Individual Susceptibility To Genotoxic Agents In The Human Population

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Individual Susceptibility to Genotoxic Agents in the Human Population

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Author : Frederick J. De Serres
Publisher : Springer Science & Business Media
ISBN 13 : 1461327652
Total Pages : 511 pages
Book Rating : 4.4/5 (613 download)

Book Synopsis Individual Susceptibility to Genotoxic Agents in the Human Population by : Frederick J. De Serres

Download or read book Individual Susceptibility to Genotoxic Agents in the Human Population written by Frederick J. De Serres and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 511 pages. Available in PDF, EPUB and Kindle. Book excerpt: As a result of the industrial revolution, man's technological achievements have been truly great, increasing the quality of life to almost unimagined proportions; but all this progress has not been accomplished without equally un imagined health risks. Sufficiently diagnostic short-term assay procedures have been developed in recent years for us to determine that there are mutagenic agents among thou sands of chemicals to which the human population is exposed today. These chemicals were not significantly present prior to the indus trial revolution. As of today, there are no procedures available which have been adequately demonstrated to assess individual sus ceptibility to genotoxic exposures, and as a result we have had to rely on extrapolating toxicological data from animal model systems. The question is can we afford to allow such an increased environ mental selection pressure via mutagenic exposures to occur without expecting adverse long-term effects on our health. It is apparent from this line of reasoning that what is lacking and immediately needed are test procedures that can be applied to humans to assess genotoxic exposure as well as individual susceptibility to it. There have already been two conferences which have focused at tention on this research area. "Guidelines for studies of human populations exposed to mutagenic and reproductive hazards" (A. D. Bloom, ed., March of Dimes Birth Defects Foundation, White Plains, New York, 1981) and "Indicators of genotoxic exposure in humans" (Banbury Report 13, B. A. Bridges, B. E. Butterworth, and I. B.

Individual Susceptibility to Genotoxic Agents in the Human Population (Volume 30).

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Author : FJ de Serres (Ed)
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (985 download)

Book Synopsis Individual Susceptibility to Genotoxic Agents in the Human Population (Volume 30). by : FJ de Serres (Ed)

Download or read book Individual Susceptibility to Genotoxic Agents in the Human Population (Volume 30). written by FJ de Serres (Ed) and published by . This book was released on 1984 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Science and Decisions

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Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309120462
Total Pages : 422 pages
Book Rating : 4.3/5 (91 download)

Book Synopsis Science and Decisions by : National Research Council

Download or read book Science and Decisions written by National Research Council and published by National Academies Press. This book was released on 2009-03-24 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt: Risk assessment has become a dominant public policy tool for making choices, based on limited resources, to protect public health and the environment. It has been instrumental to the mission of the U.S. Environmental Protection Agency (EPA) as well as other federal agencies in evaluating public health concerns, informing regulatory and technological decisions, prioritizing research needs and funding, and in developing approaches for cost-benefit analysis. However, risk assessment is at a crossroads. Despite advances in the field, risk assessment faces a number of significant challenges including lengthy delays in making complex decisions; lack of data leading to significant uncertainty in risk assessments; and many chemicals in the marketplace that have not been evaluated and emerging agents requiring assessment. Science and Decisions makes practical scientific and technical recommendations to address these challenges. This book is a complement to the widely used 1983 National Academies book, Risk Assessment in the Federal Government (also known as the Red Book). The earlier book established a framework for the concepts and conduct of risk assessment that has been adopted by numerous expert committees, regulatory agencies, and public health institutions. The new book embeds these concepts within a broader framework for risk-based decision-making. Together, these are essential references for those working in the regulatory and public health fields.

