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Integrated Molecular Imaging And Therapy For Breast Cancer
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Book Synopsis Integrated Molecular Imaging and Therapy for Breast Cancer by :
Download or read book Integrated Molecular Imaging and Therapy for Breast Cancer written by and published by . This book was released on 2007 with total page 33 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this project, we have demonstrated multi-component molecular targeting of surface receptors (IGF1R and Her2) and NIR dosing of cancer cells using SWCNT. While previous studies have shown the transport of DNA into cells using nanotubes, in this study we show multicomponent molecular targeting of both IGF1R and Her2 surface markers in cancer cells using single wall carbon nanotubes. IGF1 and Her2 specific antibodies conjugated to the SWCNT were used to target their corresponding receptors in cells and internalize the SWCNT. The cells were then dosed with NIR 808 nm photons at ~800 mW/sq cm for 3 minutes. Cells that were treated with non-specific antibody-SWCNT hybrids survived the NIR dosing compared to the dead cells with anti-IGF1- anti-Her2-SWCNT hybrids. The amount of energy consumed for cell killing was estimated to be as small as ~200 nW per cell, which is an order of magnitude smaller than competing techniques. Quantitative estimates showed that cells incubated with SWCNT-anti-Her-anti-IGF1R antibodies were completely destroyed while 80% of the non-specific-antibody-SWCNT hybrids treated cells were still alive. These results indicate that SWCNT could be used as biological transport agents and the high optical absorbance in the NIR are capable of killing cancer cells with minimum collateral damage. Further, western blots indicated the relevance of targeting IGF1R in MCF7 cancer cells and Her2 in BT474 breast cancer cells. This study is another clear example of molecular targeting and cell killing approach that can improve therapeutic efficacies. These tools can also be applied to traditional surgical oncology to improve the probability of killing cancer cells whose microscopic foci are often left behind in surgery.
Book Synopsis Breast Cancer: Uses and Opportunities for Molecular Imaging, An Issue of PET Clinics, E-Book by : Elizabeth McDonald
Download or read book Breast Cancer: Uses and Opportunities for Molecular Imaging, An Issue of PET Clinics, E-Book written by Elizabeth McDonald and published by Elsevier Health Sciences. This book was released on 2018-07-13 with total page 185 pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of PET Clinics focuses on Breast Cancer: Uses and Opportunities for Molecular Imaging, and is edited by Drs. Elizabeth McDonald and Gary A. Ulaner. Articles will include: Overview of Breast Cancer Screening and Diagnosis; Nuclear Imaging for Osseous Staging; Therapeutic Role of FDG in Breast Cancer: Treatment Response; Clinical Potential of HER2 Receptor Imaging; Novel Targets for Imaging Breast Cancer: Amino Acid Imaging with Fluciclovine; Overview of Breast Cancer Therapy; Molecular Classification of Breast Cancer; Clinical Potential of Estrogen and Progesterone Receptor Imaging; Diagnostic Role of FDG in Breast Cancer: Discovery to Current; Imaging Breast Cancer Proliferation; Dedicated Breast Gamma Camera Imaging and Breast Positron Emission Tomography: Current Status and Future Directions; and more!
