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Author : Jaebok Choi
Publisher : Frontiers Media SA
ISBN 13 : 2832511473
Total Pages : 113 pages
Book Rating : 4.8/5 (325 download)
Download or read book Interferons and graft-versus-host disease written by Jaebok Choi and published by Frontiers Media SA. This book was released on 2023-01-13 with total page 113 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Michelle Kenyon
Publisher : Springer
ISBN 13 : 3319500260
Total Pages : 318 pages
Book Rating : 4.3/5 (195 download)
Download or read book The European Blood and Marrow Transplantation Textbook for Nurses written by Michelle Kenyon and published by Springer. This book was released on 2018-03-14 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is open access under a CC BY 4.0 license. This textbook, endorsed by the European Society for Blood and Marrow Transplantation (EBMT), provides adult and paediatric nurses with a full and informative guide covering all aspects of transplant nursing, from basic principles to advanced concepts. It takes the reader on a journey through the history of transplant nursing, including essential and progressive elements to help nurses improve their knowledge and benefit the patient experience, as well as a comprehensive introduction to research and auditing methods. This new volume specifically intended for nurses, complements the ESH-EBMT reference title, a popular educational resource originally developed in 2003 for physicians to accompany an annual training course also serving as an educational tool in its own right. This title is designed to develop the knowledge of nurses in transplantation. It is the first book of its kind specifically targeted at nurses in this specialist field and acknowledges the valuable contribution that nursing makes in this area. This volume presents information that is essential for the education of nurses new to transplantation, while also offering a valuable resource for more experienced nurses who wish to update their knowledge.
Author : Eileen Haring
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (126 download)
Download or read book Interfering with Inflammation: Heterogeneous Effects of Interferons in Graft-versus-host Disease of the Gastrointestinal Tract and Inflammatory Bowel Disease written by Eileen Haring and published by . This book was released on 2021 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Mammen Chandy
Publisher : Springer
ISBN 13 : 9783030363574
Total Pages : 0 pages
Book Rating : 4.3/5 (635 download)
Download or read book Contemporary Bone Marrow Transplantation written by Mammen Chandy and published by Springer. This book was released on 2021-03-25 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bone Marrow transplantation or Hematopoietic stem cell transplantation is a life saving procedure in a number of diseases,hematological and non hematological, which fail alternative medical management or have no other treatment options. It has transformed the lives of thousands of patients and their families around the world battling with fatal or debilitating diseases.There are many unique aspects of bone marrow transplantation which makes it very different from solid organ transplants. There is an enormous amount of research going on in this field both at clinical and basic science levels.With the rapidly changing world and field of transplantation, there is a need for an authoritative and up to date resource for transplant professionals. This book titled Contemporary Bone Marrow Transplantation aims to be a reference text comprehensively covering various facets of hematopoietic stem cell transplants with latest insights about the technique and basic science behind it . The book is the product of collective effort of transplant professionals round the world, and will reflect their experience as well as the current standard of care practices in Stem cell transplantation.The book will be divided into different sections focusing on the basic science of bone marrow transplant, the technical aspects of the procedure itself and the supportive care of transplant patients.There will also be a section each on epidemiology, upcoming trends and also case studies , which will discuss real case scenarios from the experience of the authors, to illustrate the practical challenges in managing bone marrow transplant recipients.
