Read Books Online and Download eBooks, EPub, PDF, Mobi, Kindle, Text Full Free.
Insulin Like Growth Factor System In Human Central Nervous System Multiple Sclerosis And Amyotrophic Lateral Sclerosis
Download Insulin Like Growth Factor System In Human Central Nervous System Multiple Sclerosis And Amyotrophic Lateral Sclerosis full books in PDF, epub, and Kindle. Read online Insulin Like Growth Factor System In Human Central Nervous System Multiple Sclerosis And Amyotrophic Lateral Sclerosis ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!
Book Synopsis Insulin-like Growth Factor System in Human Central Nervous System, Multiple Sclerosis and Amyotrophic Lateral Sclerosis by : Nadine Wilczak
Download or read book Insulin-like Growth Factor System in Human Central Nervous System, Multiple Sclerosis and Amyotrophic Lateral Sclerosis written by Nadine Wilczak and published by . This book was released on 2003 with total page 177 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Role of Insulin-like Growth Factors in the Nervous System by : Mohan K. Raizada
Download or read book The Role of Insulin-like Growth Factors in the Nervous System written by Mohan K. Raizada and published by . This book was released on 1993 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume discusses various aspects of the insulin-like growth factors (IGFs), their binding proteins and receptors. The emphasis is on identification of these important growth factors in the nervous system and their potential role in nervous tissue physiology. The IFGs are compared to other growth factors that are important in the nervous system, including nerve growth factor.
Download or read book Amyotrophic Lateral Sclerosis written by and published by . This book was released on 1984 with total page 32 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Treatment of Neurodevelopmental Disorders by : Randi Jenssen Hagerman
Download or read book Treatment of Neurodevelopmental Disorders written by Randi Jenssen Hagerman and published by Oxford University Press, USA. This book was released on 2014 with total page 401 pages. Available in PDF, EPUB and Kindle. Book excerpt: This cutting-edge book brings advances in genetics, neurobiology, and psychopharmacology to the clinic to enhance treatment for neurodevelopmental disorders. Significant progress has been made in identifying the neurobiological mechanisms of several disorders and targeted treatments are modifying the outcome of these disorders. However, the ability to utilize this knowledge has not been summarized in one place for the practicing clinician. This book will fill that gap by providing the theoretical underpinnings and the latest advances in targeted treatments. Several neurodevelopmental disorders are reviewed in detail including clinical features and behavioral phenotypes, standard treatments and new targeted treatments based on the latest advances in neurobiology and the animal model studies that have lead to new treatments. The disorders covered include psychiatric disorders: schizophrenia, depression, autism and ADHD; single gene disorders including Tuberous Sclerosis, Fragile X Syndrome and fragile X- associated disorders, Angelman Syndrome, PKU, and Muscular Dystrophies; and complex genetic disorders such as Down syndrome. This book also highlights the commonalities across disorders and new genetic and molecular concepts in an easy to read format. This is a very exciting time for new targeted treatments and this volume is a landmark treatise on this new age of treatment.
Author : Publisher : ISBN 13 :019068609X Total Pages :329 pages Book Rating :4.1/5 (96 download)
Download or read book written by and published by . This book was released on with total page 329 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Search for a Treatment by : Michelle Renée Ohlson
Download or read book The Search for a Treatment written by Michelle Renée Ohlson and published by . This book was released on 2011 with total page 68 pages. Available in PDF, EPUB and Kindle. Book excerpt: Amyotrophic lateral sclerosis (ALS) is a progressive, fatal neurodegenerative disease. Each year, about 5,000 people in the US are diagnosed with ALS. Treatment options for ALS patients are very limited with only one FDA approved drug that extends survival by a few months. Mesenchymal stem cells (MSCs) have created a lot of interest as a possible treatment option for many difficult to treat diseases. The purpose of this project is to characterize genetically altered MSCs that overproduce IGF-1 (MSC-IGF-1), as well as, GFP (MSC-GFP) as a control as a possible, future treatment for ALS. During this research, it was found that MSC-IGF-1 produced IGF-1 at 18℗æg/mL of supernatant, while MSC-GFP produced no detectable IGF-1. MSC-IGF-1 proliferated at a slower rate than MSC-GFP during a proliferation assay. MSC-IGF-1 was found to have decreased osteogenic differentiation potential as compared to MSC-GFP. MSC-IGF-1 migrated and proliferated slower than MSC-GFP during a motility assay. In conclusion, there is still a large amount of future experimentation to be completed before this treatment plan can become an option for ALS patients, but there is a lot of potential in this research bringing hope for an effective treatment for patients that fight a tragic and fatal disease with very limited options.
