Immunoconjugate Therapy Of Hematologic Malignancies

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Immunoconjugate Therapy of Hematologic Malignancies

Author : Steven T. Rosen
Publisher : Springer Science & Business Media
ISBN 13 : 1461530768
Total Pages : 293 pages
Book Rating : 4.4/5 (615 download)

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Book Synopsis Immunoconjugate Therapy of Hematologic Malignancies by : Steven T. Rosen

Download or read book Immunoconjugate Therapy of Hematologic Malignancies written by Steven T. Rosen and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 293 pages. Available in PDF, EPUB and Kindle. Book excerpt: The hybridoma technique for producing monoclonal antibodies, developed by Drs. Kohler and Millstein in 1975, revolutionized the field of tumor immunology. It is now clear that there are antigens associated with or restricted to human neoplasms that have biologic significance. Monoclonal antibodies have already been demonstrated to have great immunodiagnostic value and it is anticipated that they will become a component of our therapeutic armamentarium. Most investigators in the field, however, feel that the true potential of monoclonal antibodies in cancer therapy remains to be determined. Clearly the most encouraging results have been witnessed in the treatment of hematologic malignancies. This volume of CANCER TREATMENT AND RESEARCH explores the current state of the art of immunoconjugate therapy of hematologic malignancies. Immunoconjugate Therapy of Hematologic Malignancies provides an update of a rapidly advancing field. The preliminary experience of a number of investigators suggests a role for targeted therapy in the treatment of hematologic malignancies. At the present time, immunoconjugates have, in most instances, been reserved for patients with advanced refractory disease. However, it is anticipated in the future that these reagents will be utilized as a complement to traditional therapy or as post-remission consolidation in patients with minimal residual disease. The obstacles have been defined; solutions will require further research and creative imagination.

Monoclonal Antibody Therapy of Hematologic Malignancies

Author : Bruce D. Cheson
Publisher :
ISBN 13 :
Total Pages : 318 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Monoclonal Antibody Therapy of Hematologic Malignancies by : Bruce D. Cheson

Download or read book Monoclonal Antibody Therapy of Hematologic Malignancies written by Bruce D. Cheson and published by . This book was released on 2001 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Precision Cancer Therapies, Volume 2: Immunologic Approaches for the Treatment of Lymphoid Malignancies

Author : Owen A. O'Connor
Publisher : John Wiley & Sons
ISBN 13 : 1119824540
Total Pages : 501 pages
Book Rating : 4.1/5 (198 download)

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Book Synopsis Precision Cancer Therapies, Volume 2: Immunologic Approaches for the Treatment of Lymphoid Malignancies by : Owen A. O'Connor

Download or read book Precision Cancer Therapies, Volume 2: Immunologic Approaches for the Treatment of Lymphoid Malignancies written by Owen A. O'Connor and published by John Wiley & Sons. This book was released on 2024-04-29 with total page 501 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presents timely and authoritative information on the development of precision cancer therapies as applied to hematologic malignancies The Precision Cancer Therapies series focuses on how to understand and translate fundamental basic science into information that can be directly applied to patients to advance care. Each volume of the series integrates the relevant biological concepts and principles necessary for translating this science to practitioners of this science. Precision Cancer Therapies, Volume Two, focuses on sophisticated immunotherapies targeting cancers affecting the blood, bone marrow, and lymph nodes. Edited and authored by the foremost authorities in the field, this comprehensive reference text covers targeting of cell surface receptors, antibody-drug conjugates (ADC), targeting immune checkpoint, targeting macrophages, EBV-directed immunotherapies, tumor-associated antigens (TAA), and chimeric antigen receptor T-cells (CAR-T). Divided into nine sections, Volume Two includes an overview of the history of immunotherapy development in cancer, as well as a concluding section addressing the mechanistic basis and role of immunomodulatory drugs, analytical tools to quantitate immune-mediated effects, and other topics in immunotherapy. Chapters on specific therapeutics or therapeutic classes include a basic explanation of the underlying pathway and target, the pharmacology of the drug/class, relevant preclinical and clinical data, and discussion of clinical management and potential predictive biomarkers of response. This book also: Delivers a definitive, state-of-the-art review of the relevant biology and its importance in the broader context of cancer biology Focuses on agents that mediate cell killing in lymphoma through a variety of immunologic mechanisms Covers FDA-approved drugs and their indications, as well as drugs currently in development Provides information on monotherapy and combination therapy, summary tables of trials, and discussion of toxicity and efficacy Includes boxed sections highlighting major unique points about the information in the chapter Precision Cancer Therapies, Volume Two: Immunologic Approaches for the Treatment of Lymphoid Malignancies, From Concept to Practice is an indispensable resource for medical, scientific, and allied medical professionals, advanced students, and interested general readers with background knowledge in the subject.

