In Vivo Models Of Inflammation Asthma

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In Vivo Models of Inflammation

Author : Lisa A. Marshall
Publisher : Birkhäuser
ISBN 13 : 3034877757
Total Pages : 352 pages
Book Rating : 4.0/5 (348 download)

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Book Synopsis In Vivo Models of Inflammation by : Lisa A. Marshall

Download or read book In Vivo Models of Inflammation written by Lisa A. Marshall and published by Birkhäuser. This book was released on 2013-11-11 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of this volume in the series Progress in Inflammation Research is to pro vide the biomedical researcher with a description of the state of the art of the devel opment and use of animal models of diseases with components of inflammation. Par ticularly highlighted are those models which can serve as in vivo correlates of diseases most commonly targeted for therapeutic intervention. The format is designed with the laboratory in mind; thus it provides detailed descriptions of the methodologies and uses of the most significant models. Also, new approaches to the development of future models in selected therapeutic areas have been highlighted. While emphasis is on the newest models, new information broadening our understanding of several well-known models of proven clinical utility is included. In addition, we have pro vided coverage of transgenic and gene transfer technologies which will undoubtedly serve as tools for many future approaches. Provocative comments on the cutting edge and future directions are meant to stimulate new thinking. Of course, it is important to recognize that the experimental use of animals for human benefit carries with it a solemn responsibility for the welfare of these animals. The reader is referred to the section on current regulations governing animal use which addresses this concern. To fulfill our purpose, the content is organized according to therapeutic areas with the associated models arranged in subcategories of each therapeutic area.

Airways Smooth Muscle: Modelling the Asthmatic Response In Vivo

Author : David Raeburn
Publisher : Birkhäuser
ISBN 13 : 3034890001
Total Pages : 296 pages
Book Rating : 4.0/5 (348 download)

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Book Synopsis Airways Smooth Muscle: Modelling the Asthmatic Response In Vivo by : David Raeburn

Download or read book Airways Smooth Muscle: Modelling the Asthmatic Response In Vivo written by David Raeburn and published by Birkhäuser. This book was released on 2012-12-06 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: Building on the existing titles in the "Airways Smooth Muscle" sub-series, the sixth volume explores physiological and pharmacological processes in the lung in vivo. The various animal models available for studying the bronchospasm and inflammation associated with human asthma are thoroughly reviewed by internationally recognised scientists. Specific chapters focus on the problems of administering drugs to animal airways, the mechanics of assessing lung function in the models, and describe in detail the species used, from rodents to primates. The use of genetically altered animals, an area of particular interest to molecular biologists, is also considered in depth. This up-to-date and extensively referenced work will prove invaluable to pharmacologists, physiologists and other biological scientists at all levels in academia and in the pharmaceutical industry.

Murine Models of Lung Inflammation

Author : Vivek Chander Mathrani
Publisher :
ISBN 13 :
Total Pages : 178 pages
Book Rating : 4.:/5 (74 download)

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Book Synopsis Murine Models of Lung Inflammation by : Vivek Chander Mathrani

Download or read book Murine Models of Lung Inflammation written by Vivek Chander Mathrani and published by . This book was released on 2006 with total page 178 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Asthma

Author : Magdalena M. Gorska
Publisher : Springer Nature
ISBN 13 : 1071623648
Total Pages : 337 pages
Book Rating : 4.0/5 (716 download)

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Book Synopsis Asthma by : Magdalena M. Gorska

Download or read book Asthma written by Magdalena M. Gorska and published by Springer Nature. This book was released on 2022-06-30 with total page 337 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume details a collection of laboratory protocols to study asthma in mice and humans. Chapters cover animal models of asthma, methods to measure asthma-related molecules, protocols to detect, isolate, culture and stimulate cells that contribute to asthma in mice and humans, methods to deplete these cells in vivo and study responses of intact airway tissues ex vivo. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, Asthma: Methods and Protocols aims to be a foundation for future studies and to be a source of inspiration for new investigations in the field.

