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Integrated Circuit Design For Miniaturized Trackable Ultrasound Based Biomedical Implants
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Book Synopsis Integrated Circuit Design for Miniaturized, Trackable, Ultrasound Based Biomedical Implants by : Yihan Zhang
Download or read book Integrated Circuit Design for Miniaturized, Trackable, Ultrasound Based Biomedical Implants written by Yihan Zhang and published by . This book was released on 2020 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Using an ion-sensitive field effect transistor (ISFET) and reference field effect transistor pair (REFET), the IC requires minimum additional post fabrication to deliver 10-bit resolution pH readouts at an end-to-end sensitivity of 65.8 LSB/pH. When working as a standalone device, this work advances the state-of-the-art of ISFET based pH sensor design. With an addition of 0.46 mm2 of area, it is possible to integrate it with the ultrasound sonography compatible implant platform. This potential integration will further advance the vision of the augmented ultrasonography: real-time display of physiological information in a B-mode film, with the help from a distributed bio-sensor system for deep-tissue physiology monitoring.
Book Synopsis Ultrasonic Wireless Power and Data Transmission to Miniaturized Biomedical Implants Using Phased Array by : Zeinab Kashani
Download or read book Ultrasonic Wireless Power and Data Transmission to Miniaturized Biomedical Implants Using Phased Array written by Zeinab Kashani and published by . This book was released on 2023 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This PhD dissertation focuses on developing efficient ultrasonic (US) wireless power and data transfer technologies for biomedical implants with millimeter (mm) dimensions. An ultrasonically interrogated (power/data) system with an external US array for beam focusing and steering through US beamforming is proposed to enable gastric electrical-wave mapping for diagnosing and eventually treating gastrointestinal motility disorders. The dissertation is divided into five parts. In the first part, the theory, design, and characterization of a wireless power transfer (WPT) link using mm-sized receivers (Rx) and a phased array (as external transmitter) are discussed. For given constraints imposed by the application and fabrication, such as the load (RL) and focal/powering distance (F), the optimal geometries of a US phased array and Rx transducer, as well as the optimal operation frequency (fc) are found through an iterative design procedure to maximize the power transfer efficiency (PTE). An optimal figure of merit (FoM) related to the link's PTE is proposed to simplify the US array design. In measurements, a fabricated 16-element array driven by 100 V pulses at an optimal frequency generated a US beam with a pressure output of 0.8 MPa and delivered up to 6 mW to a 1 mm3 Rx with a PTE of 0.14%. In the second part of this dissertation, a comprehensive study of wireless power transmission using a 32-element phased array capable of beam focusing and steering up to 50 mm depth and ±60o angle is provided. The performance of the US WPT link using mm-sized US receivers with different geometries and dimensions, the effect of different types of errors in the delay profile of the beamforming system on the delivered power, and the feasibility and efficacy of implant's localization with pulse-delay measurements with limited number of elements are investigated. The WPT link performance is evaluated based on the delivered power (within FDA safety limits) to mm-sized receivers with different geometries and diameters. In the third part of this dissertation, optimal US pulse transmission is demonstrated that could be used for data transmission to/from millimeter-sized biomedical implants in general or the self-image-guided ultrasonic (SIG-US) WPT. In SIG-US WPT, short pulses are transmitted by the implant periodically. The relative delays in the received signal by each external transducer in an array are then used to guide the beamformer for optimal steering of the power beam towards the implant. The effect of number of transmitted pulses on the iv amplitude of the received signal is studied, which is vital for low-power robust transmission. Furthermore, an adaptive application-specific integrated circuit (ASIC) for closed-loop low-power (and robust) US pulse-based data transmission is presented. The number of transmitted US pulses is changed based on the received voltage at the external unit in the closed-loop system to improve robustness and minimize the power consumption of the data transmitter. The ASIC, designed and fabricated in a 0.35[mu]m standard CMOS process, includes power management, controller/pulse driver, and envelope detector units. The fourth part of this dissertation includes ASIC design for low-frequency, low-power, and low-noise amplifiers that will be used to record gastric slow-wave signals. Simulation results and some limited measurement results are provided. The fifth part of this dissertation includes measurement results for a dual-mode ultrasonic- magnetic approach for wireless power transmission and energy harvesting. This dual-mode approach has the potential to solve the problem of power reduction when implant is rotating and to deliver high power within FDA safety limit using two different modalities. The future steps for circuit/system design, development, and testing are outlined. This dissertation represents an important step towards an implantable fully wireless gastric system, interrogated with a dual-mode ultrasonic-magnetic link for wireless power/data transfer, which can have a broad impact in the fields of health monitoring, diagnosis, and therapy.
