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Identification Et Evaluation Des Criteres De Substitution En Cancerologie Digestive
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Book Synopsis Identification et évaluation des critères de substitution en cancérologie digestive by : Nicolas Méthy
Download or read book Identification et évaluation des critères de substitution en cancérologie digestive written by Nicolas Méthy and published by . This book was released on 2010 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt: En cancérologie, le critère de jugement de référence dans les essais cliniques de phase III est la survie globale. Une longue période de suivi est parfois nécessaire à son évaluation. Le recours à un critère de substitution permet alors de réduire la durée des essais. Un critère de substitution doit permettre de prédire l’effet du traitement expérimental sur le critère clinique de référence. Deux approches statistiques sont proposées pour s’assurer de cette relation. La première consiste à estimer la proportion de l’effet traitement expliquée par le critère de substitution. La seconde, dite méta-analytique, consiste à calculer la corrélation entre les effets du traitement sur chacun des deux critères. Peu de critères de substitution sont validés en cancérologie digestive. Une enquête par questionnaires auprès de cliniciens et de méthodologistes a permis de constituer une liste ordonnée de critères candidats à de futures études de validation. Les mieux classés étaient la survie sans maladie et la survie sans progression associée on non à la qualité de vie. Dans les essais néo-adjuvants du cancer du rectum, les paramètres anatomopathologiques permettent une évaluation précoce de l’effet du traitement. Leur valeur substitutive a été évaluée dans l’essai FFCD 9203. Les analyses n’ont pas permis de valider ces paramètres comme critères de substitution de la survie globale ou du contrôle local. Des analyses poolées avec l’essai EORTC 22921 ont confirmé ces résultats. Les analyses préliminaires avec la technique méta-analytique suggèrent que la survie sans progression pourrait être substitutive de la survie globale.
Book Synopsis Safety Evaluation of Certain Contaminants in Food by : Joint FAO/WHO Expert Committee on Food Additives. Meeting
Download or read book Safety Evaluation of Certain Contaminants in Food written by Joint FAO/WHO Expert Committee on Food Additives. Meeting and published by WHO Food Additives. This book was released on 2011 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The detailed monographs in this volume summarize the technical, analytical, dietary exposure and toxicological data on a number of contaminants in food: acrylamide, arsenic, deoxydivalenol, furan, mercury and perchlorate. This volume and others in the WHO Food Additives series contain information that is useful to those who produce and use food additives and veterinary drugs and those involved with controlling contaminants in food, government and food regulatory officers, industrial testing laboratories, toxicological laboratories and universities.
Book Synopsis Parasite Diversity and Diversification by : Serge Morand
Download or read book Parasite Diversity and Diversification written by Serge Morand and published by Cambridge University Press. This book was released on 2015-02-26 with total page 503 pages. Available in PDF, EPUB and Kindle. Book excerpt: By joining phylogenetics and evolutionary ecology, this book explores the patterns of parasite diversity while revealing diversification processes.
Book Synopsis Assessing Quality of Life in Clinical Trials by : Peter M. Fayers
Download or read book Assessing Quality of Life in Clinical Trials written by Peter M. Fayers and published by . This book was released on 2005 with total page 490 pages. Available in PDF, EPUB and Kindle. Book excerpt: Researchers in all clinical fields are fully aware of the importance of Quality of Life measurements in judging the efficacy of a given treatment. Psychological criteria play an important role in this evaluation. Assessment of Quality of Life in Clinical Trials: methods and practice explores the current state of the art and illustrates the benefits and potential of health related quality of life assessment in clinical trials. It covers a wide range of analytical issues, emphasizing new and innovative approaches that are of practical and clinical importance.
Book Synopsis Coffee Biotechnology and Quality by : T. Sera
Download or read book Coffee Biotechnology and Quality written by T. Sera and published by Springer Science & Business Media. This book was released on 2013-04-17 with total page 535 pages. Available in PDF, EPUB and Kindle. Book excerpt: Coffee Biotechnology and Quality is a comprehensive volume containing 45 specialised chapters by internationally recognised experts. The book aims to provide a guide for those wishing to learn about recent advances in coffee cultivation and post-harvest technology. It provides a quantitative and rational approach to the major areas of coffee research, including breeding and cloning, tissue culture and genetics, pest control, post-harvest technology and bioconversion of coffee industry residues into commercially valuable products. The chapters review recent experimental work, allowing a conceptual framework for future research to be identified and developed. The book will be of interest to researchers and students involved in any area of coffee research. Consequently, plant breeders, microbiologists, biotechnologists and biochemical engineers will find the book to be a unique and invaluable guide.
