Immunotherapy For Head And Neck Cancer

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Immunotherapy for Head and Neck Cancer

Author : Anthony T. C. Chan
Publisher : Springer Nature
ISBN 13 : 3031292235
Total Pages : 151 pages
Book Rating : 4.0/5 (312 download)

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Book Synopsis Immunotherapy for Head and Neck Cancer by : Anthony T. C. Chan

Download or read book Immunotherapy for Head and Neck Cancer written by Anthony T. C. Chan and published by Springer Nature. This book was released on 2023-11-15 with total page 151 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a comprehensive summary of the literature on the scientific rationale and clinical development of immunotherapy for head and neck cancers. Head and neck cancer is a biologically diverse group of cancers that bear a common hallmark - evasion of host immune surveillance through innate or acquired mechanisms. The etiological association between the Human Papilloma virus (HPV) and some squamous head and neck cancers, the Epstein-Barr virus (EBV) and nasopharyngeal cancer has provided further impetus for evaluating immunotherapy in this group of cancers. The successful development of anti-programmed cell death protein-1 (PD-1)/ ligand (PD-L1) and CTLA-4 antibodies in solid tumours has gradually brought immunotherapy into mainstream oncological practice in recent years. Besides immune-checkpoint proteins inhibitors, other forms of immunotherapy such as vaccines, EBV or HPV-targeting therapies and cellular therapies are actively being investigated in clinical trials, either alone or in combination with other conventional treatments such as radiotherapy, chemotherapy and surgery. In clinical setting, the practicing oncologist need to be familiar with some unusual patterns of immunological response such as pseudo-progression and hyper-progression in patients with head and neck cancers who are undergoing treatment with immune-checkpoint inhibitors. Furthermore, the unique side effects of immune-checkpoint inhibitors such as autoimmune toxicities need to be recognized early and treated expediently. The development of biomarkers in predicting response to immune-checkpoint inhibitors has played pivotal roles in selecting patients for immunotherapy in practice or as an enrichment strategy in clinical trials. There are now emerging data on the clinical utility of biomarkers such as PD-L1 expression (Combined Positive Score), gene signatures and tumor mutational burden. This book is an invaluable companion to all those who are involved in research and clinical management of patients with head and neck cancers from any endemic regions.

Immunology and Immunotherapy of Head and Neck Cancer

Author : Panagiota Economopoulou
Publisher : Frontiers Media SA
ISBN 13 : 288974132X
Total Pages : 163 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Immunology and Immunotherapy of Head and Neck Cancer by : Panagiota Economopoulou

Download or read book Immunology and Immunotherapy of Head and Neck Cancer written by Panagiota Economopoulou and published by Frontiers Media SA. This book was released on 2022-01-21 with total page 163 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Advances in Head and Neck Cancer Immunology and Immunotherapy

Author : Rasha Abu-Eid
Publisher : Frontiers Media SA
ISBN 13 : 2889458393
Total Pages : 64 pages
Book Rating : 4.8/5 (894 download)

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Book Synopsis Advances in Head and Neck Cancer Immunology and Immunotherapy by : Rasha Abu-Eid

Download or read book Advances in Head and Neck Cancer Immunology and Immunotherapy written by Rasha Abu-Eid and published by Frontiers Media SA. This book was released on 2019-06-19 with total page 64 pages. Available in PDF, EPUB and Kindle. Book excerpt: Understanding the immunology of different cancers has led to great advances in developing cancer immunotherapies which are successfully used in generating effective anti-tumour immune responses. Head and neck cancers are no exception and various immunotherapies are now under study for the treatment of this diverse group of diseases. The articles in in this eBook provide a range of topics that highlight some of the latest advances in head and neck cancer immunology and immunotherapy. The authors of these articles provide their unique insight and expertise and suggest future directions for translational clinical research.

Immunotherapy and Multimodality Therapy for Head and Neck Cancer

Author : Sufang Qiu
Publisher : Frontiers Media SA
ISBN 13 : 2889764346
Total Pages : 168 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Immunotherapy and Multimodality Therapy for Head and Neck Cancer by : Sufang Qiu

Download or read book Immunotherapy and Multimodality Therapy for Head and Neck Cancer written by Sufang Qiu and published by Frontiers Media SA. This book was released on 2022-06-28 with total page 168 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Immunotherapy and Immune Regulation of Head and Neck Cancer

Author : Song Fan
Publisher : Frontiers Media SA
ISBN 13 : 2832508618
Total Pages : 153 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Immunotherapy and Immune Regulation of Head and Neck Cancer by : Song Fan

