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Impact Of Bisphosphonate Bone Burden On Orthodontic Tooth Movement
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Book Synopsis Impact of Bisphosphonate Bone Burden on Orthodontic Tooth Movement by : Neelambar Reddy Kaipatur
Download or read book Impact of Bisphosphonate Bone Burden on Orthodontic Tooth Movement written by Neelambar Reddy Kaipatur and published by . This book was released on 2014 with total page 183 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bisphosphonate (BP) drugs have been extensively used to prevent and treat osteoporosis and are shown to decrease the incidence of osteoporotic fractures in humans. Recent evidence has demonstrated that long term use of bisphosphonates is associated with atypical fractures of the spine, femoral head and vertebrae, and osteonecrosis of the jaw due to their effect on inhibiting osteoclast-mediated bone remodeling. Bone remodeling is important to not only maintain skeleton in natural remodeling state but also in active remodeling - such as associated with orthodontic tooth movement (OTM) and the rate of bone turnover has a direct impact on the rate and amount of OTM. As BP drugs affect the rate of bone turnover by preserving bone mass, they are evidenced to slow down tooth movement. Current research using animal models on the influence of bisphosphonate drugs on tooth movement was focused on using the drug concurrent with tooth movement. The clinical scenario that presents to an orthodontist is that of an adult male or female on years of bisphosphonate drugs to prevent or treat osteoporosis or similar disorders requiring orthodontic care for straightening teeth and improving smile esthetics. To date, there are no published studies that have investigated the effect of long term use of bisphosphonate drugs (BP burden) on OTM. We hypothesized that the bone burden of BP drugs would slow down tooth movement. Our secondary goal was also to investigate accelerators of tooth movement, to reverse the inhibitory effect of BP burden. Although many invasive and non-invasive methods to accelerate tooth movement have been attempted to date; corticotomy is the most effective and reliable method to accelerate tooth movement in both animals and human studies. The objective of the study was to investigate the bone burden effect of long term use of alendronate sodium; the most commonly used BP drug on orthodontic tooth movement and also to explore the consequence of accelerating tooth movement in BP burdened alveolar bone in a rodent model. A novel tooth movement model was developed using rat TSADs (Temporary skeletal anchorage devices) and NiTi coil springs. Finite Element analysis of TSAD stability as anchorage during tooth movement was performed. Three month-old Sprague-Dawley female rats were used as the animal model for the entire study. In vivo microcomputed tomography imaging was performed at baseline (0 week) 4 and 8 weeks for measuring tooth movement. At the experimental end point (8 weeks) all animals were euthanized using CO2 inhalation and processed for histology and Electron Probe Micro-analysis (EPMA) imaging. While concurrent dosing of alendronate drug during tooth movement showed a 56% and 65% reduction compared to control animals; the impact of bone burden on tooth movement was significant with 77% and 86% reduction in tooth movement at 4 and 8 weeks respectively in the bisphosphonate burden group compared to controls. Selective alveolar decortication surgery (SADc) did not have a substantial impact on accelerating tooth movement in control animals with only a 2% and 6% increase at 4 and 8 weeks respectively. The effect of SADc in bisphosphonate burden group was significant at 4 weeks with a 113% increase in tooth movement compared to BP burden group alone. This acceleration of tooth movement was transient with only a modest 10% increase from 4 to 8 weeks. EPMA imaging showed lack of dynamic labeling of Strontium (Sr2+ acts as surrogate for Ca2+ and gets deposited in areas of newly formed bone) in the BP burdened animals due to lack of active bone remodeling while the control animals showed robust remodeling with increase in dynamic labeling of Strontium. SADc surgery did increase tooth movement in bisphosphonate burden animals but the increase was not evident long term and was associated with areas of necrotic bone with osteolysis, accompanied by pyknotic nuclei and/or lost osteocytes with empty lacunae along with bacterial infiltration and severe buccal and interproximal bone loss. In summary, burdening of alveolar bone with BP drugs did substantially slow down tooth movement and an attempt to accelerate tooth movement in this BP burdened bone using selective alveolar decortication surgery led to a short term increase in tooth movement for 4 weeks but was associated with severe bone loss with histological evidence of bone osteonecrosis.