Book Synopsis The Role of the IGF/Insulin-IGFBP Axis in Normal Physiology and Disease by : Claire Perks
Download or read book The Role of the IGF/Insulin-IGFBP Axis in Normal Physiology and Disease written by Claire Perks and published by Frontiers Media SA. This book was released on 2022-05-17 with total page 98 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Multiple Sclerosis by : Institute of Medicine
Download or read book Multiple Sclerosis written by Institute of Medicine and published by National Academies Press. This book was released on 2001-08-10 with total page 457 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multiple sclerosis is a chronic and often disabling disease of the nervous system, affecting about 1 million people worldwide. Even though it has been known for over a hundred years, no cause or cure has yet been discovered-but now there is hope. New therapies have been shown to slow the disease progress in some patients, and the pace of discoveries about the cellular machinery of the brain and spinal cord has accelerated. This book presents a comprehensive overview of multiple sclerosis today, as researchers seek to understand its processes, develop therapies that will slow or halt the disease and perhaps repair damage, offer relief for specific symptoms, and improve the abilities of MS patients to function in their daily lives. The panel reviews existing knowledge and identifies key research questions, focusing on: Research strategies that have the greatest potential to understand the biological mechanisms of recovery and to translate findings into specific strategies for therapy. How people adapt to MS and the research needed to improve the lives of people with MS. Management of disease symptoms (cognitive impairment, depression, spasticity, vision problems, and others). The committee also discusses ways to build and financially support the MS research enterprise, including a look at challenges inherent in designing clinical trials. This book will be important to MS researchers, research funders, health care advocates for MS research and treatment, and interested patients and their families.
Book Synopsis Molecular and Cellular Therapies for Motor Neuron Diseases by : Nicholas M Boulis
Download or read book Molecular and Cellular Therapies for Motor Neuron Diseases written by Nicholas M Boulis and published by Academic Press. This book was released on 2017-01-18 with total page 337 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular and Cellular Therapies for Motor Neuron Diseases discusses the basics of the diseases, also covering advances in research and clinical trials. The book provides a resource for students that will help them learn the basics in a detailed manner that is required for scientists and clinicians. Users will find a comprehensive overview of the background of Amyotrophic Lateral Sclerosis (ALS/Lou Gehrig's Disease) and Spinal Muscular Atrophy (SMA), along with the current understanding of their genetics and mechanisms. In addition, the book details gene and cell therapies that have been developed and their translation to clinical trials. - Provides an overview of gene and cell therapies for amyotrophic lateral sclerosis (ALS) and other motor neuron diseases - Edited by a leading Neurosurgeon and two research scientists to promote synthesis between basic neuroscience and clinical relevance - Presents a great resource for researchers and practitioners in neuroscience, neurology, and gene and cell therapy
Book Synopsis Neurotrophic Factors by : Franz Hefti
Download or read book Neurotrophic Factors written by Franz Hefti and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: The pharmacology of neurotrophic factors is part of the general field called neuroprotection or neurodegeneration, which has emerged during the past two decades. This new broad research area has identified molecular mechanisms that regulate the morphological plasticity of the nervous system and, in con sequence, discovered novel pharmacological approaches to manipulate these processes in disease states. The new, structural neuropharmacology as de scribed in this volume attempts to regulate the anatomic aspects of the nervous system and is perhaps comparable to hardware manipulation in computer systems. In contrast, classical neuropharmacology identified multiple ways to modify the function of existing synapses or ion channels in the nervous system, comparable to software manipulations in the computer field. The pharmacol ogy of neurotrophic factor is at an early stage and has not produced any major drugs yet. However, the first quintessential clinical trials have been carried out in the past two years or are currently in progress. Rapid further advances can be expected. The discovery of nerve growth factor (NGF), the first protein known to promote survival and growth of nerve cells, led to the discovery of a family of related proteins, the neurotrophins and their receptors. This concept was generalized to incorporate many other protein families that are included in the functional definition of neurotrophic factors, i. e. , proteins able to regulate survival and differentiation of neurons.