Download or read book Immunotherapy and Immune Regulation of Head and Neck Cancer written by Song Fan and published by Frontiers Media SA. This book was released on 2022-12-05 with total page 153 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Critical Issues in Head and Neck Oncology

Author : Jan B. Vermorken
Publisher : Springer Nature
ISBN 13 : 3031231759
Total Pages : 361 pages
Book Rating : 4.0/5 (312 download)

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Book Synopsis Critical Issues in Head and Neck Oncology by : Jan B. Vermorken

Download or read book Critical Issues in Head and Neck Oncology written by Jan B. Vermorken and published by Springer Nature. This book was released on 2023-03-27 with total page 361 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is an open access book. With a wealth of exciting data emerging in this rapidly evolving field this book will review the state-of-the-art knowledge with emphasis on multidisciplinary decision and management of head and neck cancer. The book provides significant detail on a wide range of topics including: the role of new targets for treatment, immunotherapy, resistance mechanisms, standardizing molecular profiling programs, and new methods to guide therapeutic approaches. In addition different disease situations are addressed including different treatment approaches in primary disease and in recurrent and/or metastatic disease as well as new developments in pathology, surgery and reconstruction techniques, new systemic therapies in salivary gland cancer, and supportive care and follow-up. All disciplines involved in the treatment of head & neck cancer are covered with a focus on translation into daily practice. The 8th-THNO is designed for medical oncologists, head and neck surgeons, radiation oncologists, otolaryngologists, and other medical professionals involved in the treatment of patients with head and neck cancer.

Stereotactic Body Radiation Therapy

Author : Simon S. Lo
Publisher : Springer Science & Business Media
ISBN 13 : 364225604X
Total Pages : 433 pages
Book Rating : 4.6/5 (422 download)

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Book Synopsis Stereotactic Body Radiation Therapy by : Simon S. Lo

Download or read book Stereotactic Body Radiation Therapy written by Simon S. Lo and published by Springer Science & Business Media. This book was released on 2012-08-28 with total page 433 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stereotactic body radiation therapy (SBRT) has emerged as an important innovative treatment for various primary and metastatic cancers. This book provides a comprehensive and up-to-date account of the physical/technological, biological, and clinical aspects of SBRT. It will serve as a detailed resource for this rapidly developing treatment modality. The organ sites covered include lung, liver, spine, pancreas, prostate, adrenal, head and neck, and female reproductive tract. Retrospective studies and prospective clinical trials on SBRT for various organ sites from around the world are examined, and toxicities and normal tissue constraints are discussed. This book features unique insights from world-renowned experts in SBRT from North America, Asia, and Europe. It will be necessary reading for radiation oncologists, radiation oncology residents and fellows, medical physicists, medical physics residents, medical oncologists, surgical oncologists, and cancer scientists.

Head and Neck Cancer, An Issue of Hematology/Oncology Clinics of North America, E-Book

Author : Glenn J. Hanna
Publisher : Elsevier Health Sciences
ISBN 13 : 0323809316
Total Pages : 193 pages
Book Rating : 4.3/5 (238 download)

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Book Synopsis Head and Neck Cancer, An Issue of Hematology/Oncology Clinics of North America, E-Book by : Glenn J. Hanna

Download or read book Head and Neck Cancer, An Issue of Hematology/Oncology Clinics of North America, E-Book written by Glenn J. Hanna and published by Elsevier Health Sciences. This book was released on 2021-09-09 with total page 193 pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of Hematology/Oncology Clinics, guest edited by Dr. Glenn J. Hanna, will focus on Head and Neck Cancer. This issue is one of six selected each year by our series consulting editors, Dr. George P. Canellos and Dr. Edward J. Benz. This issue addresses the evaluation and management of the complex head and neck cancer patient with articles focused on unique epidemiology and therapeutic principles by subsite of disease. Additional information relevant to rare head and neck malignancies is included. The issue further focuses on the evolving applications of minimally invasive surgery in oropharynx cancer and the role of immunotherapy in the management of advanced disease. Topics include: Radiologic Evaluation of the Head and Neck Cancer Patient, Robotic and Endoscopic Approaches to Head and Neck Surgery, Cancer of the Oral Cavity and Lip, Cancer of the Oropharynx and the Association with Human Papillomavirus, Cancer of the Larynx and Hypopharynx, Cancer of the Nasal Cavity and Paranasal Sinuses, Cancer of the Nasopharynx and the Association with Epstein-Barr Virus, Salivary Glands Cancers, Thyroid and Parathyroid Cancers, Cutaneous Malignancies of the Head and Neck, Managing Recurrent and Metastatic Head and Neck Cancer, and Immunotherapy for Head and Neck Cancer. Provides in-depth, clinical reviews on head and neck cancer, providing actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field; Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews.

