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Author : Debashish Pal
Publisher :
ISBN 13 :
Total Pages : 266 pages
Book Rating : 4.:/5 (233 download)
Download or read book Image Reconstruction for a High Resolution PET-insert Scanner written by Debashish Pal and published by . This book was released on 2008 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Aswin John Mathews
Publisher :
ISBN 13 :
Total Pages : 132 pages
Book Rating : 4.:/5 (98 download)
Download or read book A Four-dimensional Image Reconstruction Framework for PET Under Arbitrary Geometries written by Aswin John Mathews and published by . This book was released on 2014 with total page 132 pages. Available in PDF, EPUB and Kindle. Book excerpt: Positron Emission Tomography (PET) is a functional imaging modality with applications ranging from the treatment of cancer, studying neurological diseases and disease models. Virtual-Pinhole PET technology improves the image quality in terms of resolution and contrast recovery. The technology calls for having a detector with smaller crystals placed near a region of interest in a conventional whole-body PET scanner. The improvement is from the higher spatial sampling of the imaging area near the detector. A prototype half-ring PET insert built to study head-and-neck cancer imaging was extended to breast cancer imaging. We have built a prototype half-ring PET insert for head-and-neck cancer imaging applications. In the first half of this work, we extend the use of the insert to breast imaging and show that such a system provides high resolution images of breast and axillary lymph nodes while maintaining the full imaging field of view capability of a clinical PET scanner. We are focused on designing unconventional PET geometries for specific applications. A general purpose 4D PET reconstruction framework was created to estimate the radionuclide uptake in the subject. Quantitative estimation in PET requires precise modeling of PET physics. Data acquired in a PET scanner is well modeled as a Poisson counting process. Reconstruction given the forward model is implemented using MAP-OSEM. The framework is capable of reconstructing PET data under arbitrary position of the detector elements and different crystal sizes. A novel symmetry finding algorithm is created to reduce the system matrix size, without loss of resolution. The framework motivates investigation into different PET system geometries for different applications, as well as optimizing the design of PET systems. A generalized normalization procedure was developed to model unknown components. The programs are parallelized using OpenMP and MPI to run on small workstations as well as super-computing clusters. The performance of our reconstruction framework is presented through four novel and unconventional PET systems, each designed specifically for a different geometry. The Virtual-Pinhole half-ring system is a half-ring insert integrated into a Siemens Biograph-40, for head and neck imaging. The Flat-panel system is a modular insert system integrated into the Biograph-40, designed for breast cancer imaging. The MicroInsert II is the second generation full ring insert device, integrated into the MicroPET scanner to improve the resolution and contrast recovery of the MicroPET scanner. The Plant PET system is a PET system designed to image plants vertically, and integrated into a plant growth chamber. The improvement in speed/memory from symmetry finding is as high as a factor of 50 in some cases. Further improvements to the framework and state of the field are also discussed.
