Immunology And Liver

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Liver Immunology

Author : M. Eric Gershwin
Publisher : Springer Science & Business Media
ISBN 13 : 331902096X
Total Pages : 480 pages
Book Rating : 4.3/5 (19 download)

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Book Synopsis Liver Immunology by : M. Eric Gershwin

Download or read book Liver Immunology written by M. Eric Gershwin and published by Springer Science & Business Media. This book was released on 2013-11-19 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt: Liver Immunology: Principles and Practice, Second Edition begins with important information about the epidemiology and mortality of liver disease worldwide. This information is followed by chapters related to basic immunology, application of liver immunology for diagnosis, and several excellent chapters that provide a solid foundation for understanding immune-mediated liver disease, including those associated with the biliary tree. A chapter on non-hepatic manifestations of immune mediated liver disease helps provide context for how these diseases affect the patient overall. In addition, chapters discuss various discrete immunologically-mediated infectious liver disorders including those related to bacteria, parasites, and all of the classic viruses. Chapters on the traditional autoimmune liver diseases -- primary biliary cirrhosis, autoimmune hepatitis, primary sclerosing cholangitis as well as overlap syndrome – are also included. The breadth of this comprehensive second edition is highlighted by chapters on alcoholic liver disease, non-alcoholic fatty liver disease, and drug-induced liver disease, among others. This invaluable new edition ends with a forward-looking view of future directions and how the field might meet the challenge of refractory patients. Developed by a renowned group of authors, Liver Immunology: Principles and Practice, Second Edition will again serve as a comprehensive textbook by providing an excellent overview for this rapidly evolving field. It greatly adds to the understanding of the pathogenesis of these diseases, while also providing novel insights that can be harnessed into helping improve the care of patients afflicted with various immune-mediated diseases. This volume will again be a must-read for clinicians at all levels, investigators and students.

Immunology of Liver Disease

Author : H.C. Thomas
Publisher : Springer Science & Business Media
ISBN 13 : 9401114285
Total Pages : 212 pages
Book Rating : 4.4/5 (11 download)

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Book Synopsis Immunology of Liver Disease by : H.C. Thomas

Download or read book Immunology of Liver Disease written by H.C. Thomas and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt: The role of the immune response in both the pathology of liver disease and in the modulation ofliver injury has been the subject of intense research. This book aims to present the current understanding of the involvement of the immune response in liver disease. The first chapters examine the role of the immune response in viral infections of the liver. These viruses cause hepatitis of varying severity and it is thought that many of the mechanisms responsible for liver cell injury are immunologically mediated. In addition three of these viruses, hepatitic B, C, and D, are associated with persistent infection and chronic liver disease. The role of the immune response in viral persistence is discussed. Further chapters are devoted to the three major autoimmune liver diseases which are thought to be the result of loss of tolerance to autologous liver tissue. There has been much recent research on cellular immune responses in these diseases but knowledge of the immunological processes which lead to the breakdown of tolerance and the mechanisms of tissue damage are limited. Other research has concentrated on the identification of the antigens which are the targets of this immune response. Linkage disequilibrium between MHC alleles and autoimmune diseases has suggested a role for immunogenetic factors.

Immunology and Liver

Author : M.P. Manns
Publisher : Springer Science & Business Media
ISBN 13 : 9401140006
Total Pages : 400 pages
Book Rating : 4.4/5 (11 download)

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Book Synopsis Immunology and Liver by : M.P. Manns

Download or read book Immunology and Liver written by M.P. Manns and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 1992, the Falk Symposium No. 70 dealt with the topic `Immunology and Liver'. At that time basic mechanisms of immunology as well as immunopathogenetic mechanisms in viral and autoimmune liver diseases were discussed. Now, 7 years later, the Falk Symposium No. 114, held in Basel, Switzerland, October 20-21 1999 (Part I of the Basel Liver Week 1999), focused on immunology in autoimmune liver diseases. In the first section basic mechanisms of autoimmunity are presented, including the relevance of superantigens and the role of apoptosis. A further topic is the latest developments concerning animal models for autoimmune diseases. Recently the International Autoimmune Hepatitis Group newly defined and reclassified the syndrome of autoimmune hepatitis. Autoimmune hepatitis is now identified and studied in all parts of the world, including Asia and South America. A special variant of autoimmune hepatitis was identified as one organ manifestation of the autoimmune polyendocrine syndrome type 1, a genetic disease caused by mutations in a single transcription factor. Drug- and hepatitis-virus induced immune mediated liver diseases may serve as models for nonhepatic immune mediated disorders. DNA technology has increased our knowledge of the immunogenetic background of autoimmune liver diseases. Among the cholestatic immune mediated liver diseases, significant progress has been made concerning primary biliary cirrhosis, in particular regarding the identification of mitochondrial antigens and the characterisation of the immune reactions directed at them. The involvement of infectious agents in PBC as well as the definition of overlap syndromes is a particular focus for basic and clinical research in this area. Concerning the therapy of autoimmune liver diseases, corticosteroids and azathioprin remain the state of the art for autoimmune hepatitis, while bile acids have become well established in treatment of primary biliary cirrhosis as well as primary sclerosing cholangitis. New drugs in the future will include topical steroids such as budesonide and new immunosuppressive agents like mofetil/mycophenolate. Liver transplantation is the treatment of choice for end stage liver diseases; all autoimmune liver diseases are among the best candidates for liver transplantation. Hopefully, new therapeutic strategies based on the results obtained from experimental models will become everyday clinical practice in the next decade. Therefore this symposium concludes with a discussion.

