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Imaging Biomarkers For Neurologic Disease
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Book Synopsis Imaging Biomarkers for Neurologic Disease by : Anas Zainul Abidin
Download or read book Imaging Biomarkers for Neurologic Disease written by Anas Zainul Abidin and published by . This book was released on 2019 with total page 152 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Neurological disorders constitute a major health as well as societal burden across the globe. The problem is further aggravated by the growth of geriatric population. Although the etiology of these disorders is fairly broad, a consistent observation is the prevalence of atypical connectivity changes occurring across brain regions, particularly if the diseases processes target synapses. Estimating this connectivity using functional neuroimaging continues to be one the most challenging methodological problems in the field of computational neuroscience. Brain connectivity, particularly in clinically oriented research applications of functional MRI (fMRI), is primarily studied through correlation analyses which while being computationally and conceptually simpler, tend to ignore the non-linear, directional and multivariate characteristics of the brain. The goal of this thesis is to tackle the limitations of existing methods for studying functional connectivity through novel techniques. The specific focus is to enhance the use of advanced connectivity beyond tautological deductions on brain organization to demonstration of their applicability in clinical scenarios. This is accomplished through (1) development and extensive validation of techniques based on dynamic systems modeling and Granger causality, (2) adaptation of graph theoretic analysis and network based techniques for appropriate statistical inference. The application of these methods is demonstrated on datasets from two neurologic diseases (a) HIV associated neurocognitive disorders, and (b) Autism spectrum disease. The results obtained lend credence to the utility of improved connectivity computation methods for detection of neurologic diseases and also the localization of its effects in the brain. These methods could be of significant interest for the development of non-invasive functional MRI derived biomarkers, which could be pertinent for various clinical applications, including early detection, monitoring progression or detecting response to therapy."--Pages xv-xvi.
Book Synopsis Neuroscience Biomarkers and Biosignatures by : Institute of Medicine
Download or read book Neuroscience Biomarkers and Biosignatures written by Institute of Medicine and published by National Academies Press. This book was released on 2008-01-08 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomarkers, or biological markers, are quantitative measurements that offer researchers and clinicians valuable insight into diagnosis, treatment and prognosis for many disorders and diseases. A major goal in neuroscience medical research is establishing biomarkers for disorders of the nervous system. Given the promising potential and necessity for neuroscience biomarkers, the Institute of Medicine Forum on Neuroscience and Nervous System Disorders convened a public workshop and released the workshop summary entitled Neuroscience Biomarkers and Biosignatures: Converging Technologies, Emerging Partnerships. The workshop brought together experts from multiple areas to discuss the most promising and practical arenas in neuroscience in which biomarkers will have the greatest impact. The main objective of the workshop was to identify and discuss biomarker targets that are not currently being aggressively pursued but that could have the greatest near-term impact on the rate at which new treatments are brought forward for psychiatric and neurological disorders.
Book Synopsis Biomarkers in Neurology by : Mohamed Mosaad Salama
Download or read book Biomarkers in Neurology written by Mohamed Mosaad Salama and published by Frontiers Media SA. This book was released on 2020-05-12 with total page 173 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Neuroscience Biomarkers and Biosignatures by : Institute of Medicine
Download or read book Neuroscience Biomarkers and Biosignatures written by Institute of Medicine and published by National Academies Press. This book was released on 2008-02-08 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomarkers, or biological markers, are quantitative measurements that offer researchers and clinicians valuable insight into diagnosis, treatment and prognosis for many disorders and diseases. A major goal in neuroscience medical research is establishing biomarkers for disorders of the nervous system. Given the promising potential and necessity for neuroscience biomarkers, the Institute of Medicine Forum on Neuroscience and Nervous System Disorders convened a public workshop and released the workshop summary entitled Neuroscience Biomarkers and Biosignatures: Converging Technologies, Emerging Partnerships. The workshop brought together experts from multiple areas to discuss the most promising and practical arenas in neuroscience in which biomarkers will have the greatest impact. The main objective of the workshop was to identify and discuss biomarker targets that are not currently being aggressively pursued but that could have the greatest near-term impact on the rate at which new treatments are brought forward for psychiatric and neurological disorders.
