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Immune Response To Cerebral Ischemia Exploring Mechanisms And Potential Treatment Targets
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Book Synopsis Immune Response to Cerebral Ischemia: Exploring Mechanisms and Potential Treatment Targets by : Xiaoxing Xiong
Download or read book Immune Response to Cerebral Ischemia: Exploring Mechanisms and Potential Treatment Targets written by Xiaoxing Xiong and published by Frontiers Media SA. This book was released on 2022-02-10 with total page 229 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Inflammation and Stroke by : Giora Z. Feuerstein
Download or read book Inflammation and Stroke written by Giora Z. Feuerstein and published by Springer. This book was released on 2012-12-06 with total page 351 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stroke is a leading cause of death in developed countries. However, current therapeutic strategies for stroke have been largely unsuccessful. One possible explanation is that research and pharmacological management have focused on very early events in brain ischemia. New research has shown that brain ischemia and trauma elicit strong inflammatory reactions driven by both external and brain cells. The recognition of inflammation as a fundamental response to brain ischemia provides novel opportunities for new anti-inflammatory therapies. For the first time, an international body of researchers presents the latest findings about the cellular and humoral aspects of immune and inflammatory reactions in the brain. The work may have an impact on the treatment of neuroinjuries and ancillary brain diseases, and increase the understanding of the roles infections and immune reactions play in the brain milieu.
Download or read book Brain Edema written by Jerome Badaut and published by Academic Press. This book was released on 2017-07-19 with total page 554 pages. Available in PDF, EPUB and Kindle. Book excerpt: Brain Edema: From Molecular Mechanisms to Clinical Practice brings together the most widely recognized experts in experimental and clinical brain edema research to review the current knowledge gathered on the molecular and cellular pathophysiology and clinical management of brain edema. This timely book also discusses future directions of research and treatment. Brain edema is an integral and acutely life-threatening part of the pathophysiology of multiple cerebral and non-cerebral disorders, including traumatic brain injury, cerebral ischemia, brain tumors, cardiac arrest, altitude sickness and liver failure. Affecting millions worldwide, research over the past few years has shown that a plethora of complex molecular and cellular mechanisms contribute to this pathological accumulation of water in the brain parenchyma. In parallel, the development of new neuroimaging tools has provided a new way to examine how edema develops longitudinally and in real time, both in pre-clinical models and in patients. Despite intense research over the past few decades, therapeutic options are still limited and sometimes not effective. Presents a comprehensive understanding of the molecular mechanisms involved in edema formation and resolution Discusses the specific role of edema development in several pathologies, including traumatic brain injury, stroke, brain tumors, cardiac arrest, and liver failure Proposes a new classification of edema based on molecular processes Discusses clinical management of new clinical trials coming from pre-clinical studies Addresses the possible link between edema formation, other molecular and cellular processes, including inflammation and neuroinflammation
Book Synopsis Novel Mechanisms of Memory by : Karl Peter Giese
Download or read book Novel Mechanisms of Memory written by Karl Peter Giese and published by Springer. This book was released on 2015-12-15 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book integrates discoveries from recent years to show the diversity of molecular mechanisms that contribute to memory consolidation, reconsolidation, extinction, and forgetting. It provides a special focus on the processes that govern functional and structural plasticity of dendritic spines. In nine chapters, new and important ideas related to learning and memory processes will be presented. Themes discussed include the role of AMPA receptors in memory, two signalling cascades involved in local spine remodelling and memory, the role of extracellular matrix proteins in memory, the regulation of gene expression and protein translation, and mechanisms of retrieval-induced memory modulation and forgetting. We believe that the study of these topics represents a great step toward understanding the complexity of the brain and the processes it governs.