Diagnostic and Therapeutic Advances in Hematologic Malignancies

Author : Martin S. Tallman
Publisher : Springer Science & Business Media
ISBN 13 : 0585385718
Total Pages : 383 pages
Book Rating : 4.5/5 (853 download)

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Book Synopsis Diagnostic and Therapeutic Advances in Hematologic Malignancies by : Martin S. Tallman

Download or read book Diagnostic and Therapeutic Advances in Hematologic Malignancies written by Martin S. Tallman and published by Springer Science & Business Media. This book was released on 2007-11-23 with total page 383 pages. Available in PDF, EPUB and Kindle. Book excerpt: There is no field of medicine in which advances in therapy have been so closely linked to a better understanding of molecular medicine than in the area of hematologic malignancies. Diagnostic and Therapeutic Advances in Hematologic Malignancies will provide practitioners and academic clinicians with a better understanding of the constant evolving concepts in this area.

Advances in Hematologic Malignancies

Author : Gamal Abdul Hamid
Publisher : BoD – Books on Demand
ISBN 13 : 1789239419
Total Pages : 178 pages
Book Rating : 4.7/5 (892 download)

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Book Synopsis Advances in Hematologic Malignancies by : Gamal Abdul Hamid

Download or read book Advances in Hematologic Malignancies written by Gamal Abdul Hamid and published by BoD – Books on Demand. This book was released on 2019-12-04 with total page 178 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book Advances in Hematologic Malignancies presents new knowledge of cellular disease processes, molecular pathology, and cytogenetic, epigenetic, and genomic changes that have influenced the current outlook toward hematological malignancies. This book provides a unique, practical, and concise guide that is focused on the must-know points of diagnosis, prognosis, therapeutic management, and cutting edge clinical trial opportunities for each hematologic malignancy. Advances in Hematologic Malignancies is designed and organized as an essential reference source for the hematologist, hematologic oncologist, hematopathologist, and trainee.

Hematologic Malignancies

Author : Bouthaina Dabaja, MD
Publisher : Demos Medical Publishing
ISBN 13 : 1617051497
Total Pages : 183 pages
Book Rating : 4.6/5 (17 download)

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Book Synopsis Hematologic Malignancies by : Bouthaina Dabaja, MD

Download or read book Hematologic Malignancies written by Bouthaina Dabaja, MD and published by Demos Medical Publishing. This book was released on 2012-12-17 with total page 183 pages. Available in PDF, EPUB and Kindle. Book excerpt: Radiation Medicine Rounds is a trinary hard cover periodical designed to provide an up-to- date review of a dedicated radiation medicine topic of interest to clinicians and scientists who are involved in the care of patients receiving radiotherapy. It is intended to serve as both a reference and instructional tool for students, housestaff, fellows, practicing clinicians, medical physicists, cancer biologists, radiobiologists, and interdisciplinary colleagues throughout the oncology spectrum. This issue of Radiation Medicine Rounds discusses the more salient topics surrounding the role of radiation therapy for hematologic malignancies. There are literally dozens of distinct lymphoma subtypes, each with its own unique molecular and clinical features. Although systemic cytotoxic and targeted therapies have improved dramatically, radiation therapy remains an important modality for optimal clinical outcomes. With contributions from nationally recognized experts, Hematologic Malignancies offers an overview of the full spectrum of therapy for hematologic malignancies ranging from lymphoma and leukemia to plasma cell dyscrasias. Recent advances in radiotherapy for hematologic malignancies allow for maintenance of excellent local control with improvements in toxicity achieved through reductions in field sizes, in dose delivered, and increasingly conformal delivery techniques. Hematologic Malignancies provides the practitioner with a current overview of best practices, recent research, and future directions in the management of these complex cancers.