Author : Ki Sung Lee
Publisher :
ISBN 13 :
Total Pages : 258 pages
Book Rating : 4.:/5 (55 download)
Download or read book Pragmatic Image Reconstruction for High Resolution PET Scanners written by Ki Sung Lee and published by . This book was released on 2003 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Ke Li (Electrical engineer)
Publisher :
ISBN 13 :
Total Pages : 124 pages
Book Rating : 4.:/5 (13 download)
Download or read book Novel PET Systems and Image Reconstruction with Actively Controlled Geometry written by Ke Li (Electrical engineer) and published by . This book was released on 2017 with total page 124 pages. Available in PDF, EPUB and Kindle. Book excerpt: Positron Emission Tomography (PET) provides in vivo measurement of imaging ligands that are labeled with positron emitting radionuclide. Since its invention, most PET scanners have been designed to have a group of gamma ray detectors arranged in a ring geometry, accommodating the whole patient body. Virtual Pinhole PET incorporates higher resolution detectors being placed close to the Region-of-Interest (ROI) within the imaging Field-of-View (FOV) of the whole-body scanner, providing better image resolution and contrast recover. To further adapt this technology to a wider range of diseases, we proposed a second generation of virtual pinhole PET using actively controlled high resolution detectors integrated on a robotic arm. When the whole system is integrated to a commercial PET scanner, we achieved positioning repeatability within 0.5 mm. Monte Carlo simulation shows that by focusing the high-resolution detectors to a specific organ of interest, we can achieve better resolution, sensitivity and contrast recovery.In another direction, we proposed a portable, versatile and low cost PET imaging system for Point-of-Care (POC) applications. It consists of one or more movable detectors in coincidence with a detector array behind a patient. The movable detectors make it possible for the operator to control the scanning trajectory freely to achieve optimal coverage and sensitivity for patient specific imaging tasks. Since this system does not require a conventional full ring geometry, it can be built portable and low cost for bed-side or intraoperative use. We developed a proof-of-principle prototype that consists of a compact high resolution silicon photomultiplier detector mounted on a hand-held probe and a half ring of conventional detectors. The probe is attached to a MicroScribe device, which tracks the location and orientation of the probe as it moves. We also performed Monte Carlo simulations for two POC PET geometries with Time-of-Flight (TOF) capability. To support the development of such PET systems with unconventional geometries, a fully 3D image reconstruction framework has been developed for PET systems with arbitrary geometry. For POC PET and the second generation robotic Virtual Pinhole PET, new challenges emerge and our targeted applications require more efficiently image reconstruction that provides imaging results in near real time. Inspired by the previous work, we developed a list mode GPU-based image reconstruction framework with the capability to model dynamically changing geometry. Ordered-Subset MAP-EM algorithm is implemented on multi-GPU platform to achieve fast reconstruction in the order of seconds per iteration, under practical data rate. We tested this using both experimental and simulation data, for whole body PET scanner and unconventional PET scanners. Future application of adaptive imaging requires near real time performance for large statistics, which requires additional acceleration of this framework.
Author : Abass Alavi
Publisher : Elsevier Health Sciences
ISBN 13 : 0443184038
Total Pages : 137 pages
Book Rating : 4.4/5 (431 download)
Download or read book Advances in organ-specific PET instrumentation and their clinical and research applications, An Issue of PET Clinics, E-Book written by Abass Alavi and published by Elsevier Health Sciences. This book was released on 2023-11-13 with total page 137 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this issue of PET Clinics, guest editors Drs. Abass Alavi, Habib Zaidi, and Suleman Surti bring their considerable expertise to the topic of Advances in Organ-specific PET Instrumentation and Their Clinical Applications. Top experts cover key topics such as the increasing use of silicon photomultiplier (SiPM) technology, advances in depth-of-interaction (DOI) and time-of-flight (TOF) PET detectors, the use of artificial intelligence technologies for detector development; and more. Contains 11 relevant, practice-oriented topics including advances in PET detectors and readout technologies; whole-gamma imaging; clinical applications of dedicated brain PET; clinical applications of dedicated breast PET; potential clinical applications of dedicated prostate PET; and more. Provides in-depth clinical reviews on advances in organ-specific PET instrumentation and their clinical applications, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.
Author : Jerry L. Prince
Publisher : Springer Science & Business Media
ISBN 13 : 3642024971
Total Pages : 744 pages
Book Rating : 4.6/5 (42 download)
Download or read book Information Processing in Medical Imaging written by Jerry L. Prince and published by Springer Science & Business Media. This book was released on 2009-06-19 with total page 744 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book constitutes the refeered proceedings of the 21st International Conference on Information Processing in Medical Imaging, IPMI 2009, held in Williamsburg, VA, USA, in July 2009 The 26 revised full papers and 33 revised poster papers presented were carefully reviewed and selected from 150 submissions. The papers are organized in topical sections on diffusion imaging, PET imaging, image registration, functional networks, space curves, tractography, microscopy, exploratory analyses, features and detection, image guided surgery, shape analysis, motion, and segmentation and validation.