Book Synopsis Global Burden of Disease and Risk Factors by : Alan D. Lopez
Download or read book Global Burden of Disease and Risk Factors written by Alan D. Lopez and published by World Bank Publications. This book was released on 2006-04-02 with total page 511 pages. Available in PDF, EPUB and Kindle. Book excerpt: Strategic health planning, the cornerstone of initiatives designed to achieve health improvement goals around the world, requires an understanding of the comparative burden of diseases and injuries, their corresponding risk factors and the likely effects of invervention options. The Global Burden of Disease framework, originally published in 1990, has been widely adopted as the preferred method for health accounting and has become the standard to guide the setting of health research priorities. This publication sets out an updated assessment of the situation, with an analysis of trends observed since 1990 and a chapter on the sensitivity of GBD estimates to various sources of uncertainty in methods and data.
Download or read book Lymphedema written by Byung-Boong Lee and published by Springer. This book was released on 2018-01-10 with total page 939 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of this book serves as a central source of theoretical and practical knowledge to optimize the evaluation and treatment of patients with lymphedema. The book covers all aspects of the disease from anatomical and histological features to diagnosis as well as physical/medical and surgical management of the disease. Updated from the first edition to reflect the substantial progress in diagnostics, medical care and surgical intervention for this patient population, this volume has been reorganized to meet today’s practice requirements. It addresses the challenges faced by clinicians in the management of chronic lymphedema enabling them to meet the medical needs of this large patient community. Edited by world leaders in Vascular Medicine and Surgery, this comprehensive volume provides clear, concise background and recommendations in an easy-to-use format. It is a valuable reference tool for clinical practitioners (physicians/nurse practitioners/technicians) who wish to deliver state-of-the-art health care to their patients with lymphatic and venous disorders.
Book Synopsis Core Topics in Airway Management by : Ian Calder
Download or read book Core Topics in Airway Management written by Ian Calder and published by Cambridge University Press. This book was released on 2010-12-16 with total page 331 pages. Available in PDF, EPUB and Kindle. Book excerpt: Every anaesthetist reaches the end of their career with a collection of difficult airway experiences. Managing airway challenges relies on a combination of good clinical practice, knowledge of relevant basic sciences and critical evaluation of every aspect of airway care. This new edition of Core Topics in Airway Management provides any trainee or consultant involved in airway techniques with practical, clinically relevant coverage of the core skills and knowledge required to manage airways in a wide variety of patients and clinical settings. All new procedures and equipment are reviewed, and detailed chapters advise on airway issues in a range of surgical procedures. This edition also contains a series of practical questions and answers, enabling the reader to evaluate their knowledge. Written by leading airway experts with decades of experience managing difficult airways, Core Topics in Airway Management, 2nd edition is an invaluable tool for anaesthetists, intensivists, and emergency physicians.
Book Synopsis Common Errors in English Usage by : Paul Brians
Download or read book Common Errors in English Usage written by Paul Brians and published by Franklin, Beedle & Associates, Inc.. This book was released on 2003 with total page 261 pages. Available in PDF, EPUB and Kindle. Book excerpt: Online version of Common Errors in English Usage written by Paul Brians.
Book Synopsis Outcomes Assessment in Cancer by : Joseph Lipscomb
Download or read book Outcomes Assessment in Cancer written by Joseph Lipscomb and published by Cambridge University Press. This book was released on 2011-08-18 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The U.S. National Cancer Institute established the Cancer Outcomes Measurement Working Group in 2001 to evaluate measurements of the important and diverse impacts of cancer on individuals and populations. The findings and recommendations of the working group's 35 internationally recognized members provide alternative approaches for comprehensively measuring the burden of cancer and the effectiveness of preventive and therapeutic interventions.
Book Synopsis Textbook and Guide to the Standard Nomenclature of Diseases and Operations by : Edward Theodore Thompson
Download or read book Textbook and Guide to the Standard Nomenclature of Diseases and Operations written by Edward Theodore Thompson and published by . This book was released on 1967 with total page 912 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Traditional Herbal Medicine Research Methods by : Willow J.H. Liu
Download or read book Traditional Herbal Medicine Research Methods written by Willow J.H. Liu and published by John Wiley & Sons. This book was released on 2011-03-29 with total page 393 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book introduces the methodology for collection and identification of herbal materials, extraction and isolation of compounds from herbs, in vitro bioassay, in vivo animal test, toxicology, and clinical trials of herbal research. To fully understand and make the best use of herbal medicines requires the close combination of chemistry, biochemistry, biology, pharmacology, and clinical science. Although there are many books about traditional medicines research, they mostly focus on either chemical or pharmacological study results of certain plants. This book, however, covers the systematic study and analysis of herbal medicines in general – including chemical isolation and identification, bioassay and mechanism study, pharmacological experiment, and quality control of the raw plant material and end products.