Book Synopsis Molecular Imaging in Oncology by : Martin G. Pomper
Download or read book Molecular Imaging in Oncology written by Martin G. Pomper and published by CRC Press. This book was released on 2008-10-13 with total page 762 pages. Available in PDF, EPUB and Kindle. Book excerpt: With molecular imaging becoming one the fastest growing topics in medical schools, Informa Healthcare presents Molecular Imaging in Oncology, the first comprehensive reference on molecular imaging in oncology.Giving clinicians and researchers a greater understanding of the current field, this text covers:instrumentation and techniquescancer imaging
Book Synopsis Exploring Cancer Metabolic Reprogramming through Molecular Imaging by : Franca Podo
Download or read book Exploring Cancer Metabolic Reprogramming through Molecular Imaging written by Franca Podo and published by Frontiers Media SA. This book was released on 2017-07-27 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt: The inclusion of oncogene-driven reprogramming of energy metabolism within the list of cancer hallmarks (Hanahan and Weinberg, Cell 2000, 2011) has provided major impetus to further investigate the existence of a much wider metabolic rewiring in cancer cells, which not only includes deregulated cellular bioenergetics, but also encompasses multiple links with a more comprehensive network of altered biochemical pathways. This network is currently held responsible for redirecting carbon and phosphorus fluxes through the biosynthesis of nucleotides, amino acids, lipids and phospholipids and for the production of second messengers essential to cancer cells growth, survival and invasiveness in the hostile tumor environment. The capability to develop such a concerted rewiring of biochemical pathways is a versatile tool adopted by cancer cells to counteract the host defense and eventually resist the attack of anticancer treatments. Integrated efforts elucidating key mechanisms underlying this complex cancer metabolic reprogramming have led to the identification of new signatures of malignancy that are providing a strong foundation for improving cancer diagnosis and monitoring tumor response to therapy using appropriate molecular imaging approaches. In particular, the recent evolution of positron emission tomography (PET), magnetic resonance spectroscopy (MRS), spectroscopic imaging (MRSI), functional MR imaging (fMRI) and optical imaging technologies, combined with complementary cellular imaging approaches, have created new ways to explore and monitor the effects of metabolic reprogramming in cancer at clinical and preclinical levels. Thus, the progress of high-tech engineering and molecular imaging technologies, combined with new generation genomic, proteomic and phosphoproteomic methods, can significantly improve the clinical effectiveness of image-based interventions in cancer and provide novel insights to design and validate new targeted therapies. The Frontiers in Oncology Research Topic “Exploring Cancer Metabolic Reprogramming Through Molecular Imaging” focusses on current achievements, challenges and needs in the application of molecular imaging methods to explore cancer metabolic reprogramming, and evaluate its potential impact on clinical decisions and patient outcome. A series of reviews and perspective articles, along with original research contributions on humans and on preclinical models have been concertedly included in the Topic to build an open forum on perspectives, present needs and future challenges of this cutting-edge research area.
Book Synopsis Breast Cancer: Advances in Molecular Imaging, An Issue of PET Clinics, E-Book by : Gary A. Ulaner
Download or read book Breast Cancer: Advances in Molecular Imaging, An Issue of PET Clinics, E-Book written by Gary A. Ulaner and published by Elsevier Health Sciences. This book was released on 2023-09-06 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this issue, guest editors bring their considerable expertise to this important topic. Contains 10 relevant, practice-oriented topics including current dedicated breast imaging: recent advances and current limitations; breast cancer systemic staging (comparison of CT, bone scan, FDG PET); breast cancer treatment response (comparison of CT, bone scan, FDG PET); artificial intelligence and machine learning in breast cancer imaging; molecular classification of breast cancer; and more. Provides in-depth clinical reviews on breast cancer: advances in molecular imaging, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.
Book Synopsis Integrating C-met Molecular Imaging Into the Optimisation of Cancer Therapy by : Appitha Arulappu
Download or read book Integrating C-met Molecular Imaging Into the Optimisation of Cancer Therapy written by Appitha Arulappu and published by . This book was released on 2016 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Basal-like subtypes of breast cancer (BLBC) account for about 15-20% of all breast cancer, affecting younger women (
Book Synopsis Molecular Imaging Probes For Cancer Research by : Xiaoyuan (Shawn) Chen
Download or read book Molecular Imaging Probes For Cancer Research written by Xiaoyuan (Shawn) Chen and published by World Scientific. This book was released on 2012-07-31 with total page 1102 pages. Available in PDF, EPUB and Kindle. Book excerpt: This review volume integrates the advances in cancer biology, molecular imaging techniques and imaging probes for visualization and quantitative measurement of anatomical, functional, and molecular profiles of cancer. The volume also presents a comprehensive summary of the state-of-the-art technology in molecular imaging probe design and applications in radionuclide (PET and SPECT), magnetic resonance (MR), optical (fluorescence, Raman, photoacoustic), ultrasound, CT, and multimodality imaging. Bringing together the fundamentals of molecular imaging, and the basic principles of each molecular imaging modality in this volume, readers' understanding in this field is further enhanced. With a strong emphasis on the chemistry of the design of appropriate molecular imaging probes for early cancer detection, therapy-response monitoring, and anti-cancer drug development, the process of translating novel cancer imaging probes from bench to bedside is extensively discussed.