Author : Yuji Kuge
Publisher : Springer
ISBN 13 : 4431558942
Total Pages : 328 pages
Book Rating : 4.4/5 (315 download)
Download or read book Perspectives on Nuclear Medicine for Molecular Diagnosis and Integrated Therapy written by Yuji Kuge and published by Springer. This book was released on 2016-04-02 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work is devoted to understanding the recent advances in nuclear medicine and molecular imaging technologies along with their application to integrated medical therapy and future drug development. This anthology is based on the international symposium in 2015 entitled “Perspective on Nuclear Medicine for Molecular Diagnosis and Integrated Therapy. “The symposium provided an opportunity to exchange ideas on how to promote nuclear medicine technology and how to extend the technology to medical therapy and drug development, and was also a good opportunity to discuss the future perspective of nuclear medicine and molecular imaging by worldwide leaders in the field. Molecular imaging technologies have been rapidly developed worldwide in recent years. Among those developments, nuclear medicine has come to play an important role in quantitative analysis of biological process in vivo as well as in wide clinical use. With the current progress of nuclear medicine and molecular imaging, this modality has been applied for treatment monitoring and predicting its outcome with the use of optimal imaging biomarkers and suitable quantitative analysis. Truly, a new era has arrived with clinical use of nuclear medicine and molecular imaging for personalized medicine. This volume will benefit a wide variety of researchers in life science including those working in drug development, molecular imaging, and medical therapy as well as physicians who utilize diagnostic imaging.
Author : Daniel Brian Keesing
Publisher :
ISBN 13 :
Total Pages : 159 pages
Book Rating : 4.:/5 (759 download)
Download or read book Development and Implementation of Fully 3D Statistical Image Reconstruction Algorithms for Helical CT and Half-ring PET Insert System written by Daniel Brian Keesing and published by . This book was released on 2009 with total page 159 pages. Available in PDF, EPUB and Kindle. Book excerpt: X-ray computed tomography (CT) and positron emission tomography (PET) have become widely used imaging modalities for screening, diagnosis, and image-guided treatment planning. Along with the increased clinical use are increased demands for high image quality with reduced ionizing radiation dose to the patient. Despite their significantly high computational cost, statistical iterative reconstruction algorithms are known to reconstruct high-quality images from noisy tomographic datasets. The overall goal of this work is to design statistical reconstruction software for clinical x-ray CT scanners, and for a novel PET system that utilizes high-resolution detectors within the field of view of a whole-body PET scanner. The complex choices involved in the development and implementation of image reconstruction algorithms are fundamentally linked to the ways in which the data is acquired, and they require detailed knowledge of the various sources of signal degradation. Both of the imaging modalities investigated in this work have their own set of challenges. However, by utilizing an underlying statistical model for the measured data, we are able to use a common framework for this class of tomographic problems. We first present the details of a new fully 3D regularized statistical reconstruction algorithm for multislice helical CT. To reduce the computation time, the algorithm was carefully parallelized by identifying and taking advantage of the specific symmetry found in helical CT. Some basic image quality measures were evaluated using measured phantom and clinical datasets, and they indicate that our algorithm achieves comparable or superior performance over the fast analytical methods considered in this work. Next, we present our fully 3D reconstruction efforts for a high-resolution half-ring PET insert. We found that this unusual geometry requires extensive redevelopment of existing reconstruction methods in PET. We redesigned the major components of the data modeling process and incorporated them into our reconstruction algorithms. The algorithms were tested using simulated Monte Carlo data and phantom data acquired by a PET insert prototype system. Overall, we have developed new, computationally efficient methods to perform fully 3D statistical reconstructions on clinically-sized datasets.
