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Author : Nenad Filipović
Publisher : Springer Nature
ISBN 13 : 3031600444
Total Pages : 431 pages
Book Rating : 4.0/5 (316 download)
Download or read book In Silico Clinical Trials for Cardiovascular Disease written by Nenad Filipović and published by Springer Nature. This book was released on with total page 431 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Nenad Filipovic
Publisher : Springer
ISBN 13 : 9783031600432
Total Pages : 0 pages
Book Rating : 4.6/5 (4 download)
Download or read book In Silico Clinical Trials for Cardiovascular Disease written by Nenad Filipovic and published by Springer. This book was released on 2024-10-11 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers in silico clinical trials of cardiovascular disease using a finite element and machine learning approach. Part I describes the fundamentals as well as the latest developments in the field: finite element modeling, system biology modeling for drug optimization, artificial intelligence approach for medical image processing, as well as pharmacokinetic and AI modeling. Part II provides use cases to describe how in silico clinical trials of cardiovascular disease are applied to specific cardiovascular diseases: carotid artery plaque modeling, aorta stenosis modeling, stent biodegradation modeling, surrogate AI model for left ventricle modeling, and more. This book is geared toward upper-level undergraduate and graduate students as well as for researchers in the domains of bioengineering, biomechanics, biomedical engineering and medicine.
Author : Atta ur-Rahman
Publisher : Bentham Science Publishers
ISBN 13 : 1608059685
Total Pages : 265 pages
Book Rating : 4.6/5 (8 download)
Download or read book Frontiers in Cardiovascular Drug Discovery written by Atta ur-Rahman and published by Bentham Science Publishers. This book was released on 2015-01-02 with total page 265 pages. Available in PDF, EPUB and Kindle. Book excerpt: Frontiers in Cardiovascular Drug Discovery is an eBook series devoted to publishing the latest and the most important advances in Cardiovascular drug design and discovery. Eminent scientists write contributions on all areas of rational drug design and drug discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, recent important patents, and structure-activity relationships. The eBook series should prove to be of interest to all pharmaceutical scientists involved in research in cardiovascular drug design and discovery. Each volume is devoted to the major advances in cardiovascular drug design and discovery. The eBook series is essential reading to all scientists involved in drug design and discovery who wish to keep abreast of rapid and important developments in the field.
Author : Divya Vohora
Publisher : Academic Press
ISBN 13 : 0128020989
Total Pages : 527 pages
Book Rating : 4.1/5 (28 download)
Download or read book Pharmaceutical Medicine and Translational Clinical Research written by Divya Vohora and published by Academic Press. This book was released on 2017-11-14 with total page 527 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pharmaceutical Medicine and Translational Clinical Research covers clinical testing of medicines and the translation of pharmaceutical drug research into new medicines, also focusing on the need to understand the safety profile of medicine and the benefit-risk balance. Pharmacoeconomics and the social impact of healthcare on patients and public health are also featured. It is written in a clear and straightforward manner to enable rapid review and assimilation of complex information and contains reader-friendly features.As a greater understanding of these aspects is critical for students in the areas of pharmaceutical medicine, clinical research, pharmacology and pharmacy, as well as professionals working in the pharmaceutical industry, this book is an ideal resource. Includes detailed coverage of current trends and key topics in pharmaceutical medicine, including biosimilars, biobetters, super generics, and Provides a comprehensive look at current and important aspects of the science and regulation of drug and biologics discovery
Author : Esther Pueyo
Publisher : Frontiers Media SA
ISBN 13 : 2889455394
Total Pages : 385 pages
Book Rating : 4.8/5 (894 download)
Download or read book Safety Pharmacology - Risk Assessment QT Interval Prolongation and Beyond written by Esther Pueyo and published by Frontiers Media SA. This book was released on 2018-08-16 with total page 385 pages. Available in PDF, EPUB and Kindle. Book excerpt: Current regulatory guidelines for cardiac safety utilize hERG block and QT interval prolongation as risk markers. This strategy has been successful at preventing harmful drugs from being marketed, but criticized for leading to early withdrawal of potentially safe drugs. Here we collected a series of articles presenting new technological and conceptual advances, including refinement of ex vivo and in vitro assays, screens and models, and in silico approaches reflecting the increasing effort that has been put forward by regulatory agencies, industry, and academia to try and address the need of a more accurate, mechanistically-based paradigm of proarrhythmic potential of drugs. This Research Topic is dedicated to the memory of Dr. J. Jeremy Rice, our wonderful friend and colleague.