Book Synopsis Biology of Orthodontic Tooth Movement by : Bhavna Shroff
Download or read book Biology of Orthodontic Tooth Movement written by Bhavna Shroff and published by Springer. This book was released on 2016-05-30 with total page 169 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the current knowledge and understanding of the biological processes involved in the orthodontic movement of teeth and discusses recent progress in the field. It links research advances to their immediate clinical applications and offers researchers and clinicians a state of the art reference on topical issues relating to orthodontic tooth movement. Biological events play a central role in the movement of teeth during orthodontic therapy. The basis for understanding the sequence of cellular events that leads to orthodontic movement has been well established in the literature through the use of animal models. In recent years, researchers and clinicians have focused their efforts on developing treatment modalities to increase the speed of orthodontic treatment and provide better anchorage options for noncompliant patients. This book will be an invaluable aid in understanding the biology of tooth movement and the relevance of the latest concepts to clinical practice.
Book Synopsis Biological Mechanisms of Tooth Movement by : Vinod Krishnan
Download or read book Biological Mechanisms of Tooth Movement written by Vinod Krishnan and published by John Wiley & Sons. This book was released on 2021-05-24 with total page 42 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biological Mechanisms of Tooth Movement This new edition continues to be an authoritative reference to the scientific foundations underpinning clinical orthodontics The newly and thoroughly revised Third Edition of Biological Mechanisms of Tooth Movement delivers a comprehensive reference for orthodontic trainees and specialists. It is fully updated to include new chapters on personalized orthodontics as well as the inflammatory process occurring in the dental and paradental tissues. It is heavily illustrated throughout, making it easier for readers to understand and retain the information discussed within. The topics covered range from bone biology, the effects of mechanical loading on tissues and cells, genetics, tissue remodeling, and the effects of diet, drugs, and systemic diseases. The Third Edition of Biological Mechanisms of Tooth Movement features seven sections that cover subjects such as: The development of biological concepts in orthodontics, including the cellular and molecular biology behind orthodontic tooth movement Mechanics meets biology, including the effects of mechanical loading on hard and soft tissues and cells, and biological reactions to temporary anchorage devices Inflammation and orthodontics, including markers for tissue remodeling in the gingival crevicular fluid and saliva Personalized diagnosis and treatment based on genomic criteria, including the genetic influences on orthodontic tooth movement Rapid orthodontics, including methods to accelerate or decelerate orthodontic tooth movement Perfect for residents and PhD students of orthodontic and periodontal programs, Biological Mechanisms of Tooth Movement is also useful to academics, clinicians, bone biologists, and researchers with an interest in the mechanics and biology of tooth movement.
Book Synopsis Innovative Perspectives in Oral and Maxillofacial Surgery by : Mark R. Stevens
Download or read book Innovative Perspectives in Oral and Maxillofacial Surgery written by Mark R. Stevens and published by Springer Nature. This book was released on 2021-07-30 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book examines the latest technologies and developments in oral and maxillofacial surgery. It presents information in an easy-to-read format and meticulously details each surgical technique. Thorough and accurate chapters comprehensively present procedures and treatments step-by-step procedures objectively. Each chapter follows a consistent format of which includes the scientific documentation of the procedure through clinical studies, objective benefits for the patient, detailed explanations of the procedure, levels of treatment complexity according to the SAC (simple -advanced complex) classification, and cost-effectiveness of the procedure for the patient and clinician. Extensive images, figures, and tables supplement select chapters to aid in visual learning. Extensive and unique, Innovative Perspectives in Oral and Maxillofacial Surgery is a vital tool for all dental specialists ranging from undergraduate students to established oral maxillofacial surgeons.
