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In Vitro Skin Toxicology
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Book Synopsis Principles and Practice of Skin Toxicology by : Robert Chilcott
Download or read book Principles and Practice of Skin Toxicology written by Robert Chilcott and published by John Wiley & Sons. This book was released on 2008-07-31 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by authorities in the field, this book provides a “bottom up” approach to studying skin toxicology. Principles and Practice of Skin Toxicology clearly outlines basic concepts, cites historical and modern references and contains a dictionary for easy reference. The inclusion of global legislation and regulatory aspects on the topic makes this a comprehensive review for every practitioner, clinical researcher in industry and academia, and MSc and PhD student of toxicology. Different sections cover skin structure and function, principles and measurement of skin absorption, clinical aspects of dermal toxicity and in vitro alternatives. A section on regulatory and legislative aspects includes case studies from the UK that fulfill European Union and US FDA requirements. A glossary provides definitions of technical terms, and the chapters contain an introduction, learning boxes and summary section for ease of use. Includes a chapter on drug delivery through the skin. Addresses risk assessment: a key area for the interpretation of skin absorption data that is rarely covered.
Download or read book In Vitro Skin Toxicology written by and published by . This book was released on 1994 with total page 446 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :Organisation for Economic Co-operation and Development Publisher :Organisation for Economic Co-operation and Development ; [Montréal : Renouf] ISBN 13 :9789264122215 Total Pages : pages Book Rating :4.1/5 (222 download)
Book Synopsis OECD Guidelines for Testing of Chemicals by : Organisation for Economic Co-operation and Development
Download or read book OECD Guidelines for Testing of Chemicals written by Organisation for Economic Co-operation and Development and published by Organisation for Economic Co-operation and Development ; [Montréal : Renouf]. This book was released on 1981 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis In Vitro Skin Toxicology by : Andre Rougier
Download or read book In Vitro Skin Toxicology written by Andre Rougier and published by Mary Ann Liebert. This book was released on 1994 with total page 498 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis In Vitro Toxicology Systems by : Anna Bal-Price
Download or read book In Vitro Toxicology Systems written by Anna Bal-Price and published by Humana. This book was released on 2016-09-03 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In Vitro Toxicology Systems brings together important issues and considerations needed in order to develop a workable, reliable, integrated testing strategy for the replacement of animals in toxicity testing regimes. This thorough volume includes sections on in vitro models for systemic organ toxicity, neurotoxicity, sensory organs, immunotoxicity and reproductive toxicity and addresses how stem cells may be used going forward. The book also tackles difficult areas of toxicology such as carcinogenicity and nanotoxicology, with additional chapters dedicated to kinetics, metabolism, and in vitro in vivo extrapolation. The book also addresses biological processes such as stress response pathways and mechanistic biomarkers and how these can be uncovered and measured using high content approaches. Reliable and authoritative, In Vitro Toxicology Systems will be of benefit not only to students, scientists and regulators working in the field of chemical safety assessment but also to a wider scientific audience.
Book Synopsis In Vitro Toxicology, Second Edition by : Shayne C. Gad
Download or read book In Vitro Toxicology, Second Edition written by Shayne C. Gad and published by CRC Press. This book was released on 2000-11-02 with total page 419 pages. Available in PDF, EPUB and Kindle. Book excerpt: Toxicology has made tremendous strides in the sophistication of the models used to identify and understand the mechanisms of agents that can harm or kill humand and other higher organisms. Non-animals or in vitro models started to gain significant use in the 1960s. As a result of the increased concern over animal welfare, economic factors, and the need for greater sensitivity and understanding of mechanisms, interest in in vitro^n models has risen. This volume demonstrates that there now exists a broad range of in vitro models for use in either identifying or understanding most forms of toxicity. The availability of in vitro models spans both the full range of endpoints (irritation, sensitization, lethality, mutagenicity, and devlopmental toxicity) and the full spectrum of target organ systems (skin, eye, heart, liver, kidney, nervous system, etc.). Chapters are devoted to each of these speciality areas from a perspective of presenting the principal models and their uses and limitations. Chapters that overview the principles involved in the general selection and use of models, and that address the issues of safety concerns and regulatory acceptance of these methods are also included.
