemorrhoids, IBS, lactose intolerance, pancreatic, appendicitis, celiac disease, Crohn's disease, peptic ulcer, stomach ulcer, viral hepatitis, colorectal cancer and liver transplants. The new edition is a highly referenced and useful resource for gastroenterologists, physiologists, internists, professional researchers, and instructors teaching courses for clinical and research students. - 2013 Highly Commended BMA Medical Book Award for Internal Medicine - Discusses the multiple processes governing gastrointestinal function - Each section edited by preeminent scientist in the field - Updated, four-color illustrations
Download or read book Clinical Science written by and published by . This book was released on 2009 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Perspectives in Molecular Toxinology by : A. Ménez
Download or read book Perspectives in Molecular Toxinology written by A. Ménez and published by John Wiley & Sons. This book was released on 2002-05-17 with total page 540 pages. Available in PDF, EPUB and Kindle. Book excerpt: Covering the most recent advances in our understanding of toxins from venomous animals and microbes as well as that of their targets, this book expertly addresses the many intriguing and unsolved questions concerning; proteomics studies of the "toxinome", intimate modes of toxin actions, molecular basis of specificity, pleiotropic properties of toxins and structural biology of toxins. Through twenty-seven chapters the authors discuss the role of structural genomics in toxinology, how toxins are subject to accelerated evolution, how toxins can be exploited as models for the design of new drugs, and what the future holds for the treatment of snake bites. In order to address these challenging aspects, the authors have posed crystal-clear questions. Based on the most precise knowledge the attendant reasoning shows how toxinology has become an important area of biochemistry and is directly associated with advances in cellular microbiology, molecular pharmacology, molecular physiology, cell biology, protein engineering and many other disciplines.
Book Synopsis Neuronal Activity Suppression of Kv1.1 ChannelmRNA Translation in Dendrites by : Patrick C. G. Haddick
Download or read book Neuronal Activity Suppression of Kv1.1 ChannelmRNA Translation in Dendrites written by Patrick C. G. Haddick and published by . This book was released on 2006 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt: The appendix details other candidate transcripts that were further characterized. A particular focus is on 14-3-3 eta as a candidate transcript that is locally translated as well as the functional significance of the interaction between 14-3-3 and GABA-B receptors.
Download or read book The Journal of Cell Biology written by and published by . This book was released on 2000 with total page 656 pages. Available in PDF, EPUB and Kindle. Book excerpt: No. 2, pt. 2 of November issue each year from v. 19-47; 1963-70 and v. 55- 1972- contain the Abstracts of papers presented at the annual meeting of the American Society for Cell Biology, 3d-10th; 1963-70 and 12th- 1972- .