Book Synopsis Biological Mechanisms of Tooth Movement by : Vinod Krishnan
Download or read book Biological Mechanisms of Tooth Movement written by Vinod Krishnan and published by John Wiley & Sons. This book was released on 2009-03-09 with total page 310 pages. Available in PDF, EPUB and Kindle. Book excerpt: The adaptation and development of biological concepts in orthodontics / Ze'evDavidovitch and Neal C. Murphy -- Biology of orthodontic tooth movement : an overview / Vinod Krishnan, Young Guk Park and Ze'ev Davidovitch -- The effects of mechanical loading on hard and soft tissues and cells / Itzhak Binderman . [und weitere] -- Genetic influences on orthodontic tooth movement / Maggie Zeichner-David -- The role of inflammation in defining the type and pattern of tissue response in orthodontic tooth movement / Masaru Yamaguchi -- Biological aspects of bone growth and metabolism in orthodontics / Song Chen, James K. Hartsfield Jr. and W. Eugene Roberts -- Markers of paradental tissue remodeling in the gingival crevicular fluid of -- Orthodontic patients / Laura R. Iwasaki and Jeffrey C. Nickel -- Effects of systemic diseases on orthodontic tooth movement / Ze'ev Davidovitch and Vinod Krishnan -- The effect of drugs and diet on orthodontic tooth movement / Vinod Krishnan and Ze'ev Davidovitch -- Biologically and clinically, what are optimal orthodontic forces and how are they applied in selective common malocclusions? / Vincent De Angelis and Ze'ev Davidovitch -- The biological background of relapse of orthodontic tooth movement / Jaap C. Maltha and Anne Marie Kuijpers Jagtman -- Mechanical and biological determinants of iatrogenic injuries in orthodontics / Vinod Krishnan.
Author :Sara Gordon Publisher :National Library of Canada = Bibliothèque nationale du Canada ISBN 13 : Total Pages :170 pages Book Rating :4.3/5 (91 download)
Book Synopsis Foreign Body Gingivitis by : Sara Gordon
Download or read book Foreign Body Gingivitis written by Sara Gordon and published by National Library of Canada = Bibliothèque nationale du Canada. This book was released on 1996 with total page 170 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gingival inflammation due to foreign bodies in connective tissues is termed Foreign Body Gingivitis (FBG). It is not commonly recognized by clinicians and has not been fully described in the literature. This thesis describes the demographic, clinical, and histopathological findings in 61 cases of FBG. Clinical and histologic criteria for its diagnosis are proposed. FBG presented most frequently as a red or red-and-white painful chronic lesion. It was more common in females and occurred at a mean age of 48. Microscopically, foreign bodies were seen in moderate to severe inflammation which was frequently granulomatous and sometimes lichenoid. The foreign bodies were examined by energy-dispersive x-ray microanalysis (EDX) to identify their elemental composition and potential source. This analysis indicated most foreign bodies were of probable dental material origin, usually abrasives. It is postulated that they are iatrogenically introduced during routine dental procedures.
Book Synopsis Inhibition of Matrix Metalloproteinases by : Robert A. Greenwald
Download or read book Inhibition of Matrix Metalloproteinases written by Robert A. Greenwald and published by . This book was released on 1999 with total page 792 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume contains papers from a multidisciplinary conference convened to discuss mechanisms of action, pharmacology, models for drug development, and recent positive clinical trial data relating to the inhibition of collagenases and related metalloproteinases matrix (MMPs). Excess metalloproteinase activity has been identified in many disease processes, and finally products for the specific use as metalloproteinase inhibitors are about to be marketed. In this book, two novel themes are explored: the arguments for and against broad-spectrum versus specific MMP inhibitors, and the potential usefulness of chairside diagnostic kits for clinical determination of excessive MMP activity.