Author :Public Health Agency of Canada Publisher :Canadian Museum of Civilization/Musee Canadien Des Civilisations ISBN 13 : Total Pages :368 pages Book Rating :4.:/5 (319 download)
Book Synopsis Canadian Biosafety Standards and Guidelines for Facilities Handling Human and Terrestrial Animal Pathogens, Prions, and Biological Toxins by : Public Health Agency of Canada
Download or read book Canadian Biosafety Standards and Guidelines for Facilities Handling Human and Terrestrial Animal Pathogens, Prions, and Biological Toxins written by Public Health Agency of Canada and published by Canadian Museum of Civilization/Musee Canadien Des Civilisations. This book was released on 2013 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: This first edition of the Canadian Biosafety Standards and Guidelines (CBSG) is a harmonized national standard for the handling and storing of human and terrestrial animal pathogens and toxins in Canada. The CBSG is the result of a joint initiative undertaken by the Public Health Agency of Canada (PHAC) and the Canadian Food Inspection Agency (CFIA) to update and harmonize existing Canadian biosafety standards and guidelines. It is intended to facilitate compliance by incorporating risk-, evidence- and, where possible, performance-based biosafety and biosecurity requirements, and by streamlining the requirements for handling or storing human or terrestrial animal pathogens and toxins into a single national reference document.
Book Synopsis The obligate intracellular lifestyle by : Kenneth A. Fields
Download or read book The obligate intracellular lifestyle written by Kenneth A. Fields and published by Frontiers E-books. This book was released on 2011-08-11 with total page 121 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bacterial pathogens whose development is restricted to the interior of eukaryotic cells encounter a unique set of hurdles to be overcome to enable growth. This issue is dedicated to the examination of the unique infection biology associated with this obligate intracellular existence. Distinct approaches to obligate intracellular parasitism will be covered by considering a range of molecular, cellular, and immunological mechanisms governing the overall success of pathogens including Chlamydia, Coxiella, Rickettsia, and Ehrlichia. The overall goal is to provide insight into both microbial and host mechanisms that enable colonization of a specialized intracellular niche.Bacterial pathogens whose development is restricted to the interior of eukaryotic cells encounter a unique set of hurdles to be overcome to enable growth. This issue is dedicated to the examination of the unique infection biology associated with this obligate intracellular existence. Distinct approaches to obligate intracellular parasitism will be covered by considering a range of molecular, cellular, and immunological mechanisms governing the overall success of pathogens including Chlamydia, Coxiella, Rickettsia, and Ehrlichia. The overall goal is to provide insight into both microbial and host mechanisms that enable colonization of a specialized intracellular niche.
Book Synopsis Signaling Pathways in Squamous Cancer by : Adam B. Glick
Download or read book Signaling Pathways in Squamous Cancer written by Adam B. Glick and published by Springer Science & Business Media. This book was released on 2010-11-25 with total page 471 pages. Available in PDF, EPUB and Kindle. Book excerpt: Squamous epithelia form the lining surface of tissues in contact with the environment: the skin, oral mucosa, esophagus and respiratory tract, the genital tract, and several other specialized tissues. These tissues are at highest risk for exposure to environmental carcinogens such as UV, tobacco smoke and infectious agents. Cancers that form in squamous epithelia are among the most common human solid tumors and have high morbidity and mortality. These cancers include squamous cell carcinoma of the skin, oral cancer, head and neck and esophageal cancer, certain lung cancers and cervical cancer. We propose to organize the book so that the early chapters will focus on individual pathways and more specific mechanisms in both normal function and cancer, while the later chapters will be more integrative and include overviews of biomarkers and therapeutic development. This should increase interest for clinically oriented researchers. All authors will be encouraged to provide a balanced review in addition to highlighting their own work.
Download or read book Aridity written by Monique Mainguet and published by Springer Science & Business Media. This book was released on 2013-03-14 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: At the intersection of environmental science and human biology, this book deals with dry ecosystems, the societies so affected, and the inventiveness of those living under such conditions. It also tries to answer the question of whether long-lasting development is possible in dry environments.
Book Synopsis Basic Techniques for Observing and Studying Moths & Butterflies by : Dave Winter
Download or read book Basic Techniques for Observing and Studying Moths & Butterflies written by Dave Winter and published by . This book was released on 2000 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt:
