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Author : Nathan J. Zvaifler
Publisher :
ISBN 13 :
Total Pages : 21 pages
Book Rating : 4.:/5 (482 download)
Download or read book Immunopathogenesis of Rheumatoid Arthritis and Systemic Lupus Erythematosus written by Nathan J. Zvaifler and published by . This book was released on 1974 with total page 21 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Alberta Hoi
Publisher : Springer Nature
ISBN 13 : 3030851613
Total Pages : 192 pages
Book Rating : 4.0/5 (38 download)
Download or read book Pathogenesis of Systemic Lupus Erythematosus written by Alberta Hoi and published by Springer Nature. This book was released on 2021-11-15 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: The scope of this contributed volume is to provide an overview of the latest translational research in the field of lupus pathogenesis, with particular emphasis on how these discoveries progress in parallel with therapeutic drug development. Systemic lupus erythematosus (SLE) is a multifaceted disease with a number of well-defined immune pathways that are dysregulated, resulting in an immune-mediated chronic inflammatory injury at target organs. As knowledge of these pathways evolves to provide opportunities for targeted drug therapy and lays the foundation for personalized medicine, clinicians and researchers need to keep up with the ever-expanding medical literature. This book will critically appraise the current understanding of important immunological pathways that contribute to the pathogenesis of lupus. We will review the role of interferons as part of the innate immune defects that perpetuate the loss of self-tolerance in SLE. B cell hyperactivity, as a defining hallmark of SLE, and different strategies of B cell targeted therapy will be discussed. The role of co-stimulation or immune checkpoint molecules in activating B and T cells will be reviewed, as well as other cytokines that serve in the amplification loop promoting a more proinflammatory Th1 or Th17 responses. Intracellular targets, such as signaling molecules in the JAK/STAT pathway, or a variety of kinases and proteasomes, can cause a cascading downstream effect of transcriptional responses that are important in SLE. Immune homeostasis can also be restored by bolstering the naturally occurring anti-inflammatory mechanisms. Glucocorticoid, as a potent natural anti-inflammatory hormone, can mediate its effects by recruiting histone deacetylase that serve to repress gene transcription. Glucocorticoid-induced leucine zipper is a gene upregulated by glucocorticoid that can be a potential target for development of anti-inflammatory strategy. Finally, T regulatory cells can be utilized to help restore to immune tolerance and are amongst the latest focus of therapeutic development in SLE.
Author : Qingjun Pan
Publisher : Frontiers Media SA
ISBN 13 : 2889767027
Total Pages : 126 pages
Book Rating : 4.8/5 (897 download)
Download or read book Th2-Associated Immunity in The Pathogenesis of Systemic Lupus Erythematosus and Rheumatoid Arthritis written by Qingjun Pan and published by Frontiers Media SA. This book was released on 2022-08-04 with total page 126 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : George C. Tsokos
Publisher : Elsevier Health Sciences
ISBN 13 : 0323044344
Total Pages : 602 pages
Book Rating : 4.3/5 (23 download)
Download or read book Systemic Lupus Erythematosus written by George C. Tsokos and published by Elsevier Health Sciences. This book was released on 2007-01-01 with total page 602 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new companion to Hochberg et al.'s Rheumatology masterwork provides new insights into the causes, detection and therapy of this challenging disease. In this state-of-the-art resource, you'll find 'one stop' coverage of all the latest scientific and clinical developments in SLE: new concepts in epidemiology, disease activity measures and outcomes; new concepts in immunoregulation, genetic and pathogenic mechanisms; new understanding and novel presentation of the processes of tissue/organ damage; comprehensive coverage of clinical features; and the very latest concepts in treatment. Provides the very latest understanding of the pathogenesis of SLE. Distills current understanding of the cellular, molecular, genetic and environmental factors that instigate and drive the disease. Includes comprehensive coverage of clinical features, including fatigue, organ system manifestations, overlap syndromes, infections, and more. Conveys the very latest understanding of mechanisms of tissue damage, including immune complexes, antibodies, and other mechanisms that lead to organ damage. Contains expert discussion of processes that are responsible for tissue injury - a hallmark of this text. Incorporates the latest treatment modalities, including steroids and non-steroidals, cytotoxic drug treatment, PAP's, and therapies on the horizon. Discusses the latest treatment options on disease modifying or disease controlling agents.
