Immunoglobulins Magic Bullets And Therapeutic Antibodies

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Immunoglobulins, Magic Bullets and Therapeutic Antibodies

Author : Manzoor Ahmad Mir
Publisher : Nova Science Publishers
ISBN 13 : 9781536169041
Total Pages : 322 pages
Book Rating : 4.1/5 (69 download)

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Book Synopsis Immunoglobulins, Magic Bullets and Therapeutic Antibodies by : Manzoor Ahmad Mir

Download or read book Immunoglobulins, Magic Bullets and Therapeutic Antibodies written by Manzoor Ahmad Mir and published by Nova Science Publishers. This book was released on 2020-02-19 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book "Immunoglobulins, Magic Bullets and Therapeutic Antibodies" comprises of ten chapters and it describes the origin, history, timeline, production and scope of immunoglobulins which are the central molecules of the immune system around which the field of immunology revolves. This book describes how the immune system responds to injuries and insults by foreign antigens (bacteria, viruses etc) and produces immunoglobulins, which then through various immune response mechanisms protect the body against pathogenic invasions. Further, it discusses how these antigens are involved in the differentiation and maturation of immune cells, how lymph nodes are involved in concentrating the antigens, how immunogenicity of an antigen is affected and how antigenicity of immunogens is related to the immune response. Classification of immunoglobulins and the organization and expression of immunoglobulin genes is described separately. The antigen antibody interactions and antibody dependent cell mediated cytotoxicity are also discussed in separate chapters. The magic bullets or monoclonal antibodies, which have revolutionized the field of immunology, are described in greater detail, their production by hybridoma technology and the important role played by these antibodies in research, diagnostics and therapeutics is also discussed in the book. Lastly the immunodiagnostic techniques like radioimmunoassay (RIA), Enzyme Linked Immunosorbent Assay (ELISA), flowcytometry and their importance in the detection of various kinds of diseases like cancer, HIV-AIDS, tuberculosis, malaria, etc. are discussed in detail as well in the book. The book contains a large number of flow charts, diagrams, depictions and tables highlighting the properties, characteristic features, functions and roles played by these immunoglobulins in various fields of biosciences.

Antibody-Drug Conjugates

Author : Jeffrey Wang
Publisher : Springer
ISBN 13 : 3319130811
Total Pages : 248 pages
Book Rating : 4.3/5 (191 download)

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Book Synopsis Antibody-Drug Conjugates by : Jeffrey Wang

Download or read book Antibody-Drug Conjugates written by Jeffrey Wang and published by Springer. This book was released on 2015-03-05 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: This authoritative volume provides a holistic picture of antibody-drug conjugates (ADCs). Fourteen comprehensive chapters are divided into six sections including an introduction to ADCs, the ADC construct, development issues, landscape, IP and pharmacoeconomics, case studies, and the future of the field. The book examines everything from the selection of the antibody, the drug, and the linker to a discussion of developmental issues such as formulations, bio-analysis, pharmacokinetic-pharmacodynamic relationships, and toxicological and regulatory challenges. It also explores pharmacoecomonics and intellectual properties, including recently issued patents and the cost analysis of drug therapy. Case studies are presented for the three ADCs that have received FDA approval: gemtuzumab ozogamicin (Mylotarg®), Brentuximab vedotin (Adcetris®), and ado-trastuzumab emtansine (Kadcyla®), as well as an ADC in late-stage clinical trials, glembatumumab vedotin (CDX-011). Finally, the volume presents a perspective by the editors on the future directions of ADC development and clinical applications. Antibody-Drug Conjugates is a practical and systematic resource for scientists, professors, and students interested in expanding their knowledge of cutting-edge research in this exciting field.