Book Synopsis Advances in neuroprotective agents for cerebral ischemia treatment by : Yongjun Sun
Download or read book Advances in neuroprotective agents for cerebral ischemia treatment written by Yongjun Sun and published by Frontiers Media SA. This book was released on 2023-04-20 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :National Academies of Sciences, Engineering, and Medicine Publisher :National Academies Press ISBN 13 :0309463653 Total Pages :89 pages Book Rating :4.3/5 (94 download)
Book Synopsis Biomarkers of Neuroinflammation by : National Academies of Sciences, Engineering, and Medicine
Download or read book Biomarkers of Neuroinflammation written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2018-03-16 with total page 89 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuroinflammation is a burgeoning area of interest in academia and biopharma, with a broadly acknowledged role in many central nervous system (CNS) disorders. However, there is little agreement on the pathophysiological mechanisms that underlie the manifestations of neuroinflammation in the CNS compartment and how neuroinflammation operates as a driver and also as a consequence of disease in the brain. Moreover, another unclear area is how to translate increased understanding of the mechanisms that underlie neuroinflammation and its manifestations in the CNS to therapeutics. To address these gaps in understanding mechanisms and how to translate that understanding into therapeutics, the Forum on Neuroscience and Nervous System Disorders of the National Academies of Sciences, Engineering, and Medicine convened a workshop on March 20-21, 2017, bringing together key leaders in the field from industry, academia, and governmental agencies to explore the role and mechanisms of neuroinflammation in a variety of CNS diseases. The workshop also considered strategies to advance the identification and validation of biomarkers of neuroinflammation that could accelerate development of therapies, bringing much-needed treatments to patients with disorders ranging from neuroinflammatory diseases such as multiple sclerosis (MS) to neuropsychiatric disorders such as depression. This publication summarizes the presentations and discussions from the workshop.
Book Synopsis The Immune System and Mental Health by : Hymie Anisman
Download or read book The Immune System and Mental Health written by Hymie Anisman and published by Academic Press. This book was released on 2018-07-19 with total page 700 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Immune System and Mental Health fully investigates how immune-related cellular, molecular and anatomical changes impact mental functioning. The book combines human and animal studies to reveal immunological changes related to mental-health problems. In addition, users will find comprehensive information on new research related to the microbial composition of the gut, aka, the microbiome, and how it influences brain function and mental health. Common comorbidities with mental illness and their inherent immunological or inflammatory components are also covered. Written by leaders in the field, the book synthesizes basic and clinical research to provide a thorough understanding on the role of immunity in neuropsychiatry. Sociology, psychology, psychiatry, neuroscience and genetics have provided considerable explanations and solutions to some of the most intractable mental-health problems. But researchers are increasingly relying on investigations of the immune system to identify factors that can undermine and impair mental health. This book covers devastating mental-health conditions, such as depression, anxiety, schizophrenia, and autism-like spectrum disorders. In addition, degenerative disorders of the brain, such as Parkinson’s and Alzheimer’s-like dementia are explored. Considers both basic human and animal studies that address immunological changes relating to mental health problems across the lifespan Incorporates techniques, concepts and ideas from a variety of social, behavioral and life sciences Explores the relatively new area of the microbiome and how the microbial composition of the gut influences brain function and mental health
Book Synopsis Crosstalk between Peripheral and Local Immune Response in the Pathophysiology of Stroke and Neurodegeneration Diseases by : Yuanjian Fang
Download or read book Crosstalk between Peripheral and Local Immune Response in the Pathophysiology of Stroke and Neurodegeneration Diseases written by Yuanjian Fang and published by Frontiers Media SA. This book was released on 2023-12-27 with total page 363 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis 10 Years of frontiers in genetics: Past discoveries, current challenges and future perspectives by : William C. Cho
Download or read book 10 Years of frontiers in genetics: Past discoveries, current challenges and future perspectives written by William C. Cho and published by Frontiers Media SA. This book was released on 2023-06-02 with total page 427 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Integrative Multi-Omics for Diagnosis, Treatments, and Drug Discovery of Aging-Related Neuronal Diseases by : Min Tang
Download or read book Integrative Multi-Omics for Diagnosis, Treatments, and Drug Discovery of Aging-Related Neuronal Diseases written by Min Tang and published by Frontiers Media SA. This book was released on 2022-11-23 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: As the cost of high-throughput sequencing goes down, huge volumes of biological and medical data have been produced from various sequencing platforms at multiple molecular levels including genome, transcriptome, proteome, epigenome, metabolome, and so on. For a long time, data analysis on single molecular levels has paved the way to answer many important research questions. However, many Aging-Related Neuronal Diseases (ARNDs) and Central Nervous System (CNS) aging involve interactions of molecules from multiple molecular levels, in which conclusions based on single molecular levels are usually incomplete and sometimes misleading. In these scenarios, multi-omics data analysis has unprecedentedly helped capture much more useful information for the diagnosis, treatment, prognosis, and drug discovery of ARNDs. The first step towards a multi-omics analysis is to establish reliable and robust multi-omics datasets. In