Author : Carlo Perricone
Publisher : Academic Press
ISBN 13 : 012814307X
Total Pages : 728 pages
Book Rating : 4.1/5 (281 download)
Download or read book Mosaic of Autoimmunity written by Carlo Perricone and published by Academic Press. This book was released on 2019-02-15 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Mosaic of Autoimmunity: The Novel Factors of Autoimmune Diseases describes the multifactorial origin and diversity of expression of autoimmune diseases in humans. The term implies that different combinations of factors in autoimmunity produce varying and unique clinical pictures in a wide spectrum of autoimmune diseases. Most of the factors involved in autoimmunity can be categorized into four groups: genetic, immune defects, hormonal and environmental factors. In this book, the environmental factors are reviewed, including infectious agents, vaccines as triggers of autoimmunity, smoking and its relationship with rheumatoid arthritis, systemic lupus erythematosus, thyroid disease, multiple sclerosis and inflammatory bowel diseases. An entirely new syndrome, the autoimmune/inflammatory syndrome induced by adjuvants (ASIA), is also included, along with other diseases that are now recognized as having an autoimmune etiopathogenesis. Highlights the concept of the mosaic of autoimmune manifestations Includes new visions on unsuspected molecules Provides updated knowledge to physicians helping patients with autoimmune diseases Presents thorough, up-to-date information on specific diseases, along with clinical applications
Author : Raif Geha
Publisher : Garland Science
ISBN 13 : 1136982280
Total Pages : 12 pages
Book Rating : 4.1/5 (369 download)
Download or read book Case Studies in Immunology: Rheumatoid Arthritis written by Raif Geha and published by Garland Science. This book was released on 2010-01-01 with total page 12 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents case histories that are chosen for two purposes: to illustrate in a clinical context essential points about the mechanisms of immunity; and to describe and explain some of the immunological problems often seen in the clinic.
Author : Laurent Arnaud
Publisher : Springer
ISBN 13 : 3319430351
Total Pages : 179 pages
Book Rating : 4.3/5 (194 download)
Download or read book Advanced Handbook of Systemic Lupus Erythematosus written by Laurent Arnaud and published by Springer. This book was released on 2017-09-10 with total page 179 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book will provide an introduction to the epidemiology, etiology and pathogenesis of the condition while also exploring the classification, diagnosis, and current and emerging therapies for systemic lupus erythematosus. Systemic lupus erythematosus is an autoimmune disease in which the body's immune system mistakenly attacks healthy tissue. It can affect the skin, joints, kidneys, brain, and other organs. The underlying cause of the disease is not fully known, and SLE is much more common in women than in men. It may occur at any age but most often occurs in people between 10 and 50 years of age. This is the second Adis title from Ronald F van Vollenhoven, who previously authored Biologics for the Treatment of Rheumatoid Arthritis.
Author : Josef S. Smolen
Publisher : Springer Science & Business Media
ISBN 13 : 3642716423
Total Pages : 397 pages
Book Rating : 4.6/5 (427 download)
Download or read book Systemic Lupus Erythematosus written by Josef S. Smolen and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 397 pages. Available in PDF, EPUB and Kindle. Book excerpt: More than 140 years ago, lupus erythematosus (LE) was recognized as a disease entity by clinicians working in the field of dermatology, which had only recently become an independent medical discipline. Soon after cutaneous lupus was first reported, it was realized that, apart from the skin, the disease could involve other organs and thus be systemic in nature. The latter observations were first made by MORITZ KApOSI [1], whose work has attracted renewed attention re cently and who succeeded FERDINAND VON HEBRA to the chair of dermatology at the Medical Faculty in Vienna. The early description of lupus erythematosus in both its cutaneous and systemic manifes tations was thus intimately associated with Vienna and its Medical School. The next phase in the study of lupus was characterized by an in crease in knowledge of the type and extent of organ involvement. The work by OSLER [2], LIBMANN and SACKS [3], and KLEMPERER [4] best represents these advances. The increase in clinical knowledge of LE finally led to DUBOIS' famous monograph [5], which was pub lished at a time of renewed interest in SLE, elicited by the descrip tion by HARGRAVES et al. [6] of the LE-cell phenomenon. A more detailed analysis of this finding revealed that the disease was charac terized by an abnormal immune response, although its pathogenetic implications were still unclear.