Book Synopsis PET/CT in Breast Cancer by : Rakesh Kumar
Download or read book PET/CT in Breast Cancer written by Rakesh Kumar and published by Springer Nature. This book was released on 2023-07-26 with total page 110 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aim of this book is to provide crisp information related to pathology, management and radiological/molecular imaging in breast carcinoma, along with detailed information on FDG PET-CT in breast cancer, normal variants, artefacts, pitfalls with atlas illustrations. The book is unique in providing quick reference to practice of PET/CT in breast cancer. The initial few chapters are related to the pathology and management of breast carcinoma to help understand the pathophysiology of breast cancer before going to the imaging. The chapter on imaging in breast cancer highlights the role of different imaging modalities for different indications to the reader. The last four chapters describe in detail the role, normal variants, artefacts and pitfalls of FDG PET/CT along with recent molecular imaging advances in breast cancer. Written by Pathology, Oncology, Radiology and Nuclear Medicine experts from different countries with enormous experience in breast cancer practice, the book addresses nuclear medicine physicians and radiologists, but it may be of interest to a wider medical community, including oncologists and radiotherapists.
Book Synopsis Targeted Molecular Imaging by : Michael J. Welch
Download or read book Targeted Molecular Imaging written by Michael J. Welch and published by CRC Press. This book was released on 2012-02-24 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt: Targeted Molecular Imaging covers the development of novel diagnostic approaches that use an imaging probe and agent to noninvasively visualize cellular processes in normal and disease states. It discusses the concept, development, preclinical studies, and, in many cases, translation to the clinic of targeted imaging agents. The many case studies that form the core of this book deal with the development and translation of non-nuclear probes and radiotracers; other sections address critical topics such as In vitro studies, small animal research, and the application of targeted probes for nuclear, optical and MRI imaging. The chapters use a common format to demonstrate how various investigators approach the comprehensive task of validating a new targeted probe. Targeted Molecular Imaging is a timely resource for a rapidly advancing field, and addresses: Various methods of validating a new targeted probe through examples from human studies with imaging of breast cancer, cardiovascular disease, and neurodegenerative diseases Basic principles, disease models, imaging studies in animals, imaging in initial human studies, and the application of molecular imaging in pharmacy and drug discovery In vitro studies, small animal studies, and targeted radiopharmaceuticals Using these case studies, investigators can generalize and apply the information to their own specific targeted probe. The insights provided by the contributors, experts who have developed these approaches in their own groups, help guide scientists planning to translate imaging agents from the concept stage to clinical application.
Book Synopsis In Vivo Imaging of Cancer Therapy by : Anthony F. Shields
Download or read book In Vivo Imaging of Cancer Therapy written by Anthony F. Shields and published by Springer Science & Business Media. This book was released on 2007-12-06 with total page 343 pages. Available in PDF, EPUB and Kindle. Book excerpt: A variety of cutting-edge imaging techniques, including their use for best practice, are addressed in this book. The book also provides examples of results found in both pre-clinical and clinical studies. This comprehensive text covers the entire spectrum of in vivo imaging for oncology. It will aide clinicians at all levels in keeping up with the most cutting-edge techniques.