Book Synopsis Circuit Design Considerations for Implantable Devices by : Peng Cong
Download or read book Circuit Design Considerations for Implantable Devices written by Peng Cong and published by River Publishers. This book was released on 2018-02-01 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt: Implantable devices are a unique area for circuit designers. A comprehensive understanding of design trade-offs at the system level is important to ensure device success. Circuit Design Considerations for Implantable Devices provides knowledge to CMOS circuit designers with limited biomedical background to understand design challenges and trade-offs for implantable devices, especially neural interfacing. Technical topics discussed in the book include: Neural interface Neural sensing amplifiers Electrical stimulation Embedded Signal AnalysisWireless Power Transmission to mm-Sized Free-Floating Distributed ImplantsNext Generation Neural Interface Electronics
Book Synopsis Ultrasonic Wireless Links for Next-generation Miniaturized Implantable Sensors by : Marcus Joseph Weber
Download or read book Ultrasonic Wireless Links for Next-generation Miniaturized Implantable Sensors written by Marcus Joseph Weber and published by . This book was released on 2018 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Today's implantable medical devices rely on bulky batteries for energy supply, requiring invasive implant procedures, which limits their use to only last-resort therapies. New applications of implantable devices are being proposed, such as: peripheral nerve stimulation for treating chronic pain and inflammatory disease, optogenetic stimulation for mapping of neural pathways, and even sensing applications of neural potential, pressure, and temperature monitoring. To realize these new applications, and to achieve widespread use of implantable device therapy, a new energy paradigm must be designed to replace the batteries and allow for extreme implant miniaturization for minimally invasive implant procedures. Extreme implant miniaturization is especially critical for developing sensors for continuous monitoring, due to a higher threshold for implantation. Towards this goal, we propose ultrasound for efficient power transfer to deeply implanted and miniaturized implantable devices, and demonstrate ultrasonic link utility with design of an implantable pressure sensor and optogenetic stimulator. A comprehensive analysis and methodology is presented for designing ultrasonic receivers for efficient powering of miniaturized implantable medical devices. Key ultrasonic receiver efficiencies, resonance characteristics, and the inductive band are defined, and a theoretical model is presented for first-order design insights. Methods are described to accurately characterize the ultrasonic receiver impedance and acoustic-to-electrical aperture efficiency. Ultrasonic receivers are shown to achieve favorable source resistances from kOhm to 100's of kOhm, for matching to typical implant loads, and high aperture efficiencies of 40-90%. An iterative design methodology, using the theoretical model and impedance measurements is demonstrated for an example ultrasonic receiver design. An ultrasonically powered, millimeter-sized implantable device is proposed for future optogenetic peripheral nerve stimulation in large animal models. Through system level analysis, the effective impedance match between the ultrasonic receiver and implant electronics is shown as the dominant component of the power recovery efficiency. We present a numerically solved time-domain impedance match analysis of the non-linear power electronics to derive the optimal ultrasonic receiver impedance, and the design of the ultrasonic receiver is shown to meet this specification. The implantable stimulator is characterized through both electrical and optical measurements, demonstrating high peak optical intensities of 1-15 mW/mm2 with safe levels of ultrasonic power. Finally, a high-precision implantable pressure sensor with ultrasonic power-up and data uplink is presented for applications in continuous pressure monitoring. The fully integrated implant measures 1.7 mm x 2.3 mm x 7.8 mm and includes a custom IC, a pressure transducer, an energy storage capacitor, and an ultrasonic transducer. In order to reduce overall dimensions, unique circuit and system design techniques are presented to enable a single time-multiplexed