Book Synopsis Dental Implant Treatment in Medically Compromised Patients by : Quan Yuan
Download or read book Dental Implant Treatment in Medically Compromised Patients written by Quan Yuan and published by Springer Nature. This book was released on 2019-10-04 with total page 253 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is an ideal reference guide for clinicians seeking to improve their decision making and treatment outcomes when placing dental implants in medically compromised patients, in whom conditions for osseointegration and soft tissue healing may be unfavorable. Up-to-date information is provided on the potential impacts of a wide variety of diseases and disorders on dental implant treatment and the factors that need to be considered when deciding on the feasibility of such treatment. More specifically, for each condition possible disease-related changes in the oral environment are explained and key treatment issues are identified, including surgical and prosthodontic aspects and pharmacological considerations. The book will help general dentists, periodontists, and oral surgeons to reduce the risk of treatment failure and complications and to ensure that the implant therapy is successful in achieving excellent quality of life and functional benefits, thereby improving patient satisfaction.
Book Synopsis Pediatric Board Study Guide by : Osama Naga
Download or read book Pediatric Board Study Guide written by Osama Naga and published by Springer. This book was released on 2015-03-27 with total page 611 pages. Available in PDF, EPUB and Kindle. Book excerpt: Covers the most frequently asked and tested points on the pediatric board exam. Each chapter offers a quick review of specific diseases and conditions clinicians need to know during the patient encounter. Easy-to-use and comprehensive, clinicians will find this guide to be the ideal final resource needed before taking the pediatric board exam.
Download or read book Healthy Aging written by Patrick P. Coll and published by Springer. This book was released on 2019-03-29 with total page 399 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book weaves all of these factors together to engage in and promote medical, biomedical and psychosocial interventions, including lifestyle changes, for healthier aging outcomes. The text begins with an introduction to age-related changes that increase in disease and disability commonly associated with old age. Written by experts in healthy aging, the text approaches the principles of disease and disability prevention via specific health issues. Each chapter highlights the challenge of not just increasing life expectancy but also deceasing disease burden and disability in old age. The text then shifts into the whole-person implications for clinicians working with older patients, including the social and cultural considerations that are necessary for improved outcomes as Baby Boomers age and healthcare systems worldwide adjust. Healthy Aging is an important resource for those working with older patients, including geriatricians, family medicine physicians, nurses, gerontologists, students, public health administrators, and all other medical professionals.
Book Synopsis The Biology of Tooth Movement by : Louis A. Norton
Download or read book The Biology of Tooth Movement written by Louis A. Norton and published by CRC Press. This book was released on 1988-11-30 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt: :Written by a broad spectrum of dental, medical and basic science researchers from around the world, this book presents state-of-the-art knowledge concerning the biology of connective tissues and their response to exogenous mechanical stimulation at the cell biology level. The text goes well beyond the traditional morphologic descriptions of tooth movement, covering the cell biology of the connective tissues involved, the various in vitro and in vivo research models, possible pharmacological means of influencing tissue responses, and biophysical considerations. Many cellular events that occur during tooth movement are discussed, as well as the exciting challenges, unanswered questions and possibilities in the future. This publication is extremely relevant to the work of dental specialists in orthodontics, pediatric dentistry, and periodontics plus orthopeadists and basic scientists working in connective tissue research.
Download or read book Cerebral Palsy written by Freeman Miller and published by JHU Press. This book was released on 2006-05-08 with total page 537 pages. Available in PDF, EPUB and Kindle. Book excerpt: When a child has a health problem, parents want answers. But when a child has cerebral palsy, the answers don't come quickly. A diagnosis of this complex group of chronic conditions affecting movement and coordination is difficult to make and is typically delayed until the child is eighteen months old. Although the condition may be mild or severe, even general predictions about long-term prognosis seldom come before the child's second birthday. Written by a team of experts associated with the Cerebral Palsy Program at the Alfred I. duPont Hospital for Children, this authoritative resource provides parents and families with vital information that can help them cope with uncertainty. Thoroughly updated and revised to incorporate the latest medical advances, the second edition is a comprehensive guide to cerebral palsy. The book is organized into three parts. In the first, the authors describe specific patterns of involvement (hemiplegia, diplegia, quadriplegia), explain the medical and psychosocial implications of these conditions, and tell parents how to be effective advocates for their child. In the second part, the authors provide a wealth of practical advice about caregiving from nutrition to mobility. Part three features an extensive alphabetically arranged encyclopedia that defines and describes medical terms and diagnoses, medical and surgical procedures, and orthopedic and other assistive devices. Also included are lists of resources and recommended reading.