Author : Daniele Panetta
Publisher : CRC Press
ISBN 13 : 100017588X
Total Pages : 97 pages
Book Rating : 4.0/5 (1 download)
Download or read book 3D Image Reconstruction for CT and PET written by Daniele Panetta and published by CRC Press. This book was released on 2020-10-11 with total page 97 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a practical guide to tomographic image reconstruction with projection data, with strong focus on Computed Tomography (CT) and Positron Emission Tomography (PET). Classic methods such as FBP, ART, SIRT, MLEM and OSEM are presented with modern and compact notation, with the main goal of guiding the reader from the comprehension of the mathematical background through a fast-route to real practice and computer implementation of the algorithms. Accompanied by example data sets, real ready-to-run Python toolsets and scripts and an overview the latest research in the field, this guide will be invaluable for graduate students and early-career researchers and scientists in medical physics and biomedical engineering who are beginners in the field of image reconstruction. A top-down guide from theory to practical implementation of PET and CT reconstruction methods, without sacrificing the rigor of mathematical background Accompanied by Python source code snippets, suggested exercises, and supplementary ready-to-run examples for readers to download from the CRC Press website Ideal for those willing to move their first steps on the real practice of image reconstruction, with modern scientific programming language and toolsets Daniele Panetta is a researcher at the Institute of Clinical Physiology of the Italian National Research Council (CNR-IFC) in Pisa. He earned his MSc degree in Physics in 2004 and specialisation diploma in Health Physics in 2008, both at the University of Pisa. From 2005 to 2007, he worked at the Department of Physics "E. Fermi" of the University of Pisa in the field of tomographic image reconstruction for small animal imaging micro-CT instrumentation. His current research at CNR-IFC has as its goal the identification of novel PET/CT imaging biomarkers for cardiovascular and metabolic diseases. In the field micro-CT imaging, his interests cover applications of three-dimensional morphometry of biosamples and scaffolds for regenerative medicine. He acts as reviewer for scientific journals in the field of Medical Imaging: Physics in Medicine and Biology, Medical Physics, Physica Medica, and others. Since 2012, he is adjunct professor in Medical Physics at the University of Pisa. Niccolò Camarlinghi is a researcher at the University of Pisa. He obtained his MSc in Physics in 2007 and his PhD in Applied Physics in 2012. He has been working in the field of Medical Physics since 2008 and his main research fields are medical image analysis and image reconstruction. He is involved in the development of clinical, pre-clinical PET and hadron therapy monitoring scanners. At the time of writing this book he was a lecturer at University of Pisa, teaching courses of life-sciences and medical physics laboratory. He regularly acts as a referee for the following journals: Medical Physics, Physics in Medicine and Biology, Transactions on Medical Imaging, Computers in Biology and Medicine, Physica Medica, EURASIP Journal on Image and Video Processing, Journal of Biomedical and Health Informatics.
Author : Habib Zaidi
Publisher : Elsevier Health Sciences
ISBN 13 : 032341768X
Total Pages : 129 pages
Book Rating : 4.3/5 (234 download)
Download or read book PET/MRI: Advances in Instrumentation and Quantitative Procedures, An Issue of PET Clinics, E-Book written by Habib Zaidi and published by Elsevier Health Sciences. This book was released on 2016-04-05 with total page 129 pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of PET Clinics focuses on PET/MRI: Advances in Instrumentation and Quantitative Procedures. Articles will include: Advances in clinical PET/MRI instrumentation; Magnetic resonance imaging-guided attenuation correction of positron emission tomography data in PET/MRI; Magnetic resonance imaging-guided partial volume correction of positron emission tomography data in PET/MRI; Magnetic resonance imaging-guided derivation of the input function for PET kinetic modeling; Innovations in small-animal PET/MRI instrumentation; Dual-modal PET/MRI molecular imaging probes; Magnetic resonance imaging-guided motion compensation of positron emission tomography data in PET/MRI; Attenuation correction for MR coils in combined PET/MR imaging; and more!
Author : Guillem Pratx
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (66 download)
Download or read book Image Reconstruction for High-resolution PET written by Guillem Pratx and published by . This book was released on 2009 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular imaging can interrogate subtle molecular disease signatures non-invasively in living subjects. Positron emission tomography (PET), one particular molecular imaging modality, is able to sense molecular signals deep within tissue. Although PET is well suited for imaging signals associated with cancerous lesions in humans, it is still unable to resolve very small (
Author : Brian D. Ross
Publisher : Academic Press
ISBN 13 : 0128163879
Total Pages : 1872 pages
Book Rating : 4.1/5 (281 download)
Download or read book Molecular Imaging written by Brian D. Ross and published by Academic Press. This book was released on 2021-08-03 with total page 1872 pages. Available in PDF, EPUB and Kindle. Book excerpt: The detection and measurement of the dynamic regulation and interactions of cells and proteins within the living cell are critical to the understanding of cellular biology and pathophysiology. The multidisciplinary field of molecular imaging of living subjects continues to expand with dramatic advances in chemistry, molecular biology, therapeutics, engineering, medical physics and biomedical applications. Molecular Imaging: Principles and Practice, Volumes 1 and 2, Second Edition provides the first point of entry for physicians, scientists, and practitioners. This authoritative reference book provides a comprehensible overview along with in-depth presentation of molecular imaging concepts, technologies and applications making it the foremost source for both established and new investigators, collaborators, students and anyone interested in this exciting and important field. - The most authoritative and comprehensive resource available in the molecular-imaging field, written by over 170 of the leading scientists from around the world who have evaluated and summarized the most important methods, principles, technologies and data - Concepts illustrated with over 600 color figures and molecular-imaging examples - Chapters/topics include, artificial intelligence and machine learning, use of online social media, virtual and augmented reality, optogenetics, FDA regulatory process of imaging agents and devices, emerging instrumentation, MR elastography, MR fingerprinting, operational radiation safety, multiscale imaging and uses in drug development - This edition is packed with innovative science, including theranostics, light sheet fluorescence microscopy, (LSFM), mass spectrometry imaging, combining in vitro and in vivo diagnostics, Raman imaging, along with molecular and functional imaging applications - Valuable applications of molecular imaging in pediatrics, oncology, autoimmune, cardiovascular and CNS diseases are also presented - This resource helps integrate diverse multidisciplinary concepts associated with molecular imaging to provide readers with an improved understanding of current and future applications
Author : Magdy M. Khalil
Publisher : Springer
ISBN 13 : 3319400703
Total Pages : 621 pages
Book Rating : 4.3/5 (194 download)
Download or read book Basic Science of PET Imaging written by Magdy M. Khalil and published by Springer. This book was released on 2016-11-07 with total page 621 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers a wide-ranging and up-to-date overview of the basic science underlying PET and its preclinical and clinical applications in modern medicine. In addition, it provides the reader with a sound understanding of the scientific principles and use of PET in routine practice and biomedical imaging research. The opening sections address the fundamental physics, radiation safety, CT scanning dosimetry, and dosimetry of PET radiotracers, chemistry and regulation of PET radiopharmaceuticals, with information on labeling strategies, tracer quality control, and regulation of radiopharmaceutical production in Europe and the United States. PET physics and instrumentation are then discussed, covering the basic principles of PET and PET scanning systems, hybrid PET/CT and PET/MR imaging, system calibration, acceptance testing, and quality control. Subsequent sections focus on image reconstruction, processing, and quantitation in PET and hybrid PET and on imaging artifacts and correction techniques, with particular attention to partial volume correction and motion artifacts. The book closes by examining clinical applications of PET and hybrid PET and their physiological and/or molecular basis in conjunction with technical foundations in the disciplines of oncology, cardiology and neurology, PET in pediatric malignancy and its role in radiotherapy treatment planning. Basic Science of PET Imaging will meet the needs of nuclear medicine practitioners, other radiology specialists, and trainees in these fields.