Author : Robert G. Lahita
Publisher : Elsevier
ISBN 13 : 0080474543
Total Pages : 1376 pages
Book Rating : 4.0/5 (84 download)
Download or read book Systemic Lupus Erythematosus written by Robert G. Lahita and published by Elsevier. This book was released on 2004-06-09 with total page 1376 pages. Available in PDF, EPUB and Kindle. Book excerpt: Systemic Lupus Erythematosus, Fourth Edition, provides an understanding of the basic mechanisms as well as the diagnostic and therapeutic aspects of lupus. This book is attractive to both the investigative community and clinicians. As lupus has become a paradigm for the study of autoimmune disease, immunologists investigating autoimmunity are becoming more interested in lupus. Basic immunology of phospholipid antibodies, clotting abnormailities, issues concerning pathogenetic fit with SLE, and newest methods of therapy of APLS are given in this newest edition of a classic reference. Comprehensive current coverage of basic models of etiology and pathogenesis Complete catalog of autoantibodies produced Includes an outstanding review of imaging techniques for the diagnosis of lupus and its complications for each organ system Includes CD-ROM of images excellent for teaching purposes and downloading into presentations
Author : Raif Geha
Publisher : Garland Science
ISBN 13 : 1136982272
Total Pages : 35 pages
Book Rating : 4.1/5 (369 download)
Download or read book Case Studies in Immunology: Rheumatoid Arthritis written by Raif Geha and published by Garland Science. This book was released on 2010-01-01 with total page 35 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents case histories that are chosen for two purposes: to illustrate in a clinical context essential points about the mechanisms of immunity; and to describe and explain some of the immunological problems often seen in the clinic.
Author : Alessia Alunno
Publisher : Academic Press
ISBN 13 : 012803632X
Total Pages : 346 pages
Book Rating : 4.1/5 (28 download)
Download or read book Sjogren's Syndrome written by Alessia Alunno and published by Academic Press. This book was released on 2016-06-07 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sjogren's Syndrome: Novel Insights in Pathogenic, Clinical and Therapeutic Aspects provides the reader with an overview of current knowledge about Sjogren's Syndrome. The book summarizes the huge amount of literature concerning related advances in genetic background, pathogenesis, clinical picture, and therapeutic approaches. It integrates basic immunology concepts, clinical aspects, and pharmacological issues. Scientific progress has allowed us to unmask novel pathogenic mechanisms, to perform genome wide studies, and to identify clinical and serological features associated with different disease subsets and, eventually, different disease prognoses. In addition, the increasing knowledge about SS pathogenesis provides the rationale to employ targeted therapies in SS as has already occurred in rheumatoid arthritis and systemic lupus erythematosus. Discusses heterogeneity of topics and audience, from basic immunology to clinical aspects and therapeutics Provides novel lines of investigation and supports the management of patients requiring novel therapeutic approaches Presents a deeper knowledge on SS clinical management as well as on immunological aspects possibly leading to new lines of investigation Offers a bridge between the clinician and the scientist, and vice versa Provides the reader with most recent and relevant updates due to the novelty of topics
Author : Yehuda Shoenfeld
Publisher : Springer Science & Business Media
ISBN 13 : 1603272852
Total Pages : 555 pages
Book Rating : 4.6/5 (32 download)
Download or read book Diagnostic Criteria in Autoimmune Diseases written by Yehuda Shoenfeld and published by Springer Science & Business Media. This book was released on 2010-06-08 with total page 555 pages. Available in PDF, EPUB and Kindle. Book excerpt: According to the Autoimmune Diseases Coordinating Committee (ADCC), between 14.7 and 23.5 million people in the USA – up to eight percent of the population are affected by autoimmune disease. Autoimmune diseases are a family of more than 100 chronic, and often disabling, illnesses that develop when underlying defects in the immune system lead the body to attack its own organs, tissues, and cells. In Handbook of Autoimmune Disease, the editors have gathered in a comprehensive handbook a critical review, by renowned experts, of more than 100 autoimmune diseases, divided into two main groups, namely systemic and organ-specific autoimmune diseases. A contemporary overview of these conditions with special emphasis on diagnosis is presented. Each chapter contains the essential information required by attending physicians as well as bench scientists to understand the definition of a specific autoimmune disease, the diagnostic criteria, and the treatment.