Antibodies for Treating Cancer

Author : Melvyn Little
Publisher : Springer Nature
ISBN 13 : 3030725995
Total Pages : 153 pages
Book Rating : 4.0/5 (37 download)

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Book Synopsis Antibodies for Treating Cancer by : Melvyn Little

Download or read book Antibodies for Treating Cancer written by Melvyn Little and published by Springer Nature. This book was released on 2021-05-10 with total page 153 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a compact overview of the history, evolution and fascinating novel applications of antibodies for the treatment of cancer, leading the reader step by step to the latest advances. Interesting anecdotes, together with self-explanatory and clearly structured figures with a humorous touch, facilitate the reader’s understanding of this complex topic. Clinical cases round out the book, making it a valuable aid for professionals in their everyday practice. The growing importance of the topics covered here was highlighted by the joint award of the 2018 Nobel Prize in Chemistry to Frances H. Arnold (directed evolution of enzymes), George P. Smith (phage display of peptides) and Sir Gregory P. Winter (phage display of antibodies). Furthermore, the 2018 Nobel Prize in Physiology or Medicine was awarded to James P. Allison and Tasuku Honjo for their discovery of cancer therapy by inhibition of negative immune regulation. Many of the antibodies that are now being brought to market target precisely these immune checkpoint modulators. The book addresses a broad readership, ranging from professionals and experts in the field to residents and medical students.

Therapeutic Monoclonal Antibodies

Author : Zhiqiang An
Publisher : John Wiley & Sons
ISBN 13 : 1118210263
Total Pages : 932 pages
Book Rating : 4.1/5 (182 download)

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Book Synopsis Therapeutic Monoclonal Antibodies by : Zhiqiang An

Download or read book Therapeutic Monoclonal Antibodies written by Zhiqiang An and published by John Wiley & Sons. This book was released on 2011-09-20 with total page 932 pages. Available in PDF, EPUB and Kindle. Book excerpt: 70-chapter authoritative reference that covers therapeutic monoclonal antibody discovery, development, and clinical applications while incorporating principles, experimental data, and methodologies. First book to address the discovery and development of antibody therapeutics in their entirety. Most chapters contain experimental data to illustrate the principles described in them. Authors provide detailed methodologies that readers can take away with them and use in their own laboratories.

Therapeutic Antibodies

Author :
Publisher :
ISBN 13 :
Total Pages : 231 pages
Book Rating : 4.:/5 (94 download)

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Book Synopsis Therapeutic Antibodies by :

Download or read book Therapeutic Antibodies written by and published by . This book was released on 1995 with total page 231 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Therapeutic Antibodies

Author :
Publisher :
ISBN 13 :
Total Pages : 380 pages
Book Rating : 4.:/5 (119 download)

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Book Synopsis Therapeutic Antibodies by :

Download or read book Therapeutic Antibodies written by and published by . This book was released on 2007 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Recombinant Antibodies for Immunotherapy

Author : Melvyn Little
Publisher : Cambridge University Press
ISBN 13 : 1139481096
Total Pages : 445 pages
Book Rating : 4.1/5 (394 download)

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Book Synopsis Recombinant Antibodies for Immunotherapy by : Melvyn Little

Download or read book Recombinant Antibodies for Immunotherapy written by Melvyn Little and published by Cambridge University Press. This book was released on 2009-07-27 with total page 445 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recombinant Antibodies for Immunotherapy provides a comprehensive overview of the field of monoclonal antibodies (mAbs), a market that has grown tremendously in recent years. Twenty-five articles by experienced and innovative authors cover the isolation of specific human mAbs, humanization, immunogenicity, technologies for improving efficacy, 'arming' mAbs, novel alternative Ab constructs, increasing half-lives, alternative concepts employing non-immunoglobulin scaffolds, novel therapeutic approaches, a market analysis of therapeutic mAbs, and future developments in the field. The concepts and technologies are illustrated by examples of recombinant antibodies being used in the clinic or in development. This book will appeal to both newcomers and experienced scientists in the field, biology and biotechnology students, research and development departments in the pharmaceutical industry, medical researchers, clinicians, and biotechnology investors.

