Innate and Acquired Resistance to Chlamydia in Mice

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Publisher :
ISBN 13 :
Total Pages : 496 pages
Book Rating : 4.:/5 (89 download)

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Book Synopsis Innate and Acquired Resistance to Chlamydia in Mice by : Dee Anne Lacy

Download or read book Innate and Acquired Resistance to Chlamydia in Mice written by Dee Anne Lacy and published by . This book was released on 1993 with total page 496 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Crossroads between Innate and Adaptive Immunity II

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Author :
Publisher : Springer Science & Business Media
ISBN 13 : 0387793119
Total Pages : 138 pages
Book Rating : 4.3/5 (877 download)

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Book Synopsis Crossroads between Innate and Adaptive Immunity II by : Stephen P. Schoenberger

Download or read book Crossroads between Innate and Adaptive Immunity II written by Stephen P. Schoenberger and published by Springer Science & Business Media. This book was released on 2008-12-10 with total page 138 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aegean Conferences is an independent, nonprofit, educational organization directed and managed by the scientific community. The board is made up of nine researchers/scientists in various disciplines from Harvard, Brown, University of Pennsylvania, UCSD, Princeton, Biovista and the Foundation for Biomedical Research Academy of Athens. The board both invites and approves unsolicited proposals for Conferences in all fields of Science, Engineering, Arts, and Humanities. The purpose of the Conferences is to bring together individuals with common interests to examine the emerging and most advanced aspects of their particular field. This volume will include mini-reviews derived from work to be presented at the Aegean Conference: Second Crossroads between Innate and Adaptive Immunity, in Crete, Greece, June 17-22, 2007. This meeting is designed to serve as a forum to discuss the most recent progress in complement research as it pertains to human disease pathogenesis and therapeutics. The rapid pace of development in complement basic research and the advent and application of new experimental approaches in this field have now allowed us to take an integrated view of the in vivo biology of the complement system. The availability of new reagents (e.g. synthetic and recombinant inhibitors) and animal models (e.g. transgenic and knockout mice) has enabled us to address, in an in vivo setting, its involvement in various pathophysiological conditions. Such studies are shedding new light on the pathogenetic mechanism of complement-related diseases such as autoimmune diseases and inflammatory tissue damage as well as defining new areas of high interest such as the developmental biology of complement. They also provide the basis for developing new therapeutic strategies for these diseases through manipulation of in vivo complement activity. This volume will serve as a resource where the latest development in these specific areas will be discussed in a more focused and detailed manner.

Diagnostic Procedure in Veterinary Bacteriology and Mycology

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Publisher : Academic Press
ISBN 13 : 0323138187
Total Pages : 641 pages
Book Rating : 4.3/5 (231 download)

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Book Synopsis Diagnostic Procedure in Veterinary Bacteriology and Mycology by : Grace R. Carter

Download or read book Diagnostic Procedure in Veterinary Bacteriology and Mycology written by Grace R. Carter and published by Academic Press. This book was released on 2012-12-02 with total page 641 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new edition of a standard reference includes classical methods and information on newer technologies, such as DNA hybridization and monoclonal antibodies.

Dissertation Abstracts International

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Publisher :
ISBN 13 :
Total Pages : 1006 pages
Book Rating : 4.F/5 ( download)

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Book Synopsis Dissertation Abstracts International by :

Download or read book Dissertation Abstracts International written by and published by . This book was released on 2008 with total page 1006 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Mouse in Biomedical Research

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Publisher : Elsevier
ISBN 13 : 0080467717
Total Pages : 773 pages
Book Rating : 4.0/5 (84 download)

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Book Synopsis The Mouse in Biomedical Research by :

Download or read book The Mouse in Biomedical Research written by and published by Elsevier. This book was released on 2006-11-30 with total page 773 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diseases, the second volume in the four volume set, The Mouse in Biomedical Research, departs from the first edition, by discussing specific disease causing microorganisms, rather than the format used in the first edition which discussed infectious diseases affecting specific organs and tissues. As such, the volume consists of 26 chapters subdivided into RNA viruses and DNA viruses, as well as bacterial, mycotic, and parasitic infections. These chapters not only provide updates on pathogenesis, epidemiology and prevention of previously recognized murine pathogens, but also include information on newly recognized disease-causing organisms: mouse parvovirus, cilia associated respiratory bacilli and Helicobacter spp. A separate category, consisting of 3 chapters, discusses zoonoses, tumor pathology of genetically engineered mice, and spontaneous diseases in commonly used mouse strains.