Download or read book Brain Imaging written by David B. Teplow and published by Academic Press. This book was released on 2019-09-01 with total page 441 pages. Available in PDF, EPUB and Kindle. Book excerpt: Brain Imaging, Volume 164, the latest release in the Progress in Molecular Biology and Translational Science series, provides informative monographs on a variety of research topics related to neuroimaging in aging and neurodegenerative disease. Topics covered in this new release include FTD spectrum, Cerebrovascular disease, HIV, Huntington’s Disease, Development of brain PET imaging agents, and Disclosure of imaging biomarker results. Includes comprehensive coverage of molecular biology Presents ample use of tables, diagrams, schemata and color figures to enhance the reader's ability to rapidly grasp the information provided Contains contributions from renowned experts in the field
Book Synopsis Cerebrospinal Fluid Biomarkers by : Charlotte E. Teunissen
Download or read book Cerebrospinal Fluid Biomarkers written by Charlotte E. Teunissen and published by Humana. This book was released on 2022-05-19 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume covers the latest methods used in clinical neurochemistry laboratories for both clinical practice and research. Chapters in this book discuss topics such as techniques for cerebrospinal fluid (CSF) collection, pre-analytical processing, and basic CSF analysis; an examination of biomarkers including ELISA and automated immunochemical assays for amyloid and tau markers for Alzheimer’s disease; the analysis of neurofilaments by digital ELISA; and an example of successful novel immunoassay development. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and thorough, Cerebrospinal Fluid Biomarkers is a valuable resource for clinicians and researchers to use in CSF labs and CSF courses.
Book Synopsis Biomarkers of Neurological and Psychiatric Disease by :
Download or read book Biomarkers of Neurological and Psychiatric Disease written by and published by Academic Press. This book was released on 2011-10-29 with total page 471 pages. Available in PDF, EPUB and Kindle. Book excerpt: Published since 1959, International Review of Neurobiology is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research. This volume reviews existing theories and current research surrounding the movement disorder Dyskinesia. Leading authors review state-of-the-art in their field of investigation and provide their views and perspectives for future research Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist
Book Synopsis Neuroimaging biomarkers in Alzheimer’s disease by : Samuel Barrack
Download or read book Neuroimaging biomarkers in Alzheimer’s disease written by Samuel Barrack and published by iMedPub. This book was released on 2013-10-20 with total page 134 pages. Available in PDF, EPUB and Kindle. Book excerpt: In view of the growing prevalence of AD worldwide, there is an urgent need for the development of better diagnostic tools and more effective therapeutic interventions. Indeed, much work in this field has been done during last decades. As such, a major goal of current clinical research in AD is to improve early detection of disease and presymptomatic detection of neuronal dysfunction, concurrently with the development of better tools to assess disease progression in this group of disorders. All these putative correlates are commonly referred to as AD-related biomarkers. The ideal biomarker should be easy to quantify and measure, reproducible, not subject to wide variation in the general population and unaffected by co- morbid factors. For evaluation of therapies, a biomarker needs to change linearly with disease progression and closely correlate with established clinico-pathological parameters of the disease. There is growing evidence that the use of biomarkers will increase our ability to better indentify the underlying biology of AD, especially in its early stages. These biomarkers will improve the detection of the patients suitable for research studies and drug trials, and they will contribute to a better management of the disease in the clinical practice. Indeed, much work in this field has been done during last decades. The vast number of important applications, combined with the untamed diversity of already identified biomarkers, show that there is a pressing need to structure the research made on AD biomarkers into a solid, comprehensive and easy to use tool to de deployed in clinical settings. To date there are few publications compiling results on this topic. That is why when I was asked to address this task I accepted inmediately. I am happy to present you a bundle of the best articles published about biomarkers for Alzheimer’s disease in recent times.
Book Synopsis Imaging Biomarkers in Epilepsy by : Andrea Bernasconi
Download or read book Imaging Biomarkers in Epilepsy written by Andrea Bernasconi and published by Cambridge University Press. This book was released on 2019-01-10 with total page 263 pages. Available in PDF, EPUB and Kindle. Book excerpt: Epilepsy is a prevalent and serious neurological disorder. This vital textbook addresses the role of neuroimaging as a unique tool to provide in vivo biomarkers aimed at furthering our understanding of causes and consequences of epilepsy in a day-to-day clinical context. Unique in its approach, this translational book presents a critical appraisal of advanced pre-clinical biomarkers that allows capturing epileptogenesis at molecular, cellular, and neuronal system levels. The book is divided into four sections. Part I includes a series of chapters focused on imaging of early disease stages. Part II discusses lesion detection and network analysis methods. Part III focuses on imaging methods used to predict response to antiepileptic drugs and surgery. Finally, Part IV presents imaging techniques used to evaluate disease consequence.