Therapeutic Antibodies

Author : Antony S. Dimitrov
Publisher : Humana Press
ISBN 13 : 9781627038690
Total Pages : 0 pages
Book Rating : 4.0/5 (386 download)

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Book Synopsis Therapeutic Antibodies by : Antony S. Dimitrov

Download or read book Therapeutic Antibodies written by Antony S. Dimitrov and published by Humana Press. This book was released on 2014-11-25 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over 2000 years ago in China, antibodies elicited by early forms of vaccination likely played a major role in the protection of the population from infectious agents. Vac- nation has been further developed in Europe and described by Edward Jenner in the late-eighteenth century, then successfully implemented worldwide. The idea to use theactiveingredientinthebloodofvaccinated(orimmunized)animalsorhumansfor the treatment of diseases came a century later. It was made possible by a series of discoveries,suchastherealizationthattheserumfromanimalsimmunizedwithtoxins, for example, diphtheria toxin or viruses, is an effective therapeutic against the disease causedbythesameagentinhumans. Inthe1880s,vonBehringdevelopedanantitoxin (anti-body) that did not kill the bacteria but neutralized the bacterial toxin. The first Nobel Prize in Medicine (1901) was given to him for the discovery of the serum therapy. Acenturylater,22monoclonalantibodies(mAbs)areapprovedbytheUnited States Food and Drug Administration (FDA) for clinical use, and hundreds are in clinicaltrialsforthetreatmentofvariousdiseasesincludingcancers,immunedisorders, and infections. The revenues from the top-five therapeutic antibodies reached $11. 7 billion in 2006, and major pharmaceutical companies raced to acquire antibody biotech companies with a recent example of MedImmune, Inc. , which was acquired for $15. 6 billion by AstraZeneca in 2007. This explosion of research and development in the field of therapeutic antibodies prompted the publication of the MiMB volume Therapeutic Antibodies: Methods and Protocols. The book’s major goal is to present a set of protocols useful for researchers discoveringanddevelopingtherapeuticantibodies. Currentadvancesandfuturetrends in the antibody therapeutics are analyzed in the lead-in review article.

Therapeutic Antibodies

Author : Yuti Chernajovsky
Publisher : Springer
ISBN 13 : 9783642092305
Total Pages : 0 pages
Book Rating : 4.0/5 (923 download)

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Book Synopsis Therapeutic Antibodies by : Yuti Chernajovsky

Download or read book Therapeutic Antibodies written by Yuti Chernajovsky and published by Springer. This book was released on 2010-11-17 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This essential work, edited by two researchers at London’s famous Queen Mary’s medical school targets one of the most important areas in medical development today. These days, antibody therapeutics are the treatment of choice for several autoimmune and oncological conditions. They are, indeed, becoming the molecules of choice for further combination therapies and cell engineering. In this timely work, a slew of expert in the field of drug development summarize all the current developments and clinical successes.

Diagnostic and Therapeutic Antibodies

Author : Andrew J.T. George
Publisher : Springer Science & Business Media
ISBN 13 :
Total Pages : 522 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Diagnostic and Therapeutic Antibodies by : Andrew J.T. George

Download or read book Diagnostic and Therapeutic Antibodies written by Andrew J.T. George and published by Springer Science & Business Media. This book was released on 2000-08 with total page 522 pages. Available in PDF, EPUB and Kindle. Book excerpt: A team of experts comprehensively review the theoretical and practical aspects of applying antibodies in both the laboratory and clinic. For general understanding, the book thoroughly introduces the basic science of the antibody molecule, including recombinant engineering. Several novel in vivo applications of therapeutic antibodies are then presented to illustrate their special value in varied clinical settings. For those new to the field, there are readily reproducible methods for generating and purifying antibodies and for modifying them for clinical application. Timely and comprehensive, Diagnostic and Therapeutic Antibodies offers today's researchers a concise introduction to the field, as well as a highly useful compendium of practical protocols that will greatly facilitate the application of these powerful new diagnostic and therapeutic agents.