Studies on the Mechanisms of Pulmonary Inflammation and Airway Hyperreactivity in Animal Models of Asthma

Author : Stephen L. Underwood
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (594 download)

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Book Synopsis Studies on the Mechanisms of Pulmonary Inflammation and Airway Hyperreactivity in Animal Models of Asthma by : Stephen L. Underwood

Download or read book Studies on the Mechanisms of Pulmonary Inflammation and Airway Hyperreactivity in Animal Models of Asthma written by Stephen L. Underwood and published by . This book was released on 1997 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Inflammatory Cells and Mediators in Bronchial Asthma

Author : Devendra K. Agrawal
Publisher : CRC Press
ISBN 13 : 100014206X
Total Pages : 272 pages
Book Rating : 4.0/5 (1 download)

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Book Synopsis Inflammatory Cells and Mediators in Bronchial Asthma by : Devendra K. Agrawal

Download or read book Inflammatory Cells and Mediators in Bronchial Asthma written by Devendra K. Agrawal and published by CRC Press. This book was released on 2020-10-28 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: Inflammatory Cells and Mediators in Bronchial Asthma provides reviews and summaries regarding state-of-the-art articles that examine the role of various inflammatory cells and their mediators in the pathogenesis of asthma. Topics include pharmacological and biochemical regulation of the airways; involvement of key inflammatory cells and the release and effect of their mediators in airway function; and the characteristics of receptors for leukotriene B4, C4, and D4, adenosine, platelet-activating factor, sensory and inflammatory peptides, and the effect of various anti-asthmatic drugs on airway inflammation. Physicians, allergists, immunologists, and pulmonary disease research scientists will find this book to be an invaluable reference resource.

T-Lymphocyte and Inflammatory Cell Research in Asthma

Author : G. Jolles
Publisher : Academic Press
ISBN 13 : 0080984266
Total Pages : 391 pages
Book Rating : 4.0/5 (89 download)

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Book Synopsis T-Lymphocyte and Inflammatory Cell Research in Asthma by : G. Jolles

Download or read book T-Lymphocyte and Inflammatory Cell Research in Asthma written by G. Jolles and published by Academic Press. This book was released on 2012-12-02 with total page 391 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is well established that asthma is an inflammatory disease of the airway mucosa and drugs like inhaled glucocorticoids are now commonly introduced early in therapy. A characteristic feature of this disease is the vast number of eosinophils in airway tissue, although many other migratory and resident inflammatory cells with the capacity to synthesize and release cytokines and putative asthma mediators are present in the inflamed mucosa. The cross-talk between lymphocytes and these cells and the role of cytokines in complex biological networks are currently areas of intense research. This volume gathers together chapters and discussions on the biology of immunocompetent and inflammatory cells, cellular interplay and communication, and on the relative importance of cells and mediators in disease. It should help contribute to further insights into the pathology of asthma and to the development of novel efficacious drugs for the treatment of asthma and related respiratory disorders.

Human Eosinophils

Author : Gianni Marone
Publisher : Karger Medical Scientific
ISBN 13 : 9783805569743
Total Pages : 0 pages
Book Rating : 4.5/5 (697 download)

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Book Synopsis Human Eosinophils by : Gianni Marone

Download or read book Human Eosinophils written by Gianni Marone and published by Karger Medical Scientific. This book was released on 2000 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Eosinophils represent approximately 1% of peripheral blood leukocytes and play a central proinflammatory and immunoregulatory role in various immune disorders. This volume provides the reader with a comprehensive survey of the major aspects of human eosinophilic biology and immunology as well as the most clinically relevant aspects of eosinophil-related disorders. Expert contributions cover the ultrastructural and phenotypic characteristics of human eosinophils, and their fundamental biochemical features including receptors for IgE and chemokines. The production of cytokines and their role in the activation of eosinophils are reviewed. Furthermore, the classic eosinophil-related disorders such as hypereosinophilia, drug reactions, allergic disorders and some cardiovascular diseases are described. Each of the chapters is written by an investigator actively engaged in research on the topic under consideration. The well-edited and stimulating material compiled in this volume will be of interest to all those working in allergology, immunology, biochemistry and pulmonary medicine.