Book Synopsis Diffusion Tensor Imaging and Fractional Anisotropy by : Rahul P. Kotian
Download or read book Diffusion Tensor Imaging and Fractional Anisotropy written by Rahul P. Kotian and published by Springer Nature. This book was released on 2022-11-03 with total page 172 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book covers all aspects of one of the most advanced magnetic resonance imaging techniques, namely Diffusion Tensor Imaging (DTI) and Fractional Anisotropy (FA) values in early Parkinson’s disease (PD) patients. It provides step-by-step descriptions of DTI and its use in the early diagnosis of Parkinson’s disease by using FA values at several grey and white matter regions of the brain with helpful MRI DTI images. It includes clear flow charts with MRI DTI imaging protocol for Parkinson’s disease to aid in early diagnosis and treatment. The book covers essential information on anatomy and pathology in Parkinson’s disease and includes dedicated chapters on diffusion tensor imaging and FA in Parkinson’s disease. Additionally, it covers the role of magnetic resonance imaging in Parkinson’s disease with routine findings for Parkinson’s disease in MRI, followed by advanced imaging biomarkers and predictors in Parkinson’s disease. The book will assist the practitioners in the early detection of Parkinson’s disease using specific imaging biomarkers with the help of FA values, which will help in the early treatment of PD patients and thus extend and improve their quality of life. It will also be relevant for MD radiology, M.Sc. medical imaging technology students/trainees and Ph.D. medical imaging graduates as well as B.Sc MIT students.
Book Synopsis Advanced Biomarkers for Neurological Diseases by : Noah Benge
Download or read book Advanced Biomarkers for Neurological Diseases written by Noah Benge and published by American Medical Publishers. This book was released on 2023-09-19 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The diseases of the central or peripheral nervous system are called neurological disorders. These disorders include epilepsy, Alzheimer's disease, and other dementias. Cerebrovascular diseases such as stroke, migraine, multiple sclerosis, Parkinson's disease, etc. are also considered as neurological diseases. A biomarker or biological marker is a cell, tissue, or body fluid cell that can be measured and evaluated to indicate a pharmacological response to a normal biological process, pathogenic process, or therapeutic intervention. Biomarkers characterize the progression of the disease from the earliest natural signs of the disease. Biomarkers assess the disease susceptibility and severity enabling prediction of outcomes, deciding interventions, and assessing the therapeutic responses. Based on clinical applications, biomarkers can be categorized as molecular biomarkers, cellular biomarkers, or imaging biomarkers. This book aims to shed light on some of the unexplored aspects of biomarkers. It presents researches and studies performed by experts across the globe on the topic in detail. It attempts to assist those with a goal of furthering their studies in the field of biomarkers and biomarker development.
Book Synopsis PET and SPECT in Neurology by : Rudi A.J.O. Dierckx
Download or read book PET and SPECT in Neurology written by Rudi A.J.O. Dierckx and published by Springer. This book was released on 2014-06-02 with total page 1103 pages. Available in PDF, EPUB and Kindle. Book excerpt: PET and SPECT in Neurology highlight the combined expertise of renowned authors whose dedication to the investigation of neurological disorders through nuclear medicine technology has achieved international recognition. Classical neurodegenerative disorders are discussed as well as cerebrovascular disorders, brain tumors, epilepsy, head trauma, coma, sleeping disorders and inflammatory and infectious diseases of the CNS. The latest results in nuclear brain imaging are detailed. Most chapters are written jointly by a clinical neurologist and a nuclear medicine specialist to ensure a multidisciplinary approach. This state-of-the-art compendium will be valuable not only to neurologists and radiologists/nuclear medicine specialists but also to interested general practitioners and geriatricians. It is the second volume of a trilogy on PET and SPECT imaging in the neurosciences, the other volumes covering PET and SPECT in psychiatry and in neurobiological systems.