Management of Hematologic Malignancies

Author : Susan O'Brien
Publisher : Cambridge University Press
ISBN 13 : 1139493655
Total Pages : 527 pages
Book Rating : 4.1/5 (394 download)

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Book Synopsis Management of Hematologic Malignancies by : Susan O'Brien

Download or read book Management of Hematologic Malignancies written by Susan O'Brien and published by Cambridge University Press. This book was released on 2010-11-18 with total page 527 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hematologic malignancies were the first human cancers to be studied in depth at the molecular level, and recent years have seen important advances in treatment. This comprehensive reference book covers the full range of hematologic malignancies, including all subtypes of leukemias, lymphomas, and plasma cell dyscrasias. Authored by internationally known experts, each chapter emphasizes diagnostic work-up, staging, and therapeutic approaches. Up-to-date hematopathology, treatment, and outcomes data are presented in a way which is directly applicable to patient care. Highly illustrated with color images, graphs, flowcharts and treatment algorithms, the book is perfect for quick clinical reference as well as providing detailed reference lists for further study. With its authoritative and practical focus and visually stimulating presentation, this is a key text for hematology and oncology fellows, physicians, oncology nurses, physician assistants and other healthcare workers in the field of oncology.

Immunologic Approaches for the Treatment of Lymphoid Malignancies

Author : Owen A. O'Connor
Publisher : Wiley-Blackwell
ISBN 13 : 9781119824572
Total Pages : 0 pages
Book Rating : 4.8/5 (245 download)

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Book Synopsis Immunologic Approaches for the Treatment of Lymphoid Malignancies by : Owen A. O'Connor

Download or read book Immunologic Approaches for the Treatment of Lymphoid Malignancies written by Owen A. O'Connor and published by Wiley-Blackwell. This book was released on 2024-02 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presents timely and authoritative information on the development of precision cancer therapies as applied to hematologic malignancies The Precision Cancer Therapies series focuses on how to understand and translate fundamental basic science into information that can be directly applied to patients to advance care. Each volume of the series integrates the relevant biological concepts and principles necessary for translating this science to practitioners of this science. Precision Cancer Therapies, Volume Two, focuses on sophisticated immunotherapies targeting cancers affecting the blood, bone marrow, and lymph nodes. Edited and authored by the foremost authorities in the field, this comprehensive reference text covers targeting of cell surface receptors, antibody-drug conjugates (ADC), targeting immune checkpoint, targeting macrophages, EBV-directed immunotherapies, tumor-associated antigens (TAA), and chimeric antigen receptor T-cells (CAR-T). Divided into nine sections, Volume Two includes an overview of the history of immunotherapy development in cancer, as well as a concluding section addressing the mechanistic basis and role of immunomodulatory drugs, analytical tools to quantitate immune-mediated effects, and other topics in immunotherapy. Chapters on specific therapeutics or therapeutic classes include a basic explanation of the underlying pathway and target, the pharmacology of the drug/class, relevant preclinical and clinical data, and discussion of clinical management and potential predictive biomarkers of response. This book also: Delivers a definitive, state-of-the-art review of the relevant biology and its importance in the broader context of cancer biology Focuses on agents that mediate cell killing in lymphoma through a variety of immunologic mechanisms Covers FDA-approved drugs and their indications, as well as drugs currently in development Provides information on monotherapy and combination therapy, summary tables of trials, and discussion of toxicity and efficacy Includes boxed sections highlighting major unique points about the information in the chapter Precision Cancer Therapies, Volume Two: Immunologic Approaches for the Treatment of Lymphoid Malignancies, From Concept to Practice is an indispensable resource for medical, scientific, and allied medical professionals, advanced students, and interested general readers with background knowledge in the subject.