Inflammatory Mechanisms in Asthma

Author : Stephen Holgate
Publisher : Routledge
ISBN 13 : 1351438492
Total Pages : 1006 pages
Book Rating : 4.3/5 (514 download)

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Book Synopsis Inflammatory Mechanisms in Asthma by : Stephen Holgate

Download or read book Inflammatory Mechanisms in Asthma written by Stephen Holgate and published by Routledge. This book was released on 2018-12-07 with total page 1006 pages. Available in PDF, EPUB and Kindle. Book excerpt: This timely volume brings together the latest basic and clinical insights on the cellular and mediator mechanisms involved in the induction and persistence of airway dysfunction of asthma by over 90 experts in the field-paving the way for developing novel and more effective antiinflammatory therapeutic agents and strategies. Furnishing a comprehensive and up-to-date view of the expanding and interrelated components underlying asthma pathogenesis, Inflammatory Mechanisms in Asthma describes how evidence on airway inflammation is obtained with invasive and noninvasive procedures, such as bronchoalveolar lavage and sputum analysis reviews the complex interactions of inflammatory cells that contribute to chronic inflammation and bronchial hyperreactivity, including eosinophils, basophils, neutrophils, fibroblasts, epithelial cells, and macrophages considers mast cells, cytokines, neural factors, leukotrienes, kinins, and other mediators that regulate the development, establishment, or resolution of asthma exacerbations presents new information suggesting that airway changes in asthma can lead to remodeling or airway fibrosis and more! Enhanced with over 4700 references, tables, drawings, and photographs, this compelling investigation into the pathophysiology of asthma is an indispensable resource for pulmonologists, physiologists, immunologists, allergists, epidemiologists, biochemists, molecular biologists, and graduate and medical school students in these disciplines.

Models of Exacerbations in Asthma and COPD

Author : Ulf Sjöbring
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 380558332X
Total Pages : 155 pages
Book Rating : 4.8/5 (55 download)

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Book Synopsis Models of Exacerbations in Asthma and COPD by : Ulf Sjöbring

Download or read book Models of Exacerbations in Asthma and COPD written by Ulf Sjöbring and published by Karger Medical and Scientific Publishers. This book was released on 2007-01-01 with total page 155 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides an overview of exacerbation models of asthma and chronic obstructive pulmonary disease (COPD). Within this wide field the book focuses on experimental systems that mimic pathobiological processes likely to be critical in exacerbations of these conditions. To generate insight into the mechanisms of exacerbation of pulmonary disease and to promote the discovery of future treatments, both animal models and human experimental models are described. For this update some of the most eminent scientists within the area of pulmonology could be recruited to share their knowledge of this evolving field of human medicine. Models of Exacerbations in Asthma and COPD will be of great interest to pulmonologists, allergologists, specialists in internal medicine and critical care, as well as to microbiologists, infectiologists and pharmacologists studying the response to respiratory infections.

In Vivo Models of Inflammation

Author : Douglas W. Morgan
Publisher : Springer Science & Business Media
ISBN 13 : 9783764358761
Total Pages : 368 pages
Book Rating : 4.3/5 (587 download)

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Book Synopsis In Vivo Models of Inflammation by : Douglas W. Morgan

Download or read book In Vivo Models of Inflammation written by Douglas W. Morgan and published by Springer Science & Business Media. This book was released on 1999 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: Purpose of In vivo Models of Inflammation is to provide the biomedical researcher in both the pharmaceutical industry and academia with a description of the state of the art animal model systems used to emulate diseases with components of inflammation. The aim of this second edition is to act as a complement to the first by describing and updating the standard models that are most utilized for specific disease areas. In addition, this 2nd edition includes new models exploring emerging areas of inflammation research. It provides detailed descriptions of the methodologies and uses of the most significant models. This includes current information regarding agents that demonstrate efficacy, those that do not and those that can be used as standard controls. The focus remains on those models that serve as pre-clinical correlates to human disease as well as those that represent components of the inflammatory response. New approaches to the development of future models in selected therapeutic areas have been highlighted. The focus on novel technologies that are vital for innovative in vivo research has also been expanded to include chapters on the use of transgenic and gene transfer technologies, nanotechnology, and stem cells. The book provides the scientist with an up-to-date reference manual for selecting the best animal model for their specific question. Chapters describing current regulations in the United States, United Kingdom, and Japan are also included.