Book Synopsis Bisphosphonates in Bone Disease by : Herbert Fleisch
Download or read book Bisphosphonates in Bone Disease written by Herbert Fleisch and published by Elsevier. This book was released on 2000-06-12 with total page 225 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is an essential handbook on bisphosphonates, the most widely used new class of drugs for osteoporosis therapy. It reviews basic physiology in addition to the indications and adverse reactions of these drugs. Bisphosphonates in Bone Disease, Fourth Edition, discusses the compounds' chemistry, mechanisms of action, and animal toxicology before presenting a clinical picture of the diseases treated by bisphosphonates. The book provides a table listing the trade names of the commercially available bisphosphonates, registered indications, and the available forms for various countries. The revised Fourth Edition contains approximately 50% new material, including information on all of the latest drugs. - The revised fourth edition contains approximately 50% new material - Includes information on all the latest drugs
Book Synopsis Pediatric Head and Neck Tumors by : Reza Rahbar
Download or read book Pediatric Head and Neck Tumors written by Reza Rahbar and published by Springer Science & Business Media. This book was released on 2013-12-02 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt: The pediatric head and neck cancer patient necessitates a multidisciplinary team of specialists to provide an optimal continuum of care. This A-Z guide provides practical, in-depth information for all medical professionals involved in the evaluation and treatment of these patients. Written in an easy to follow format, each entry contains illustrative figures to aid in pathological and radiographical diagnosis, as well as structured discussion of evaluation and multimodality management. The alphabetical layout eliminates redundancy and allows the busy physician to quickly locate relevant information. Pediatric Head and Neck Tumors is ideal for young physicians as well as attending physicians seeking to expand their knowledgebase to the various subspecialties involved in the multidisciplinary care of their patients.
Book Synopsis Regenerative Strategies for Maxillary and Mandibular Reconstruction by : James C. Melville
Download or read book Regenerative Strategies for Maxillary and Mandibular Reconstruction written by James C. Melville and published by Springer. This book was released on 2019-03-25 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is designed as a comprehensive and up-to-date instructional guide to the strategies employed for regeneration of the maxillomandibular region, with emphasis on allogeneic and tissue engineering principles. Readers will find information on indications and contraindications for procedures, pertinent anatomy, surgical techniques, postoperative management, and management of complications. Current surgical techniques utilizing biotechnology for regeneration and reconstruction are described in depth, with explanation of their benefits in minimizing patient morbidity. In addition, state of the art free vascular transfer for maxillary and mandibular reconstruction is extensively discussed, with a particular focus on indications and step-by-step technique. The authors are well-known experts in their field who are keen to share their extensive experience and preferred approaches. The book is intended for all oral and maxillofacial surgeons, head and neck surgeons, and plastic and reconstruction surgeons who wish to increase their knowledge on the latest modalities of maxillary and mandibular reconstruction.
Book Synopsis Contemporary Oral Medicine by : Camile S. Farah
Download or read book Contemporary Oral Medicine written by Camile S. Farah and published by Springer. This book was released on 2019-03-07 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book, written by world authorities in the field, is a comprehensive, up-to-date guide to the specialty of Oral Medicine, which is concerned with the diagnosis, prevention, and predominantly non-surgical management of medically related disorders and conditions affecting the oral and maxillofacial region. The pathophysiology, clinical presentation, diagnostic evaluation, and treatment of all relevant diseases and disorders are described with the aid of a wealth of clinical cases and illustrations that enable the reader to appreciate the diversity and potential complexity of Oral Medicine. In addition to the wide-ranging coverage of oral conditions, separate sections are devoted to bone and cutaneous pathology and to orofacial pain and its management, in addition to dental sleep medicine. The clinician who treats Oral Medicine patients will find this book to be an excellent aid to optimal management grounded in a sound knowledge of basic science and the dental and medical aspects of each disorder. In addition, it will serve as an outstanding textbook for undergraduate and postgraduate students.