Handbook of Hematologic Malignancies

Author : David A. Sallman, MD
Publisher : Springer Publishing Company
ISBN 13 : 0826149774
Total Pages : 571 pages
Book Rating : 4.8/5 (261 download)

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Book Synopsis Handbook of Hematologic Malignancies by : David A. Sallman, MD

Download or read book Handbook of Hematologic Malignancies written by David A. Sallman, MD and published by Springer Publishing Company. This book was released on 2020-12-19 with total page 571 pages. Available in PDF, EPUB and Kindle. Book excerpt: This revised and updated second edition of Handbook of Hematologic Malignancies continues to be an essential and "go-to" resource for the busy hematologist, hematologic oncologist, hematopathologist, oncology advanced practice provider, oncology nurse, and trainee. Concisely organized, each chapter provides the most current, need-to-know points of diagnosis, prognosis, therapeutic management, and clinical trial opportunities for each hematological malignancy. Chapters are complete with richly illustrated figures to highlight the hematopathologic characteristics of diseases in addition to helpful tables on differential diagnosis, prognostic scoring systems, molecular profiles, and therapeutic options. A new case-based chapter concludes the handbook with clinical cases designed to test a clinician's knowledge of pathologic diagnosis and clinical presentation of diseases covered in the book. With over twenty new FDA-approved indications since publication of the first edition, including breakthroughs with CAR-T therapy, and other evidence-based treatment options for patients with hematologic disease, this book serves as quick reference to practice changing information on challenging diagnostic dilemmas, frontline and refractory treatment scenarios, and more. The subspecialty field of hematologic oncology is ever-changing and expanding with available treatment options and this second edition keeps the busy clinician abreast of recent findings and their impact on evidence-based treatment and management. Written by experienced clinicians at the world-renowned Moffitt Cancer Center in Tampa, Florida, as well as contributions from leading academicians, hematologists, and oncologists throughout the country, this unique handbook is packed with authoritative knowledge and clinical insight into all known hematologic cancers. Key Features: Includes seven new chapters covering CAR-T and novel therapeutic options including CD19 CAR-T therapy, novel cellular therapies, cytokine release syndrome, cancer associated thrombosis, and more Comprises compact and updated disease-site chapters describing new standards of care and management considerations in bullet point format with key references Highlights important diagnostic tools that assist with conducting key differential diagnoses and unveiling answers to diagnostic dilemmas Provides updates of potential practice-changing clinical trials and paradigm shifting treatment considerations in each disease-based chapter

Overcoming Physiologic Barriers to Treatments for Hematologic Malignancies by Molecularly Targeting the Tumor Microenvironment

Download Overcoming Physiologic Barriers to Treatments for Hematologic Malignancies by Molecularly Targeting the Tumor Microenvironment PDF Online Free

Author : Qin Wang
Publisher : Frontiers Media SA
ISBN 13 : 283254360X
Total Pages : 109 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Overcoming Physiologic Barriers to Treatments for Hematologic Malignancies by Molecularly Targeting the Tumor Microenvironment by : Qin Wang

Download or read book Overcoming Physiologic Barriers to Treatments for Hematologic Malignancies by Molecularly Targeting the Tumor Microenvironment written by Qin Wang and published by Frontiers Media SA. This book was released on 2024-01-29 with total page 109 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hematologic malignancies (HMs) represent a group of hematologic cancers originating from bone marrow or lymphoid organs. Currently, leukaemia, lymphoma, and multiple myeloma are the most common HMs. Conventional treatments for HMs include bone marrow transplantation, radiotherapy, chemotherapy, and immunotherapy. Despite the significant achievements obtained over the past decade in the drug therapy of HMs, tumor metastasis and relapse in patients often occurred after an initial response, indicating the generation of drug resistance to current therapies. Moreover, many clinically used therapeutic drugs are often associated with dose-related side effects and a lack of specificity to tumor tissues. The tumor microenvironment (TME) in HMs consists of a complicated network of cellular interactions and signaling cross-talking within the bone marrow cavity, and it plays an essential role in the progression and metastasis of HM. Furthermore, the TME in HMs has formed physiologic barriers such as immunosuppressive microenvironment, upregulated anti-apoptotic system, drug resistance, etc. to facilitate drug resistance and relapse of HMs. It has become widely accepted that effective treatment against HMs may require targeting both the cancer cell and TME.