Animal Models for Asthma

Author : Reinhard Pabst
Publisher : S Karger Ag
ISBN 13 : 9783805575898
Total Pages : 56 pages
Book Rating : 4.5/5 (758 download)

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Book Synopsis Animal Models for Asthma by : Reinhard Pabst

Download or read book Animal Models for Asthma written by Reinhard Pabst and published by S Karger Ag. This book was released on 2003 with total page 56 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent findings by leading asthma researchers Worldwide, the incidence of asthma has increased dramatically over the last few years. While a multitude of studies on the pathobiology of this disease have been published, both the morphological and functional aspects of asthma are still far from being well defined. The contributions to this special issue discuss the relevance of animal models to asthma research. Rodents, the most commonly used animal model for asthma, offer a good system to study specific aspects of its development but also have clear limitations as they only partly reflect the pathology of human disease. The roles of the heterogeneous cell types in immune reactions in the lung are also analyzed and promising new treatment strategies for the chronic inflammation in asthma are presented. Animal models for chronic obstructive pulmonary disease are also considered. Elucidating controversial aspects and defining future areas of research, this workshop summary will be of special interest to experimental pathologists, pneumologists and allergologists working on the pathophysiology and treatment of asthma.

Animal Models for the Selection of Anti-inflammatory Compounds for the Treatment of Bronchial Hyperreactivity in Asthma

Author : Marcellus Jacobus Henricus Linssen
Publisher :
ISBN 13 : 9789062569038
Total Pages : 219 pages
Book Rating : 4.5/5 (69 download)

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Book Synopsis Animal Models for the Selection of Anti-inflammatory Compounds for the Treatment of Bronchial Hyperreactivity in Asthma by : Marcellus Jacobus Henricus Linssen

Download or read book Animal Models for the Selection of Anti-inflammatory Compounds for the Treatment of Bronchial Hyperreactivity in Asthma written by Marcellus Jacobus Henricus Linssen and published by . This book was released on 1990 with total page 219 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Asthma

Author : Thomas A.E. Platts-Mills
Publisher : CRC Press
ISBN 13 : 9781566703734
Total Pages : 260 pages
Book Rating : 4.7/5 (37 download)

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Book Synopsis Asthma by : Thomas A.E. Platts-Mills

Download or read book Asthma written by Thomas A.E. Platts-Mills and published by CRC Press. This book was released on 1999-04-27 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: Asthma is a disease which, beginning in the 1980s, increased in the United States and other countries in both its prevalence and mortality. According to reports by the Center for Disease Control, the number of people with asthma increased by 42% in the last decade, with children, ethnic minorities and the urban poor being most at risk. Timely research on the causes and mechanisms behind the dramatic increase of asthma in the United States and other nations-to epidemic proportions-is presented in this volume. Investigators heading up eight research groups in asthma and/or allergy present their most recent findings, funded by the Center for Indoor Air Research. In addition to the work underway and discussions/suggestions on present research problems, ASTHMA: Causes and Mechanisms of an Epidemic Inflammatory Disease provides a chapter on the causes of asthma-and the reasons for its recent spread, so hotly discussed in the current literature. Researchers in the fields of asthma and allergy, health care providers, and others who follow research in either of these two developing areas will benefit from this book. The book is written at the level of one investigator to another.