Author : Yutong Samuel Cai
Publisher : Frontiers Media SA
ISBN 13 : 2832525679
Total Pages : 128 pages
Book Rating : 4.8/5 (325 download)
Download or read book Epidemiology and Clinical Researches in Atherosclerosis and Cardiovascular Disease written by Yutong Samuel Cai and published by Frontiers Media SA. This book was released on 2023-06-29 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Evan M. Zahn
Publisher : Elsevier Health Sciences
ISBN 13 : 0323653928
Total Pages : 214 pages
Book Rating : 4.3/5 (236 download)
Download or read book 3-Dimensional Modeling in Cardiovascular Disease written by Evan M. Zahn and published by Elsevier Health Sciences. This book was released on 2019-09-14 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by physicians and surgeons, imaging specialists, and medical technology engineers, and edited by Dr. Evan M. Zahn of the renowned Cedars-Sinai Heart Institute, this concise, focused volume covers must-know information in this new and exciting field. Covering everything from the evolution of 3D modeling in cardiac disease to the various roles of 3D modeling in cardiology to cardiac holography and 3D bioprinting, 3-Dimensional Modeling in Cardiovascular Disease is a one-stop resource for physicians, cardiologists, radiologists, and engineers who work with patients, support care providers, and perform research. Provides history and context for the use of 3D printing in cardiology settings, discusses how to use it to plan and evaluate treatment, explains how it can be used as an education resource, and explores its effectiveness with medical interventions. Presents specific uses for 3D modeling of the heart, examines whether it improves outcomes, and explores 3D bioprinting. Consolidates today’s available information and guidance into a single, convenient resource.
Author : Benjamin E. Blass
Publisher : Academic Press
ISBN 13 : 0128172150
Total Pages : 712 pages
Book Rating : 4.1/5 (281 download)
Download or read book Basic Principles of Drug Discovery and Development written by Benjamin E. Blass and published by Academic Press. This book was released on 2021-03-30 with total page 712 pages. Available in PDF, EPUB and Kindle. Book excerpt: Basic Principles of Drug Discovery and Development presents the multifaceted process of identifying a new drug in the modern era, which requires a multidisciplinary team approach with input from medicinal chemists, biologists, pharmacologists, drug metabolism experts, toxicologists, clinicians, and a host of experts from numerous additional fields. Enabling technologies such as high throughput screening, structure-based drug design, molecular modeling, pharmaceutical profiling, and translational medicine are critical to the successful development of marketable therapeutics. Given the wide range of disciplines and techniques that are required for cutting edge drug discovery and development, a scientist must master their own fields as well as have a fundamental understanding of their collaborator’s fields. This book bridges the knowledge gaps that invariably lead to communication issues in a new scientist’s early career, providing a fundamental understanding of the various techniques and disciplines required for the multifaceted endeavor of drug research and development. It provides students, new industrial scientists, and academics with a basic understanding of the drug discovery and development process. The fully updated text provides an excellent overview of the process and includes chapters on important drug targets by class, in vitro screening methods, medicinal chemistry strategies in drug design, principles of in vivo pharmacokinetics and pharmacodynamics, animal models of disease states, clinical trial basics, and selected business aspects of the drug discovery process. Provides a clear explanation of how the pharmaceutical industry works, as well as the complete drug discovery and development process, from obtaining a lead, to testing the bioactivity, to producing the drug, and protecting the intellectual property Includes a new chapter on the discovery and development of biologics (antibodies proteins, antibody/receptor complexes, antibody drug conjugates), a growing and important area of the pharmaceutical industry landscape Features a new section on formulations, including a discussion of IV formulations suitable for human clinical trials, as well as the application of nanotechnology and the use of transdermal patch technology for drug delivery Updated chapter with new case studies includes additional modern examples of drug discovery through high through-put screening, fragment-based drug design, and computational chemistry
Author : Atta-ur-Rahman
Publisher : Bentham Science Publishers
ISBN 13 : 1681080729
Total Pages : 273 pages
Book Rating : 4.6/5 (81 download)
Download or read book Frontiers in Clinical Drug Research - Anti-Cancer Agents written by Atta-ur-Rahman and published by Bentham Science Publishers. This book was released on 2015-07-09 with total page 273 pages. Available in PDF, EPUB and Kindle. Book excerpt: Frontiers in Clinical Drug Research - Anti-Cancer Agents should prove to be a valuable resource for pharmaceutical scientists and postgraduate students seeking updated and critical information for developing clinical trials and devising research plans in the field. The chapters featured in each volume are written by leading experts in oncology and clinical pharmacology. The eBook series is essential reading for all scientists involved in clinical drug research who wish to keep abreast of rapid and important developments in the development of anti-cancer agents. The contents of this volume include reviews on dendrimers for anti-cancer drug delivery, treatment methods for advanced cutaneous squamous cell carcinoma, targeting heat shock proteins for cancer treatment, Bayesian systems for optimizing treatment protocols in oncology and much more.