Book Synopsis Toxicology of the Skin by : Nancy A. Monteiro-Riviere
Download or read book Toxicology of the Skin written by Nancy A. Monteiro-Riviere and published by CRC Press. This book was released on 2010-02-17 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt: This key volume of the Target Organ Toxicology Series provides a fresh and modern approach to the subject of skin toxicology from the perspective of how the skin forms a barrier that protects the body from the external environment and how chemicals and drugs interact with the barrier properties of the skin. Any defects or perturbations to this barr
Book Synopsis Dermal Absorption and Toxicity Assessment, Second Edition by : Michael S. Roberts
Download or read book Dermal Absorption and Toxicity Assessment, Second Edition written by Michael S. Roberts and published by CRC Press. This book was released on 2008 with total page 714 pages. Available in PDF, EPUB and Kindle. Book excerpt: The source Dermal Absorption and Toxicity Assessment supplies a state-of-the-art overview of the dermal absorption process, and is divided into six well organized sections. Written by internationally recognized experts in the field, this Second Edition is a complete revised and updated text, covering the wide range of methods used to assess skin absorption and the various governmental and industrial programs concerned with skin permeation and toxicity. These include alternative in silico, in vitro, and in vivo strategies to conduct studies for regulatory requirements. To make room for this new expanded content, the editors are publishing a concurrent text entitled: Dermatological and Cosmetic Development with a concentration on subjects concerned with dermatological and cosmetic therapies
Book Synopsis Dermal and Ocular Toxicology by : David W. Hobson
Download or read book Dermal and Ocular Toxicology written by David W. Hobson and published by CRC Press. This book was released on 2020-11-25 with total page 664 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dermal and Ocular Toxicology: Fundamentals and Methods is a procedurally-oriented volume of detailed methods and practical examples discussing the dermal and ocular aspects of toxicology. The book is divided into a dermal section and an ocular section. Each section begins with a chapter on the anatomy and physiology of each organ system and then progresses to more specialized chapters discussing such topics as the toxicological pathology of each system, state-of-the-art in vitro and in vivo evaluatory procedures, statistical considerations for test design and data interpretation, and the utilization of test findings. Test methods are provided for acute dermal exposure effects, dermal hypersensitivity and photoallergy assessment, dermal and ocular 0.pharmacokinetics, skin flap and skin grafting techniques, and in vitro alternative methods. This book can be used as an instructional text or as a sourcebook for practicing toxicologists, pharmacologists, industrial hygienists, occupational health professionals, and graduate students.
Book Synopsis Alternatives for Dermal Toxicity Testing by : Chantra Eskes
Download or read book Alternatives for Dermal Toxicity Testing written by Chantra Eskes and published by Springer. This book was released on 2017-11-21 with total page 585 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides comprehensive information on the alternative (non-animal) dermal toxicity test methods currently available for industrial, regulatory, and academic use and also explores potential future developments. It encompasses all areas of dermal toxicity, including skin irritation, skin corrosion, skin sensitization, UV-induced effects, and skin genotoxicity. An individual chapter is devoted to each test method, with coverage of the scientific basis, validation status and regulatory acceptance, applications and limitations, available protocols, and potential role within testing strategies. In addition, perspectives from the test developer are presented, for example regarding critical steps in the protocol. The closing section addresses areas that may be of relevance for the future of dermal toxicity safety testing, including the validation and regulatory acceptance of integrated testing strategies, novel complex skin models, and high-throughput screening techniques.