Book Synopsis Insulin-like Growth Factor Receptor Signalling by : Derek Leroith
Download or read book Insulin-like Growth Factor Receptor Signalling written by Derek Leroith and published by Springer Science & Business Media. This book was released on 2003-07-31 with total page 524 pages. Available in PDF, EPUB and Kindle. Book excerpt: Insulin-like growth factors are ubiquitously expressed and are crucial for growth and function of almost all cells. Together with their binding proteins and receptors, they form a widely studied biological system involving many proteins and characterized by complex interactions. In addition to its significance in growth and development, the insulin-like growth factor system also has important roles in a wide variety of pathological states. This has led to interest in the therapeutic potential of insulin-like growth factors and their binding proteins as candidate drug targets. This comprehensive book contains current information on both basic science and clinical aspects of IGFs and their regulatory proteins, with emphasis on their relevance to cancer.
Book Synopsis Neuroimmune Pharmacology by : Tsuneya Ikezu
Download or read book Neuroimmune Pharmacology written by Tsuneya Ikezu and published by Springer Science & Business Media. This book was released on 2008-03-21 with total page 850 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuroimmune pharmacology seeks to harness the immune system to provide pharmacological intervention to combat neurodegenerative diseases. This book provides a comprehensive overview of topics that embrace the link between the immune system and the pathogenesis of neurodegenerative disorders. Results from recent studies strongly suggest that a major part of the process in diseases including Alzheimer’s and Parkinson’s as well as Prion diseases, comes from changes in the innate and adaptive arms of the brain and peripheral immune systems. Thus, the book provides an in-depth study of numerous fields including immunology, pharmacology, neuroscience and neurovirology. It is accompanied by a CD-ROM that includes access to lectures, slide presentations, and question and answers on neuroimmune pharmacology.
Book Synopsis Investigating the Role of the Insulin-like Growth Factor Receptor (IGF1R) on Axonal Transport as a Target for Pharmacological Intervention in Amyotrophic Lateral Sclerosis by : Alexander Douglas Fellows
Download or read book Investigating the Role of the Insulin-like Growth Factor Receptor (IGF1R) on Axonal Transport as a Target for Pharmacological Intervention in Amyotrophic Lateral Sclerosis written by Alexander Douglas Fellows and published by . This book was released on 2019 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Update on Amyotrophic Lateral Sclerosis by : Humberto Foyaca Sibat
Download or read book Update on Amyotrophic Lateral Sclerosis written by Humberto Foyaca Sibat and published by BoD – Books on Demand. This book was released on 2016-09-14 with total page 281 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book contains selected peer-reviewed chapters which cover updated information on ALS written by international researchers. Update on Amyotrophic Lateral Sclerosis is comprised of 13 chapters from some of the world's top central nervous system researchers and neurologists to provide a timely review of the most recent developments in ALS, covering historic aspects, experimental animal models, genetics, pathogenesis, clinical aspects and imagenology among others. Contributors from Belgium, France, Japan, India, Italy, Mexico, Russia, South Africa, and Switzerland have collaborated enthusiastically and efficiently, dedicating their time to create this reader-friendly yet comprehensive work which includes many explanatory figures, tables and photos to enhance legibility and make the book clinically useful. We are looking forward with confidence and pride in the remarkable role that this book will play for a new vision and mission.
Book Synopsis Basic Neurochemistry by : George J. Siegel
Download or read book Basic Neurochemistry written by George J. Siegel and published by Lippincott Raven. This book was released on 1999 with total page 1216 pages. Available in PDF, EPUB and Kindle. Book excerpt: Illustrations by Lorie M. Gavulic, MFA Sponsored by the American Society for Neurochemistry.
Book Synopsis The Role of Actr10 in Nervous System Development and Disease by : Amy Louise Herbert
Download or read book The Role of Actr10 in Nervous System Development and Disease written by Amy Louise Herbert and published by . This book was released on 2018 with total page 229 pages. Available in PDF, EPUB and Kindle. Book excerpt: The vertebrate nervous system requires myelinating glia for the fast propagation of action potentials, as well as for vital trophic support to axons. Myelinating glia produce myelin, which is a lipid-rich, multi-lamellar sheath that surrounds axons and allows for rapid electrical signaling. In the central nervous system (CNS), myelin is produced by oligodendrocytes, while in the peripheral nervous system (PNS), Schwann cells perform this function. Although glia have historically been understudied compared to neurons, recent research has uncovered critical roles for glia in nervous system development and disease. Disruption to myelin or to the glial cells that generate myelin can have severe consequences for human health, as demonstrated by the debilitating symptoms of multiple sclerosis (MS) and Charcot-Marie-Tooth disease (CMT). In order to improve patient health, it is necessary to determine the etiology of demyelinating diseases, which in turn requires a comprehensive understanding of glial cell development and myelination. The scientific advances made in our understanding of myelinating glial cell development will be discussed in Chapter 1 of this dissertation. Although great progress has been achieved, our understanding of the molecular mechanisms that regulate myelination is incomplete. The zebrafish has emerged as an important model organism for studying myelin. In particular, the ability to perform forward genetic screens in zebrafish has greatly increased our understanding of the individual genes involved in myelination in both the CNS and the PNS. Although several myelin-related forward genetic screens have been previously performed in zebrafish, these screens were not done to saturation, potentially leaving essential genes unidentified. Our lab therefore performed a large scale forward genetic screen to uncover new players in myelin development. The screen was a collaborative effort between students in the Monk lab and members of the Solnica-Krezel lab. The myelin screen was highly successful, uncovering 31 mutants. The set-up and outcome of the screen is described in more detail in Chapter 2. One of the mutants identified in the screen was found to be the result of a mutation in the gene actin related protein 10 (actr10). Actr10 (or Arp11) is a component of the dynactin complex, which is necessary for retrograde transport of cargo by cytoplasmic dynein. Two alleles of actr10 zebrafish mutants, actr10stl83 (the allele originally identified in the screen) and actr10nl15 (a presumptive null generously shared by the Nechiporuk lab) exhibited reduced myelin in the CNS and in the PNS, as well as a punctate expression of myelin basic protein (mbp) in the hindbrain. Mbp has important roles in myelin compaction as well as in initiating wrapping of myelin around axon segments. Initial characterization of actr10nl15/nl15 mutants revealed a reduction in oligodendrocyte precursor cells, fewer myelinated axons by ultrastructural analysis, and increased cell division in mutant oligodendrocytes. Moreover, the punctate mbp phenotype was reminiscent of another zebrafish mutant in the anterograde kinesin motor kif1b. Importantly, mbp mRNA is transported and translated locally at the developing myelin sheath. I hypothesized that dynein/dynactin regulates anterograde transport of mbp mRNA in oligodendrocytes. To test this, I collaborated with another lab and found that indeed, mbp mRNA transport was arrested/perturbed in both rat oligodendrocyte cell culture and zebrafish in response to dynein inhibition, demonstrating a previously unknown role for dynein/dynactin in mbp transport. This published work can be found in its entirety in Chapter 3. In addition to myelin