Immunological Aspects of Liver Disease

Author : H.C. Thomas
Publisher : Springer Science & Business Media
ISBN 13 : 3642684467
Total Pages : 210 pages
Book Rating : 4.6/5 (426 download)

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Book Synopsis Immunological Aspects of Liver Disease by : H.C. Thomas

Download or read book Immunological Aspects of Liver Disease written by H.C. Thomas and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt: Howard C. Thomas In normal subjects the regulatory apparatus of the immune system permits responses to foreign antigens but suppresses those directed to "self' components. Autoimmune disease occurs as a failure ofthis system either as a result of a primary defect in the regulatory apparatus (primary autoimmunization) or because of a change in the antigenicity of the tissues (secondary autoimmunization). Autoaggressive reactions are characterised by the presence of autoantibodies. When these are directed to membrane displayed antigens (Fig. 1) they are probably of importance in the lysis of hepatocytes. Those directed to cytoplasmic antigens may be useful diagnostically but are of unknown pathogenic significance. When no extrinsic aetiological factor can be identified, the process is assumed to be the result of a failure ofthe regulatory system, allowing the spontaneous expansion of a clone of autoreactive lymphocytes. The defect may be generalised or specific to certain groups of self-antigens and thus the autoimmune disease may be either multi- or unisystemic. The recent development of techniques to enumerate and measure the functional activity of the suppressor lymphocytes which control the effector limbs of the immune system has enabled investigators to test whether the various purported autoimmune diseases do have as their basis a generalised defect in immunoregu lation. Assessment of antigen-specific immunoregulatory function is, however, not yet readily available. liver Membrane I Antigen (LIM) I Liver I HLA, A, B, C, Sensitisation to Specific -;::!IIIL. .

Gastrointestinal and Hepatic Immunology

Author : Richard Heatley
Publisher : Cambridge University Press
ISBN 13 : 0521445094
Total Pages : 412 pages
Book Rating : 4.5/5 (214 download)

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Book Synopsis Gastrointestinal and Hepatic Immunology by : Richard Heatley

Download or read book Gastrointestinal and Hepatic Immunology written by Richard Heatley and published by Cambridge University Press. This book was released on 1994-10-27 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt: This 1994 volume summarizes basic scientific advances in the area of the gut immune system and the immune abnormalities relevant to gastrointestinal and liver disease.

Immunology of the Liver

Author : Martin Smith
Publisher : Butterworth-Heinemann
ISBN 13 : 1483162818
Total Pages : 330 pages
Book Rating : 4.4/5 (831 download)

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Book Synopsis Immunology of the Liver by : Martin Smith

Download or read book Immunology of the Liver written by Martin Smith and published by Butterworth-Heinemann. This book was released on 2014-05-20 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: Immunology of the Liver contains the proceedings of an International Meeting held at King's College Hospital Medical School in London on July 6-7, 1970. The meeting provided a forum for discussing progress made in understanding the immunology of the liver and tackled topics ranging from the pathology of chronic hepatitis to the occurrence and distribution of tissue antibodies in liver diseases. Cell-mediated responses and manifestations of immunological damage are also explored. Comprised of 33 chapters, this book begins with an introduction to the clinical, morphological, and virological aspects of liver disease. In particular, the clinical spectrum of autoimmune liver disease is considered, along with the pathology of chronic hepatitis. Morphological and immunological studies on chronic aggressive hepatitis and primary biliary cirrhosis are presented. Subsequent chapters focus on antibodies related to mitochondria; leukocyte migration in active chronic hepatitis and primary biliary cirrhosis; immunologic observations and electron microscopy of halothane-induced hepatic injury; and humoral and delayed hypersensitivity in chronic hepatitis. The final sections deal with results of immunosuppressive therapy and the immunology of liver transplantation. This monograph will be of interest to immunologists, pathologists, physiologists, clinicians, and research workers in the field of medicine.

