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Interleukin 2
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Book Synopsis The role of interleukin-2 in the treatment of cancer patients by : J. Wagstaff
Download or read book The role of interleukin-2 in the treatment of cancer patients written by J. Wagstaff and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 195 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recombinant human interleukin-2 became available for clinical use in the mid 1980s. Recent years have seen an enormous amount of clinical research with this cytokine and interleukin-2 has now been registered for use in a number of European countries for the treatment of metastatic renal cell carcinoma. This book is designed to provide the clinical oncologist wishing to use interleukin-2 with a basic background concerning the biology of the agent, a discussion concerning practical aspects, of its clinical use including management of toxicity and an overview of the clinical results together with a description of how this internesting cytokine might be developed in the future.
Download or read book Interleukin 2 written by Kendall A Smith and published by Elsevier. This book was released on 2012-12-02 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt: Interleukin 2 focuses on interleukin 2 (IL-2) and its impact on immunology. Topics covered include IL-2's mechanism of action, the structure of the IL-2 receptor, the characteristics of natural and recombinant human IL-2, regulation of IL-2 production by the T cell antigen receptor, how IL-2 binding induces the transcription of a novel set of genes, and the pathological roles of IL-2 receptor inducers in adult T cell leukemia. This book is comprised of 12 chapters and begins with a historical overview of IL-2, from the discovery of soluble mitogenic factors in culture media of stimulated lymphocytes to the discovery of IL-2 as the molecule responsible for stimulating T cell proliferation. The physicochemical and biological properties of purified recombinant IL-2 are then described, paying particular attention to natural IL-2 derived from human peripheral blood leukocytes. The chapters that follow discuss the different techniques used to gain insight into the functionally important regions of IL-2, the role of the T cell antigen receptor in regulating the production of IL-2, and the structure of the human high-affinity IL-2 receptor. The book also describes transmembrane signaling by IL-2, IL-2-inducible gene expression in T lymphocytes, abnormal IL-2 receptor expression in adult T cell leukemia, the use of IL-2 receptors in immunosuppressive therapy, and the use of IL-2 as a pharmacologic reagent. This book will be of interest to students and researchers in immunology and biochemistry.
Book Synopsis Between Bench and Bedside by : Ilana Löwy
Download or read book Between Bench and Bedside written by Ilana Löwy and published by Harvard University Press. This book was released on 1996 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: Between Bench and Bedside is a compelling account of the clinical trials of interleukin-2 at a major French cancer hospital. Löwy's book offers a remarkable insider's view of the culture of clinical experimentation in oncology.
Book Synopsis Cooperation of Liver Cells in Health and Disease by : Z. Kmiec
Download or read book Cooperation of Liver Cells in Health and Disease written by Z. Kmiec and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 154 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is only during the last decade that the functions of sinusoidal endothelial cells, Kupffer cells, hepatic stellate cells, pit cells and other intrahepatic lymphocytes have been better understood. The development of methods for isolation and co-culturing various types of liver cells has established that they communicate and cooperate via secretion of various intercellular mediators. This monograph summarizes multiple data that suggest the important role of cellular cross-talk for the functions of both normal and diseased liver. Special features of the book include concise presentation of the majority of detailed data in 19 tables. Original schemes allow for the clear illustration of complicated intercellular relationships. This is the first ever presentation of the newly emerging field of liver biology, which is important for hepatic function in health and disease and opens new avenues for therapeutic interventions.
Book Synopsis Encyclopedia of Inflammatory Diseases by :
Download or read book Encyclopedia of Inflammatory Diseases written by and published by Birkhäuser. This book was released on 2016-09-15 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Inflammation has become one of the most exciting and rewarding areas of medical research. Recent years have seen a revolution in our understanding of how blood and tissue cells interact and of the intracellular mechanisms controlling their activation. This has revealed the underlying inflammatory pathology of many diseases and provided multiple new targets for anti-inflammatory and immunomodulatory therapy. The Encyclopedia of Inflammatory Diseases will cover the following areas: Inflammatory Processes and Cells Inflammatory Diseases Mediators of Inflammation Pharmacology of Inflammation Since inflammatory diseases and their therapy cover a broad range of scientific and medical fields, the encyclopedia will be co-edited by four international experts, a clinician and three researchers from the disciplines of immunology, biochemistry, and pharmacology, in this way providing students, basic and clinical scientists and practitioners in academia, hospitals and industry with valuable interlinked information. This living project will serve as a reliable and comprehensive data pool for everybody working in inflammation research. Owing to its dynamic nature, it will grow with time and future editions, becoming an indispensible source of information for academia, clinical practitioners and industry.