Carcinogens and Anticarcinogens in the Human Diet

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Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309175712
Total Pages : 433 pages
Book Rating : 4.3/5 (91 download)

Book Synopsis Carcinogens and Anticarcinogens in the Human Diet by : National Research Council

Download or read book Carcinogens and Anticarcinogens in the Human Diet written by National Research Council and published by National Academies Press. This book was released on 1996-02-12 with total page 433 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite increasing knowledge of human nutrition, the dietary contribution to cancer remains a troubling question. Carcinogens and Anticarcinogens assembles the best available information on the magnitude of potential cancer riskâ€"and potential anticarcinogenic effectâ€"from naturally occurring chemicals compared with risk from synthetic chemical constituents. The committee draws important conclusions about diet and cancer, including the carcinogenic role of excess calories and fat, the anticarcinogenic benefit of fiber and other substances, and the impact of food additive regulation. The book offers recommendations for epidemiological and diet research. Carcinogens and Anticarcinogens provides a readable overview of issues and addresses critical questions: Does diet contribute to an appreciable proportion of human cancer? Are there significant interactions between carcinogens and anticarcinogens in the diet? The volume discusses the mechanisms of carcinogenic and anticarcinogenic properties and considers whether techniques used to evaluate the carcinogenic potential of synthetics can be used with naturally occurring chemicals. The committee provides criteria for prioritizing the vast number of substances that need to be tested. Carcinogens and Anticarcinogens clarifies the issues and sets the direction for further investigations into diet and cancer. This volume will be of interest to anyone involved in food and health issues: policymakers, regulators, researchers, nutrition professionals, and health advocates.

How Tobacco Smoke Causes Disease

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Author : United States. Public Health Service. Office of the Surgeon General
Publisher :
ISBN 13 :
Total Pages : 728 pages
Book Rating : 4.:/5 (318 download)

Book Synopsis How Tobacco Smoke Causes Disease by : United States. Public Health Service. Office of the Surgeon General

Download or read book How Tobacco Smoke Causes Disease written by United States. Public Health Service. Office of the Surgeon General and published by . This book was released on 2010 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.

Journal of the National Cancer Institute

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Author :
Publisher :
ISBN 13 :
Total Pages : 940 pages
Book Rating : 4.E/5 ( download)

Book Synopsis Journal of the National Cancer Institute by :

Download or read book Journal of the National Cancer Institute written by and published by . This book was released on 1996 with total page 940 pages. Available in PDF, EPUB and Kindle. Book excerpt:

National Library of Medicine Current Catalog

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Author : National Library of Medicine (U.S.)
Publisher :
ISBN 13 :
Total Pages : 420 pages
Book Rating : 4.F/5 ( download)

Book Synopsis National Library of Medicine Current Catalog by : National Library of Medicine (U.S.)

Download or read book National Library of Medicine Current Catalog written by National Library of Medicine (U.S.) and published by . This book was released on with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt:

EHP

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Author :
Publisher :
ISBN 13 :
Total Pages : 546 pages
Book Rating : 4.:/5 (319 download)

Book Synopsis EHP by :

Download or read book EHP written by and published by . This book was released on 1993 with total page 546 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Encyclopedia of Environmental Management, Four Volume Set

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Author : Sven Erik Jorgensen
Publisher : CRC Press
ISBN 13 : 1439829330
Total Pages : 3513 pages
Book Rating : 4.4/5 (398 download)

Book Synopsis Encyclopedia of Environmental Management, Four Volume Set by : Sven Erik Jorgensen