Control of Innate and Adaptive Immune Responses during Infectious Diseases

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Publisher : Springer Science & Business Media
ISBN 13 : 1461404843
Total Pages : 186 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis Control of Innate and Adaptive Immune Responses during Infectious Diseases by : Julio Aliberti

Download or read book Control of Innate and Adaptive Immune Responses during Infectious Diseases written by Julio Aliberti and published by Springer Science & Business Media. This book was released on 2011-09-21 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt: Upon infection the host needs to mount vigorous immune response against pathogen in order to successfully control its replication. However, once the infectious agent is controlled or eliminated, host cells need to signal the immune system to slow or cease its activities. While vast knowledge has been accumulated through the years on the mechanisms involved in the initiation and effector phases of the immune responses, the pathways triggered in order to modulate or end innate and acquired immunity are becoming more evident as evidence for its relevance comes to surface. Due to its biological power, evidence has surfaced indicating that eventually pathogens may take advantage of such regulatory pathways in order to escape effector mechanisms and progress to persistence. This book will discuss several cellular pathways involved in controlling immune response in the context of infectious diseases, their biological consequences and potential "hijack" of these pathways for the benefit of pathogen leading towards pathogen persistence as opposed to clearance.

Current Therapy in Large Animal Theriogenology

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Publisher : Elsevier Health Sciences
ISBN 13 : 1437713408
Total Pages : 1087 pages
Book Rating : 4.4/5 (377 download)

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Book Synopsis Current Therapy in Large Animal Theriogenology by : Robert S. Youngquist

Download or read book Current Therapy in Large Animal Theriogenology written by Robert S. Youngquist and published by Elsevier Health Sciences. This book was released on 2006-10-10 with total page 1087 pages. Available in PDF, EPUB and Kindle. Book excerpt: An essential resource for both students and practitioners, this comprehensive text provides practical, up-to-date information about normal reproduction and reproductive disorders in horses, cattle, small ruminants, swine, llamas, and other livestock. Featuring contributions from experts in the field, each section is devoted to a different large animal species and begins with a review of the clinically relevant aspects of the reproductive anatomy and physiology of both males and females. Key topics include the evaluation of breeding soundness, pregnancy diagnosis, diagnosis and treatment of infertility, abortion, obstetrics, surgery of the reproductive tract, care of neonates, and the latest reproductive technology. - Includes coverage of all large animal species. - All sections provide a review of clinically pertinent reproductive physiology and anatomy of males and females of each species. - Complete coverage of the most current reproductive technology, including embryo transfer, estrous synchronization, and artificial insemination. - A new section on alternative farming that addresses reproduction in bison, elk, and deer. - New to the equine section: stallion management, infertility, and breeding soundness evaluation. - New to the bovine section: estrous cycle synchronization, reproductive biotechnology, ultrasonographic determination of fetal gender, heifer development, and diagnosis of abortion. - New to the porcine section: artificial insemination, boar/stud management, diseases of postpartum period, and infectious disease control. - New to the llama section: infectious disease and nutrition.