Author : Clay Houghton Holdsworth
Publisher :
ISBN 13 :
Total Pages : 574 pages
Book Rating : 4.:/5 ( download)
Download or read book Investigation of PET Image Reconstruction and Data Correction Techniques with Emphasis on an Accelerated Monte Carlo Simulation for Correction and Evaluation of PET written by Clay Houghton Holdsworth and published by . This book was released on 2002 with total page 574 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Miles N. Wernick
Publisher : Elsevier
ISBN 13 : 0080521878
Total Pages : 597 pages
Book Rating : 4.0/5 (85 download)
Download or read book Emission Tomography written by Miles N. Wernick and published by Elsevier. This book was released on 2004-12-07 with total page 597 pages. Available in PDF, EPUB and Kindle. Book excerpt: PET and SPECT are two of today's most important medical-imaging methods, providing images that reveal subtle information about physiological processes in humans and animals. Emission Tomography: The Fundamentals of PET and SPECT explains the physics and engineering principles of these important functional-imaging methods. The technology of emission tomography is covered in detail, including historical origins, scientific and mathematical foundations, imaging systems and their components, image reconstruction and analysis, simulation techniques, and clinical and laboratory applications. The book describes the state of the art of emission tomography, including all facets of conventional SPECT and PET, as well as contemporary topics such as iterative image reconstruction, small-animal imaging, and PET/CT systems. This book is intended as a textbook and reference resource for graduate students, researchers, medical physicists, biomedical engineers, and professional engineers and physicists in the medical-imaging industry. Thorough tutorials of fundamental and advanced topics are presented by dozens of the leading researchers in PET and SPECT. SPECT has long been a mainstay of clinical imaging, and PET is now one of the world's fastest growing medical imaging techniques, owing to its dramatic contributions to cancer imaging and other applications. Emission Tomography: The Fundamentals of PET and SPECT is an essential resource for understanding the technology of SPECT and PET, the most widely used forms of molecular imaging.*Contains thorough tutorial treatments, coupled with coverage of advanced topics*Three of the four holders of the prestigious Institute of Electrical and Electronics Engineers Medical Imaging Scientist Award are chapter contributors*Include color artwork
Author : Nicholas Ayache
Publisher : Springer
ISBN 13 : 3642334547
Total Pages : 689 pages
Book Rating : 4.6/5 (423 download)
Download or read book Medical Image Computing and Computer-Assisted Intervention -- MICCAI 2012 written by Nicholas Ayache and published by Springer. This book was released on 2012-09-22 with total page 689 pages. Available in PDF, EPUB and Kindle. Book excerpt: The three-volume set LNCS 7510, 7511, and 7512 constitutes the refereed proceedings of the 15th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2012, held in Nice, France, in October 2012. Based on rigorous peer reviews, the program committee carefully selected 252 revised papers from 781 submissions for presentation in three volumes. The third volume includes 79 papers organized in topical sections on diffusion imaging: from acquisition to tractography; image acquisition, segmentation and recognition; image registration; neuroimage analysis; analysis of microscopic and optical images; image segmentation; diffusion weighted imaging; computer-aided diagnosis and planning; and microscopic image analysis.
Author : Lin Fu
Publisher :
ISBN 13 : 9781124025315
Total Pages : pages
Book Rating : 4.0/5 (253 download)
Download or read book Residual Correction Algorithms for Statistical Image Reconstruction in Positron Emission Tomography written by Lin Fu and published by . This book was released on 2010 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Positron emission tomography (PET) is a radionuclide imaging modality that plays important roles in visualizing, targeting, and quantifying functional processes in vivo. High-resolution and quantitative PET images are reconstructed by solving large-scale inverse problems with iterative methods that incorporate accurate physics and noise modeling of the imaging process. The computation demands of PET image reconstruction are rapidly increasing as higher-resolution detectors, larger imaging field-of-view, and dynamic or adaptive data acquisition modes are being adopted by modern PET scanners. The trend of the increase in the computation demands is even faster than Moore's law that describes the exponential growth in the number of transistors placed on an integrated circuit. In this project a residual correction mechanism is introduced to PET image reconstruction to create computationally efficient yet accurate tomographic reconstruction algorithms. By using residual correction, reconstruction methods are able to adopt a more simplified physical model for fast computation while retaining the accuracy of the final solution. Residual correction can accelerate existing image reconstruction packages. It allows iterative reconstruction with more accurate physical models which are currently impractical due to the high computation cost. Two illustrative applications of the residual correction approach are provided. One is image reconstruction with an object-dependent Monte Carlo based physics model. The other is image reconstruction using an ultra fast GPU-accelerated simplified geometric model.