ultrasonic transducer for both power recovery and data uplink transmission. Implant performance is characterized at significant depths, 12 cm in a tissue phantom, offering a > 13x improvement over the state of the art in the depth/volume figure of merit, while demonstrating a robust ultrasonic data uplink with better than 1e-5 bit error rate. A transient charging analysis is presented to derive the optimal ultrasonic receiver impedance and charging specifications to maximize overall harvesting efficiency. The IC features a front-end with a 10-bit SAR ADC, achieving a pressure full-scale range of 800 mmHg with a pressure resolution of 0.78 mmHg, exceeding the requirements for a wide range of pressure sensing applications, while accounting for various nonidealities. The pressure sampling rate is fully externally controlled, up to 1 ksps, in order to significantly decrease implant energy consumption and to allow for adaptable programming for specific applications. The implantable sensor is packaged in biocompatible materials and wirelessly characterized in a custom-built pressure chamber, and in situ, using sheep tissue.
Book Synopsis Wearable Sensors by : Edward Sazonov
Download or read book Wearable Sensors written by Edward Sazonov and published by Elsevier. This book was released on 2014-08-14 with total page 649 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by industry experts, this book aims to provide you with an understanding of how to design and work with wearable sensors. Together these insights provide the first single source of information on wearable sensors that would be a valuable addition to the library of any engineer interested in this field. Wearable Sensors covers a wide variety of topics associated with the development and application of various wearable sensors. It also provides an overview and coherent summary of many aspects of current wearable sensor technology. Both industry professionals and academic researchers will benefit from this comprehensive reference which contains the most up-to-date information on the advancement of lightweight hardware, energy harvesting, signal processing, and wireless communications and networks. Practical problems with smart fabrics, biomonitoring and health informatics are all addressed, plus end user centric design, ethical and safety issues. Provides the first comprehensive resource of all currently used wearable devices in an accessible and structured manner Helps engineers manufacture wearable devices with information on current technologies, with a focus on end user needs and recycling requirements Combines the expertise of professionals and academics in one practical and applied source
Book Synopsis Mems for Biomedical Applications by : Shekhar Bhansali
Download or read book Mems for Biomedical Applications written by Shekhar Bhansali and published by Elsevier. This book was released on 2012-07-18 with total page 511 pages. Available in PDF, EPUB and Kindle. Book excerpt: The application of Micro Electro Mechanical Systems (MEMS) in the biomedical field is leading to a new generation of medical devices. MEMS for biomedical applications reviews the wealth of recent research on fabrication technologies and applications of this exciting technology.The book is divided into four parts: Part one introduces the fundamentals of MEMS for biomedical applications, exploring the microfabrication of polymers and reviewing sensor and actuator mechanisms. Part two describes applications of MEMS for biomedical sensing and diagnostic applications. MEMS for in vivo sensing and electrical impedance spectroscopy are investigated, along with ultrasonic transducers, and lab-on-chip devices. MEMS for tissue engineering and clinical applications are the focus of part three, which considers cell culture and tissue scaffolding devices, BioMEMS for drug delivery and minimally invasive medical procedures. Finally, part four reviews emerging biomedical applications of MEMS, from implantable neuroprobes and ocular implants to cellular microinjection and hybrid MEMS.With its distinguished editors and international team of expert contributors, MEMS for biomedical applications provides an authoritative review for scientists and manufacturers involved in the design and development of medical devices as well as clinicians using this important technology. Reviews the wealth of recent research on fabrication technologies and applications of Micro Electro Mechanical Systems (MEMS) in the biomedical field Introduces the fundamentals of MEMS for biomedical applications, exploring the microfabrication of polymers and reviewing sensor and actuator mechanisms Considers MEMS for biomedical sensing and diagnostic applications, along with MEMS for in vivo sensing and electrical impedance spectroscopy