the past years, a few important ARNDs-associated multi-omics databases like Allen Brain have been constructed, which raised immediate needs like data curation, normalization, interpretation, and visualization for integrative multi-omics explorations. Though there have been several well-established multi-omics databases for ARNDs like Alzheimer’s disease, similar databases for other ARNDs are still in urgent need. After the databases establish, many computational tools and experiential strategies should be developed specifically for them. First, the multi-omics data are usually extremely noisy, complex, heterogeneous and in high dimension, which presents the need for appropriate denoising and dimension reduction methods. Second, since the multi-omics and non-omics data like pathological and clinical data are usually in different data spaces, a useful algorithm to mapping them into the same data space and integrate them is nontrivial. In the multi-omics era, there are numerous data-centric tools for the integration of multi-omics datasets, which could be generally divided into three categories: unsupervised, supervised, and semi-supervised methods. Commonly used algorithms include but not limited to Bayesian-based methods, Network-based methods, multi-step analysis methods, and multiple kernel learning methods. Third, methods are needed in studying and verifying the association between two or more levels of multi-omics data and non-omics data. For example, expression quantitative trait loci (eQTL) analysis is widely used to infer the association between a single nucleotide polymorphism (SNP) and the expression of a gene. Recently, the association between omics data and more complex data like pathological and clinical imaging data has been a hot research topic. The outcomes may reveal the underlying molecular mechanism and promote de novo drug design as well as drug repurposing for ARNDs. Here, we welcome investigators to share their Original Research, Review, Mini Review, Hypothesis and Theory, Perspective, Conceptual Analysis, Data Report, Brief Research Report, Code related to multi-omics studies of ARNDs, which can be applied for better diagnosis, treatment, prognosis and drug discovery of human diseases in the future era of precision medicine. Potential contents include but are not limited to the following: ▪ Methods for integrating, interpreting, or visualizing two or more omics data. ▪ Methods for identifying interactions between different data modalities. ▪ Methods for disease subtyping, biomarker prediction. ▪ Machine learning or deep learning methods on dimensional reduction and feature selection for big noisy data. ▪ Methods for studying the association among different omics data or between omics and non-omics data like clinical, pathological, and imaging data. ▪ Review of multi-omics resource about ARNDs and/or CNS aging. ▪ Experimental validation of biomarkers identified from multi-omics data analysis. ▪ Disease diagnosis and prognosis prediction from imaging and non-imaging data analysis, or both. ▪ Clinical applications or validations of findings from multi-omics data analysis.
Book Synopsis Neuroprotective Effects of Phytochemicals in Neurological Disorders by : Tahira Farooqui
Download or read book Neuroprotective Effects of Phytochemicals in Neurological Disorders written by Tahira Farooqui and published by John Wiley & Sons. This book was released on 2017-01-03 with total page 648 pages. Available in PDF, EPUB and Kindle. Book excerpt: Phytochemicals are naturally occurring bioactive compounds found in edible fruits, plants, vegetables, and herbs. Unlike vitamins and minerals, phytochemicals are not needed for the maintenance of cell viability, but they play a vital role in protecting neural cells from inflammation and oxidative stress associated with normal aging and acute and chronic age-related brain diseases. Neuroprotective Effects of Phytochemicals in Neurological Disorders explores the advances in our understanding of the potential neuroprotective benefits that these naturally occurring chemicals contain. Neuroprotective Effects of Phytochemicals in Neurological Disorders explores the role that a number of plant-based chemical compounds play in a wide variety of neurological disorders. Chapters explore the impact of phytochemicals on neurotraumatic disorders, such as stroke and spinal cord injury, alongside neurodegenerative diseases such as Alzheimer's and Parkinson's Disease, as well as neuropsychiatric disorders such as depression and schizophrenia. The chapters and sections of this book provide the reader with a big picture view of this field of research. Neuroprotective Effects of Phytochemicals in Neurological Disorders aims to present readers with a comprehensive and cutting edge look at the effects of phytochemicals on the brain and neurological disorders in a manner useful to researchers, neuroscientists, clinical nutritionists, and physicians.
Book Synopsis Advances in brain disorders: From mechanisms to therapeutic targets by : Arianna Bellucci
Download or read book Advances in brain disorders: From mechanisms to therapeutic targets written by Arianna Bellucci and published by Frontiers Media SA. This book was released on 2023-12-20 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Neuroinflammation in Stroke by : Ulrich Dirnagl
Download or read book Neuroinflammation in Stroke written by Ulrich Dirnagl and published by Springer Science & Business Media. This book was released on 2013-04-17 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: The successful treatment of acute stroke remains one of the major challenges in clinical medicine. Over the last decades, the understanding of stroke pathophysiology has greatly improved, while the therapeutic options in stroke therapy remain very limited. Today, hyperacute mechanisms of damage, such as excitotoxicity, can be discriminated from delayed ones, such as inflammation and apoptosis. Targeting of inflammation has already been successfully applied in various stroke models, but translation into a clinically efficacious strategy has not been achieved so far. In this book, leading experts in basic cerebrovascular research as well as stroke treatment review the current evidence for and against an important role for inflammation in stroke, and explore the potential of treating or modulating inflammation in stroke therapy.