Handbook of Therapeutic Antibodies

Author : Stefan Dübel
Publisher :
ISBN 13 :
Total Pages : 2187 pages
Book Rating : 4.:/5 (928 download)

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Book Synopsis Handbook of Therapeutic Antibodies by : Stefan Dübel

Download or read book Handbook of Therapeutic Antibodies written by Stefan Dübel and published by . This book was released on 2014 with total page 2187 pages. Available in PDF, EPUB and Kindle. Book excerpt: Still the most comprehensive reference source on the development, production and therapeutic application of antibodies, this second edition is thoroughly updated and now has 30% more content. Volume I covers selection and engineering strategies for new antibodies, while the second volume look at novel therapeutic concepts and antibodies in clinical trial phases, as well as their potential. Volume III features detailed and specific information about each antibody currently approved for therapeutic purposes, including the clinical data. Beyond providing current knowledge, the authors discuss emerging technologies, future developments, and intellectual property issues, such that this handbook meets the needs of academic researchers, decision makers in industry and healthcare professionals in the clinic.

Monoclonal Antibody Production

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309173051
Total Pages : 74 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Monoclonal Antibody Production by : National Research Council

Download or read book Monoclonal Antibody Production written by National Research Council and published by National Academies Press. This book was released on 1999-05-06 with total page 74 pages. Available in PDF, EPUB and Kindle. Book excerpt: The American Anti-Vivisection Society (AAVS) petitioned the National Institutes of Health (NIH) on April 23, 1997, to prohibit the use of animals in the production of mAb. On September 18, 1997, NIH declined to prohibit the use of mice in mAb production, stating that "the ascites method of mAb production is scientifically appropriate for some research projects and cannot be replaced." On March 26, 1998, AAVS submitted a second petition, stating that "NIH failed to provide valid scientific reasons for not supporting a proposed ban." The office of the NIH director asked the National Research Council to conduct a study of methods of producing mAb. In response to that request, the Research Council appointed the Committee on Methods of Producing Monoclonal Antibodies, to act on behalf of the Institute for Laboratory Animal Research of the Commission on Life Sciences, to conduct the study. The 11 expert members of the committee had extensive experience in biomedical research, laboratory animal medicine, animal welfare, pain research, and patient advocacy (Appendix B). The committee was asked to determine whether there was a scientific necessity for the mouse ascites method; if so, whether the method caused pain or distress; and, if so, what could be done to minimize the pain or distress. The committee was also asked to comment on available in vitro methods; to suggest what acceptable scientific rationale, if any, there was for using the mouse ascites method; and to identify regulatory requirements for the continued use of the mouse ascites method. The committee held an open data-gathering meeting during which its members summarized data bearing on those questions. A 1-day workshop (Appendix A) was attended by 34 participants, 14 of whom made formal presentations. A second meeting was held to finalize the report. The present report was written on the basis of information in the literature and information presented at the meeting and the workshop.

Handbook of Therapeutic Antibodies

Author : Stefan Dübel
Publisher : John Wiley & Sons
ISBN 13 : 3527329374
Total Pages : 2538 pages
Book Rating : 4.5/5 (273 download)

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Book Synopsis Handbook of Therapeutic Antibodies by : Stefan Dübel

Download or read book Handbook of Therapeutic Antibodies written by Stefan Dübel and published by John Wiley & Sons. This book was released on 2014-12-03 with total page 2538 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dieses Nachschlagewerk zu therapeutischen Antikörpern sucht auch in der komplett überarbeiteten 2. Auflage seinesgleichen und bietet 30 % neue Inhalte zu Entwicklung, Herstellung und therapeutischen Anwendungen dieser Biomoleküle.