Author : Krikor Kichian
Publisher :
ISBN 13 :
Total Pages : 160 pages
Book Rating : 4.:/5 (428 download)
Download or read book Interferon Gamma Regulatory Mechanisms During Acute Graft-versus-host Disease written by Krikor Kichian and published by . This book was released on 1995 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: "The onset of acute graft-versus host disease (aGVHD) is accompanied by macrophage priming and the presence of bacteria derived lipopolysaccharide (LPS) in the sera and organs of transplanted animals. Priming of macrophages occurs despite suppression of T cell function. We have investigated whether interleukin 12 (IL-12) mediates the continued production of interferon gamma (IFN-$ gamma$) during the state of T cell immunosuppression accompanying aGVHD. AGVHD was induced in non-irradiated AxC57BL/6 mice by an injection of C57BL/6 lymphoid cells. Despite T cell immunosuppression, macrophages remained primed as shown by their expression of inducible nitric oxide synthase (iNOS) mRNA and production of nitric oxide (NO) in response to exogenous LPS. Continued exposure to IFN-$ gamma$ was found to be required in order to maintain the primed state of macrophages during aGVHD; IFN-$ gamma$ mRNA within target organs of aGVHD including thymus, salivary gland, and lung was increased between day 7 and 14 after transplantation and was accompanied by the induction of the p40 peptide of IL-12 and iNOS mRNA. p40 peptide mRNA was also increased in macrophages purified on day 14 of aGVHD. These results provide evidence for localized production of IFN-$ gamma$ in aGVHD target organs and suggest that it is mediated by LPS induced IL-12 production by macrophages." --
Author : Nicolaus Kröger
Publisher :
ISBN 13 : 9781013273674
Total Pages : 688 pages
Book Rating : 4.2/5 (736 download)
Download or read book The EBMT Handbook written by Nicolaus Kröger and published by . This book was released on 2020-10-08 with total page 688 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Open Access edition of the European Society for Blood and Marrow Transplantation (EBMT) handbook addresses the latest developments and innovations in hematopoietic stem cell transplantation and cellular therapy. Consisting of 93 chapters, it has been written by 175 leading experts in the field. Discussing all types of stem cell and bone marrow transplantation, including haplo-identical stem cell and cord blood transplantation, it also covers the indications for transplantation, the management of early and late complications as well as the new and rapidly evolving field of cellular therapies. This book provides an unparalleled description of current practices to enhance readers' knowledge and practice skills. This work was published by Saint Philip Street Press pursuant to a Creative Commons license permitting commercial use. All rights not granted by the work's license are retained by the author or authors.
Author : Georgia B. Vogelsang
Publisher : Cambridge University Press
ISBN 13 : 1139478893
Total Pages : 427 pages
Book Rating : 4.1/5 (394 download)
Download or read book Chronic Graft Versus Host Disease written by Georgia B. Vogelsang and published by Cambridge University Press. This book was released on 2009-04-20 with total page 427 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chronic graft versus host disease (GVHD) is the most common complication of allogenic bone marrow transplantation. Because of the protracted clinical course of chronic GVHD, transplant centers and hematology/oncology offices are inadequately equipped to manage these immuno-incompetent patients with a multi-system disorder. Practitioners need to be able to recognize and effectively manage chronic GVHD as a late effect of more than half of allogenic transplantations. The text is oriented for the clinician, with chapters covering staging, organ site and system-specific manifestations, treatment options, and supportive care. Drs Georgia B. Vogelsang and Steven Z. Pavletic have been pioneers in the recognition of the multi-organ complexity of this disease and have gathered the input of a variety of subspecialist physicians for this book. This book fills the gap in practical literature on chronic GVHD, providing a comprehensive, up-to-date, and clinically relevant resource for anyone who deals with cancer patients post-transplant.
Author : Emanuel Lebenthal
Publisher : Raven Press (ID)
ISBN 13 :
Total Pages : 854 pages
Book Rating : 4.3/5 (91 download)
Download or read book Human Gastrointestinal Development written by Emanuel Lebenthal and published by Raven Press (ID). This book was released on 1989 with total page 854 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Nelson J. Chao
Publisher : R. G. Landes
ISBN 13 :
Total Pages : 168 pages
Book Rating : 4.3/5 (91 download)
Download or read book Graft-versus-host Disease written by Nelson J. Chao and published by R. G. Landes. This book was released on 1994 with total page 168 pages. Available in PDF, EPUB and Kindle. Book excerpt: This reference presents comprehensive coverage of graft-versus-host disease. A historical overview of graft-versus-host disease is provided, followed by a description of the major histo-compatibility complex. The results of the experimental models of graft-versus-host disease are also described. The second half of the book examines both acute and chronic graft-versus-host disease, as well as clinical trials involved in both of these entities. Promising approaches for the prevention and treatment of graft-versus-host disease are also investigated.