Book Synopsis Piezoelectric Energy Harvesting by : Alper Erturk
Download or read book Piezoelectric Energy Harvesting written by Alper Erturk and published by John Wiley & Sons. This book was released on 2011-04-04 with total page 377 pages. Available in PDF, EPUB and Kindle. Book excerpt: The transformation of vibrations into electric energy through the use of piezoelectric devices is an exciting and rapidly developing area of research with a widening range of applications constantly materialising. With Piezoelectric Energy Harvesting, world-leading researchers provide a timely and comprehensive coverage of the electromechanical modelling and applications of piezoelectric energy harvesters. They present principal modelling approaches, synthesizing fundamental material related to mechanical, aerospace, civil, electrical and materials engineering disciplines for vibration-based energy harvesting using piezoelectric transduction. Piezoelectric Energy Harvesting provides the first comprehensive treatment of distributed-parameter electromechanical modelling for piezoelectric energy harvesting with extensive case studies including experimental validations, and is the first book to address modelling of various forms of excitation in piezoelectric energy harvesting, ranging from airflow excitation to moving loads, thus ensuring its relevance to engineers in fields as disparate as aerospace engineering and civil engineering. Coverage includes: Analytical and approximate analytical distributed-parameter electromechanical models with illustrative theoretical case studies as well as extensive experimental validations Several problems of piezoelectric energy harvesting ranging from simple harmonic excitation to random vibrations Details of introducing and modelling piezoelectric coupling for various problems Modelling and exploiting nonlinear dynamics for performance enhancement, supported with experimental verifications Applications ranging from moving load excitation of slender bridges to airflow excitation of aeroelastic sections A review of standard nonlinear energy harvesting circuits with modelling aspects.
Book Synopsis Nano-Bio- Electronic, Photonic and MEMS Packaging by : C.P. Wong
Download or read book Nano-Bio- Electronic, Photonic and MEMS Packaging written by C.P. Wong and published by Springer Science & Business Media. This book was released on 2009-12-23 with total page 761 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanotechnologies are being applied to the biotechnology area, especially in the area of nano material synthesis. Until recently, there has been little research into how to implement nano/bio materials into the device level. “Nano and Bio Electronics Packaging” discusses how nanofabrication techniques can be used to customize packaging for nano devices with applications to biological and biomedical research and products. Covering such topics as nano bio sensing electronics, bio device packaging, NEMs for Bio Devices and much more.
Book Synopsis Neural Interface Engineering by : Liang Guo
Download or read book Neural Interface Engineering written by Liang Guo and published by Springer Nature. This book was released on 2020-05-04 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive reference to major neural interfacing technologies used to transmit signals between the physical world and the nervous system for repairing, restoring and even augmenting body functions. The authors discuss the classic approaches for neural interfacing, the major challenges encountered, and recent, emerging techniques to mitigate these challenges for better chronic performances. Readers will benefit from this book’s unprecedented scope and depth of coverage on the technology of neural interfaces, the most critical component in any type of neural prostheses. Provides comprehensive coverage of major neural interfacing technologies; Reviews and discusses both classic and latest, emerging topics; Includes classification of technologies to provide an easy grasp of research and trends in the field.