Immunology of the Liver

Author : International Meeting on the Immunology of the Liver. 1970, London
Publisher :
ISBN 13 : 9780433307259
Total Pages : 314 pages
Book Rating : 4.3/5 (72 download)

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Book Synopsis Immunology of the Liver by : International Meeting on the Immunology of the Liver. 1970, London

Download or read book Immunology of the Liver written by International Meeting on the Immunology of the Liver. 1970, London and published by . This book was released on 1971 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Immunological Aspects of the Liver and Gastrointestinal Tract

Author : A. Ferguson
Publisher : Springer Science & Business Media
ISBN 13 : 940116150X
Total Pages : 413 pages
Book Rating : 4.4/5 (11 download)

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Book Synopsis Immunological Aspects of the Liver and Gastrointestinal Tract by : A. Ferguson

Download or read book Immunological Aspects of the Liver and Gastrointestinal Tract written by A. Ferguson and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 413 pages. Available in PDF, EPUB and Kindle. Book excerpt: We have been privileged to start our academic careers at the begin ning of the decade in which the immunological roles and hypersensitivity diseases of the gastrointestinal tract and liver have been defined. In the early 1960s IgA was reported to be the main secretory immunoglobulin, immunoblasts were shown to home to the intestinal mucosa and certain serum autoantibodies were described in patients with chronic liver disease. Shortly thereafter IgE and Australia antigen were discovered. Parallel advances in clinical investigation, in particular closed biopsy techniques, facilitated correlation of morphological changes with im munological mechanisms in disease of the gastrointestinal tract and liver. Only 10 years later, the concepts of immunity and hypersensitivity are regularly applied to the pathogenesis, diagnosis, treatment and prog nosis of many chronic diseases in these organs. In designing this book we have attempted to integrate theorectical and clinical immunology as they pertain in 1975; our ultimate aim is aptly described by Brachet as quoted by Professor Paronetto (page 319). We would like to think that this review provides a basis for the next major advances in the fields of gastrointestinal and hepatic immunology. As we see it, the outstanding problem in both sites is how to produce protective immunity without hypersensitivity.

Immunology of the Liver

Author :
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (79 download)

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Book Synopsis Immunology of the Liver by :

Download or read book Immunology of the Liver written by and published by . This book was released on 1970 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Clinical Immunology of the Liver and Gastrointestinal Tract

Author : David R. Triger
Publisher : Butterworth-Heinemann
ISBN 13 :
Total Pages : 260 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Clinical Immunology of the Liver and Gastrointestinal Tract by : David R. Triger

Download or read book Clinical Immunology of the Liver and Gastrointestinal Tract written by David R. Triger and published by Butterworth-Heinemann. This book was released on 1986 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt:

T Lymphocytes in the Liver

Author : I. N. Crispe
Publisher : John Wiley & Sons
ISBN 13 : 9780471192183
Total Pages : 272 pages
Book Rating : 4.1/5 (921 download)

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Book Synopsis T Lymphocytes in the Liver by : I. N. Crispe

Download or read book T Lymphocytes in the Liver written by I. N. Crispe and published by John Wiley & Sons. This book was released on 1999-01-19 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: T Lymphocytes in the Liver is the first book to offer a comprehensive review of the newly understood relationship between the liver and the immune system. This edited volume examines the immunobiology of T cells - the way their behavior in the liver differs from that in other organs, and, conversely, the liver's ability to effect changes in the activity of such immune cells. A number of relevant, cutting-edge issues are considered, including vaccine development, the liver's potential role in autoimmune tissue damage, tolerance and transplant rejection, and the use of animal organs for human patients. Contributing authors from diverse specialties discuss topics including: * T cells expressing antigen receptors in the liver * Active T cells in the liver * Extrathymic T cells in the liver * The induction of peripheral tolerance by portal vein administration of antigen * The immunobiology of viral hepatitis * Immunity to Listeria monocytogenes infection of the liver * Malaria and the liver * T cells and autoimmune liver disease * Hepatic T cells in primary sclerosing cholangitis and autoimmune hepatitis

Drug-Induced Liver Injury

Author :
Publisher : Academic Press
ISBN 13 : 0128173173
Total Pages : 288 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Drug-Induced Liver Injury by :