Download or read book Encyclopedia of Environmental Management, Four Volume Set written by Sven Erik Jorgensen and published by CRC Press. This book was released on 2012-12-13 with total page 3513 pages. Available in PDF, EPUB and Kindle. Book excerpt: Winner of an Outstanding Academic Title Award from CHOICE Magazine Encyclopedia of Environmental Management gives a comprehensive overview of environmental problems, their sources, their assessment, and their solutions. Through in-depth entries and a topical table of contents, readers will quickly find answers to questions about specific pollution and management issues. Edited by the esteemed Sven Erik Jørgensen and an advisory board of renowned specialists, this four-volume set shares insights from more than 500 contributors—all experts in their fields. The encyclopedia provides basic knowledge for an integrated and ecologically sound management system. Nearly 400 alphabetical entries cover everything from air, soil, and water pollution to agriculture, energy, global pollution, toxic substances, and general pollution problems. Using a topical table of contents, readers can also search for entries according to the type of problem and the methodology. This allows readers to see the overall picture at a glance and find answers to the core questions: What is the pollution problem, and what are its sources? What is the "big picture," or what background knowledge do we need? How can we diagnose the problem, both qualitatively and quantitatively, using monitoring and ecological models, indicators, and services? How can we solve the problem with environmental technology, ecotechnology, cleaner technology, and environmental legislation? How do we address the problem as part of an integrated management strategy? This accessible encyclopedia examines the entire spectrum of tools available for environmental management. An indispensable resource, it guides environmental managers to find the best possible solutions to the myriad pollution problems they face. Also Available Online This Taylor & Francis encyclopedia is also available through online subscription, offering a variety of extra benefits for researchers, students, and librarians, including: Citation tracking and alerts Active reference linking Saved searches and marked lists HTML and PDF format options Contact us to inquire about subscription options and print/online combination packages. US: (Tel) 1.888.318.2367 / (email) [email protected] International: (Tel) +44 (0) 20 7017 6062 / (email) [email protected]

Some Drinking-water Disinfectants and Contaminants, Including Arsenic

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Author : IARC Working Group on the Evaluation of Carcinogenic Risks to Humans
Publisher : IARC
ISBN 13 : 9789283212843
Total Pages : 540 pages
Book Rating : 4.2/5 (128 download)

Book Synopsis Some Drinking-water Disinfectants and Contaminants, Including Arsenic by : IARC Working Group on the Evaluation of Carcinogenic Risks to Humans

Download or read book Some Drinking-water Disinfectants and Contaminants, Including Arsenic written by IARC Working Group on the Evaluation of Carcinogenic Risks to Humans and published by IARC. This book was released on 2004 with total page 540 pages. Available in PDF, EPUB and Kindle. Book excerpt: A working group of 23 experts from 13 countries met in Lyon to evaluate the evidence for carcinogenicity of arsenic (mostly naturally occurring) as a contaminant of drinking-water, and of the water-disinfectant chloramine. The working group also evaluated or re-evaluated four chlorination by-products found in drinking-water, namely chloral hydrate, di- and trichloroacetic acids, and 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (also known as MX). High-level exposure to arsenic in drinking-water occurs in some regions such as China, Latin America, Bangladesh and West Bengal. The Working Group reviewed epidemiological studies of human cancer (mainly ecological studies in Taiwan and Chile, and several case-control and cohort studies) in relation to arsenic in drinking-water. Arsenic in drinking-water (primarily inorganic, as arsenate and to a lesser extent arsenite) was evaluated as carcinogenic to humans (Group 1) on the basis of sufficient evidence for an increased risk for cancer of the urinary bladder, lung and skin. Studies on inorganic arsenic in experimental animals provided limited evidence for its carcinogenicity, but sufficient evidence was found in experimental animals for the carcinogenicity of dimethylarsinic acid (an organic form of arsenic), which produced urinary bladder tumours in rats and lung tumours in mice after oral administration.

Current Catalog

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Author : National Library of Medicine (U.S.)
Publisher :
ISBN 13 :
Total Pages : 1712 pages
Book Rating : 4.3/5 (91 download)

Book Synopsis Current Catalog by : National Library of Medicine (U.S.)

Download or read book Current Catalog written by National Library of Medicine (U.S.) and published by . This book was released on with total page 1712 pages. Available in PDF, EPUB and Kindle. Book excerpt: First multi-year cumulation covers six years: 1965-70.