Book Synopsis High-Density Integrated Electrocortical Neural Interfaces by : Sohmyung Ha
Download or read book High-Density Integrated Electrocortical Neural Interfaces written by Sohmyung Ha and published by Academic Press. This book was released on 2019-08-03 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt: High-Density Integrated Electrocortical Neural Interfaces provides a basic understanding, design strategies and implementation applications for electrocortical neural interfaces with a focus on integrated circuit design technologies. A wide variety of topics associated with the design and application of electrocortical neural implants are covered in this book. Written by leading experts in the field— Dr. Sohmyung Ha, Dr. Chul Kim, Dr. Patrick P. Mercier and Dr. Gert Cauwenberghs —the book discusses basic principles and practical design strategies of electrocorticography, electrode interfaces, signal acquisition, power delivery, data communication, and stimulation. In addition, an overview and critical review of the state-of-the-art research is included. These methodologies present a path towards the development of minimally invasive brain-computer interfaces capable of resolving microscale neural activity with wide-ranging coverage across the cortical surface. Written by leading researchers in electrocorticography in brain-computer interfaces Offers a unique focus on neural interface circuit design, from electrode to interface, circuit, powering, communication and encapsulation Covers the newest ECoG interface systems and electrode interfaces for ECoG and biopotential sensing
Book Synopsis Antenna and Sensor Technologies in Modern Medical Applications by : Yahya Rahmat-Samii
Download or read book Antenna and Sensor Technologies in Modern Medical Applications written by Yahya Rahmat-Samii and published by John Wiley & Sons. This book was released on 2021-02-25 with total page 624 pages. Available in PDF, EPUB and Kindle. Book excerpt: A guide to the theory and recent development in the medical use of antenna technology Antenna and Sensor Technologies in Modern Medical Applications offers a comprehensive review of the theoretical background, design, and the latest developments in the application of antenna technology. Written by two experts in the field, the book presents the most recent research in the burgeoning field of wireless medical telemetry and sensing that covers both wearable and implantable antenna and sensor technologies. The authors review the integrated devices that include various types of sensors wired within a wearable garment that can be paired with external devices. The text covers important developments in sensor-integrated clothing that are synonymous with athletic apparel with built-in electronics. Information on implantable devices is also covered. The book explores technologies that utilize both inductive coupling and far field propagation. These include minimally invasive microwave ablation antennas, wireless targeted drug delivery, and much more. This important book: Covers recent developments in wireless medical telemetry Reviews the theory and design of in vitro/in vivo testing Explores emerging technologies in 2D and 3D printing of antenna/sensor fabrication Includes a chapter with an annotated list of the most comprehensive and important references in the field Written for students of engineering and antenna and sensor engineers, Antenna and Sensor Technologies in Modern Medical Applications is an essential guide to understanding human body interaction with antennas and sensors.
Book Synopsis Design and Development of Medical Electronic Instrumentation by : David Prutchi
Download or read book Design and Development of Medical Electronic Instrumentation written by David Prutchi and published by John Wiley & Sons. This book was released on 2005-01-28 with total page 479 pages. Available in PDF, EPUB and Kindle. Book excerpt: Design and Development of Medical Electronic Instrumentation fills a gap in the existing medical electronic devices literature by providing background and examples of how medical instrumentation is actually designed and tested. The book includes practical examples and projects, including working schematics, ranging in difficulty from simple biopotential amplifiers to computer-controlled defibrillators. Covering every stage of the development process, the book provides complete coverage of the practical aspects of amplifying, processing, simulating and evoking biopotentials. In addition, two chapters address the issue of safety in the development of electronic medical devices, and providing valuable insider advice.
Book Synopsis VLSI Circuits for Biomedical Applications by : Krzysztof Iniewski
Download or read book VLSI Circuits for Biomedical Applications written by Krzysztof Iniewski and published by Artech House. This book was released on 2008 with total page 453 pages. Available in PDF, EPUB and Kindle. Book excerpt: Supported with over 280 illustrations and over 160 equations, the book offers cutting-edge guidance on designing integrated circuits for wireless biosensing, body implants, biosensing interfaces, and molecular biology. You discover innovative design techniques and novel materials to help you achieve higher levels circuit and system performance.