Book Synopsis In Vitro Toxicology by : Alok Dhawan
Download or read book In Vitro Toxicology written by Alok Dhawan and published by Academic Press. This book was released on 2017-11-13 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: In Vitro Toxicology details the protocols and methods of in vitro testing, highlighting the usefulness of models, methods and the cost-effectiveness and reproducibility of such methodologies. The current approaches and strategies required to develop an easy, reliable, validated and high throughput system for use in alternative animal models to circumvent in vivo testing are discussed in detail. The book also includes chapters on the principles involved in the general selection and use of models that address safety concerns, regulatory acceptance and the current understandings and strategies for the identification of biomarkers in toxicity testing. Furthermore, principles involved in the general selection and use of models that address the issues of safety concerns and regulatory acceptance of these models are discussed, making the book beneficial to students, scientists, and regulators working in toxicology, as well as those in the field of chemicals and the safety assessment of novel materials. Discusses new techniques and protocols in a clear and concise manner includes examinations of nanotoxicity, genotoxicity and carcinogenicity Explains practical laboratory methods and the theories behind in vitro testing
Book Synopsis Toxicology of Skin by : Howard I. Maibach
Download or read book Toxicology of Skin written by Howard I. Maibach and published by CRC Press. This book was released on 2001-03-15 with total page 573 pages. Available in PDF, EPUB and Kindle. Book excerpt: Toxic injury to the skin in the general population, and particularly in western populations, is on the increase. This is partly due to the expanding number of natural and man-made chemicals present in our everyday environment. The need for a thorough understanding of the skin, and the mechanisms of toxicity therein, has never been more pressing. Th
Book Synopsis In Vitro Biological Systems by : Charles A. Tyson
Download or read book In Vitro Biological Systems written by Charles A. Tyson and published by Elsevier. This book was released on 2013-10-22 with total page 595 pages. Available in PDF, EPUB and Kindle. Book excerpt: Methods in Toxicology, Volume 1: In Vitro Biological Systems, Part A provides basic techniques employed by widely recognized scientists to prepare and maintain the biological components of in vitro model systems. The book discusses the in vitro models of neural and neuromuscular systems; ocular system; respiratory system; cardiovascular system; and gastrointestinal system. The text also describes liver slices; liver hepatocytes; other liver cell systems; proximal tubule fragments; kidney cell culture; reproductive and developmental systems; immune system; and skin. Pharmacologists, toxicologists, cell biologists, physiologists, immunotoxicologists, and molecular toxicologists will find the book invaluable.
Book Synopsis In Vitro Integrated Approach to Skin Pharmaco-toxicology by : European Laboratory without Walls
Download or read book In Vitro Integrated Approach to Skin Pharmaco-toxicology written by European Laboratory without Walls and published by . This book was released on 1994* with total page 22 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Dermatotoxicology by : Klaus Peter Wilhelm
Download or read book Dermatotoxicology written by Klaus Peter Wilhelm and published by CRC Press. This book was released on 2007-11-26 with total page 1044 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reflecting the embryonic state of the field, the first edition of Dermatoxicology, published in 1977, numbered 567 pages. Now the foundational reference in dermal toxicology, this seventh edition consists of 1,032 pages and defines what was once a largely intuitive field but has evolved into an established science of metrics and mechanisms. Updated
Book Synopsis Dermal Absorption Models in Toxicology and Pharmacology by : Jim E. Riviere
Download or read book Dermal Absorption Models in Toxicology and Pharmacology written by Jim E. Riviere and published by CRC Press. This book was released on 2005-08-24 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many experimental methods and mathematical modeling approaches rooted in disciplines outside of toxicology can be effectively applied to estimating dermal absorption. Dermal Absorption Models in Toxicology and Pharmacology explores current approaches and techniques that can be used to quantify dermal absorption with endpoints useful in both toxicology and pharmacology. The book begins with a review of basic principles and the in vitro and in vivo experimental approaches available for assessing dermal absorption of drugs and chemicals. This is followed by coverage of mathematical or in silico models for quantitating percutaneous absorption and the applications of these techniques to the risk assessment process. The remainder of the book explores scenarios where the unique properties of the chemicals being studied or the matrix in which they are exposed must be considered and then wraps up with a comparative analysis of chemical permeability in human and animal skin. Many of the books covering this subject are just too comprehensive and serve primarily as reference works. This book takes a different approach. Jim Riviere's editorial guidance ensures that the information is readable, accessible, authoritative, and concise, making it the perfect resource for familiarizing new researchers and students to the field and updating established scientists.
Book Synopsis Dermatotoxicology Methods by : Francis N. Marzulli
Download or read book Dermatotoxicology Methods written by Francis N. Marzulli and published by CRC Press. This book was released on 2019-05-07 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work presents and evaluates methods employed to identify the potential of certain types of chemicals to adversely affect the skin. A variety of test methods are included such as tests for skin penetration, metabolism, irritation, the skin immune system, photo effects, skin cancer, and topical effects of retinoids and depigmenting chemicals. Tests for chemicals that affect the reproductive and nervous system are also included. Both animal and human tests that have been standardised and tests that are under development and employ animal alternatives are addressed in this book. Besides different testing methods, a rationale for accepting non-animal models and a review of some regulatory agency discussions about animal alternative tests are included.