Novel Therapies in Head and Neck Cancer: Beyond the Horizon

Author : Maie A. St. John
Publisher : Academic Press
ISBN 13 : 0128209291
Total Pages : 268 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Novel Therapies in Head and Neck Cancer: Beyond the Horizon by : Maie A. St. John

Download or read book Novel Therapies in Head and Neck Cancer: Beyond the Horizon written by Maie A. St. John and published by Academic Press. This book was released on 2020-06-29 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt: Novel Therapies in Head and Neck Cancer: Beyond the Horizon, Volume Twelve, provides a high-level synthesis of the latest treatments and outcomes relating to head and neck cancer. Chemotherapy and immunotherapy for those cancer types are rapidly evolving, and an updated source based on the expertise of internationally renowned researchers is necessary. This book discusses the outcome of recent trials using chemotherapy, novel approaches for HPV+ SCCA, cases in which immunotherapy is more likely to be successful, and precision medicine based on target therapies. Additionally, new approaches for rare diseases in head and neck and novel drug delivery platforms are presented. This book will be a very useful source so that students, scientists and clinicians who can be facile with the data, build on what is known, and continue to offer cutting-edge, validated therapies to all patients. Covers new chemotherapy trials, specifically on HPV and non-HPV related cancer types Discusses the application of immunotherapy to treat rare types of head and neck cancer Presents updated information on targeted therapies, specifically focusing on skin cancer in the region

Preoperative (Neoadjuvant) Chemotherapy

Author : Joseph Ragaz
Publisher : Springer Science & Business Media
ISBN 13 : 3642826717
Total Pages : 172 pages
Book Rating : 4.6/5 (428 download)

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Book Synopsis Preoperative (Neoadjuvant) Chemotherapy by : Joseph Ragaz

Download or read book Preoperative (Neoadjuvant) Chemotherapy written by Joseph Ragaz and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 172 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite recent advances in adjuvant therapies of cancer, the regi mens of postoperative adjuvant chemotherapy treatment which are presently available fail to cure the majority of cancer patients. Pre operative (neoadjuvant) chemotherapy represents a new approach in drug scheduling, based on sound theoretical, pharmacokinetic, and experimental principles. The preoperative timing of chemotherapy before definitive sur gery is not a minor change in the therapy of cancer. To be successful, large numbers of practitioners and their patients must participate. Substantial alterations of many aspects of the present management of cancer will have to follow. Therefore, before such therapy can be fully and routinely implemented, results of the novel treatment and its rationale have to be carefully evaluated. In preoperative treatment, other features will likely gain impor tance. For the first time, clinicians have a chance to follow the in vivo response of the tumor exposed to preoperative chemotherapy. The subsequent histological assessment of the tumor sample may likely become an important prognostic guide, permitting more re fined individual approaches to the planning of postoperative adju vant treatment. The value of such a treatment strategy can already be appreciated in the clinical setting, as seen from the therapy of osteosarcoma. Furthermore, preoperative chemotherapy might render previously inoperable tumors operable and hence resectable with a curative intention. The preoperative reduction of tumor bulk may also effectively decrease the need for more radical operations, permitting a more uniform adoption of conservative surgery.

Research, Clinical Trials, Drug Resistance and Safety for Cancer Immunotherapy in Head and Neck Cancers and Brain Tumors

Author : Ling Zhang
Publisher : Frontiers Media SA
ISBN 13 : 2832509584
Total Pages : 132 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Research, Clinical Trials, Drug Resistance and Safety for Cancer Immunotherapy in Head and Neck Cancers and Brain Tumors by : Ling Zhang

Download or read book Research, Clinical Trials, Drug Resistance and Safety for Cancer Immunotherapy in Head and Neck Cancers and Brain Tumors written by Ling Zhang and published by Frontiers Media SA. This book was released on 2023-11-10 with total page 132 pages. Available in PDF, EPUB and Kindle. Book excerpt: Head and neck cancers (HNCs) and brain tumors continue to be fatal diseases in most countries of the world. In the past decade, cancer immunotherapy has emerged as a promising therapeutic strategy and achieved unprecedented bench-to-bedside clinical success in the field of oncology. Different from traditional surgery, chemotherapy, and radiotherapy, the current cancer immunotherapy aims to recover or enhance the immune system of a patient, to recognize and eliminate cancerous cells from the primary tumor and metastases. Numerous immunotherapy strategies, in particular immune checkpoint inhibitors, adoptive cellular therapies, and cancer vaccines, are under pre-clinical investigations or in ongoing clinical trials in a range of cancer types. Among them, novel drugs have continued to be approved by the FDA, which has revolutionized the current cancer treatment by prolonging the survival time of the patients, especially in advanced unresectable tumors. However, not all patients achieve complete responses to immunotherapy due to de novo or acquired resistance. Also, immunotherapy-related adverse events are common, although it has a better safety profile than the traditional treatments. It has limited the application and efficacy of cancer immunotherapy in tumors, including the HNCs and brain tumors, and highlights the need for new strategies.