Basic Serological Testing

Author : Rowa Yousef Alhabbab
Publisher : Springer
ISBN 13 : 3319776940
Total Pages : 144 pages
Book Rating : 4.3/5 (197 download)

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Book Synopsis Basic Serological Testing by : Rowa Yousef Alhabbab

Download or read book Basic Serological Testing written by Rowa Yousef Alhabbab and published by Springer. This book was released on 2018-05-23 with total page 144 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses in detail various serological tests that are used to identify medical conditions and diseases, from a general overview of each test to the equipment and steps needed to carry them out. The book is aimed specifically at immunology students and professionals who may occasionally need to use these tests, and thus lack training and experience in performing them. The book provides a brief overview of the immune system, including antibodies, antigens, and their interactions. The bulk of the book is comprised of 16 chapters that each explain different serological tests. These chapters start with a general introduction of the test or disease being detected, followed by the test principle, reagents required for the test, procedures and steps to perform the test, and, finally, result interpretation. Both test principles and result interpretation segments include illustrations to aid comprehension. In addition, the book also enables the reader to distinguish between positive and negative results in serological testing.

Monoclonal Antibodies in Headache

Author : Antoinette Maassen van den Brink
Publisher : Springer Nature
ISBN 13 : 3030690326
Total Pages : 172 pages
Book Rating : 4.0/5 (36 download)

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Book Synopsis Monoclonal Antibodies in Headache by : Antoinette Maassen van den Brink

Download or read book Monoclonal Antibodies in Headache written by Antoinette Maassen van den Brink and published by Springer Nature. This book was released on 2021-04-28 with total page 172 pages. Available in PDF, EPUB and Kindle. Book excerpt: Intended to promote a more appropriate and modern therapeutic approach to migraine management, this book is the first to deal with monoclonal antibodies in this context. Authored by the most respected migraine experts from around the globe and drawing on the lessons learned in both clinical trials and clinical practice, it reviews the current state of knowledge on this important therapeutic innovation, which has produced impressive data in randomized controlled trials, and the efficacy and safety of which have been confirmed in day-to-day real-world use. Given its scope, the book will appeal to a broad range of specialists, including pharmacologists, clinical pharmacologists, neurologists and internists, but also to residents and medical students.

Immunopharmacology

Author : Manzoor M. Khan
Publisher : Springer Science & Business Media
ISBN 13 : 0387779760
Total Pages : 275 pages
Book Rating : 4.3/5 (877 download)

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Book Synopsis Immunopharmacology by : Manzoor M. Khan

Download or read book Immunopharmacology written by Manzoor M. Khan and published by Springer Science & Business Media. This book was released on 2008-12-19 with total page 275 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the past decades, with the introduction of the recombinant DNA, hybridoma and transgenic technologies there has been an exponential evolution in understanding the pathogenesis, diagnosis and treatment of a large number of human diseases. The technologies are evident with the development of cytokines and monoclonal antibodies as therapeutic agents and the techniques used in gene therapy. Immunopharmacology is that area of biomedical sciences where immunology, pharmacology and pathology overlap. It concerns the pharmacological approach to the immune response in physiological as well as pathological events. This goals and objectives of this textbook are to emphasize the developments in immunology and pharmacology as they relate to the modulation of immune response. The information includes the pharmacology of cytokines, monoclonal antibodies, mechanism of action of immune-suppressive agents and their relevance in tissue transplantation, therapeutic strategies for the treatment of AIDS and the techniques employed in gene therapy. The book is intended for health care professional students and graduate students in pharmacology and immunology.

Antibody Drug Discovery

Author : Clive R. Wood
Publisher : World Scientific
ISBN 13 : 1848166281
Total Pages : 490 pages
Book Rating : 4.8/5 (481 download)

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Book Synopsis Antibody Drug Discovery by : Clive R. Wood

Download or read book Antibody Drug Discovery written by Clive R. Wood and published by World Scientific. This book was released on 2012 with total page 490 pages. Available in PDF, EPUB and Kindle. Book excerpt: Antibody-based therapeutics are a central driver of the success of biopharmaceuticals. The discovery technology of this field is isolated to a limited number of centers of excellence in industry and academia. The objective of this volume is to provide a series of guides to those evaluating and preparing to enter particular areas within the field. Each chapter is written with a historical perspective that sets into context the significance of the key developments, and with the provision of “points to consider” for the reader as a value-added feature of the volume. All contributors are experts in their fields and have played pivotal roles in the creation of the technology.