Book Synopsis Interleukin-2 and Killer Cells in Cancer by : Eva Lotzova
Download or read book Interleukin-2 and Killer Cells in Cancer written by Eva Lotzova and published by CRC Press. This book was released on 2018-02-01 with total page 556 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first-and only-publication available which provides the most recent information in this particular field of biomedicine. Interleukin-2 (IL-2) and IL-2 activated killer cells have been shown to have a potential in the treatment of a variety of human malignant diseases. This work comprehensively summarizes basic aspects of IL-2 as well as its clinical application, therefore making all these aspects easily accessible to the readers. Because of the clinical significance of this molecule in the treatment of cancer, the basic and clinical investigations in the IL-2 field are rapidly expanding, together with the interest of the scientific and medical community. This book is an excellent educational and teaching tool for scientists, clinicians, and students. Those who already have expertise in research in the IL-2 area will find this reference indispensible.
Author :National Institutes of Health (U.S.). Clinical Center. Cancer Nursing Service. 2 East Nursing Staff Publisher : ISBN 13 : Total Pages :20 pages Book Rating :4.3/5 (121 download)
Book Synopsis Managing Interleukin-2 Therapy by : National Institutes of Health (U.S.). Clinical Center. Cancer Nursing Service. 2 East Nursing Staff
Download or read book Managing Interleukin-2 Therapy written by National Institutes of Health (U.S.). Clinical Center. Cancer Nursing Service. 2 East Nursing Staff and published by . This book was released on 1989 with total page 20 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Cytokine Knockouts by : Scott K. Durum
Download or read book Cytokine Knockouts written by Scott K. Durum and published by Springer Science & Business Media. This book was released on 2013-04-17 with total page 498 pages. Available in PDF, EPUB and Kindle. Book excerpt: My personal history in the field of cytokines had an initial period of several years during which my student and then colleague, Werner Muller, tried in vain to attract me to them. My interest always vanished when I was confronted with complex data pointing to func tional redundancy of cytokines in cell culture systems. When gene targeting in the mouse germline became possible, this frustration came to an end. We and others immediately embarked on analyzing the in vivo function of cytokines and the problem of functional redundancy with this powerful new approach. The early cytokine gene knockouts performed by colleagues in Wiirzburg (IL-2) and by ourselves (IL-4 and IL-l 0) seemed to give clear answers and at the same time led to surprises: Each of these cytokines apparently had its own special and irreplaceable function, and this function could be quite distinct from what had been anticipated from functional experiments in vitro. Al though the latter finding is of course a wonderful incentive for fur ther research, the former is pleasing in a general sense since it highlights the value of each of those one hundred thousand genes or so in our genome, cherished by evolution to become respectable mem bers of the community. Even in the present era of "genomics" there will be no way around the careful functional analysis of each gene by itself.
Book Synopsis Dynamics of the Il-2 Cytokine Network and T-cell Proliferation by : Dorothea Busse
Download or read book Dynamics of the Il-2 Cytokine Network and T-cell Proliferation written by Dorothea Busse and published by Logos Verlag Berlin GmbH. This book was released on 2010 with total page 114 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book adds to a intensively investigated question of immunological research. How do regulatory T cells mediate their function to ensure tolerance against self-antigen? The author analyzes the interaction via the cytokine interleukin 2 between T helper cells, which mediate immune responses, and regulatory T cells. Since both cell types depend on interleukin 2 to mediate their functions, competition for interleukin 2 is likely. A mathematical model is developed to describe the interaction. This model focuses on the interleukin 2 receptor dynamics on helper and regulatory T cells and the extracellular interleukin 2 diffusion. The interleukin 2 receptor dynamics is governed mainly by an autocrine positive feedback loop on both cell types. However, its differential regulation results in a switch-like up-regulation of the receptors on T helper cells and a gradual adaptation of the receptor levels to extracellular interleukin 2 supply on regulatory T cells. This difference enables regulatory T cells to efficiently compete for interleukin 2 and deprive T helper cells of their growth factor. Cell culture experiments verify these findings. It can be shown that the antigen stimulus and the intercellular distance are relevant control parameters for competition. Other mechanisms are described for suppression of T helper cell action by regulatory T cells; competition for interleukin 2 may act in concert with them.