Cancer Immunotherapy Principles and Practice

Author : Lisa H. Butterfield
Publisher :
ISBN 13 : 9781620700976
Total Pages : 0 pages
Book Rating : 4.7/5 (9 download)

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Book Synopsis Cancer Immunotherapy Principles and Practice by : Lisa H. Butterfield

Download or read book Cancer Immunotherapy Principles and Practice written by Lisa H. Butterfield and published by . This book was released on 2017 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Part 1: Intratumoral Signatures Associated With Immune Responsiveness

Improving the Therapeutic Ratio in Head and Neck Cancer

Author :
Publisher : Academic Press
ISBN 13 : 0128178698
Total Pages : 376 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Improving the Therapeutic Ratio in Head and Neck Cancer by :

Download or read book Improving the Therapeutic Ratio in Head and Neck Cancer written by and published by Academic Press. This book was released on 2019-10-04 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: Improving the Therapeutic Ratio in Head and Neck Cancer provides a complete review of current approaches to modulating therapeutic sensitivity in head and neck cancer. It presents a broad background of current approaches and by highlighting the potential for clinical translational, introduces a roadmap for how to move promising preclinical findings into the clinic. The book discusses topics such as immunotherapy and molecularly targeted therapies in head and neck cancer, PI3k/mTOR pathway, autophagy inhibition to sensitize HNC to radiation and chemotherapy, TAM and Eph/Ephrin family proteins and metabolic reprogramming to modulate therapeutic sensitivity. Additionally, it details approaches to improve the response to immunotherapy, and Chk1/2 inhibition in radiation and cetuximab resistance. This book is a valuable source to head and neck cancer researchers and advanced students, and to those studying specific approaches in other model systems and disease sites. Provides key scientific background for clinicians when developing novel clinical trials and important examples for basic scientists of the types of work required to move a concept from the lab to the clinic Presents consistent pathway diagrams in each chapter, thus making it easier to understand complicated pathways Includes chapter summaries of the critical next steps needed to move studies from their current state into practice changing clinical data

Multidisciplinary Management of Head and Neck Cancer

Author : Ravi A. Chandra
Publisher : Springer Nature
ISBN 13 : 3031059735
Total Pages : 247 pages
Book Rating : 4.0/5 (31 download)

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Book Synopsis Multidisciplinary Management of Head and Neck Cancer by : Ravi A. Chandra

Download or read book Multidisciplinary Management of Head and Neck Cancer written by Ravi A. Chandra and published by Springer Nature. This book was released on 2022-09-09 with total page 247 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a multidisciplinary guide to head and neck cancer.Head and neck cancer remains one of the most technically complex cancer subsites to manage. This field involves highly specialized, multidisciplinary management and collaboration amongst surgeons, radiation oncologists, medical oncologists, radiologists, pathologists, and other health disciplines. The clinical and research landscape for head and neck oncology continues to evolve at a rapid pace. This multidisciplinary book provides the latest updates in the contemporary understanding and management of these tumors. The text incorporates updates in surgical techniques (minimally invasive and robotic techniques, reconstructive approaches), radiation medicine (new data on dose and fields, oligometastatic/oligoprogressive disease, retreatment), medical oncology (targeted, immunotherapy and molecular agents), in addition to other overarching topics such as side effects, biomarkers/nanotechnology, and epidemiology. Written by experts in their respective fields, chapters include the most up to date scientific and clinical information with perspectives from each relevant subspeciality. These sections are concise and accessible, yet comprehensive. Palliative medicine, pathologic and imaging principles, and health systems/economics considerations are also described. This book is an ideal resource for clinicians, trainees, and researchers dealing with, and interested in, this challenging malignancy.