Book Synopsis Pathophysiologic Insights from Biomarker Studies in Neurological Disorders by : Tobias Ruck
Download or read book Pathophysiologic Insights from Biomarker Studies in Neurological Disorders written by Tobias Ruck and published by Frontiers Media SA. This book was released on 2020-04-01 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Imaging in Neurodegenerative Disorders by : Luca Saba
Download or read book Imaging in Neurodegenerative Disorders written by Luca Saba and published by OUP Oxford. This book was released on 2015-01-08 with total page 585 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diagnosing neurodegenerative diseases can prove particularly intimidating to clinicians, because many times the diagnosis cannot be critically "confirmed" by a simple test. New imaging modalities have advanced to the point of high resolution, morphological, metabolic and functional analysis. Computed tomography, magnetic resonance, nuclear medicine and molecular imaging have recently emerged as outstanding non-invasive techniques for the study of the neurodegenerative disorders. Imaging in Neurodegenerative Disorders covers all the imaging techniques and new exciting methods like new tracers, biomarker, metabolomic and gene-array profiling, potential for applying such techniques clinically, and offers present and future applications as applied to the neurodegenerative disorders with the most world renowned scientists in these fields. This book is an invaluable resource for researchers, clinicians, and trainees in neuroscience, neurology, psychiatry, and radiology.
Book Synopsis Imaging Biomarkers by : Luis Martí-Bonmatí
Download or read book Imaging Biomarkers written by Luis Martí-Bonmatí and published by Springer. This book was released on 2016-11-03 with total page 313 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first book to cover all aspects of the development of imaging biomarkers and their integration into clinical practice, from the conceptual basis through to the technical aspects that need to be considered in order to ensure that medical imaging can serve as a powerful quantification instrument capable of providing valuable information on organ and tissue properties. The process of imaging biomarker development is considered step by step, covering proof of concept, proof of mechanism, image acquisition, image preparation, imaging biomarker analysis and measurement, detection of measurement biases (proof of principle), proof of efficacy and effectiveness, and reporting of results. Sources of uncertainty in the accuracy and precision of measurements and pearls and pitfalls in gold standards and biological correlation are discussed. In addition, practical use cases are included on imaging biomarker implementation in brain, oncologic, cardiovascular, musculoskeletal, and abdominal diseases. The authors are a multidisciplinary team of expert radiologists and engineers, and the book will be of value to all with an interest in the quantitative imaging of biomarkers in personalized medicine.
Book Synopsis Identifying Neuroimaging-Based Markers for Distinguishing Brain Disorders by : Yuhui Du
Download or read book Identifying Neuroimaging-Based Markers for Distinguishing Brain Disorders written by Yuhui Du and published by Frontiers Media SA. This book was released on 2020-07-10 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: There has been increasing interests in exploring biomarkers from brain images, aiming to have a better understanding and a more effective diagnosis of brain disorders such as schizophrenia, bipolar disorder, schizoaffective disorder, autism spectrum disorder, attention-deficit/hyperactivity disorder, Alzheimer’s disease and so on. Therefore, it is important to identify disease-specific changes for distinguishing healthy controls and patients with brain disorders as well as for differentiating patients with different disorders showing similar clinical symptoms. Biomarkers can be identified from different types of brain Imaging techniques including functional magnetic resonance imaging (fMRI), structural MRI, positron emission tomography (PET), electroencephalography (EEG), and magnetoencephalography (MEG) by using statistical analysis methods. Furthermore, based on measures from brain imaging techniques, machine learning techniques can help to classify or predict disease for individual subjects. In fact, fusion of features from multiple modalities may benefit the understanding of disease mechanism and improve the classification performance. This Research Topic further explores the functional or structural alterations in brain disorders.
Book Synopsis Imaging Dementia by : Massimo Filippi
Download or read book Imaging Dementia written by Massimo Filippi and published by Springer Nature. This book was released on 2021-02-20 with total page 138 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book helps physicians select from among the currently available imaging tools, promoting the correct and cost-saving diagnosis and management of common dementias. Magnetic resonance (MR) and nuclear medicine techniques are routinely used to facilitate diagnosis, select therapies, provide information regarding the prognosis, and monitor therapy response in patients with cognitive impairment and dementia. Furthermore, the advent of quantitative MR techniques, such as diffusion-weighted imaging, perfusion imaging, etc. have opened up new opportunities to diagnose neurological diseases based on objective findings, and offer unique new insights into the main neurodegenerative diseases of the human brain. However, the practical value of various neuroimaging techniques in clinical practice has yet to be clearly defined, and their potential for future development is not yet fully appreciated. To help remedy the situation, this book offers practical and useful algorithms and rules that can be directly applied in the clinical setting. It provides concise content, together with a wealth of clinical case material.