Book Synopsis The Biology and Clinical Applications of Interleukin-2 by : Robert C. Rees
Download or read book The Biology and Clinical Applications of Interleukin-2 written by Robert C. Rees and published by IRL Press. This book was released on 1990 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: The molecular structure of interleukin-2 (IL-2) and that of its receptor subunits provide a basis for understanding lymphocyte activation by IL-2 and the generation of effector cells capable of mediating cytotoxicity towards tumors. This book provides an up-to-date account of IL-2, its effect on lymphocyte function, and clinical applications. Internationally know experts review the molecular aspects of cell signalling, giving insight on the in vivo pathways of activation likely to be important in determining clinical responses. They also examine the use of cytokines, particularly IL-2, in the treatment of cancer, and describe the results of recent clinical trials using IL-2, as well as of adoptive cell therapy. Providing a clear account of recent progress, the book also reviews the problems involved in attempting to improve the therapeutic benefit of IL-2, along with the importance of mechanisms which subverse IL-2 responses. This is the most up-to-date account of molecular research and clinical trials in this area, and will be of great benefit to students and researchers in immunology, pharmacology, biochemistry, and oncology who are interested in this vitally important topic.
Book Synopsis Interleukin 2 in the in Vitro Generation and in Vivo Effectiveness of Tumor Specific T Lymphocytes [microform] by : Gordon B. Mills
Download or read book Interleukin 2 in the in Vitro Generation and in Vivo Effectiveness of Tumor Specific T Lymphocytes [microform] written by Gordon B. Mills and published by National Library of Canada. This book was released on 1984 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In order to respond to a foreign challenge, cells of the immune system must recognize the pathogen as foreign and must also receive a "second signal'. Both signals are required to induce the proliferation and differentiation of effector cells. Malignant disease in the otherwise immunocompetent host could escape immune control through failure to recognize tumor cells as foreign or through lack of the required "second signal". Previous work suggested that Interleukin 2 may be one of the second signals stimulating immune cells. Failure of Interleukin 2 production or action may allow malignant cells to escape the immune system. Therefore, an attractive method of immunotherapy would be to increase the positive immunoregulatory action of IL2 in vivo. Unfortunately, methods for modulating Interleukin action in vivo are not available. Therefore, removing lymphocytes from tumor-bearing mice, culturing them with exogenous Interleukin 2 and, subsequently, reinfusing the programed cells into tumor-bearing mice was explored as a model of a possible immunotherapeutic technique. Spleen cells from tumor-bearing mice contain populations of precursor cells reactive to autologous tumor. Culture of these cells with exogenous Interleukin 2 generated a population of helper lymphocytes able to recruit host anti-tumor activity. Culture with IL2 also generated two populations of lymphocytes directly cytotoxic to tumor cells. One of the populations of cytotoxic lymphocytes, generated by culture with Interleukin 2 and autologous tumor, was relatively specific to the sensitizing tumor. These are probably "classical" cytotoxic T lymphocytes. The second population of cytotoxic cells, generated by culture with Interleukin 2 alone, demonstrated a broader spectrum of anti-tumor reactivity. Identifying the origin of the cell responsible for this non-specific activity has proven to be difficult. The broad spectrum of activity, the lack of requirement for antigen sensitization, and the lack of H2 restriction are appropriate for "natural killer" cells; whereas, the time course of activation and the surface marker phenotype are appropriate for "classical" cytotoxic lymphocytes. The precursors of both cytolytic cell populations, described above, are significantly increased in tumor-bearing animals. This suggests that tumor recognition occurs in tumor-bearing animals but that the "second signal" required for proliferation and differentiation is not present or not received. Interleukin 2 can provide this signal at least in vitro. Culture of peripheral blood cells from ovarian cancer patients with either human IL2 or murine IL2 generated cytotoxic lymphocytes which were active against autologous tumor. In the immunotherapy of murine tumors, the cytotoxic lymphocyte containing populations were most effective if given shortly after injection of the tumor. The response was dose related. Repeated injections were more effective than single injections. The cultured cells homed poorly to the tumor, therefore injection directly into the tumor site was more effective than intravenous administration. Therapy with cytotoxic lymphocytes was synergistic with surgical therapy of CaD2 tumors. Therapy with cytotoxic lymphocyte containing populations consistently improved the survival of mice with intraperitoneal P815 tumors. Despite the improved survival of mice following therapy, there were few long term survivors. Therapy with cytotoxic lymphocyte containing populations cured some mice with subcutaneous P815 tumors. The mice that died of the tumor did not demonstrate an improvement in survival times compared to untreated mice. Mice cured of the P8 15 tumor by treatment with cytotoxic lymphocyte containing preparations remain tumor-immune. There were no significant detrimental side effects of therapy with cytotoxic lymphocytes.