Author : Geling Li
Publisher :
ISBN 13 :
Total Pages : 238 pages
Book Rating : 4.:/5 (963 download)
Download or read book Dynamics of Interferon-y, Interleukin-12 and Interleukin-18 in Acute Graft-versus-host Disease written by Geling Li and published by . This book was released on 2000 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Akimasa Saito
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (116 download)
Download or read book Interferon-u03b3 Deficiency Attenuates Skin Fibrosis in a Murine Model of Chronic Graft-versus-host Disease-like Scleroderma written by Akimasa Saito and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: There are few effective treatments for sclerotic skin disorders including systemic scleroderma, chronic graft-versus-host disease (GVHD) and morphea. Because interferon (IFN)-u03b3 directly inhibits the proliferation of skin fibroblasts and the production of collagen in vitro, IFN-u03b3 is known as an antifibrotic factor. However, administration of recombinant IFN-u03b3 could not inhibit fibrosis in patients with systemic scleroderma. To elucidate the role of IFN-u03b3 on skin fibrosis, we established a new murine model of scleroderma. We found that chicken ovalbumin (OVA)-specific CD8 T cell (OT-I cell)-transferred transgenic mice that express membrane-bound OVA under the control of a keratin 14 promoter (K14-mOVA Tg mice), which develop acute GVHD-like mucocutaneous disease 14 days after the transfer, present chronic GVHD-like scleroderma 28 days after the transfer. While GFP+IFN-u03b3-/-OT-I cells-transferred K14-mOVA Tg mice developed acute GVHD-like mucocutaneous disease as severe as GFP+OT-I cell-transferred mice 14 days after the transfer, GFP+IFN-u03b3-/-OT-I cells-transferred K14-mOVA Tg mice developed significantly milder scleroderma than GFP+OT-I cell-transferred mice 28 days after the transfer, which were assessed by dermal thickness (the averages: 93.1 v.s. 118.6u03bcm), the numbers of infiltrating u03b1SMA+ fibroblasts (126 v.s. 291/HPF), and hydroxyproline contents (5.9 v.s. 10.9u03bcg/mg). In addition, the levels of mRNA of Col1a2 (30.5 v.s. 90.0), u03b1SMA (0.6 v.s. 1.3) 28 days after the transfer, TGFu03b2 (0.7 v.s. 1.3) 14 days after the transfer were significantly lower in the skins of GFP+IFN-u03b3-/-OT-I cell-transferred K14-mOVA Tg mice than in those of GFP+OT-I cell-transferred mice by quantitative real-time PCR. Moreover, immunostaining with anti-GFP antibodies detected more GFP+OT-I cells infiltrating in the skins of K14-mOVA Tg mice than GFP+IFN-u03b3-/-OT-I cells 21 days after the transfer, which correlated to the levels of mRNA of IFN-u03b3-inducible chemokines (CXCL9, CXCL10 and CXCL11). Collectively, IFN-u03b3 may play a crucial role as a trigger in the pathogenesis of skin fibrosis.
Author : Gerard Socie
Publisher : Academic Press
ISBN 13 : 0128134399
Total Pages : 430 pages
Book Rating : 4.1/5 (281 download)
Download or read book Immune Biology of Allogeneic Hematopoietic Stem Cell Transplantation written by Gerard Socie and published by Academic Press. This book was released on 2018-11-22 with total page 430 pages. Available in PDF, EPUB and Kindle. Book excerpt: Immune Biology of Allogeneic Hematopoietic Stem Cell Transplantation: Models in Discovery and Translation, Second Edition once again provides clinical and scientific researchers with a deep understanding of the current research in this field and the implications for translational practice. By providing an overview of the immune biology of HSCT, an explanation of immune rejection, and detail on antigens and their role in HSCT success, this book embraces biologists and clinicians who need a broad view of the deeply complex processes involved. It then moves on to discuss the immunobiology mechanisms that influence graft-versus-host disease (GVHD), graft-versus-leukemia effect, and transplantation success. Using illustrative figures, highlighting key issues, describing recent successes, and discussing unanswered questions, this book sums up the current state of HSCT to enhance the prospects for the future. The second edition is fully revised and includes new chapters on microbiome, metabolism, kinase targets, micro-RNA and mRNA regulatory mechanisms, signaling pathways in GVHD, innate lymphoid system development, recovery and function in GVHD, genetically engineered T-cell therapies, immune system engagers for GVHD and graft-versus-tumor, and hematopoietic cell transplant for tolerance induction in solid organ grafts. Brings together perspectives from leading laboratories and clinical research groups to highlight advances from bench to the bedside Guides readers through the caveats that must be considered when drawing conclusions from studies with animal models before correlating to clinical allogeneic hematopoietic stem cell transplantation (HSCT) scenarios Categorizes the published advances in various aspects of immune biology of allogeneic HSCT to illustrate opportunities for clinical applications
Author :
Publisher : John Wiley & Sons
ISBN 13 : 111817979X
Total Pages : 744 pages
Book Rating : 4.1/5 (181 download)
Download or read book Biotechnology and Biopharmaceuticals written by and published by John Wiley & Sons. This book was released on 2013-12-16 with total page 744 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biotechnology and Biopharmaceuticals: Transforming Proteins and Genes into Drugs, Second Edition addresses the pivotal issues relating to translational science, including preclinical and clinical drug development, regulatory science, pharmaco-economics and cost-effectiveness considerations. The new edition also provides an update on new proteins and genetic medicines, the translational and integrated sciences that continue to fuel the innovations in medicine, as well as the new areas of therapeutic development including cancer vaccines, stem cell therapeutics, and cell-based therapies.