Download or read book Drug-Induced Liver Injury written by and published by Academic Press. This book was released on 2019-07-13 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug-Induced Liver Injury, Volume 85, the newest volume in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this new release include Cell death mechanisms in DILI, Mitochondria in DILI, Primary hepatocytes and their cultures for the testing of drug-induced liver injury, MetaHeps an alternate approach to identify IDILI, Autophagy and DILI, Biomarkers and DILI, Regeneration and DILI, Drug-induced liver injury in obesity and nonalcoholic fatty liver disease, Mechanisms of Idiosyncratic Drug-Induced Liver Injury, the Evaluation and Treatment of Acetaminophen Toxicity, and much more. Includes the authority and expertise of leading contributors in pharmacology Presents the latest release in the Advances in Pharmacology series

Immunology and Immunopathology of the Liver and Gastrointestinal Tract

Author : Stephan R. Targan
Publisher : Igaku-Shoin Medical Publishers
ISBN 13 :
Total Pages : 680 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Immunology and Immunopathology of the Liver and Gastrointestinal Tract by : Stephan R. Targan

Download or read book Immunology and Immunopathology of the Liver and Gastrointestinal Tract written by Stephan R. Targan and published by Igaku-Shoin Medical Publishers. This book was released on 1990 with total page 680 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Immune Reactions in Liver Disease

Author : A. L. W. F. Eddleston
Publisher :
ISBN 13 :
Total Pages : 344 pages
Book Rating : 4.:/5 (43 download)

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Book Synopsis Immune Reactions in Liver Disease by : A. L. W. F. Eddleston

Download or read book Immune Reactions in Liver Disease written by A. L. W. F. Eddleston and published by . This book was released on 1979 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Immunology of the Gastrointestinal Tract and Liver

Author : Martin F. Heyworth
Publisher : Lippincott Williams & Wilkins
ISBN 13 :
Total Pages : 250 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Immunology of the Gastrointestinal Tract and Liver by : Martin F. Heyworth

Download or read book Immunology of the Gastrointestinal Tract and Liver written by Martin F. Heyworth and published by Lippincott Williams & Wilkins. This book was released on 1988 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Immunology of Gastrointestinal and Liver Disease

Author : Ralph Wright (M.D.)
Publisher : Hodder Education
ISBN 13 :
Total Pages : 148 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Immunology of Gastrointestinal and Liver Disease by : Ralph Wright (M.D.)

Download or read book Immunology of Gastrointestinal and Liver Disease written by Ralph Wright (M.D.) and published by Hodder Education. This book was released on 1977 with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Liver Transplantation

Author : James Neuberger
Publisher : John Wiley & Sons
ISBN 13 : 1119633990
Total Pages : 592 pages
Book Rating : 4.1/5 (196 download)

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Book Synopsis Liver Transplantation by : James Neuberger

Download or read book Liver Transplantation written by James Neuberger and published by John Wiley & Sons. This book was released on 2021-02-25 with total page 592 pages. Available in PDF, EPUB and Kindle. Book excerpt: Explore this practical and step-by-step guide to managing liver transplant patients from leading international clinicians in Hepatology The newly revised Second Edition of Liver Transplantation: Clinical Assessment and Management delivers expert clinical guidance on best practices in managing the care of liver transplant patients. Authors are all experts in their field and cover a world-wide perspective. Organized in an accessible, stepwise fashion and packed with text features such as key points, the book covers all critical areas of each stage of the liver transplant journey, from assessment, to management on the list, to long term care. Readers will learn when to refer a patient for liver transplantation, how to assess a potential liver transplant recipient, learn the principles of the procedure and the long term management of the transplant recipient. Liver Transplantation provides the entire hepatology and surgical team the information required for a sound understanding of the entire procedure, from pre- to post-operative care and management. Clinically oriented and management-focused, the book is far more accessible than the liver transplant sections in traditional hepatology textbooks. Readers will also enjoy: A thorough discussion of when to refer a patient for liver transplantation, including general considerations and the use and abuse of prognostic models An exploration of the selection, assessment, and management of patients on the transplant list, including how to manage a patient with chronic liver disease while on the waiting list A treatment of liver transplantation for acute liver failure (ALF), including assessment and management of ALF patients on the transplant waiting list A discussion of care of the liver transplant recipient after the procedure in the short and long term Perfect for gastroenterologists, hepatologists, and surgeons and other health care professionals managing patients with liver disease who are awaiting, undergoing and following liver transplantation, Liver Transplantation: Clinical Assessment and Management will also earn a place in the libraries of medical students, residents, internal medicine physicians, and GI/Hepatology trainees and all health care professionals providing clinical care to people with liver disease, before, during and after transplantation.