NIH Publication

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Author :
Publisher :
ISBN 13 :
Total Pages : 140 pages
Book Rating : 4.:/5 (319 download)

Book Synopsis NIH Publication by :

Download or read book NIH Publication written by and published by . This book was released on 1983 with total page 140 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Oxidative Stress Biomarkers and Antioxidant Protocols

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Author : Donald Armstrong
Publisher : Springer Science & Business Media
ISBN 13 : 1592591736
Total Pages : 320 pages
Book Rating : 4.5/5 (925 download)

Book Synopsis Oxidative Stress Biomarkers and Antioxidant Protocols by : Donald Armstrong

Download or read book Oxidative Stress Biomarkers and Antioxidant Protocols written by Donald Armstrong and published by Springer Science & Business Media. This book was released on 2008-02-04 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first protocols book, Free Radical and Antioxidant Protocols (1) was published in late 1998. Sections were divided into three parts, covering selected biochemical techniques for measuring oxidative stress, antioxidant (AOX) activity, and combined applications. In choosing the 40 methods to be included in that book, I realized there were considerably more of equal value than that which we could have presented in a single volume. To produce a comprehensive resource, this book and a third are being compiled to expand coverage of the field. A summary of papers (2) published on this important subject emphasizes the continuing rapid growth in oxidative stress investigations relating to our understanding of biochemical reactions, their relevance to pathophysiological mechanisms, how disease may arise, and how therapeutic intervention may be achieved(3). Although there is some overlap between the categories, the ana- sis shown below illustrates where current studies are concentrated and are almost evenly distributed between free radicals and AOX. Over the last 4 yr, there has been a 55% increase in the number of papers published in the area.

Age and Susceptibility to Toxic Substances

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Author : Edward J. Calabrese
Publisher : Wiley-Interscience
ISBN 13 :
Total Pages : 330 pages
Book Rating : 4.:/5 (45 download)

Book Synopsis Age and Susceptibility to Toxic Substances by : Edward J. Calabrese

Download or read book Age and Susceptibility to Toxic Substances written by Edward J. Calabrese and published by Wiley-Interscience. This book was released on 1986-09-22 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: Investigates the relationship between age and environmentally induced diseases, which must be taken into consideration in establishing acceptable exposure standards for high-risk groups in society. Assesses the effect of age on gastrointestinal and dermal absorption of toxic substances and drugs, and age differences in plasma protein binding and xenobiotic metabolism. Contains several chapters on organ-specific toxicity differences according to age. Also discusses genotoxicity and environmentally induced cancer. A final chapter synthesizes the information and addresses the relevance of this knowledge to biological basis of safety considerations.

Cumulated Index Medicus

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Author :
Publisher :
ISBN 13 :
Total Pages : 1348 pages
Book Rating : 4.:/5 (31 download)

Book Synopsis Cumulated Index Medicus by :

Download or read book Cumulated Index Medicus written by and published by . This book was released on 1989 with total page 1348 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Catalog of Federal Domestic Assistance, 1993

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Author :
Publisher : DIANE Publishing
ISBN 13 : 9780788105210
Total Pages : 370 pages
Book Rating : 4.1/5 (52 download)

Book Synopsis Catalog of Federal Domestic Assistance, 1993 by :

Download or read book Catalog of Federal Domestic Assistance, 1993 written by and published by DIANE Publishing. This book was released on 1994-06 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: Shows how you can qualify for the billions of Federal dollars available through grants from the U.S. Gov't. A comprehensive listing of over 1,200 Gov't. grants & assistance programs for practically every conceivable area from: adult education to disease research, from community development to environmental programs, & more. 4 indexes. Each grant listing includes: program objectives & goals; types of assistance offered; eligibility requirements; examples of funded projects; & criteria for selecting proposals.

Reproductive Hazards in the Workplace

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Author :
Publisher :
ISBN 13 :
Total Pages : 182 pages
Book Rating : 4.:/5 (31 download)

Book Synopsis Reproductive Hazards in the Workplace by :

Download or read book Reproductive Hazards in the Workplace written by and published by . This book was released on 1994 with total page 182 pages. Available in PDF, EPUB and Kindle. Book excerpt: