Identification Of Biomarkers New Treatments And Vaccines For Covid 19

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Identification of Biomarkers, New Treatments, and Vaccines for COVID-19

Author : Paul C. Guest
Publisher : Springer Nature
ISBN 13 : 303071697X
Total Pages : 234 pages
Book Rating : 4.0/5 (37 download)

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Book Synopsis Identification of Biomarkers, New Treatments, and Vaccines for COVID-19 by : Paul C. Guest

Download or read book Identification of Biomarkers, New Treatments, and Vaccines for COVID-19 written by Paul C. Guest and published by Springer Nature. This book was released on 2021-07-19 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt: The novel coronavirus 2019 (COVID-19) has caused a serious global pandemic in just one year. Nearly every country and territory in the world has been affected by the virus. The virulence and infection rate of the virus are profound, and has required extreme social distancing measures across the globe in order to prevent overwhelming the healthcare services and hospitals. COVID-19 appears to have the greatest effects on elderly individuals and those who have co-morbid diseases, such as diabetes and obesity. As the cases and death rate remain high, there are justified fears of this virus remaining for several months or years to come. To address this, a rapid and unprecedented worldwide mobilization effort has begun to identify effective treatments and develop vaccines. As these begin to be deployed and administered across the globe, many now feel the virus will be brought under control and lives will eventually return to normal. This new volume will increase readers’ understanding of the ongoing COVID-19 pandemic through a series of chapters that address these concerns. Leading experts will discuss new treatment approaches, vaccine development, mental health aspects of the pandemic, and convey the results of survey studies. The book will be an excellent resource for researchers studying virology, metabolic diseases, respiratory disorders, and clinical scientists, physicians, drug companies, and healthcare services and workers.

Application of Omic Techniques to Identify New Biomarkers and Drug Targets for COVID-19

Author : Paul C. Guest
Publisher :
ISBN 13 : 9783031280146
Total Pages : 0 pages
Book Rating : 4.2/5 (81 download)

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Book Synopsis Application of Omic Techniques to Identify New Biomarkers and Drug Targets for COVID-19 by : Paul C. Guest

Download or read book Application of Omic Techniques to Identify New Biomarkers and Drug Targets for COVID-19 written by Paul C. Guest and published by . This book was released on 2023 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The COVID-19 pandemic caused by the SARS-CoV-2 virus has affected nearly every country and territory in the world. Although worldwide vaccination efforts have reduced the risk of serious disease outcomes, disparities in distribution have led to multiple waves of SARS-CoV-2 outbreaks and the emergence of variants of concern, some of which have enhanced infectivity and ability to evade existing vaccines. Hence there is an increasing interest in understanding the evolution of viruses like SARS-CoV-2, as well as improving our capacity to effectively current and manage future pandemics. This new volume reviews the most effective omic techniques for increasing our understanding of COVID-19, to improve diagnostics, prognostics, and genomic surveillance, and to facilitate development of effective treatments and vaccines. Chapters are written by an international team of experts and explore methods in the areas of genomics, transcriptomics, proteomics, and metabolomics. Techniques used to assess physiological function at the molecular level and artificial intelligence approaches used for more effective validation and translation of biomarker candidates into clinical use are also discussed. This book is an excellent resource for researchers studying biomarkers, virology, metabolic diseases, and infectious diseases, as well as clinical scientists, physicians, drug company scientists, and healthcare workers.

Application of Omic Techniques to Identify New Biomarkers and Drug Targets for COVID-19

Author : Paul C. Guest
Publisher : Springer Nature
ISBN 13 : 3031280121
Total Pages : 503 pages
Book Rating : 4.0/5 (312 download)

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Book Synopsis Application of Omic Techniques to Identify New Biomarkers and Drug Targets for COVID-19 by : Paul C. Guest

Download or read book Application of Omic Techniques to Identify New Biomarkers and Drug Targets for COVID-19 written by Paul C. Guest and published by Springer Nature. This book was released on 2023-06-28 with total page 503 pages. Available in PDF, EPUB and Kindle. Book excerpt: The COVID-19 pandemic caused by the SARS-CoV-2 virus has affected nearly every country and territory in the world. Although worldwide vaccination efforts have reduced the risk of serious disease outcomes, disparities in distribution have led to multiple waves of SARS-CoV-2 outbreaks and the emergence of variants of concern, some of which have enhanced infectivity and ability to evade existing vaccines. Hence there is an increasing interest in understanding the evolution of viruses like SARS-CoV-2, as well as improving our capacity to effectively current and manage future pandemics. This new volume reviews the most effective omic techniques for increasing our understanding of COVID-19, to improve diagnostics, prognostics, and genomic surveillance, and to facilitate development of effective treatments and vaccines. Chapters are written by an international team of experts and explore methods in the areas of genomics, transcriptomics, proteomics, and metabolomics. Techniques used to assess physiological function at the molecular level and artificial intelligence approaches used for more effective validation and translation of biomarker candidates into clinical use are also discussed. This book is an excellent resource for researchers studying biomarkers, virology, metabolic diseases, and infectious diseases, as well as clinical scientists, physicians, drug company scientists, and healthcare workers.

Multiplex Biomarker Techniques

Author : Paul C. Guest
Publisher : Springer Nature
ISBN 13 : 1071623958
Total Pages : 414 pages
Book Rating : 4.0/5 (716 download)

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Book Synopsis Multiplex Biomarker Techniques by : Paul C. Guest

Download or read book Multiplex Biomarker Techniques written by Paul C. Guest and published by Springer Nature. This book was released on 2022-07-15 with total page 414 pages. Available in PDF, EPUB and Kindle. Book excerpt: This detailed volume explores the application of multiplex biomarker methods in the critical area of COVID-19 research through state-of-the-art technologies in the fields of genomics, proteomics, transcriptomics, metabolomics, and imaging. The book features a series of protocols from labs across the globe employing multiplex molecular approaches, which can be applied to accelerate progress in the research of SARS-CoV-2 and other infectious illnesses. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and essential, Multiplex Biomarker Techniques: Methods and Applications for COVID-19 Disease Diagnosis and Risk Stratification serves as a vital resource for researchers in the areas of virology, metabolic diseases, respiratory disorders, as well as to clinical scientists, physicians, pharmacologists, and the healthcare services.

Pandemic Communication

Author : Stephen M. Croucher
Publisher : Taylor & Francis
ISBN 13 : 1000841553
Total Pages : 312 pages
Book Rating : 4.0/5 (8 download)

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Book Synopsis Pandemic Communication by : Stephen M. Croucher

Download or read book Pandemic Communication written by Stephen M. Croucher and published by Taylor & Francis. This book was released on 2023-02-28 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book details how the processes of communication are affected by the presence of a pandemic and establishes a research agenda for those effects across the broad field of communication studies. Through contributions from experts in communication subdisciplines such as crisis, organizational, interpersonal, health, intergroup, and intercultural, this book provides the reader with a comprehensive view of the emerging field of study "pandemic communication." Each chapter has four primary objectives to: (1) define critical issues for pandemic communication from its subdiscipline’s perspective, (2) examine how communication varies during pandemic(s), (3) provide examples of how pandemic(s) havefor affected communication, and (4) propose a research agenda to build pandemic communication theory. This book is suited to undergraduate or post-graduate courses or modules in communication studies across a variety of subdisciplines as well as a reference for researchers in the subject.

Sex Differences in Inflammatory Diseases

Author : Antonietta Rossi
Publisher : Frontiers Media SA
ISBN 13 : 2889767299
Total Pages : 158 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Sex Differences in Inflammatory Diseases by : Antonietta Rossi

Download or read book Sex Differences in Inflammatory Diseases written by Antonietta Rossi and published by Frontiers Media SA. This book was released on 2022-08-05 with total page 158 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Deep Learning Approaches for Early Diagnosis of Neurodegenerative Diseases

Author : Rodriguez, Raul Villamarin
Publisher : IGI Global
ISBN 13 :
Total Pages : 346 pages
Book Rating : 4.3/5 (693 download)

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Book Synopsis Deep Learning Approaches for Early Diagnosis of Neurodegenerative Diseases by : Rodriguez, Raul Villamarin

Download or read book Deep Learning Approaches for Early Diagnosis of Neurodegenerative Diseases written by Rodriguez, Raul Villamarin and published by IGI Global. This book was released on 2024-02-14 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt: Within the context of global health challenges posed by intractable neurodegenerative diseases like Alzheimer's and Parkinson's, the significance of early diagnosis is critical for effective intervention, and scientists continue to discover new methods of detection. However, actual diagnosis goes beyond detection to include a significant analysis of combined data for many cases, which presents a challenge of several complicated calculations. Deep Learning Approaches for Early Diagnosis of Neurodegenerative Diseases stands as a groundbreaking work at the intersection of artificial intelligence and neuroscience. The book orchestrates a symphony of cutting-edge techniques and progressions in early detection by assembling eminent experts from the domains of deep learning and neurology. Through a harmonious blend of research areas and pragmatic applications, this monumental work charts the transformative course to revolutionize the landscape of early diagnosis and management of neurodegenerative disorders. Within the pages, readers will embark through the intricate landscape of neurodegenerative diseases, the fundamental underpinnings of deep learning, the nuances of neuroimaging data acquisition and preprocessing, the alchemy of feature extraction and representation learning, and the symphony of deep learning models tailored for neurodegenerative disease diagnosis. The book also delves into integrating multimodal data to augment diagnosis, the imperative of rigorously evaluating and validating deep learning models, and the ethical considerations and challenges entwined with deep learning for neurodegenerative diseases.

Current Challenges in Complement Diagnostics

Author : Erik J.M. Toonen
Publisher : Frontiers Media SA
ISBN 13 : 2832540880
Total Pages : 364 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Current Challenges in Complement Diagnostics by : Erik J.M. Toonen

Download or read book Current Challenges in Complement Diagnostics written by Erik J.M. Toonen and published by Frontiers Media SA. This book was released on 2023-12-14 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt: The complement system is an important innate immune surveillance network that has a key role in protecting our bodies against pathogens and other threats. It is a highly complex system consisting of approximately 50 soluble and cell surface-bound proteins that interact to eliminate danger signals. These signals include factors such as invading microorganisms, necrotic cells, and immune complexes. Furthermore, complement can link innate and adaptive immune responses by regulating T cell and B cell responses. The complement system is tightly regulated to avoid uncontrolled activation. Dysregulation of the complement system has been linked to numerous diseases, both rare and common. Uncontrolled or exaggerated activation can lead to life-threatening conditions such as dysregulation of coagulation, fibrinolysis, systemic inflammation and shock, and possible failure of a variety of organs such as the eyes, kidneys, skin, brain, and vascular system. In recent years, the complement system has gained increased interest, especially as a promising candidate for therapeutic intervention. Eculizumab, the first approved complement inhibitor, is highly effective for treating atypical hemolytic uremic syndrome (aHUS) and paroxysmal nocturnal hemoglobinuria (PNH). Many more drug candidates are currently evaluated in ongoing clinical trials.

Emerging Technologies for Combatting Pandemics

Author : M. Rubaiyat Hossain Mondal
Publisher : CRC Press
ISBN 13 : 1000777715
Total Pages : 267 pages
Book Rating : 4.0/5 (7 download)

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Book Synopsis Emerging Technologies for Combatting Pandemics by : M. Rubaiyat Hossain Mondal

Download or read book Emerging Technologies for Combatting Pandemics written by M. Rubaiyat Hossain Mondal and published by CRC Press. This book was released on 2022-11-25 with total page 267 pages. Available in PDF, EPUB and Kindle. Book excerpt: The COVID-19 pandemic has significantly affected the healthcare sector across the globe. Artificial Intelligence (AI) and the Internet of Medical Things (IoMT) play important roles when dealing with emerging challenges. These technologies are being applied to problems involving the early detection of infections, fast contact tracing, decision-making models, risk profiling of cohorts, and remote treatment. Applying these technologies runs against challenges including interoperability, lack of unified structure for eHealth, and data privacy and security. Emerging Technologies for Combatting Pandemics: AI, IoMT, and Analytics examines multiple models and solutions for various settings including individual, home, work, and society. The world’s healthcare systems are battling the novel coronavirus, and government authorities, scientists, medical practitioners, and medical services are striving hard to surmount these challenges. This book focuses on the design and implementation of AI-based approaches in the proposed COVID-19 solutions that are enabled and supported by IoMT, sensor networks, cloud and edge computing, robotics, and analytics. It covers technologies under the umbrella of AI that include data science, big data, machine learning (ML), semantic technologies, analytics, and cyber security. Highlights of the book include: Epidemic forecasting models Surveillance and tracking systems IoMT and Internet of Healthcare Things-based integrated systems for COVID-19 Social network analysis systems Radiological image- based diagnosis systems Computational intelligence methods This reference work is beneficial for interdisciplinary students, researchers, and healthcare and technology professionals who need to know how computational intelligence could be used for surveillance, control, prevention, prediction, diagnosis, and potential treatment of the disease.

COVID-19: Integrating artificial intelligence, data science, mathematics, medicine and public health, epidemiology, neuroscience, and biomedical science in pandemic management

Download COVID-19: Integrating artificial intelligence, data science, mathematics, medicine and public health, epidemiology, neuroscience, and biomedical science in pandemic management PDF Online Free

Author : Reza Lashgari
Publisher : Frontiers Media SA
ISBN 13 : 2889766012
Total Pages : 1029 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis COVID-19: Integrating artificial intelligence, data science, mathematics, medicine and public health, epidemiology, neuroscience, and biomedical science in pandemic management by : Reza Lashgari

Download or read book COVID-19: Integrating artificial intelligence, data science, mathematics, medicine and public health, epidemiology, neuroscience, and biomedical science in pandemic management written by Reza Lashgari and published by Frontiers Media SA. This book was released on 2023-02-09 with total page 1029 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Pharmacogenomics in Drug Discovery and Development

Author : Qing Yan
Publisher : Springer Nature
ISBN 13 : 107162573X
Total Pages : 618 pages
Book Rating : 4.0/5 (716 download)

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Book Synopsis Pharmacogenomics in Drug Discovery and Development by : Qing Yan

Download or read book Pharmacogenomics in Drug Discovery and Development written by Qing Yan and published by Springer Nature. This book was released on 2022-09-06 with total page 618 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new edition offers a state-of-the-art and integrative vision of pharmacogenomics by exploring new concepts and practical methodologies focusing on disease treatments, from cancers to cardiovascular and neurodegenerative disorders and more. The collection of these theoretical and experimental approaches facilitates problem-solving by tackling the complexity of personalized drug discovery and development. Written by leading experts in their fields for the highly successful Methods in Molecular Biology series, the book aims to provide across-the-board resources to support the translation of pharmacogenomics into better individualized health care. Authoritative and up-to-date, Pharmacogenomics in Drug Discovery and Development, Third Edition aims to aid researchers in approaching the challenges in pharmacogenomics and personalized medicine with the introduction of these novel ideas and cutting-edge methodologies.

COVID-19

Author : Debmalya Barh
Publisher : CRC Press
ISBN 13 : 1000510123
Total Pages : 402 pages
Book Rating : 4.0/5 (5 download)

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Book Synopsis COVID-19 by : Debmalya Barh

Download or read book COVID-19 written by Debmalya Barh and published by CRC Press. This book was released on 2022-03-03 with total page 402 pages. Available in PDF, EPUB and Kindle. Book excerpt: The COVID-19 pandemic has affected the entire world in an unprecedented way, and this book provides an overview of the historical facts as well as ongoing approaches to tackle the COVID-19 pandemic. Experts of the respective domains provide details on anti-SARS-CoV-2 drug strategies, including repurposing drugs used for other indications and the development of novel drugs looking at different approaches to target virus entry and replication. COVID-19 vaccine development based on inactivated and attenuated live virus, protein subunit and peptide-based vaccines and utilization of vaccine candidates based on viral vectors, DNA and RNA are presented for both preclinical studies and clinical trials. Key Features Explains the background of the COVID-19 pandemic, the current progress in the development of treatments and prevention of COVID-19 including future aspects of dealing with the pandemic Serves as a timely repository of knowledge on COVID-19 for researchers and medical professionals engaged in its management

Blockchain, IoT, and AI Technologies for Supply Chain Management

Author : Priyanka Chawla
Publisher : CRC Press
ISBN 13 : 1000855074
Total Pages : 374 pages
Book Rating : 4.0/5 (8 download)

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Book Synopsis Blockchain, IoT, and AI Technologies for Supply Chain Management by : Priyanka Chawla

Download or read book Blockchain, IoT, and AI Technologies for Supply Chain Management written by Priyanka Chawla and published by CRC Press. This book was released on 2023-05-05 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt: Supply chain management, often known as SCM, refers to the extensive variety of operations that are required to plan, monitor, and coordinate the movement of a product from its raw materials to its finished state in the most time- and money-efficient manner possible. How the supply chain is managed has an impact not only on the quality of the product and the service but also on the distribution, costs, and overall customer experience. Supply chain management is a massive undertaking that needs firms to reevaluate the method in which they operate their supply chains. Blockchain, IoT, and AI Technologies for Supply Chain Management discusses the problems and difficulties that the facilitators of the supply chain confront, in addition to the possible solutions to such problems and difficulties. This book will be the only one of its kind to address the impact of COVID-19 on supply chain systems involving different stakeholders such as producers, dealers, and manufacturers and will provide a foundation for future research opportunities that will allow for the unrestricted expansion and prosperity of business. It will serve as a foundation for academics, scientists, and educationists interested in the use of modern technologies in the field of supply chain management, such as the Internet of Things (IoT), Artificial Intelligence (AI), and Blockchain. In addition to those engaged in research, undergraduate and postgraduate students in higher education can also use this publication as a reference book. This book also presents a multifaceted perspective for the general public, including topics such as computer science, the food business, hotel management, fashion, medical, inventory management, and agricultural spheres.

Data Science and Applications

Author : Satyasai Jagannath Nanda
Publisher : Springer Nature
ISBN 13 : 9819978173
Total Pages : 596 pages
Book Rating : 4.8/5 (199 download)

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Book Synopsis Data Science and Applications by : Satyasai Jagannath Nanda

Download or read book Data Science and Applications written by Satyasai Jagannath Nanda and published by Springer Nature. This book was released on 2024-01-17 with total page 596 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book gathers outstanding papers presented at the International Conference on Data Science and Applications (ICDSA 2023), organized by Soft Computing Research Society (SCRS) and Malaviya National Institute of Technology Jaipur, India, from 14 to 15 July 2023. The book is divided into four volumes, and it covers theoretical and empirical developments in various areas of big data analytics, big data technologies, decision tree learning, wireless communication, wireless sensor networking, bioinformatics and systems, artificial neural networks, deep learning, genetic algorithms, data mining, fuzzy logic, optimization algorithms, image processing, computational intelligence in civil engineering, and creative computing.

Contemporary Accounts in Drug Discovery and Development

Author : Xianhai Huang
Publisher : John Wiley & Sons
ISBN 13 : 1119627818
Total Pages : 484 pages
Book Rating : 4.1/5 (196 download)

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Book Synopsis Contemporary Accounts in Drug Discovery and Development by : Xianhai Huang

Download or read book Contemporary Accounts in Drug Discovery and Development written by Xianhai Huang and published by John Wiley & Sons. This book was released on 2022-03-11 with total page 484 pages. Available in PDF, EPUB and Kindle. Book excerpt: CONTEMPORARY ACCOUNTS IN DRUG DISCOVERY AND DEVELOPMENT A useful guide for medicinal chemists and pharmaceutical scientists Drug discovery is a lengthy and complex process that typically involves identifying an unmet medical need, determining a biological target, chemical library screening to identify a lead, chemical optimization, preclinical studies and clinical trials. This process often takes many years to complete, and relies on practitioners’ knowledge of chemistry and biology, but also—and perhaps more importantly—on experience. Improving the success rate in discovery and development through a thorough knowledge of drug discovery principles and advances in technology is critical for advancement in the field. Contemporary Accounts in Drug Discovery and Development provides drug discovery scientists with the knowledge they need to quickly gain mastery of the drug discovery process. A thorough accounting is given for each drug covered within the book, as the authors provide pharmacology, drug metabolism, biology, drug development, and clinical studies for every case, with modern drug discovery principles and technologies incorporated throughout. Contemporary Accounts in Drug Discovery and Development readers will also find Case histories used as an engaging way of learning about the drug discovery/development process Detailed biological rational and background information, drug design principles, SAR development, ADMET considerations, and clinical studies The full history of individual marketed small molecule drugs Coverage of drug candidates that have passed Phase I clinical trials with different modalities, such as antibody drug conjugates (ADC), proteolysis-targeting chimera (PROTAC), and peptide drugs The application of new technologies in drug discovery such as DNA-encoded libraries (DEL), positron emission tomography (PET), and physics-based computational modeling employing free energy perturbation (FEP) Contemporary Accounts in Drug Discovery and Development is a helpful tool for medicinal chemists, organic chemists, pharmacologists, and other scientists in drug research and process development. It may be considered essential reading for graduate courses in drug discovery, medicinal chemistry, drug synthesis, pharmaceutical science, and pharmacology. It is also a useful resource for pharmaceutical industry labs, as well as for libraries.

Mycobacteria and the Macrophage

Author : Suzie Hingley-Wilson
Publisher : Frontiers Media SA
ISBN 13 : 2832519164
Total Pages : 297 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Mycobacteria and the Macrophage by : Suzie Hingley-Wilson

Download or read book Mycobacteria and the Macrophage written by Suzie Hingley-Wilson and published by Frontiers Media SA. This book was released on 2023-12-28 with total page 297 pages. Available in PDF, EPUB and Kindle. Book excerpt: The macrophage (or “big eater”) is often considered the first cell type to encounter the causative agent of Tuberculosis (TB), Mycobacterium tuberculosis, upon entry to the lung. Once inside the macrophage the tubercle bacillus can survive and even replicate where many other invading pathogens perish. Recent research suggests the bacilli adapts within this hostile environment, treating the macrophage like a Trojan horse. Indeed, cutting-edge techniques have revealed that the degree of bacterial heterogeneity and resistance to antibiotics changes within the macrophage. M. tuberculosis spends most of its life cycle within the macrophage and has adopted specific mechanisms to survive, egress and to recruit more of this niche cell (eg the Type VII secretion system ESX-1). Understanding the host-pathogen interaction in tuberculous infection is key to understanding TB, which remains the number one cause of death from a bacterial infection. In this research topic we aim to cover advances in understanding how the tubercle bacillus adapts and survives within the host cell. Determining the responsible mechanisms may reveal novel ways to target this deadly pathogen and halt its adaptation and transformation within these potentially destructive or permissive cells.

Coronavirus Disease (COVID-19): Pathophysiology, Epidemiology, Clinical Management and Public Health Response (volume I.C)

Author : Zisis Kozlakidis
Publisher : Frontiers Media SA
ISBN 13 : 2832522319
Total Pages : 694 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Coronavirus Disease (COVID-19): Pathophysiology, Epidemiology, Clinical Management and Public Health Response (volume I.C) by : Zisis Kozlakidis

Download or read book Coronavirus Disease (COVID-19): Pathophysiology, Epidemiology, Clinical Management and Public Health Response (volume I.C) written by Zisis Kozlakidis and published by Frontiers Media SA. This book was released on 2023-04-25 with total page 694 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume I.C An outbreak of a respiratory disease first reported in Wuhan, China in December 2019 and the causative agent was discovered in January 2020 to be a novel betacoronovirus of the same subgenus as SARS-CoV and named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Coronavirus disease 2019 (COVID-19) has rapidly disseminated worldwide, with clinical manifestations ranging from mild respiratory symptoms to severe pneumonia and a fatality rate estimated around 2%. Person to person transmission is occurring both in the community and healthcare settings. The World Health Organization (WHO) has recently declared the COVID-19 epidemic a public health emergency of international concern. The ongoing outbreak presents many clinical and public health management challenges due to limited understanding of viral pathogenesis, risk factors for infection, natural history of disease including clinical presentation and outcomes, prognostic factors for severe illness, period of infectivity, modes and extent of virus inter-human transmission, as well as effective preventive measures and public health response and containment interventions. There are no antiviral treatment nor vaccine available but fast track research and development efforts including clinical therapeutic trials are ongoing across the world. Managing this serious epidemic requires the appropriate deployment of limited human resources across all cadres of health care and public health staff, including clinical, laboratory, managerial and epidemiological data analysis and risk assessment experts. It presents challenges around public communication and messaging around risk, with the potential for misinformation and disinformation. Therefore, integrated operational research and intervention, learning from experiences across different fields and settings should contribute towards better understanding and managing COVID-19. This Research Topic aims to highlight interdisciplinary research approaches deployed during the COVID-19 epidemic, addressing knowledge gaps and generating evidence for its improved management and control. It will incorporate critical, theoretically informed and empirically grounded original research contributions using diverse approaches, experimental, observational and intervention studies, conceptual framing, expert opinions and reviews from across the world. The Research Topic proposes a multi-dimensional approach to improving the management of COVID-19 with scientific contributions from all areas of virology, immunology, clinical microbiology, epidemiology, therapeutics, communications as well as infection prevention and public health risk assessment and management studies.