Book Synopsis Cancer Theranostics by : Xiaoyuan Chen
Download or read book Cancer Theranostics written by Xiaoyuan Chen and published by Academic Press. This book was released on 2014-03-20 with total page 543 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aiding researchers seeking to eliminate multi-step procedures, reduce delays in treatment and ease patient care, Cancer Theranostics reviews, assesses, and makes pertinent clinical recommendations on the integration of comprehensive in vitro diagnostics, in vivo molecular imaging, and individualized treatments towards the personalization of cancer treatment. Cancer Theranostics describes the identification of novel biomarkers to advance molecular diagnostics of cancer. The book encompasses new molecular imaging probes and techniques for early detection of cancer, and describes molecular imaging-guided cancer therapy. Discussion also includes nanoplatforms incorporating both cancer imaging and therapeutic components, as well as clinical translation and future perspectives. - Supports elimination of multi-step approaches and reduces delays in treatments through combinatorial diagnosis and therapy - Fully assesses cancer theranostics across the emergent field, with discussion of biomarkers, molecular imaging, imaging guided therapy, nanotechnology, and personalized medicine - Content bridges laboratory, clinic, and biotechnology industries to advance biomedical science and improve patient management
Book Synopsis Multi-modality Molecular Imaging of Adoptive Immune Cell Therapy in Breast Cancer by : Fatma Mousa Youniss
Download or read book Multi-modality Molecular Imaging of Adoptive Immune Cell Therapy in Breast Cancer written by Fatma Mousa Youniss and published by . This book was released on 2014 with total page 146 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Cancer Therapeutics And Imaging: Molecular And Cellular Engineering And Nanobiomedicine by : Kaushal Rege
Download or read book Cancer Therapeutics And Imaging: Molecular And Cellular Engineering And Nanobiomedicine written by Kaushal Rege and published by World Scientific. This book was released on 2017-12-05 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the latest advancements in molecular and cellular engineering approaches in addition to nanotechnology for cancer therapeutics and imaging. It also provides an excellent background and state-of-the-art developments in the fields of drug and gene delivery, engineering nanoparticles for therapy and diagnostics, and cancer imaging techniques.The contents of this book include chapters on cutting-edge science in molecular and cellular engineering and nanotechnology as applied to therapeutics and imaging in cancer diseases. The chapters also provide a comprehensive overview on gene therapy and delivery methods for cancer treatment, oral drug delivery and barriers, cancer imaging for diagnostics and therapy, and the latest developments in these fields.
Book Synopsis Current Advances in Breast Cancer Research: A Molecular Approach by : Shankar Suman
Download or read book Current Advances in Breast Cancer Research: A Molecular Approach written by Shankar Suman and published by Bentham Science Publishers. This book was released on 2020-04-30 with total page 401 pages. Available in PDF, EPUB and Kindle. Book excerpt: Breast cancer is a recognized disease around the world with varying patient outcomes based on the type of breast cancer, access to healthcare and other factors. Survival rates for breast cancer are significantly lower in metastatic cases than localized cases. Early diagnosis and effective treatments for the efficient management of breast cancer are now in demand , as they help to prolong patient life. There have been many breakthrough developments in the molecular biology of breast cancer research in recent times. Advancements in diagnostic techniques (imaging and biomarker detection) for breast cancer have improved the screening of the disease and have improved patient outcomes. Despite these enhancements, the disease is still lethal for patients and the search for a cure requires a complete understanding of the disease. Current Advances in Breast Cancer Research: A Molecular Approach presents a comprehensive overview of current basic and translational research on the subject. The 14 chapters of the book give emphasis to current knowledge about breast cancer, ongoing challenges, and innovative research findings by different research groups. Readers will find detailed information about breast cancer biology, genetics, clinical diagnostics and treatments. Additional information for advanced readers in life sciences, such as techniques relevant to genomics (including genetic fingerprinting), proteomics, metabolomics and medicine (such as imaging and molecular diagnostics) is also provided. The combination of both basic and advanced information makes this book a useful reference to the student and researcher, alike, seeking an understanding about breast cancer at a molecular level.