Download or read book Medical Device Design written by and published by Academic Press. This book was released on 2012-12-17 with total page 369 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides the bridge between engineering design and medical device development. There is no single text that addresses the plethora of design issues a medical devices designer meets when developing new products or improving older ones. It addresses medical devices' regulatory (FDA and EU) requirements--some of the most stringent engineering requirements globally. Engineers failing to meet these requirements can cause serious harm to users as well as their products’ commercial prospects. This Handbook shows the essential methodologies medical designers must understand to ensure their products meet requirements. It brings together proven design protocols and puts them in an explicit medical context based on the author's years of academia (R&D phase) and industrial (commercialization phase) experience. This design methodology enables engineers and medical device manufacturers to bring new products to the marketplace rapidly. The medical device market is a multi-billion dollar industry. Every engineered product for this sector, from scalpelsstents to complex medical equipment, must be designed and developed to approved procedures and standards. This book shows how Covers US, and EU and ISO standards, enabling a truly international approach, providing a guide to the international standards that practicing engineers require to understand Written by an experienced medical device engineers and entrepreneurs with products in the from the US and UK and with real world experience of developing and commercializing medical products
Book Synopsis Electromagnetic Actuation and Sensing in Medical Robotics by : Hongliang Ren
Download or read book Electromagnetic Actuation and Sensing in Medical Robotics written by Hongliang Ren and published by Springer. This book was released on 2017-12-30 with total page 221 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book highlights electromagnetic actuation (EMA) and sensing systems for a broad range of applications including targeted drug delivery, drug-release-rate control, catheterization, intravitreal needleless injections, wireless magnetic capsule endoscopy, and micromanipulations. It also reviews the state-of-the-art magnetic actuation and sensing technologies with remotely controlled targets used in biomedicine.
Book Synopsis Artificial Intelligence in Medical Imaging by : Erik R. Ranschaert
Download or read book Artificial Intelligence in Medical Imaging written by Erik R. Ranschaert and published by Springer. This book was released on 2019-01-29 with total page 373 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a thorough overview of the ongoing evolution in the application of artificial intelligence (AI) within healthcare and radiology, enabling readers to gain a deeper insight into the technological background of AI and the impacts of new and emerging technologies on medical imaging. After an introduction on game changers in radiology, such as deep learning technology, the technological evolution of AI in computing science and medical image computing is described, with explanation of basic principles and the types and subtypes of AI. Subsequent sections address the use of imaging biomarkers, the development and validation of AI applications, and various aspects and issues relating to the growing role of big data in radiology. Diverse real-life clinical applications of AI are then outlined for different body parts, demonstrating their ability to add value to daily radiology practices. The concluding section focuses on the impact of AI on radiology and the implications for radiologists, for example with respect to training. Written by radiologists and IT professionals, the book will be of high value for radiologists, medical/clinical physicists, IT specialists, and imaging informatics professionals.
Book Synopsis Converging Technologies for Improving Human Performance by : Mihail C. Roco
Download or read book Converging Technologies for Improving Human Performance written by Mihail C. Roco and published by Springer Science & Business Media. This book was released on 2013-04-17 with total page 477 pages. Available in PDF, EPUB and Kindle. Book excerpt: M. C. Roco and W.S. Bainbridge In the early decades of the 21st century, concentrated efforts can unify science based on the unity of nature, thereby advancing the combination of nanotechnology, biotechnology, information technology, and new technologies based in cognitive science. With proper attention to ethical issues and societal needs, converging in human abilities, societal technologies could achieve a tremendous improvement outcomes, the nation's productivity, and the quality of life. This is a broad, cross cutting, emerging and timely opportunity of interest to individuals, society and humanity in the long term. The phrase "convergent technologies" refers to the synergistic combination of four major "NBIC" (nano-bio-info-cogno) provinces of science and technology, each of which is currently progressing at a rapid rate: (a) nanoscience and nanotechnology; (b) biotechnology and biomedicine, including genetic engineering; (c) information technology, including advanced computing and communications; (d) cognitive science, including cognitive neuroscience. Timely and Broad Opportunity. Convergence of diverse technologies is based on material unity at the nanoscale and on technology integration from that scale.