Book Synopsis Multiple Sclerosis by : Institute of Medicine
Download or read book Multiple Sclerosis written by Institute of Medicine and published by National Academies Press. This book was released on 2001-08-10 with total page 457 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multiple sclerosis is a chronic and often disabling disease of the nervous system, affecting about 1 million people worldwide. Even though it has been known for over a hundred years, no cause or cure has yet been discovered-but now there is hope. New therapies have been shown to slow the disease progress in some patients, and the pace of discoveries about the cellular machinery of the brain and spinal cord has accelerated. This book presents a comprehensive overview of multiple sclerosis today, as researchers seek to understand its processes, develop therapies that will slow or halt the disease and perhaps repair damage, offer relief for specific symptoms, and improve the abilities of MS patients to function in their daily lives. The panel reviews existing knowledge and identifies key research questions, focusing on: Research strategies that have the greatest potential to understand the biological mechanisms of recovery and to translate findings into specific strategies for therapy. How people adapt to MS and the research needed to improve the lives of people with MS. Management of disease symptoms (cognitive impairment, depression, spasticity, vision problems, and others). The committee also discusses ways to build and financially support the MS research enterprise, including a look at challenges inherent in designing clinical trials. This book will be important to MS researchers, research funders, health care advocates for MS research and treatment, and interested patients and their families.
Book Synopsis Translational Research in Traumatic Brain Injury by : Daniel Laskowitz
Download or read book Translational Research in Traumatic Brain Injury written by Daniel Laskowitz and published by CRC Press. This book was released on 2015-12-01 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt: Traumatic brain injury (TBI) remains a significant source of death and permanent disability, contributing to nearly one-third of all injury related deaths in the United States and exacting a profound personal and economic toll. Despite the increased resources that have recently been brought to bear to improve our understanding of TBI, the development of new diagnostic and therapeutic approaches has been disappointingly slow. Translational Research in Traumatic Brain Injury attempts to integrate expertise from across specialties to address knowledge gaps in the field of TBI. Its chapters cover a wide scope of TBI research in five broad areas: Epidemiology Pathophysiology Diagnosis Current treatment strategies and sequelae Future therapies Specific topics discussed include the societal impact of TBI in both the civilian and military populations, neurobiology and molecular mechanisms of axonal and neuronal injury, biomarkers of traumatic brain injury and their relationship to pathology, neuroplasticity after TBI, neuroprotective and neurorestorative therapy, advanced neuroimaging of mild TBI, neurocognitive and psychiatric symptoms following mild TBI, sports-related TBI, epilepsy and PTSD following TBI, and more. The book integrates the perspectives of experts across disciplines to assist in the translation of new ideas to clinical practice and ultimately to improve the care of the brain injured patient.
Book Synopsis Rational Basis for Clinical Translation in Stroke Therapy by : Giuseppe Micieli
Download or read book Rational Basis for Clinical Translation in Stroke Therapy written by Giuseppe Micieli and published by CRC Press. This book was released on 2014-08-27 with total page 538 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stroke remains one of the major causes of death and long-term disability worldwide. Currently, the only approved therapy for the acute treatment of this disease is thrombolysis, a strategy that can only be applied to a small percentage of patients due to its narrow therapeutic window. Unfortunately, during the last years numerous promising drugs th
Book Synopsis Brain Repair After Stroke by : Steven C. Cramer
Download or read book Brain Repair After Stroke written by Steven C. Cramer and published by Cambridge University Press. This book was released on 2010-10-28 with total page 307 pages. Available in PDF, EPUB and Kindle. Book excerpt: Increasing evidence identifies the possibility of restoring function to the damaged brain via exogenous therapies. One major target for these advances is stroke, where most patients can be left with significant disability. Treatments have the potential to improve the victim's quality of life significantly and reduce the time and expense of rehabilitation. Brain Repair After Stroke reviews the biology of spontaneous brain repair after stroke in animal models and in humans. Detailed chapters cover the many forms of therapy being explored to promote brain repair and consider clinical trial issues in this context. This book provides a summary of the neurobiology of innate and treatment-induced repair mechanisms after hypoxia and reviews the state of the art for human therapeutics in relation to promoting behavioral recovery after stroke. Essential reading for stroke physicians, neurologists, rehabilitation physicians and neuropsychologists.