Airway Wall Remodelling in Asthma

Author : A. G. Stewart
Publisher : CRC Press
ISBN 13 : 1000099040
Total Pages : 371 pages
Book Rating : 4.0/5 ( download)

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Book Synopsis Airway Wall Remodelling in Asthma by : A. G. Stewart

Download or read book Airway Wall Remodelling in Asthma written by A. G. Stewart and published by CRC Press. This book was released on 2020-10-28 with total page 371 pages. Available in PDF, EPUB and Kindle. Book excerpt: Asthma is a disease of high prevalence that has shown a trend toward increasing incidence, morbidity, and mortality over the last three decades despite apparently effective drug treatments and increasing awareness of the need for better disease management. Often the inflammatory component of asthma is studied; however, the tissue remodelling process is a significant process that should not be overlooked. This valuable reference synthesizes current data and concepts developed to determine the relationship between airway wall remodelling and the pathogenesis of asthma. It discusses evidence for structural changes in asthmatic airway, the relationship between airway thickening and hyperresponsiveness, the relationship between cytokine production and tissue remodelling and inflammation, the significance of epithelial changes and the extracellular matrix, and in vivo and in vitro experimental approaches to the assessment of remodelling. Pharmacological and biochemical mechanisms that control cell proliferation are also examined. The consequences of airway wall remodelling for airway hyperresponsiveness is the unique focus of this volume, offering a fresh perspective of advances in asthma research.

Airway Remodeling

Author : Peter Howarth
Publisher : CRC Press
ISBN 13 : 9780429132582
Total Pages : 328 pages
Book Rating : 4.1/5 (325 download)

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Book Synopsis Airway Remodeling by : Peter Howarth

Download or read book Airway Remodeling written by Peter Howarth and published by CRC Press. This book was released on 2001 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: This landmark volume discusses the characteristics and impact of the remodeling process on airway function and clinical disease expression within the airway in asthma, covering pharmacological therapies and possible future targets relevant to regulating the remodeling process. Emphasizes the importance of treating underlying airway inflammation and the relevance of structural alterations to the airway wall, including glandular increases, enhanced collagen deposition within the submucosa, increased vasculature, smooth hypertrophy, and hyperplasias! Tracing the development and maintenance of bronchial hyperresponsiveness, decline in lung function, and loss of reversibility evident in chronic asthma, Airway Remodelingdescribes the contribution of inflammatory cells in the development of airway structural changes examines how pharmaceutical agents act and whether existing treatments modify or prevent remodeling in chronically inflamed asthmatic airways considers whether neural pathways initiate as well as contribute to the airway inflammatory cascade that leads to remodeling reviews the action of cytokines and growth factors on ASM signaling outlines novel approaches to regulating smooth muscle growth clarifies whether permanent ventilatory incapacity in asthma is caused by the uncoupling of the airway and the role of the lung parenchyma details high-resolution computerized tomography scan to measure the internal size of the airway at baseline, during challenge, or after bronchodilatation and more!Improving lung function and quality of life by reducing the need for emergency care, hospital admissions, and systemic steroid administration, Airway Remodeling is a superb reference for pulmonologists and respiratory system specialists; physiologists; pneumologists; allergists; pharmacologists; molecular, cellular, and lung biologists; and graduate and medical school students in these disciplines.

Severe Asthma

Author : Kian Fan Chung
Publisher : European Respiratory Society
ISBN 13 : 1849841047
Total Pages : 360 pages
Book Rating : 4.8/5 (498 download)

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Book Synopsis Severe Asthma by : Kian Fan Chung

Download or read book Severe Asthma written by Kian Fan Chung and published by European Respiratory Society. This book was released on 2019-06-01 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: Severe asthma is a form of asthma that responds poorly to currently available medication, and its patients represent those with greatest unmet needs. In the last 10 years, substantial progress has been made in terms of understanding some of the mechanisms that drive severe asthma; there have also been concomitant advances in the recognition of specific molecular phenotypes. This ERS Monograph covers all aspects of severe asthma – epidemiology, diagnosis, mechanisms, treatment and management – but has a particular focus on recent understanding of mechanistic heterogeneity based on an analytic approach using various ‘omics platforms applied to clinically well-defined asthma cohorts. How these advances have led to improved management targets is also emphasised. This book brings together the clinical and scientific expertise of those from around the world who are collaborating to solve the problem of severe asthma.