Chlamydial Infection

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Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3318023981
Total Pages : 170 pages
Book Rating : 4.3/5 (18 download)

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Book Synopsis Chlamydial Infection by : C. M. Black

Download or read book Chlamydial Infection written by C. M. Black and published by Karger Medical and Scientific Publishers. This book was released on 2013 with total page 170 pages. Available in PDF, EPUB and Kindle. Book excerpt: New insights into one of the world's most common infectious diseases Chlamydiae are obligate intracellular bacteria that cause one of the most common sexually transmitted infectious diseases in the world. The infection disproportionately impacts women and the highest prevalence of infection is found in adolescents. Most chlamydial infections are asymptomatic. Untreated infections are sources of further spread of infection and can lead to serious consequences including pelvic inflammatory disease, infertility and chronic pelvic pain. Chlamydial infections also increase a person's susceptibility to HIV and other STDs. Featuring contributions by internationally recognized experts in epidemiology, infectious disease research and chlamydial biology, this book provides up-to-date reviews from a clinical and public health perspective on chlamydia epidemiology and control programs, genomics and pathogenicity, diagnosis, treatment, host immune responses, and the latest on the search for an effective vaccine. Also included are chapters on the impact of chlamydial infection on specific populations such as the lesbian, gay, bisexual and transgender community, and an update on the outbreak in Europe of the invasive chlamydial infection, lymphogranuloma venereum or LGV. This comprehensive publication is intended for clinicians, public health workers and scientists with interest in sexually transmitted diseases, medical microbiology, infectious diseases and clinical research.

Atlas of Sexually Transmitted Diseases and AIDS E-Book

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Publisher : Elsevier Health Sciences
ISBN 13 : 0702047643
Total Pages : 389 pages
Book Rating : 4.7/5 (2 download)

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Book Synopsis Atlas of Sexually Transmitted Diseases and AIDS E-Book by : Stephen A. Morse

Download or read book Atlas of Sexually Transmitted Diseases and AIDS E-Book written by Stephen A. Morse and published by Elsevier Health Sciences. This book was released on 2010-09-17 with total page 389 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Atlas of Sexually Transmitted Diseases and AIDS, 4th Edition, by Drs. Stephen A. Morse, King K. Holmes, Adele A. Moreland, MD, and Ronald C. Ballard, provides you with an exclusive gallery of STD and AIDS images so you can better diagnose and treat these diseases. Approximately 1,100 unique images – most in full color and 30% new to this edition – depict the clinical signs associated with each type of infection. You’ll also find expert guidance on new vaccines, screening techniques, treatment guidelines, and best practices in the field. Get expert advice on the tests available to reach a definitive diagnosis and review therapeutic options, treatment guidelines, prevention strategies, and management of complications. Access appendices on the selection and evaluation of diagnostic tests, quality control, and test technologies. Effectively diagnose all types of STDs and HIV/AIDS with approximately 1,100 images—most in full color and more than 30% new to this edition―that depict the epidemiology as well as the clinical manifestations of these diseases. Effectively utilize new vaccines for HPV and Hepatitis B, new screening tests for Chlamydia, new drugs under development, new treatment guidelines and best practices in HIV screening, and much more.

Chlamydia Infections: New Insights for the Healthcare Professional: 2012 Edition

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Publisher : ScholarlyEditions
ISBN 13 : 1464974314
Total Pages : 67 pages
Book Rating : 4.4/5 (649 download)

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Book Synopsis Chlamydia Infections: New Insights for the Healthcare Professional: 2012 Edition by :

Download or read book Chlamydia Infections: New Insights for the Healthcare Professional: 2012 Edition written by and published by ScholarlyEditions. This book was released on 2012-12-10 with total page 67 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chlamydia Infections: New Insights for the Healthcare Professional / 2012 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Chlamydia Infections in a concise format. The editors have built Chlamydia Infections: New Insights for the Healthcare Professional / 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Chlamydia Infections in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Chlamydia Infections: New Insights for the Healthcare Professional / 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

The Microbe-Host Interface in Respiratory Tract Infections

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Publisher : CRC Press
ISBN 13 : 9780849336461
Total Pages : 338 pages
Book Rating : 4.3/5 (364 download)

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Book Synopsis The Microbe-Host Interface in Respiratory Tract Infections by : Jan L. L. Kimpen

Download or read book The Microbe-Host Interface in Respiratory Tract Infections written by Jan L. L. Kimpen and published by CRC Press. This book was released on 2004-12-22 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: The molecular pathogenesis of microbial agents responsible for respiratory tract infections (RTIs) has been the focus of much research in recent years. The emphasis has been on developing new treatments such as novel antimicrobials and more effective vaccines. Significant attention has also been paid to improving molecular diagnostic methods to identify RTI-causing microbes, as well as understanding the host response to them. The Microbe-Host Interface in Respiratory Tract Infections presents an overview of the current knowledge in this area. It provides us with the first coherent picture of emerging strategies for controlling the microbes responsible for RTIs. This comprehensive volume is divided into three sections: the first reviews topics of general interest; the second focuses on bacterial and atypical RTIs; while the final section covers viral RTIs. Each of the chapters is the work of two or more of the top scientists in the field writing about their own pioneering research. Various chapters comment on vaccines, antibiotics, and molecular diagnostic methods. This cutting-edge work is essential reading for research microbiologists and other scientists involved in the investigation and treatment of RTIs.

Microbiology and pathogenesis of Chlamydia, Coxiella, and Rickettsia

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Publisher : Frontiers Media SA
ISBN 13 : 2832551394
Total Pages : 223 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Microbiology and pathogenesis of Chlamydia, Coxiella, and Rickettsia by : Rey Carabeo

Download or read book Microbiology and pathogenesis of Chlamydia, Coxiella, and Rickettsia written by Rey Carabeo and published by Frontiers Media SA. This book was released on 2024-07-08 with total page 223 pages. Available in PDF, EPUB and Kindle. Book excerpt: Obligate intracellular parasitism is the associated with genome reduction, which is the process of reconfiguring the genome through systematic elimination of genetic loci deemed unnecessary. The end-result is an increasing dependence on the host for various factors essential for growth, such as nutrients and a protective intracellular replicative niche. The extreme genome reduction that some of the obligate intracellular bacteria have undergone, while maintaining viability and virulence has revealed the level of adaptability, including a plethora of survival strategies that more often than not functionally converge to modulate similar host cell processes, such as cytoskeletal dynamics, vesicular transport, and pathogen recognition, among others. With the advent of molecular genetic approaches, and in the case of Coxiella, growth in axenic media, the field of obligate intracellular pathogen research has progressed rapidly in the past five years, redefining obligate intracellular parasitism as the field transitions from descriptive to mechanism-based research. An emerging theme is the adaptability and ingenuity of this class of pathogens. Genome reduction prioritizes survival, but because this occurs within a host, there is also the need to maintain virulence. As such, survival strategies become intertwined, and likely inseparable from virulence strategies. The purpose of this Special Topics Issue is to bring together in one volume review articles from experts in the field. This issue will have a broad scope. Articles will describe the current state of knowledge in genetics and genomics, metabolism, cell biology of infection, immune evasion, and vaccine design. Importantly, cutting-edge information will also be discussed in the context of past seminal findings, and future directions of research. Overall, this Special Topics Issue should serve as a valuable reference to colleagues and those new to the field of obligate intracellular pathogens research. We welcome submission of review and mini-review articles on the following topics: • Genome structure • Development of genetic tools • Molecular mechanisms of adhesion, invasion, and other early events in infection • Establishment of the intracellular niche • Niche interactions with organelles • Translocation of effectors • Metabolism and metabolic adaptations • Gene regulation during stress response • Pathogen recognition and immune evasion strategies • Innate and adaptive immunity during infection • Experimental models

Assessment of Long-Term Health Effects of Antimalarial Drugs When Used for Prophylaxis

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Publisher : National Academies Press
ISBN 13 : 0309672104
Total Pages : 427 pages
Book Rating : 4.3/5 (96 download)

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Book Synopsis Assessment of Long-Term Health Effects of Antimalarial Drugs When Used for Prophylaxis by : National Academies of Sciences, Engineering, and Medicine

Download or read book Assessment of Long-Term Health Effects of Antimalarial Drugs When Used for Prophylaxis written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2020-04-24 with total page 427 pages. Available in PDF, EPUB and Kindle. Book excerpt: Among the many who serve in the United States Armed Forces and who are deployed to distant locations around the world, myriad health threats are encountered. In addition to those associated with the disruption of their home life and potential for combat, they may face distinctive disease threats that are specific to the locations to which they are deployed. U.S. forces have been deployed many times over the years to areas in which malaria is endemic, including in parts of Afghanistan and Iraq. Department of Defense (DoD) policy requires that antimalarial drugs be issued and regimens adhered to for deployments to malaria-endemic areas. Policies directing which should be used as first and as second-line agents have evolved over time based on new data regarding adverse events or precautions for specific underlying health conditions, areas of deployment, and other operational factors At the request of the Veterans Administration, Assessment of Long-Term Health Effects of Antimalarial Drugs When Used for Prophylaxis assesses the scientific evidence regarding the potential for long-term health effects resulting from the use of antimalarial drugs that were approved by FDA or used by U.S. service members for malaria prophylaxis, with a focus on mefloquine, tafenoquine, and other antimalarial drugs that have been used by DoD in the past 25 years. This report offers conclusions based on available evidence regarding associations of persistent or latent adverse events.

Should we aim for genetic improvement in host resistance or tolerance to infectious disease?

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Author :
Publisher : Frontiers E-books
ISBN 13 : 2889191052
Total Pages : 100 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis Should we aim for genetic improvement in host resistance or tolerance to infectious disease? by : Andrea B. Doeschl-Wilson

Download or read book Should we aim for genetic improvement in host resistance or tolerance to infectious disease? written by Andrea B. Doeschl-Wilson and published by Frontiers E-books. This book was released on with total page 100 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent advances in quantitative genetic and genomic studies have shed light on the important role of genetic control strategies for reducing disease risk and severity in livestock populations. There are two alternative host defence strategies to infectious pathogens that could be enhanced by genetic selection: improvement of host resistance versus improvement of host tolerance to infectious pathogens. Resistance refers to mechanisms that restrict the reproduction rate of a pathogen within a host, whilst tolerance mechanisms focus on minimising the damage that a pathogen inflicts on the host. Both strategies may have a similar impact on individual host fitness and performance, but can have contrasting effects on population performance and disease risk and severity. For example, improving host resistance may result in successful eradication of a disease from a livestock population, whereas disease eradication may be difficult if hosts are tolerant as these can harbour the pathogen without showing obvious or severe symptoms. On the other hand, it has been argued that increasing host resistance would fuel the arms race between host and pathogen and stimulate pathogen evolution towards higher virulence. Increasing tolerance, in contrast, imposes no or little selection pressure on the pathogen. Further, whereas disease resistance mechanisms may be specific to a particular pathogen (e.g. development of specific antibodies), tolerance mechanisms that repair damaged tissues are associated with the host rather than the pathogen, and are thus more likely to be generic to a range of pathogens. Hence, improving tolerance may be beneficial if individuals are exposed to a variety of pathogens or pathogen strains, and disease eradication has proven difficult. In contrast to evolutionary biology and plant breeding, animal breeding has only recently started to seriously consider a distinction between disease resistance and tolerance and their consequences. However, a deeper understanding of the underlying mechanisms and implications of improving either or both of the host defence mechanisms on future disease risk and severity is urgently needed by animal scientists, veterinarians and breeders to make informed decisions that help to maintain healthy livestock populations and guarantee food security. The topic ‘genetic improvement of disease resistance v tolerance’ would lend itself to research papers covering a variety of aspects that need to be considered, such as ‘how to obtain genetic parameter estimates and genomic breeding values related to disease resistance / tolerance’, ‘evidence for host genetic influence of resistance or tolerance’, ‘genetic, genomic and immunological understanding of resistance / tolerance mechanisms’, ‘epidemiological consequences of improving disease resistance / tolerance’. I believe that this research topic is both timely and relevant, and that sufficient knowledge is available across disciplines for composing valuable research / review articles that stimulate interest to a wide range of readers of Frontiers, and thus promote the growth of this journal.

Hunter's Tropical Medicine and Emerging Infectious Diseases E-Book

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Author :
Publisher : Elsevier Health Sciences
ISBN 13 : 0323625509
Total Pages : 1265 pages
Book Rating : 4.3/5 (236 download)

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Book Synopsis Hunter's Tropical Medicine and Emerging Infectious Diseases E-Book by : Edward T Ryan

Download or read book Hunter's Tropical Medicine and Emerging Infectious Diseases E-Book written by Edward T Ryan and published by Elsevier Health Sciences. This book was released on 2019-03-25 with total page 1265 pages. Available in PDF, EPUB and Kindle. Book excerpt: New emerging diseases, new diagnostic modalities for resource-poor settings, new vaccine schedules ... all significant, recent developments in the fast-changing field of tropical medicine. Hunter's Tropical Medicine and Emerging Infectious Diseases, 10th Edition, keeps you up to date with everything from infectious diseases and environmental issues through poisoning and toxicology, animal injuries, and nutritional and micronutrient deficiencies that result from traveling to tropical or subtropical regions. This comprehensive resource provides authoritative clinical guidance, useful statistics, and chapters covering organs, skills, and services, as well as traditional pathogen-based content. You'll get a full understanding of how to recognize and treat these unique health issues, no matter how widespread or difficult to control. - Includes important updates on malaria, leishmaniasis, tuberculosis and HIV, as well as coverage of Ebola, Zika virus, Chikungunya, and other emerging pathogens. - Provides new vaccine schedules and information on implementation. - Features five all-new chapters: Neglected Tropical Diseases: Public Health Control Programs and Mass Drug Administration; Health System and Health Care Delivery; Zika; Medical Entomology; and Vector Control – as well as 250 new images throughout. - Presents the common characteristics and methods of transmission for each tropical disease, as well as the applicable diagnosis, treatment, control, and disease prevention techniques. - Contains skills-based chapters such as dentistry, neonatal pediatrics and ICMI, and surgery in the tropics, and service-based chapters such as transfusion in resource-poor settings, microbiology, and imaging. - Discusses maladies such as delusional parasitosis that are often seen in returning travelers, including those making international adoptions, transplant patients, medical tourists, and more. - Enhanced eBook version included with purchase, which allows you to access all of the text, figures, and references from the book on a variety of devices.

Severe Community Acquired Pneumonia

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Publisher : Springer Science & Business Media
ISBN 13 : 1461516315
Total Pages : 200 pages
Book Rating : 4.4/5 (615 download)

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Book Synopsis Severe Community Acquired Pneumonia by : Jordi Rello

Download or read book Severe Community Acquired Pneumonia written by Jordi Rello and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: Severe Community Acquired Pneumonia is a book in which chapters are authored and the same topics discussed by North American and European experts. This approach provides a unique opportunity to view the different perspectives and points of view on this subject. Severe CAP is a common clinical problem encountered in the ICU setting. This book reviews topics concerning the pathogenesis, diagnosis and management of SCAP. The discussions on the role of alcohol in severe CAP and adjunctive therapies are important topics that further our understanding of this severe respiratory infection.

Human Herpesviruses

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Publisher : Cambridge University Press
ISBN 13 : 1139461648
Total Pages : 1325 pages
Book Rating : 4.1/5 (394 download)

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Book Synopsis Human Herpesviruses by : Ann Arvin

Download or read book Human Herpesviruses written by Ann Arvin and published by Cambridge University Press. This book was released on 2007-08-16 with total page 1325 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive account of the human herpesviruses provides an encyclopedic overview of their basic virology and clinical manifestations. This group of viruses includes human simplex type 1 and 2, Epstein–Barr virus, Kaposi's Sarcoma-associated herpesvirus, cytomegalovirus, HHV6A, 6B and 7, and varicella-zoster virus. The viral diseases and cancers they cause are significant and often recurrent. Their prevalence in the developed world accounts for a major burden of disease, and as a result there is a great deal of research into the pathophysiology of infection and immunobiology. Another important area covered within this volume concerns antiviral therapy and the development of vaccines. All these aspects are covered in depth, both scientifically and in terms of clinical guidelines for patient care. The text is illustrated generously throughout and is fully referenced to the latest research and developments.