Book Synopsis The Cytokines of the Immune System by : Zlatko Dembic
Download or read book The Cytokines of the Immune System written by Zlatko Dembic and published by Academic Press. This book was released on 2015-05-23 with total page 323 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Cytokines of the Immune System catalogs cytokines and links them to physiology and pathology, providing a welcome and hugely timely tool for scientists in all related fields. In cataloguing cytokines, it lists their potential for therapeutic use, links them to disease treatments needing further research and development, and shows their utility for learning about the immune system. This book offers a new approach in the study of cytokines by combining detailed guidebook-style cytokine description, disease linking, and presentation of immunologic roles. - Supplies new ideas for basic and clinical research - Provides cytokine descriptions in a guidebook-style, cataloging the origins, structures, functions, receptors, disease-linkage, and therapeutic potentials - Offers a textbook-style view on the immune system with the immunologic role of each cytokine
Download or read book Interleukin 2 written by Kendall A. Smith and published by . This book was released on 1984 with total page 15 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Role of Interleukin-2 in the Treatment of Cancer Patients by : J. Wagstaff
Download or read book The Role of Interleukin-2 in the Treatment of Cancer Patients written by J. Wagstaff and published by . This book was released on 2014-01-15 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Interleukin-2 and Killer Cells in Cancer by : Eva Lotzova
Download or read book Interleukin-2 and Killer Cells in Cancer written by Eva Lotzova and published by CRC Press. This book was released on 2018-02-01 with total page 381 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first-and only-publication available which provides the most recent information in this particular field of biomedicine. Interleukin-2 (IL-2) and IL-2 activated killer cells have been shown to have a potential in the treatment of a variety of human malignant diseases. This work comprehensively summarizes basic aspects of IL-2 as well as its clinical application, therefore making all these aspects easily accessible to the readers. Because of the clinical significance of this molecule in the treatment of cancer, the basic and clinical investigations in the IL-2 field are rapidly expanding, together with the interest of the scientific and medical community. This book is an excellent educational and teaching tool for scientists, clinicians, and students. Those who already have expertise in research in the IL-2 area will find this reference indispensible.
Download or read book Itch written by E. Carstens and published by CRC Press. This book was released on 2014-02-25 with total page 482 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in itch research have elucidated differences between itch and pain but have also blurred the distinction between them. There is a long debate about how somatic sensations including touch, pain, itch, and temperature sensitivity are encoded by the nervous system. Research suggests that each sensory modality is processed along a fixed, direct-line communication system from the skin to the brain. Itch: Mechanisms and Treatment presents a timely update on all aspects of itch research and the clinical treatment of itch that accompanies many dermatological conditions including psoriasis, neuropathic itch, cutaneous t-cells lymphomas, and systemic diseases such as kidney and liver disease and cancer. Composed of contributions from distinguished researchers around the world, the book explores topics such as: Neuropathic itch Peripheral neuronal mechanism of itch The role of PAR-2 in neuroimmune communication and itch Mrgprs as itch receptors The role of interleukin-31 and oncostatin M in itch and neuroimmune communication Spinal coding of itch and pain Spinal microcircuits and the regulation of itch Examining new findings on cellular and molecular mechanisms, the book is a compendium of the most current research on itch, its prevalence in society, and the problems associated with treatment.
Book Synopsis Integrating Conventional and Chinese Medicine in Cancer Care by : Tai Lahans
Download or read book Integrating Conventional and Chinese Medicine in Cancer Care written by Tai Lahans and published by Elsevier Health Sciences. This book was released on 2007-06-05 with total page 414 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new clinical resource clearly explains how to approach integrated care in a way that combines Chinese herbal medicine with Western medicine to enhance and improve medical care for patients with cancer - without undermining or negatively impacting patients' medical treatment. Each chapter covers a different type of cancer, first introducing the conventional medical understanding of that cancer including its etiology, diagnosis, and treatment according to staging and type. The chapter then covers that cancer from the perspective of Oriental medicine. Case studies illustrate the integration of treatment for each cancer type, raising important issues and considerations associated with specific cancers and treatments. Formulas are presented within the context of conventional treatment, intended to enhance the effectiveness of treatment and/or treat side effects without undermining the treatment's function. Each formula is followed by a discussion of how and why the herbs are used, including classical Chinese theory and relevant pharmaceutical studies. Staging and the age and performance status of various patients is used as a means by which to explain how formulas are changed. Case studies explore issues related to the integration of treatment for each type of cancer.
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