Author :
Publisher : ScholarlyEditions
ISBN 13 : 1464902003
Total Pages : 200 pages
Book Rating : 4.4/5 (649 download)
Download or read book Systemic Lupus Erythematosus: New Insights for the Healthcare Professional: 2011 Edition written by and published by ScholarlyEditions. This book was released on 2012-01-09 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: Systemic Lupus Erythematosus: New Insights for the Healthcare Professional: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Systemic Lupus Erythematosus. The editors have built Systemic Lupus Erythematosus: New Insights for the Healthcare Professional: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Systemic Lupus Erythematosus in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Systemic Lupus Erythematosus: New Insights for the Healthcare Professional: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Author : Ellen M. Ginzler
Publisher : Elsevier Health Sciences
ISBN 13 : 032332388X
Total Pages : 185 pages
Book Rating : 4.3/5 (233 download)
Download or read book Systemic Lupus Erythematosus, An Issue of Rheumatic Disease Clinics written by Ellen M. Ginzler and published by Elsevier Health Sciences. This book was released on 2014-08-28 with total page 185 pages. Available in PDF, EPUB and Kindle. Book excerpt: In only the last four years, there have been dramatic changes in the understanding of the immunology, genetic/epigenetic associations, and identification of new targets for therapy in Systemic Lupus Erythematosus. The editors have enlisted a superb group of authors to present articles detailing cutting-edge advances in these areas.
Author : George Tsokos
Publisher : Elsevier Health Sciences
ISBN 13 : 0323070876
Total Pages : 607 pages
Book Rating : 4.3/5 (23 download)
Download or read book Systemic Lupus Erythematosus E-Book written by George Tsokos and published by Elsevier Health Sciences. This book was released on 2007-02-23 with total page 607 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new companion to Hochberg et al.'s Rheumatology masterwork provides new insights into the causes, detection and therapy of this challenging disease. In this state-of-the-art resource, you'll find ‘one stop' coverage of all the latest scientific and clinical developments in SLE: new concepts in epidemiology, disease activity measures and outcomes; new concepts in immunoregulation, genetic and pathogenic mechanisms; new understanding and novel presentation of the processes of tissue/organ damage; comprehensive coverage of clinical features; and the very latest concepts in treatment. Provides the very latest understanding of the pathogenesis of SLE. Distills current understanding of the cellular, molecular, genetic and environmental factors that instigate and drive the disease. Includes comprehensive coverage of clinical features, including fatigue, organ system manifestations, overlap syndromes, infections, and more. Conveys the very latest understanding of mechanisms of tissue damage, including immune complexes, antibodies, and other mechanisms that lead to organ damage. Contains expert discussion of processes that are responsible for tissue injury - a hallmark of this text. Incorporates the latest treatment modalities, including steroids and non-steroidals, cytotoxic drug treatment, PAP's, and therapies on the horizon. Discusses the latest treatment options on disease modifying or disease controlling agents.
Author : George Tsokos
Publisher : Academic Press
ISBN 13 : 9780128019177
Total Pages : 0 pages
Book Rating : 4.0/5 (191 download)
Download or read book Systemic Lupus Erythematosus written by George Tsokos and published by Academic Press. This book was released on 2016-02-09 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Systemic Lupus Erythematosus combines basic science with clinical science to provide a translational treatment of the disease and is a useful reference for specialists in the diagnosis and management of patients with SLE, a tool for measurement of clinical activity for pharmaceutical development and basic research of the disease and a reference work for hospital libraries.
Author : P. E. Bigazzi
Publisher : CRC Press
ISBN 13 : 9780824785505
Total Pages : 328 pages
Book Rating : 4.7/5 (855 download)
Download or read book Systemic Autoimmunity written by P. E. Bigazzi and published by CRC Press. This book was released on 1991-08-30 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: Surveys the biotechnologically influenced advances in the understanding of systemic autoimmune disorders, highlighting recent research using cell biology and biochemistry, the cloning of immune cells, recombinant DNA, and molecular genetics. Among the topics are the role of complement in inflammatio