defects, actr10 zebrafish mutants exhibited axonal swellings in both the CNS and in the PNS. Electron microscopy revealed neurofilament accumulation in the axons of mutant animals, which is a hallmark of many neurodegenerative disorders. We therefore wondered whether ACTR10 might have a role in human disease. In collaboration with a neurologist at Washington University, several patients diagnosed with amyotrophic lateral sclerosis (ALS), distal myopathy and CMT were also found to have mutations in ACTR10. Using genome editing technologies in zebrafish, we generated a line of zebrafish containing the CMT2 patient ACTR10 mutant single nucleotide polymorphism (SNP), thereby generating a patient specific disease zebrafish model. Current work is ongoing to characterize the zebrafish mutant and future experiments could include drug screens to identify compounds that may ameliorate CMT mutant phenotypes. Generation of the this CMT zebrafish line and future directions for this project are described in Chapter 4. From a forward genetic screen to identify novel regulators of myelination to generating patient specific mutations in zebrafish, my dissertation has involved a broad range of genetic and molecular techniques in the study of nervous system development in general, and myelinating glial development in particular. The identification of Actr10 as a player in oligodendrocyte development and myelination, as well as a potential regulator of a major human demyelinating disorder, demonstrates the power of zebrafish to address both basic and biomedical questions directly relevant to human patients.
Book Synopsis Hematopoietic Cells as Delivery Vehicles to the Central Nervous System by : Jennifer N. Solomon
Download or read book Hematopoietic Cells as Delivery Vehicles to the Central Nervous System written by Jennifer N. Solomon and published by . This book was released on 2009 with total page 418 pages. Available in PDF, EPUB and Kindle. Book excerpt: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder associated with motor neuron loss and extensive microglial proliferation within the central nervous system (CNS). Transgenic mice over-expressing human mutant superoxide dismutase 1 (mSOD) develop a disorder closely resembling ALS and are used as a model for this disease. To evaluate the possible recruitment of bone marrow-derived cells (BMDCs) in spinal cord tissue, green fluorescent protein (GFP)-labeled BMDCs were transplanted into myeloablated mSOD mice. Under these conditions, BMDCs entered the CNS and expressed markers also found on resident microglia (F4/80, CD11b). The number of GFP+ BMDCs found in spinal cords of mSOD mice was significantly greater than in age-matched controls, and increased GFP+ cell infiltration paralleled disease progression. In spinal cords of recipient mice, GFP+ cells constituted a minority of the total number of F4/80+ or CD11b+ cells (20%), indicating that the majority of microglia were CNS-derived. Nonetheless, as BMDCs enter the CNS, these studies provide a rationale for the use of BMDCs as vehicles for therapeutic gene delivery to the CNS for the treatment of murine ALS. To explore this possibility, we utilized genetically modified hematopoietic cells expressing neurotrophic factor genes previously identified as having neuroprotective or neuroregenerative abilities. The gene encoding vascular endothelial growth factor (VEGF) was cloned into a lentiviral vector and used to generate virus to transduce murine BMDCs that secreted VEGF. Although transduced cells comprised approximately 5% of the total peripheral blood mononuclear cell (PBMC) population in mice transplanted with VEGF-expressing cells, significantly elevated levels of circulating VEGF were observed throughout the life-span of treated mice (41-93% above baseline), compared to controls. No infiltration of BMDCs into the CNS was observed. In a separate study, BMDCs were isolated from transgenic mice that over-expressed brain-derived neurotrophic factor (BDNF) and were transplanted into irradiated mSOD mice. Although we observed 80% circulating BDNF PBMCs and significantly elevated levels of BDNF in the circulation of transplanted mice compared to non-transplanted controls (on average a 350-fold increase), we did not detect significant changes in CNS BDNF levels, motor neuron survival, motor performance, or lifespan of mSOD mice, compared to untreated mSOD mice.