Author : O. Van Bekkum
Publisher : Academic Press
ISBN 13 : 9780127103501
Total Pages : pages
Book Rating : 4.1/5 (35 download)
Download or read book Radiation Chimeras written by O. Van Bekkum and published by Academic Press. This book was released on 1967-01-01 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : M. Eric Gershwin
Publisher : Springer Science & Business Media
ISBN 13 : 331902096X
Total Pages : 482 pages
Book Rating : 4.3/5 (19 download)
Download or read book Liver Immunology written by M. Eric Gershwin and published by Springer Science & Business Media. This book was released on 2013-11-19 with total page 482 pages. Available in PDF, EPUB and Kindle. Book excerpt: Liver Immunology: Principles and Practice, Second Edition begins with important information about the epidemiology and mortality of liver disease worldwide. This information is followed by chapters related to basic immunology, application of liver immunology for diagnosis, and several excellent chapters that provide a solid foundation for understanding immune-mediated liver disease, including those associated with the biliary tree. A chapter on non-hepatic manifestations of immune mediated liver disease helps provide context for how these diseases affect the patient overall. In addition, chapters discuss various discrete immunologically-mediated infectious liver disorders including those related to bacteria, parasites, and all of the classic viruses. Chapters on the traditional autoimmune liver diseases -- primary biliary cirrhosis, autoimmune hepatitis, primary sclerosing cholangitis as well as overlap syndrome – are also included. The breadth of this comprehensive second edition is highlighted by chapters on alcoholic liver disease, non-alcoholic fatty liver disease, and drug-induced liver disease, among others. This invaluable new edition ends with a forward-looking view of future directions and how the field might meet the challenge of refractory patients. Developed by a renowned group of authors, Liver Immunology: Principles and Practice, Second Edition will again serve as a comprehensive textbook by providing an excellent overview for this rapidly evolving field. It greatly adds to the understanding of the pathogenesis of these diseases, while also providing novel insights that can be harnessed into helping improve the care of patients afflicted with various immune-mediated diseases. This volume will again be a must-read for clinicians at all levels, investigators and students.
Author : Joseph H. Antin
Publisher : Cambridge University Press
ISBN 13 : 1107661544
Total Pages : 204 pages
Book Rating : 4.1/5 (76 download)
Download or read book Manual of Stem Cell and Bone Marrow Transplantation written by Joseph H. Antin and published by Cambridge University Press. This book was released on 2013-10-17 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt: The fully revised second edition is a practical manual for all members of the stem cell and bone marrow transplant team.
Author : Ann M. Berger
Publisher : Lippincott Williams & Wilkins
ISBN 13 : 1469822512
Total Pages : 1950 pages
Book Rating : 4.4/5 (698 download)
Download or read book Principles and Practice of Palliative Care and Supportive Oncology written by Ann M. Berger and published by Lippincott Williams & Wilkins. This book was released on 2012-12-03 with total page 1950 pages. Available in PDF, EPUB and Kindle. Book excerpt: Unlike other textbooks on this subject, which are more focused on end of life, the 4th edition of Principles and Practice of Palliative Care and Supportive Oncology focuses on supportive oncology. In fact, the goal of this textbook is to provide a source of both help and inspiration to all those who care for patients with cancer. Written in a more reader-friendly format, this textbook not only offers authoritative and up-to-date reviews of research and clinical care best practices, but also practical clinical applications to help readers put everything they learn to use.