Treatment of Bone and Soft Tissue Sarcomas

Author : Per-Ulf Tunn
Publisher : Springer Science & Business Media
ISBN 13 : 3540779604
Total Pages : 372 pages
Book Rating : 4.5/5 (47 download)

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Book Synopsis Treatment of Bone and Soft Tissue Sarcomas by : Per-Ulf Tunn

Download or read book Treatment of Bone and Soft Tissue Sarcomas written by Per-Ulf Tunn and published by Springer Science & Business Media. This book was released on 2008-12-28 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bone and soft tissue sarcomas represent only about 2% of all malignancies; however, their treatment – with the goal of curing the patient while preserving the functionality of the affected body part – can, unlike other malignancies, only be successful with therapy concepts devised by interdisciplinary teams. This volume provides an extensive up-to-date overview of the specific diagnostics and current treatment standards of these rare entities, presenting the various limb-sparing modalities for patients with bone and soft tissue sarcomas with special regard to innovative reconstructive options. The evaluation of quality of life based on validated scores and the individual methods of coping with the illness through creative artistic projects are also acknowledged and integrated in the whole concept.

Cancer Immunotherapy Principles and Practice

Author : Lisa H. Butterfield, PhD
Publisher : Springer Publishing Company
ISBN 13 : 1617052736
Total Pages : 920 pages
Book Rating : 4.6/5 (17 download)

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Book Synopsis Cancer Immunotherapy Principles and Practice by : Lisa H. Butterfield, PhD

Download or read book Cancer Immunotherapy Principles and Practice written by Lisa H. Butterfield, PhD and published by Springer Publishing Company. This book was released on 2017-06-28 with total page 920 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer Immunotherapy Principles and Practice, from the Society of Immunotherapy of Cancer (SITC), is the authoritative reference on cancer immunobiology and the immunotherapy treatments that harness the immune system to combat malignant disease. Featuring five sections and over 50 chapters covering the Basic Principles of Tumor Immunology, Cancer Immunotherapy Targets and Classes, Immune Function in Cancer Patients, Disease Specific Treatments and Outcomes, and Regulatory Aspects of Cancer Immunotherapy, this book covers all major topics that have shaped the development of immunotherapy and propelled it to its current place at the forefront of cancer treatment innovation. This volume is a comprehensive resource for oncologists and fellows, immunologists, cancer researchers, and related practitioners seeking understanding of the basic science and clinical applications of cancer immunotherapy. As well as presenting the evidence for immune-based cancer treatment, it positions immunotherapy in the context of other available cancer treatments and provides data on response rates, risks, and toxicities across a variety of diseases. Filled with detailed tables, and instructive illustrations, as well as key points for quick reference, Cancer Immunotherapy Principles and Practice simplifies a challenging and dynamic subject. Key Features: Clearly summarizes the basic principles and research supporting cancer immunotherapy clinical translation Contains expert guidance and treatment strategies for all immunotherapy classes and agents, including cell-based therapies, monoclonal antibodies, cytokine therapies, checkpoint inhibitors, oncolytic viruses, adjuvant approaches, and treatment combinations Includes expert perspectives from leading authorities in the field Provides information on all FDA-approved immunotherapies, including clinical management and outcome data Discusses clinical aspects of immunotherapy for individual cancer types, including melanoma and other skin cancers, lung cancers, gynecologic cancers, gastrointestinal cancers, hematologic cancers, genitourinary cancers, head and neck cancers, sarcomas, brain and other CNS cancers, breast cancer, and pediatric malignancies. Explains regulatory aspects behind the development and approval of immunotherapy drugs Includes Online Access to the Digital Book

Tertiary Lymphoid Structures

Author : Marie-Caroline Dieu-Nosjean
Publisher : Humana
ISBN 13 : 9781493993727
Total Pages : 289 pages
Book Rating : 4.9/5 (937 download)

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Book Synopsis Tertiary Lymphoid Structures by : Marie-Caroline Dieu-Nosjean

Download or read book Tertiary Lymphoid Structures written by Marie-Caroline Dieu-Nosjean and published by Humana. This book was released on 2019-09-07 with total page 289 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume explores the various methods used to study tertiary lymphoid structures (TLS) in pathological situations. Pre-clinical models are also discussed in detail to show how TLS structure, development, and maintenance can be targeted and studied in vivo. The chapters in this book cover topics such as humans and mice; strategies to quantify TLS in order to use it in stained tissue sections; classifying a gene signature form fixed and paraffin-embedded tissues; and development of murine inflammatory models to help look at TLS in the context of infection or malignancy. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and thorough, Tertiary Lymphoid Structures: Methods and Protocols is a valuable resource that increases the reader’s knowledge on immune functions and how they will pave the way to future therapeutic applications.