Molecular Aspects of Hematologic Malignancies

Author : Michal Witt
Publisher : Springer Science & Business Media
ISBN 13 : 3642294677
Total Pages : 468 pages
Book Rating : 4.6/5 (422 download)

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Book Synopsis Molecular Aspects of Hematologic Malignancies by : Michal Witt

Download or read book Molecular Aspects of Hematologic Malignancies written by Michal Witt and published by Springer Science & Business Media. This book was released on 2012-06-30 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a state-of-the-art approach to the molecular basis of hematologic diseases and its translation into improved diagnostics and novel therapeutic strategies. Several representative hemato-oncologic malignancies are analyzed in detail: acute lymphoblastic leukemia, acute myeloid leukemia, B-cell Non-Hodgkin lymphomas, multiple myeloma, chronic lymphocytic leukemia, chronic myeloid leukemia, myelodysplastic syndromes, and myeloproliferative neoplasms. Experts in the field describe the molecular methods applied for modern diagnostics and therapies, such as hematopoietic stem cell transplantation, donor recipient matching, banking of biological material, analyses of post-transplant chimerism, and minimal residual disease monitoring. The volume concludes with an extensive section comprising thorough step-by-step protocols of molecular techniques in hematology, all of them validated in the authors’ own laboratories.

Antibody-Drug Conjugates and Immunotoxins

Author : Gail Lewis Phillips
Publisher : Springer Science & Business Media
ISBN 13 : 1461454565
Total Pages : 370 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis Antibody-Drug Conjugates and Immunotoxins by : Gail Lewis Phillips

Download or read book Antibody-Drug Conjugates and Immunotoxins written by Gail Lewis Phillips and published by Springer Science & Business Media. This book was released on 2012-12-13 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume gathers the leading research on antibody-drug conjugates and immunotoxins. Following a rigorous overview, the volume delves into focused sections on all aspects of ADCs and ITs from clinical development through to targeted therapeutic applications and the latest technologies.

Case Studies in Hematologic Malignancies

Author : Ronan Allen
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.8/5 (874 download)

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Book Synopsis Case Studies in Hematologic Malignancies by : Ronan Allen

Download or read book Case Studies in Hematologic Malignancies written by Ronan Allen and published by . This book was released on 2023-10-10 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hematologic malignancies, also known as blood cancers, refer to a wide range of cancers that originate in the bone marrow or the lymphatic system. These cancers can affect the production and function of blood cells, including white blood cells, red blood cells and platelets. Hematologic malignancies include leukemia, lymphoma, and multiple myeloma. The treatment of hematologic malignancies depends on the specific type and stage of the cancer, as well as individual patient factors. These malignancies can be treated through radiation therapy, chemotherapy, immunotherapy, targeted therapy and stem cell transplantation. Radiation therapy uses high-energy radiation to target and kill cancer cells. Chemotherapy makes use of powerful medications to destroy cancer cells or prevent their growth. This book brings forth some of the most innovative concepts and elucidates the unexplored aspects of hematological malignancies. It will serve as a valuable source of reference for graduate and postgraduate students.