Author : Emerson c. Perin
Publisher : Academic Press
ISBN 13 : 0128018631
Total Pages : 538 pages
Book Rating : 4.1/5 (28 download)
Download or read book Stem Cell and Gene Therapy for Cardiovascular Disease written by Emerson c. Perin and published by Academic Press. This book was released on 2015-08-21 with total page 538 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stem Cell and Gene Therapy for Cardiovascular Disease is a state-of-the-art reference that combines, in one place, the breadth and depth of information available on the topic. As stem cell and gene therapies are the most cutting-edge therapies currently available for patients with heart failure, each section of the book provides information on medical trials from contributors and specialists from around the world, including not only what has been completed, but also what is planned for future research and trials. Cardiology researchers, basic science clinicians, fellows, residents, students, and industry professionals will find this book an invaluable resource for further study on the topic. Provides information on stem and gene therapy medical trials from contributors and specialists around the world, including not only what has been completed, but also what is planned for future research and trials Presents topics that can be applied to allogeneic cells, mesenchymal cells, gene therapy, cardiomyoctyes, iPS cells, MAPC's, and organogenesis Covers the three areas with the greatest clinical trials to date: chronic limb ischemia, chronic angina, and acute MI Covers the prevailing opinions on how to harness the body’s natural repair mechanisms Ideal resource for cardiology researchers, basic science clinicians, fellows, residents, students, and industry professionals
Author : Catriona Jennings
Publisher : Oxford University Press, USA
ISBN 13 : 0199236305
Total Pages : 239 pages
Book Rating : 4.1/5 (992 download)
Download or read book Preventive Cardiology written by Catriona Jennings and published by Oxford University Press, USA. This book was released on 2009-02-12 with total page 239 pages. Available in PDF, EPUB and Kindle. Book excerpt: Preventive Cardiology provides practical advice on how to structure and run a preventive cardiology program for existing patients, those at risk of developing cardiovascular disease, and their families, including patient identification and recruitment, assessment of lifestyle and risk factors, and implementing lifestyle change.
Author : Dimitrios I. Fotiadis
Publisher : John Wiley & Sons
ISBN 13 : 1119517346
Total Pages : 404 pages
Book Rating : 4.1/5 (195 download)
Download or read book Multiscale Modelling in Biomedical Engineering written by Dimitrios I. Fotiadis and published by John Wiley & Sons. This book was released on 2023-06-07 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multiscale Modelling in Biomedical Engineering Discover how multiscale modeling can enhance patient treatment and outcomes In Multiscale Modelling in Biomedical Engineering, an accomplished team of biomedical professionals delivers a robust treatment of the foundation and background of a general computational methodology for multi-scale modeling. The authors demonstrate how this methodology can be applied to various fields of biomedicine, with a particular focus on orthopedics and cardiovascular medicine. The book begins with a description of the relationship between multiscale modeling and systems biology before moving on to proceed systematically upwards in hierarchical levels from the molecular to the cellular, tissue, and organ level. It then examines multiscale modeling applications in specific functional areas, like mechanotransduction, musculoskeletal, and cardiovascular systems. Multiscale Modelling in Biomedical Engineering offers readers experiments and exercises to illustrate and implement the concepts contained within. Readers will also benefit from the inclusion of: A thorough introduction to systems biology and multi-scale modeling, including a survey of various multi-scale methods and approaches and analyses of their application in systems biology Comprehensive explorations of biomedical imaging and nanoscale modeling at the molecular, cell, tissue, and organ levels Practical discussions of the mechanotransduction perspective, including recent progress and likely future challenges In-depth examinations of risk prediction in patients using big data analytics and data mining Perfect for undergraduate and graduate students of bioengineering, biomechanics, biomedical engineering, and medicine, Multiscale Modelling in Biomedical Engineering will also earn a place in the libraries of industry professional and researchers seeking a one-stop reference to the basic engineering principles of biological systems.
Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309224187
Total Pages : 354 pages
Book Rating : 4.3/5 (92 download)
Download or read book Evolution of Translational Omics written by Institute of Medicine and published by National Academies Press. This book was released on 2012-09-13 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: Technologies collectively called omics enable simultaneous measurement of an enormous number of biomolecules; for example, genomics investigates thousands of DNA sequences, and proteomics examines large numbers of proteins. Scientists are using these technologies to develop innovative tests to detect disease and to predict a patient's likelihood of responding to specific drugs. Following a recent case involving premature use of omics-based tests in cancer clinical trials at Duke University, the NCI requested that the IOM establish a committee to recommend ways to strengthen omics-based test development and evaluation. This report identifies best practices to enhance development, evaluation, and translation of omics-based tests while simultaneously reinforcing steps to ensure that these tests are appropriately assessed for scientific validity before they are used to guide patient treatment in clinical trials.
Author : Peter Schueler
Publisher : Academic Press
ISBN 13 : 0128244909
Total Pages : 202 pages
Book Rating : 4.1/5 (282 download)
Download or read book Innovation in Clinical Trial Methodologies written by Peter Schueler and published by Academic Press. This book was released on 2020-11-20 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt: Innovation in Clinical Trial Methodologies: Lessons Learned during the Corona Pandemic presents a selection of updated chapters from Re-Engineering Clinical Trials that feature innovative options and methods in clinical trials. The Coronavirus pandemic is an accelerator for digitalization in many industries, including clinical trials. This book considers best practices, alternative study concepts requiring fewer patients, studies with less patient interaction, the design of "virtualized" protocols, and moving from data to decisions. This book will be helpful to pharmacologists, physicians and clinical researchers involved in the process of clinical development and clinical trial design. Considers multiple digital and virtual strategies Explores best practices, including the use of reduced patient involvement Brings together expert, trusted information to increase the efficiency and effectiveness of clinical trials
Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309162327
Total Pages : 442 pages
Book Rating : 4.3/5 (91 download)
Download or read book Redesigning the Clinical Effectiveness Research Paradigm written by Institute of Medicine and published by National Academies Press. This book was released on 2010-09-20 with total page 442 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent scientific and technological advances have accelerated our understanding of the causes of disease development and progression, and resulted in innovative treatments and therapies. Ongoing work to elucidate the effects of individual genetic variation on patient outcomes suggests the rapid pace of discovery in the biomedical sciences will only accelerate. However, these advances belie an important and increasing shortfall between the expansion in therapy and treatment options and knowledge about how these interventions might be applied appropriately to individual patients. The impressive gains made in Americans' health over the past decades provide only a preview of what might be possible when data on treatment effects and patient outcomes are systematically captured and used to evaluate their effectiveness. Needed for progress are advances as dramatic as those experienced in biomedicine in our approach to assessing clinical effectiveness. In the emerging era of tailored treatments and rapidly evolving practice, ensuring the translation of scientific discovery into improved health outcomes requires a new approach to clinical evaluation. A paradigm that supports a continual learning process about what works best for individual patients will not only take advantage of the rigor of trials, but also incorporate other methods that might bring insights relevant to clinical care and endeavor to match the right method to the question at hand. The Institute of Medicine Roundtable on Value & Science-Driven Health Care's vision for a learning healthcare system, in which evidence is applied and generated as a natural course of care, is premised on the development of a research capacity that is structured to provide timely and accurate evidence relevant to the clinical decisions faced by patients and providers. As part of the Roundtable's Learning Healthcare System series of workshops, clinical researchers, academics, and policy makers gathered for the workshop Redesigning the Clinical Effectiveness Research Paradigm: Innovation and Practice-Based Approaches. Participants explored cutting-edge research designs and methods and discussed strategies for development of a research paradigm to better accommodate the diverse array of emerging data resources, study designs, tools, and techniques. Presentations and discussions are summarized in this volume.
Author : Jyoti Sharma
Publisher : Frontiers Media SA
ISBN 13 : 2889661253
Total Pages : 154 pages
Book Rating : 4.8/5 (896 download)
Download or read book Multi-Omics Approaches to Study Signaling Pathways written by Jyoti Sharma and published by Frontiers Media SA. This book was released on 2020-11-18 with total page 154 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Author : Derek Hausenloy
Publisher : Oxford University Press
ISBN 13 : 019954476X
Total Pages : 138 pages
Book Rating : 4.1/5 (995 download)
Download or read book Cardioprotection written by Derek Hausenloy and published by Oxford University Press. This book was released on 2009-08-20 with total page 138 pages. Available in PDF, EPUB and Kindle. Book excerpt: Coronary heart disease (CHD) is the leading cause of death worldwide. Cardioprotection refers to the prevention of CHD and the clinical improvement in patients suffering from cardiovascular problems.