Book Synopsis Breast Cancer Management and Molecular Medicine by : Martine J. Piccart
Download or read book Breast Cancer Management and Molecular Medicine written by Martine J. Piccart and published by Springer Science & Business Media. This book was released on 2007-05-31 with total page 1048 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tailoring treatment for individual breast cancers is no longer a dream and is now the main goal for current research. This book gives an overview of the most recent techniques, agents and approaches for breast cancer and the individualization of treatment. Particular attention is given to organ-specific tailored approaches, specific populations, patients’ preferences and rehabilitation. Contributions from experts focus on the biomedical research behind the transfer of molecular biology knowledge into the clinical management of patients. This has led to increased survival as well as improved quality of life. The book gives an overview of the latest achievements in breast cancer and their use in clinical practice.
Book Synopsis Personalized Pathway-Activated Systems Imaging in Oncology by : Tomio Inoue
Download or read book Personalized Pathway-Activated Systems Imaging in Oncology written by Tomio Inoue and published by Springer. This book was released on 2017-03-01 with total page 245 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive volume covers radiopharmaceuticals developed for pathway-directed systems in imaging and theranostic applications. We now are at the cutting edge of providing personalized treatment with increased use in oncology of these new radiopharmaceuticals. Trends in high-resolution instrumentation development, quality assurance systems and regulatory compliance for radiopharmaceuticals, clinical evaluation of radiopharmaceuticals, and benefits and pitfalls of the current clinical FDG PET are discussed. Radiopharmaceuticals are used for diagnosis of diseases of the central nervous and cardiovascular systems and for staging, restaging, and treatment planning for cancers. Nuclear biomarkers allow precise measurement of molecular pathways on a whole-body image upon administration of functional radiolabeled agents, and nuclear imaging agents have potential use in patient selection, pharmacokinetic, dosage-finding, and proof-of-concept studies. Nuclear imaging agents and hybrid instrumentation also provide sensitive and specific answers for differential responsiveness in therapeutic outcome. This book serves as a reference for moving the discovery and development of radiopharmaceuticals from the workbench to clinical applications. It thus benefits not only clinicians but also translational research scientists—molecular biologists, chemists, imaging scientists, pharmaceutical developers, physicists, and support staff.
Book Synopsis Molecular Pathology of Breast Cancer by : Sunil Badve
Download or read book Molecular Pathology of Breast Cancer written by Sunil Badve and published by Springer. This book was released on 2016-11-26 with total page 427 pages. Available in PDF, EPUB and Kindle. Book excerpt: The complex landscape of breast cancer requires distinct strategies for the management of various molecular subtypes of this disease. Rapid advances in the field of molecular biology have been bewildering for those involved in its study and management. “Molecular Pathology of Breast Cancer” aims to close this knowledge gap by discussing comprehensively the evolution, biological basis and clinical applications with a focus on the “what, when, and how” of the most significant molecular markers known to date. These markers are evaluated in the context of genomic, transcriptomic and proteomic profiles, which is integral to the practice of precision medicine. The application of next generation sequencing (NGS) has provided new insights in the regulation of genomic and transcriptomic structure and function. Alterations in DNA such as mutations and single nucleotide polymorphisms (SNPs) have been correlated with outcomes and provide for novel therapeutic approaches. These NGS analyses have also revealed the extensive contributions of epigenetic mechanisms such as histone modifications, non-coding RNA and alternative splicing. All of these changes together contribute to alterations in proteome. Newer assays that allow greater stability and analytical consistency are emerging. These alterations in tumor profiles can be also now detected by imaging techniques. The heterogeneity of both tumor and tumor microenvironment, an inevitable reality, is discussed in detail with particular focus on cancer stem cells and immune signaling. A chapter is dedicated to the emerging technology of “liquid biopsy”, which opens a novel approach for “continuous” monitoring of cancer that might be superior to conventional diagnostics, “Molecular Pathology of Breast Cancer” provides a quick and easy, not to mention essential, tour for clinicians, pathologists and scientists who are seeking to understand the integration of molecular biology into the diagnosis, prognosis and management of breast cancer.