Hematologic Malignancies

Author : Barth Hoogstraten
Publisher : Springer
ISBN 13 : 9783540162933
Total Pages : 0 pages
Book Rating : 4.1/5 (629 download)

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Book Synopsis Hematologic Malignancies by : Barth Hoogstraten

Download or read book Hematologic Malignancies written by Barth Hoogstraten and published by Springer. This book was released on 1986-09-01 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new series on the treatment of cancer is sponsored by the VICe. The editors and authors feel strongly that more standardiza tion is needed on a worldwide basis in cancer therapy. This, of course, is only possible if experts from all countries subscribe to a joint policy of making their treatment designs available to practising oncologists all over the world. Current Treatment of Cancer will discuss all the equipment and methods now in use in cancer therapy. It will cover all types of cancer, thus providing the reader with comprehensive information on cancer management. In recent decades there has been a tremendous improvement in the treatment of cancer, and there is hope for even further success in this fight. We are convinced that this series will help us to make a concerted response to the challenge of cancer. VICC Treatment and Rehabilitation Programme Ismail Elsebai Chairman VII Preface During the past two decades we have witnessed an exciting evolution in the un derstanding and management of hematologic malignancies. The number of drugs available 20 years ago for the treatment of acute leukemia was so small that the disease in children and in adults could be discussed within one chapter. Since then, rapid progress has been made in the management of childhood leukemia, making for a much better prognosis. Over the past 10 years we have seen the same developments in respect of leukemia in adults.

Hematologic Malignancies

Author : Barth Hoogstraten
Publisher : Springer Verlag
ISBN 13 : 9780387162935
Total Pages : 111 pages
Book Rating : 4.1/5 (629 download)

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Book Synopsis Hematologic Malignancies by : Barth Hoogstraten

Download or read book Hematologic Malignancies written by Barth Hoogstraten and published by Springer Verlag. This book was released on 1986-01-01 with total page 111 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Hematologic Cancers: From Molecular Pathobiology to Targeted Therapeutics

Author : Jianguo Tao
Publisher : Springer Science & Business Media
ISBN 13 : 9400750285
Total Pages : 430 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Hematologic Cancers: From Molecular Pathobiology to Targeted Therapeutics by : Jianguo Tao

Download or read book Hematologic Cancers: From Molecular Pathobiology to Targeted Therapeutics written by Jianguo Tao and published by Springer Science & Business Media. This book was released on 2012-11-13 with total page 430 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the last decade, there has been a remarkable explosion of knowledge in hematologic cancer from basic molecular biology and pathology to clinical therapy. This has led to many new advance and insights in the understanding of pathobiology of malignant hematology. New knowledge of disease molecular pathology, cytogenetic, epigenetic and genomic alterations have provided new strategies to attack and eradicate tumor cells at molecular level and significantly impacted our current therapeutics for hematological malignancies. The recent and ongoing rapid expansion of knowledge in this area has become extensive, dynamic and diffuse over the literature and research publications. This has led to the need to capture and compile the new and current information about hematologic cancer with special emphasis on translation from molecular pathobiology to targeted therapeutics. In this book experts from around the world share their thoughts and knowledge about the pathobiology of hematologic cancer, as well as their view on current treatment approaches and future development in these malignant hematologic diseases. This book is well suited for hematology residents, fellows and hematology-oncology physicians, hematopathologist as well as basic research scientist in the area of hematologic malignancies.

Hematologic Malignancies: Multiple Myeloma and Related Plasma Cell Disorders

Author : Morie A. Gertz
Publisher : Springer Science & Business Media
ISBN 13 : 9783540008118
Total Pages : 494 pages
Book Rating : 4.0/5 (81 download)

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Book Synopsis Hematologic Malignancies: Multiple Myeloma and Related Plasma Cell Disorders by : Morie A. Gertz

Download or read book Hematologic Malignancies: Multiple Myeloma and Related Plasma Cell Disorders written by Morie A. Gertz and published by Springer Science & Business Media. This book was released on 2003-11-24 with total page 494 pages. Available in PDF, EPUB and Kindle. Book excerpt: This handbook provides up-to-date and comprehensive treatment of all plasma cell disorders, including both common and rare disorders. All disease aspects from pathogenesis to most recent therapy are covered. The text originates from the Mayo Clinic, the world's most experienced institution in plasma cell disorders. Comprehensive treatise on all plasma cell disorders from the gene level to treatment of emergencies Chapters are uniformly organized for easy data access All authors are important authorities in their field with extensive clinical experience